The effect of endurance exercise combined with Shilajit supplementation on bone health-related factors in male Wistar rats
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Abstract
Introduction: The skeletal system represents a vital and physiologically complex structure that plays a crucial role in maintaining overall health. This study aimed to investigate the effects of endurance exercise combined with Shilajit supplementation on bone health parameters in male Wistar rats. Materials and methods: Twenty-eight adult male Wistar rats (200-250 g) were randomly divided into four groups (n = 7 per group): Control (no treatment), Shilajit supplementation (150 mg/kg/day, administered orally), Endurance exercise (treadmill running, five days/week for eight weeks), and Combined Shilajit supplementation and endurance exercise. Following the eight-week intervention and a 48-h recovery period, blood samples were collected via cardiac puncture under deep anaesthesia after an overnight fast. Serum biomarkers were analysed using ELISA. Also, the femur bones was extracted for tissue staining. Results: The results showed that a period of endurance exercise training along with the Shilajit supplementation caused a significant increase in the mean trabecular area of the femur (P = 0.001) and an increase in the level of alkaline phosphatase in the blood (P = 0.046) compared to the control group. Also, the results showed that there is no significant difference in the cortical thickness of the femur and the number of osteocytes between the different groups. Conclusion: The results of this study indicate the beneficial effects of endurance exercise and Shilajit supplementation on some bone health indicators. Therefore, combining aerobic exercise with Shilajit supplementation may be an effective strategy for improving bone health and preventing bone-related disorders.
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The effect of endurance exercise combined with Shilajit supplementation on bone health-related factors in male Wistar rats
In: Comparative Exercise PhysiologySearch for other papers by Z. Abadi in
Current site
Google Scholar
PubMed
Search for other papers by N. Shamsaei in
Current site
Google Scholar
PubMed
Search for other papers by H. Abdi in
Current site
Google Scholar
PubMed
Abstract
Introduction: The skeletal system represents a vital and physiologically complex structure that plays a crucial role in maintaining overall health. This study aimed to investigate the effects of endurance exercise combined with Shilajit supplementation on bone health parameters in male Wistar rats. Materials and methods: Twenty-eight adult male Wistar rats (200-250 g) were randomly divided into four groups (n = 7 per group): Control (no treatment), Shilajit supplementation (150 mg/kg/day, administered orally), Endurance exercise (treadmill running, five days/week for eight weeks), and Combined Shilajit supplementation and endurance exercise. Following the eight-week intervention and a 48-h recovery period, blood samples were collected via cardiac puncture under deep anaesthesia after an overnight fast. Serum biomarkers were analysed using ELISA. Also, the femur bones was extracted for tissue staining. Results: The results showed that a period of endurance exercise training along with the Shilajit supplementation caused a significant increase in the mean trabecular area of the femur (P = 0.001) and an increase in the level of alkaline phosphatase in the blood (P = 0.046) compared to the control group. Also, the results showed that there is no significant difference in the cortical thickness of the femur and the number of osteocytes between the different groups. Conclusion: The results of this study indicate the beneficial effects of endurance exercise and Shilajit supplementation on some bone health indicators. Therefore, combining aerobic exercise with Shilajit supplementation may be an effective strategy for improving bone health and preventing bone-related disorders.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 245 | 245 | 10 |
| Full Text Views | 5 | 5 | 0 |
| PDF Views & Downloads | 21 | 21 | 0 |
