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Endurance-strength training intervention program as a mediator in improving metabolic health in obesity
in Comparative Exercise PhysiologySearch for other papers by S. Sugiharto in
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Sport and Exercise Research Center, Universitas Negeri Surabaya, Surabaya, East Java 60213, Indonesia
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Abstract
A sedentary lifestyle and lack of physical exercise are key contributors to excessive adipose tissue accumulation and the increasing prevalence of obesity. This study aims to evaluate the effects of an endurance-strength training intervention on changes in adipokine and cytokine concentrations, with a focus on metabolic performance. The study involved young adult obese women as subjects. A total of 24 obese young adult women (body mass index ≥ 25 kg/m2) with normal blood glucose concentrations, blood pressure, oxygen saturation, and resting heart rate (60-80 bpm) were recruited. The participants were randomly assigned into two groups: the control group (CNR; n = 12) and the endurance-strength training group (EST; n = 12). The EST group underwent an eight-week intervention consisting of endurance training on a treadmill and strength training using fitness machines, with a frequency of five sessions per week at moderate intensity. The results revealed significant differences in the concentrations of adipsin, IL-1β, and irisin between the intervention and control groups (P ≤ 0.05) after periodes of training. Compared to pre-intervention values, adipsin and IL-1β concentrations showed a significant reduction (P ≤ 0.05), whereas irisin concentrations significantly increased (P ≤ 0.05) in EST group. These findings indicate that an eight-week endurance-strength training program may contribute to metabolic improvements and modulate specific adipokines and cytokines. However, given that only IL-1β was assessed as an inflammatory marker, the study does not provide sufficient evidence to make broad conclusions regarding inflammation. Further research involving a more comprehensive panel of metabolic and inflammatory biomarkers is needed to confirm these findings and evaluate the long-term efficacy of this intervention.
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-
Ahima, R.S. and Park, H.K., 2015. Connecting myokines and metabolism. Endocrinology and Metabolism 30: 235-245. https://doi.org/10.3803/EnM.2015.30.3.235
-
Alizadeh Pahlavani, H., 2022. Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors. Frontiers in Endocrinology 13: 811751. https://doi.org/10.3389/fendo.2022.811751
-
Best, A., 2020. Why does strength training improve endurance performance?. American Journal of Human Biology 33. https://doi.org/10.1002/ajhb.23526
-
Brellenthin, A.G., Lee, D.C., Bennie, J.A., Sui, X. and Blair, S.N., 2021. Resistance exercise, alone and in combination with aerobic exercise, and obesity in Dallas, Texas, US: a prospective cohort study. PLoS Medicine 18: e1003687. https://doi.org/10.1371/journal.pmed.1003687
-
Calcaterra, V., Vandoni, M., Rossi, V., Berardo, C., Grazi, R., Cordaro, E., Tranfaglia, V., Carnevale Pellino, V., Cereda, C. and Zuccotti, G., 2022. Use of physical activity and exercise to reduce inflammation in children and adolescents with obesity. International Journal of Environmental Research and Public Health 19: 6908. https://doi.org/10.3390/ijerph19116908
-
Cao, X. and Thyfault, J.P., 2023. Exercise drives metabolic integration between muscle, adipose and liver metabolism and protects against aging-related diseases. Experimental Gerontology 176: 112178. https://doi.org/10.1016/j.exger.2023.112178
-
Cheragh Birjandi, K., Sharafi, J., Etemadizade, A. and Ghasemi, E., 2022. Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis. Hormone Molecular BIiology and Clinical Investigation 44: 45-51. https://doi.org/10.1515/hmbci-2022-0027
-
Chou, T.J., Lin, L.Y., Lu, C.W., Hsu, Y.J., Huang, C.C. and Huang, K.C., 2024. Effects of aerobic, resistance, and high-intensity interval training on thermogenic gene expression in white adipose tissue in high fat diet induced obese mice. Obesity Research and Clinical Practice 18: 64-72. https://doi.org/10.1016/j.orcp.2024.01.003
-
Dare, A. and Chen, S.-Y., 2024. Adipsin in the pathogenesis of cardiovascular diseases. Vascular Pharmacology 154: 107270. https://doi.org/10.1016/j.vph.2023.107270
-
Del Rosso, S., Baraquet, M., Barale, A., Defagó, M., Tortosa, F., Perovic, N. and Aoki, M., 2023. Long-term effects of different exercise training modes on cytokines and adipokines in individuals with overweight/obesity and cardiometabolic diseases: a systematic review, meta-analysis, and meta-regression of randomized controlled trials. Obesity Reviews 24. https://doi.org/10.1111/obr.13564
-
Delfan, M., Behzadi, N.J., Amadeh Juybari, R., Daneshyar, S., Saeidi, A., Willems, M.E.T., Hackney, A.C., Laher, I. and Zouhal, H., 2024. Adipokine modulation in obesity: evaluating the integrative impact of chlorella vulgaris supplementation and interval resistance training in obese males. Journal of Functional Foods 119: 106315. https://doi.org/10.1016/j.jff.2024.106315
-
Ding, Y. and Xu, X., 2022. Anti-inflammatory effect of exercise training through reducing inflammasome activation-related inflammatory cytokine levels in overweight/obese populations: a systematic review and meta-analysis. Complementary Therapies in Clinical Practice 49: 101656. https://doi.org/10.1016/j.ctcp.2022.101656
-
El Sehmawy, A.A., Diab, F.E.A., Hassan, D.A., Mohammed, D.S., Gamal El Din Al Anany, M., Eldesoky, N.A. and Elamir, R.Y., 2022. Utility of adipokines and IL-10 in association with anthropometry in prediction of insulin resistance in obese children. Diabetes, Metabolic Syndrome and Obesity 15: 3231-3241. https://doi.org/10.2147/DMSO.S377072
-
Farkhondeh, T., Llorens, S., Pourbagher-Shahri, A.M., Ashrafizadeh, M., Talebi, M., Shakibaei, M. and Samarghandian, S., 2020. An overview of the role of adipokines in cardiometabolic diseases. Molecules 25: 5218. https://doi.org/10.3390/molecules25215218
-
Fasshauer, M. and Blüher, M., 2015. Adipokines in health and disease. Trends in Pharmacological Sciences 36: 461-470. https://doi.org/10.1016/j.tips.2015.04.014
-
Gastaldelli, A., Miyazaki, Y., Pettiti, M., Matsuda, M., Mahankali, S., Santini, E., DeFronzo, R.A. and Ferrannini, E., 2002. Metabolic effects of visceral fat accumulation in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism 87: 5098-5103. https://doi.org/10.1210/jc.2002-020696
-
Guilherme, A., Virbasius, J.V., Puri, V. and Czech, M.P., 2008. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nature Reviews Molecular Cell Biology 9: 367-377. https://doi.org/10.1038/nrm2391
-
Hagströmer, M., Oja, P. and Sjöström, M., 2006. The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity. Public Health Nutrition 9(6): 755-762. https://doi.org/10.1079/phn2005898
-
Headid III, R.J. and Park, S.Y., 2021. The impacts of exercise on pediatric obesity. Clinical and Experimental Pediatrics 64: 196-207. https://doi.org/10.3345/cep.2020.00997
-
Ibeas, K., Herrero, L., Mera, P. and Serra, D., 2021. Hypothalamus-skeletal muscle crosstalk during exercise and its role in metabolism modulation. Biochemical Pharmacology 190: 114640. https://doi.org/10.1016/j.bcp.2021.114640
-
Khalafi, M., Hossein Sakhaei, M., Kheradmand, S., Symonds, M.E. and Rosenkranz, S.K., 2023. The impact of exercise and dietary interventions on circulating leptin and adiponectin in individuals who are overweight and those with obesity: a systematic review and meta-analysis. Advances in Nutrition 14: 128-146. https://doi.org/10.1016/j.advnut.2022.10.001
-
Kim, S.H., Kim, S.E., Kim, S., Ahn, M.B., Cho, W.K., Cho, K.S. and Jung, M.H., 2024. The association of serum irisin with anthropometric, metabolic, and bone parameters in obese children and adolescents. Frontiers in Endocrinology 14: 1326851. https://doi.org/10.3389/fendo.2023.1326851
-
Kirichenko, T.V., Markina, Y.V., Bogatyreva, A.I., Tolstik, T.V., Varaeva, Y.R. and Starodubova, A.V., 2022. The role of adipokines in inflammatory mechanisms of obesity. International Journal of Molecular Sciences 23: 14982. https://doi.org/10.3390/ijms232314982
-
Kurşunoğlu, N.E. and Sarer Yurekli, B.P., 2022. Endocrine disruptor chemicals as obesogen and diabetogen: clinical and mechanistic evidence. World Journal of Clinical Cases 10: 11226-11239. https://doi.org/10.12998/wjcc.v10.i31.11226
-
Kwon, H. and Pessin, J.E., 2013. Adipokines mediate inflammation and insulin resistance. Frontiers in Endocrinology 4: 71. https://doi.org/10.3389/fendo.2013.00071
-
Lehr, S., Hartwig, S. and Sell, H., 2012. Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics. Clinical Applications 6: 91-101. https://doi.org/10.1002/prca.201100052
-
Liu, L., Shi, Z., Ji, X., Zhang, W., Luan, J., Zahr, T. and Qiang, L., 2022. Adipokines, adiposity, and atherosclerosis. Cellular and Molecular Life Sciences 79: 272. https://doi.org/10.1007/s00018-022-04286-2
-
Mancinelli, R., Checcaglini, F., Coscia, F., Gigliotti, P., Fulle, S. and Fanò-Illic, G., 2021. Biological aspects of selected myokines in skeletal muscle: focus on aging. International Journal of Molecular Sciences 22: 8520. https://doi.org/10.3390/ijms22168520
-
Markov, A., Hauser, L. and Chaabène, H., 2022. Effects of concurrent strength and endurance training on measures of physical fitness in healthy middle-aged and older adults: a systematic review with meta-analysis. Sports Medicine 53: 437-455. https://doi.org/10.1007/s40279-022-01764-2
-
Martinez Munoz, I.Y., Camarillo Romero, E.D.S. and Garduno Garcia, J.J., 2018. Irisin a novel metabolic biomarker: present knowledge and future directions. International Journal of Endocrinology 2018: 7816806. https://doi.org/10.1155/2018/7816806
-
Merawati, D., Sugiharto Susanto, H., Taufiq, A., Pranoto, A., Amelia, D. and Rejeki, P.S., 2023. Dynamic of irisin secretion change after moderate-intensity chronic physical exercise on obese female. Journal of Basic and Clinical Physiology and Pharmacology 34: 539-547. https://doi.org/10.1515/jbcpp-2023-0041
-
Metz, S., Huang, L.O. and Kilpeläinen, T.O., 2020. Genetic variation, adipokines, and cardiometabolic disease. Current Opinion in Pharmacology 52: 33-39. https://doi.org/10.1016/j.coph.2020.04.006
-
Mikkonen, R., Ihalainen, J., Hackney, A. and Häkkinen, K., 2023. Perspectives on concurrent strength and endurance training in healthy adult females: a systematic review. Sports Medicine 54: 673-696. https://doi.org/10.1007/s40279-023-01955-5
-
Montgomery, M.K., De Nardo, W. and Watt, M.J., 2023. Exercise training induces depot-specific remodeling of protein secretion in skeletal muscle and adipose tissue of obese male mice. American Journal of Physiology: Endocrinology and Metabolism 325: E227-E238. https://doi.org/10.1152/ajpendo.00178.2023
-
Müller, D., Izquierdo, M., Boeno, F., Aagaard, P., Teodoro, J., Grazioli, R., Radaelli, R., Bayer, H., Neske, R., Pinto, R. and Cadore, E., 2020. Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. European Journal of Applied Physiology 120: 1165-1177. https://doi.org/10.1007/s00421-020-04355-z
-
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A.J., Gojobori, T. and Isenovic, E.R., 2021. Leptin and obesity: role and clinical implication. Frontiers in Endocrinology 12: 585887. https://doi.org/10.3389/fendo.2021.585887
-
Pelczyńska, M., Miller-Kasprzak, E., Piątkowski, M., Mazurek, R., Klause, M., Suchecka, A., Bucoń, M. and Bogdański, P., 2023. The role of adipokines and myokines in the pathogenesis of different obesity phenotypes-new perspectives. Antioxidants 12: 2046. https://doi.org/10.3390/antiox12122046
-
Pestel, J., Blangero, F., Watson, J., Pirola, L. and Eljaafari, A., 2023. Adipokines in obesity and metabolic-related-diseases. Biochimie 212: 48-59. https://doi.org/10.1016/j.biochi.2023.04.008
-
Pihlainen, K., Kyröläinen, H., Santtila, M., Ojanen, T., Raitanen, J. and Häkkinen, K., 2020. Effects of combined strength and endurance training on body composition, physical fitness, and serum hormones during a 6-month crisis management operation. Journal of Strength and Conditioning Research 36: 2361-2370. https://doi.org/10.1519/JSC.0000000000003902
-
Ramos-Campo, D., Andreu-Caravaca, L., Clemente-Suárez, V. and Rubio-Arias, J., 2025. The effect of strength training on endurance performance determinants in middle- and long-distance endurance athletes: an umbrella review of systematic reviews and meta-analysis. Journal of Strength and Conditioning Research 39: 492-506. https://doi.org/10.1519/JSC.0000000000005056
-
Schleinitz, D., Böttcher, Y., Blüher, M. and Kovacs, P., 2014. The genetics of fat distribution. Diabetologia 57: 1276-1286. https://doi.org/10.1007/s00125-014-3214-z
-
Shen, S., Liao, Q., Chen, X., Peng, C. and Lin, L., 2022. The role of irisin in metabolic flexibility: beyond adipose tissue browning. Drug Discovery Today 27: 2261-2267. https://doi.org/10.1016/j.drudis.2022.03.019
-
Shi, Z., Wang, L., Luan, J., Yin, L., Ji, X., Zhang, W., Xu, B., Chen, L., He, Y., Wang, R. and Liu, L., 2022. Exercise promotes bone marrow microenvironment by inhibiting adipsin in diet-induced male obese mice. Nutrients 15: 19. https://doi.org/10.3390/nu15010019
-
Shobeiri, N. and Bendeck, M.P., 2017. Interleukin-1β is a key biomarker and mediator of inflammatory vascular calcification. Arteriosclerosis, Thrombosis, and Vascular Biology 37(2): 179-180. https://doi.org/10.1161/atvbaha.116.308724
-
Sugiharto Merawati, D., Pranoto, A. and Susanto, H., 2022. Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s. Journal of Basic and Clinical Physiology and Pharmacology 34: 61-67. https://doi.org/10.1515/jbcpp-2022-0060
-
Susanto, H., Sugiharto Taufiq, A., Pranoto, A. and Dwi Trijoyo Purnomo, J., 2023. Dynamic alteration of plasma levels of betatrophin in younger female onset obesity post acute moderate-intensity exercise training. Saudi Journal of Biological Sciences 30: 103546. https://doi.org/10.1016/j.sjbs.2022.103546
-
Tafere, G.G., Wondafrash, D.Z., Zewdie, K.A., Assefa, B.T. and Ayza, M.A., 2020. Plasma adipsin as a biomarker and its implication in type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity 13: 1855-1861. https://doi.org/10.2147/dmso.s253967
-
Taipale, R., Forssell, J., Ihalainen, J., Kyröläinen, H. and Häkkinen, K., 2020. A 10-week block of combined high-intensity endurance and strength training produced similar changes in dynamic strength, body composition, and serum hormones in women and men. Frontiers in Sports and Active Living 2. https://doi.org/10.3389/fspor.2020.581305
-
Tilg, H., Ianiro, G., Gasbarrini, A. and Adolph, T.E., 2024. Adipokines: masterminds of metabolic inflammation. Nature Reviews Immunology. Advance online publication. https://doi.org/10.1038/s41577-024-01103-8
-
Vikestad, V. and Dalen, T., 2024. Effect of strength and endurance training sequence on endurance performance. Sports 12. https://doi.org/10.3390/sports12080226
-
Wei, W., Zhang, X., Zhou, B., Ge, B., Tian, J. and Chen, J., 2022. Effects of female obesity on conception, pregnancy and the health of offspring. Frontiers in Endocrinology 13: 949228. https://doi.org/10.3389/fendo.2022.949228
-
Yano, N., Zhao, Y.T. and Zhao, T.C., 2021. The physiological role of irisin in the regulation of muscle glucose homeostasis. Endocrines 2(3): 266-283. https://doi.org/10.3390/endocrines2030025
-
Zhang, N., Zhou, H., Xu, Y., Zhang, Y., Yu, F., Gui, L., Zhang, Q. and Lu, Y., 2024. Liraglutide promotes UCP1 expression and lipolysis of adipocytes by promoting the secretion of irisin from skeletal muscle cells. Molecular and Cellular Endocrinology 588: 112225. https://doi.org/10.1016/j.mce.2024.112225
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
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Endurance-strength training intervention program as a mediator in improving metabolic health in obesity
in Comparative Exercise PhysiologySearch for other papers by S. Sugiharto in
Current site
Google Scholar
PubMed
Sport and Exercise Research Center, Universitas Negeri Surabaya, Surabaya, East Java 60213, Indonesia
Search for other papers by A. Pranoto in
Current site
Google Scholar
PubMed
Search for other papers by P.S. Rejeki in
Current site
Google Scholar
PubMed
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Current site
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PubMed
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PubMed
Search for other papers by R. Ismalasari in
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PubMed
Search for other papers by H. Susanto in
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PubMed
Search for other papers by A. Taufiq in
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PubMed
Abstract
A sedentary lifestyle and lack of physical exercise are key contributors to excessive adipose tissue accumulation and the increasing prevalence of obesity. This study aims to evaluate the effects of an endurance-strength training intervention on changes in adipokine and cytokine concentrations, with a focus on metabolic performance. The study involved young adult obese women as subjects. A total of 24 obese young adult women (body mass index ≥ 25 kg/m2) with normal blood glucose concentrations, blood pressure, oxygen saturation, and resting heart rate (60-80 bpm) were recruited. The participants were randomly assigned into two groups: the control group (CNR; n = 12) and the endurance-strength training group (EST; n = 12). The EST group underwent an eight-week intervention consisting of endurance training on a treadmill and strength training using fitness machines, with a frequency of five sessions per week at moderate intensity. The results revealed significant differences in the concentrations of adipsin, IL-1β, and irisin between the intervention and control groups (P ≤ 0.05) after periodes of training. Compared to pre-intervention values, adipsin and IL-1β concentrations showed a significant reduction (P ≤ 0.05), whereas irisin concentrations significantly increased (P ≤ 0.05) in EST group. These findings indicate that an eight-week endurance-strength training program may contribute to metabolic improvements and modulate specific adipokines and cytokines. However, given that only IL-1β was assessed as an inflammatory marker, the study does not provide sufficient evidence to make broad conclusions regarding inflammation. Further research involving a more comprehensive panel of metabolic and inflammatory biomarkers is needed to confirm these findings and evaluate the long-term efficacy of this intervention.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 279 | 279 | 13 |
| Gesamttextansichten | 6 | 6 | 2 |
| PDF-Downloads | 97 | 97 | 4 |
