Selective androgen receptor modulators effect on metabolic indices and sleep duration in male rats
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Research Institute, Medical University of Plovdiv, 15A V. Aprilov Blvd., Plovdiv 4002, Bulgaria
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Abstract
Although selective androgen receptor modulators (SARMs) are not yet approved for clinical use, their anabolic potential has led to widespread usage among amateur bodybuilders seeking increased muscle mass. Given their tissue-selective anabolic and metabolic actions, SARMs may also influence physiological adaptations relevant to endurance training, such as energy metabolism and recovery. This study investigated the effects of two SARMs, ostarine and ligandrol, and their interaction with endurance training, on metabolic markers and sleep duration in healthy male rats. The study was organised in two 8-week experiments. The rats were randomised into four groups per each experiment – two undergoing treadmill training and two sedentary. In the first experiment, one sedentary and one trained group received ostarine, while in the second, one sedentary and one trained group were administered ligandrol. Control experimental groups received only vehicle. Metabolic indices and sleep were assessed using Comprehensive Laboratory Animal Monitoring System chambers. Neither SARMs nor endurance training significantly affected resting oxygen consumption, energy expenditure, respiratory exchange ratio, or food intake. However, both ostarine and ligandrol significantly prolonged sleep duration. These findings suggest that SARMs may modulate recovery-related processes such as sleep, even in the absence of major metabolic alterations. The combination of SARMs and training did not yield additional effects beyond those of SARMs alone. While non-steroidal SARMs did not alter resting metabolic indices, they significantly increased sleep duration. Endurance training, alone or combined with SARMs, did not significantly impact the studied parameters.
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Selective androgen receptor modulators effect on metabolic indices and sleep duration in male rats
In: Comparative Exercise PhysiologySearch for other papers by V. Vasilev in
Current site
Google Scholar
PubMed
Search for other papers by N. Georgiev in
Current site
Google Scholar
PubMed
Search for other papers by M. Kraeva in
Current site
Google Scholar
PubMed
Search for other papers by P. Stanchev in
Current site
Google Scholar
PubMed
Research Institute, Medical University of Plovdiv, 15A V. Aprilov Blvd., Plovdiv 4002, Bulgaria
Search for other papers by N. Boyadjiev in
Current site
Google Scholar
PubMed
Abstract
Although selective androgen receptor modulators (SARMs) are not yet approved for clinical use, their anabolic potential has led to widespread usage among amateur bodybuilders seeking increased muscle mass. Given their tissue-selective anabolic and metabolic actions, SARMs may also influence physiological adaptations relevant to endurance training, such as energy metabolism and recovery. This study investigated the effects of two SARMs, ostarine and ligandrol, and their interaction with endurance training, on metabolic markers and sleep duration in healthy male rats. The study was organised in two 8-week experiments. The rats were randomised into four groups per each experiment – two undergoing treadmill training and two sedentary. In the first experiment, one sedentary and one trained group received ostarine, while in the second, one sedentary and one trained group were administered ligandrol. Control experimental groups received only vehicle. Metabolic indices and sleep were assessed using Comprehensive Laboratory Animal Monitoring System chambers. Neither SARMs nor endurance training significantly affected resting oxygen consumption, energy expenditure, respiratory exchange ratio, or food intake. However, both ostarine and ligandrol significantly prolonged sleep duration. These findings suggest that SARMs may modulate recovery-related processes such as sleep, even in the absence of major metabolic alterations. The combination of SARMs and training did not yield additional effects beyond those of SARMs alone. While non-steroidal SARMs did not alter resting metabolic indices, they significantly increased sleep duration. Endurance training, alone or combined with SARMs, did not significantly impact the studied parameters.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 137 | 137 | 17 |
| Full Text Views | 6 | 6 | 0 |
| PDF Views & Downloads | 20 | 20 | 0 |
