The effect of high intensity interval training on asprosin and oxidative stress in the heart tissue of diabetic male rats
In: Comparative Exercise PhysiologySearch for other papers by M.R. Tabatabaei in
Current site
Google Scholar
Search for other papers by M. Nikbakht in
Current site
Google Scholar
Search for other papers by R. Ranjbar in
Current site
Google Scholar
Search for other papers by F. Daryanoosh in
Current site
Google Scholar
Search for other papers by M. Ghanbarzadeh in
Current site
Google Scholar
Abstract
The release of adipokines from adipose tissue depots plays a crucial role in regulating metabolic homeostasis and several other physiological processes in cardiovascular diseases caused by diabetes. In this study, we investigated the effect of high-intensity interval training (HIIT) on asprosin and oxidative stress of heart tissue type 2 diabetic male rats. 24 male Sprague-Dawley rats were divided into four groups: control (C), control training (CT), diabetes (D), and diabetes training (DT). Diabetes was induced by a high-fat diet and low-dose streptozotocin injection. The training group performed 8-week HIIT program on the treadmill. Two-way ANOVA was used to analyse data (
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Ahmed, B., Sultana, R. and Greene, M.W., 2021. Adipose tissue and insulin resistance in obese. Biomedicine and Pharmacotherapy 137: 111315.
-
Akbulut, T., Cinar, V., Ugur, K., Yardim, M., Karagoz, Z. and Aydin, S., 2022. Effect of regular exercise on the levels of subfatin and asprosin: a trial with different types of exercise. European Review for Medical and Pharmacological Sciences 26: 2683-2691.
-
Astorino, T.A. and Schubert, M.M., 2018. Changes in fat oxidation in response to various regimes of high intensity interval training (HIIT). European Journal of Applied Physiology 118: 51-63.
-
Ceylan, H.İ., Saygın, Ö. and Özel Türkçü, Ü., 2020. Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men. Chronobiology International 37: 1252-1268.
-
Chodari, L., Mohammadi, M., Mohaddes, G., Alipour, M.R., Ghorbanzade, V., Dariushnejad, H. and Mohammadi, S., 2016. Testosterone and voluntary exercise, alone or together increase cardiac activation of AKT and ERK1/2 in diabetic rats. Arquivos Brasileiros de Cardiologia 107: 532-541.
-
Dariushnejad, H., Mohammadi, M. and Ghorbanzadeh, V., 2018. Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats. Bratislavske Lekarske Listy 119: 757-761.
-
De Nardi, A.T., Tolves, T., Lenzi, T.L., Signori, L.U. and da Silva, A.M.V., 2018. High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: a meta-analysis. Diabetes Research and Clinical Practice 137: 149-159.
-
Feng, J., Yang, Y., Yang, Y. and Pei, H., 2018. GW29-e0080 The protective role of asprosin against diabetes in cardiomyocytes. Journal of the American College of Cardiology 72 Suppl. 16: C2.
-
Gallo, S., Vitacolonna, A., Bonzano, A., Comoglio, P. and Crepaldi, T., 2019. ERK: a key player in the pathophysiology of cardiac hypertrophy. International Journal of Molecular Sciences 20: 2164.
-
Glovaci, D., Fan, W. and Wong, N.D., 2019. Epidemiology of diabetes mellitus and cardiovascular disease. Current Cardiology Reports 21: 1-8.
-
Groener, J.B., Valkanou, A., Kender, Z., Pfeiffenberger, J., Kihm, L., Fleming, T., Nawroth, P.P. and Kopf, S., 2019. Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes. PLoS ONE 14: e0222771.
-
Hafstad, A.D., Boardman, N.T., Lund, J., Hagve, M., Khalid, A.M., Wisløff, U., Larsen, T.S. and Aasum, E., 2011. High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. Journal of Applied Physiology 111: 1235-1241.
-
Høydal, M.A., Wisløff, U., Kemi, O.J. and Ellingsen, Ø., 2007. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. European Journal of Preventive Cardiology 14: 753-760.
-
Huang, R., Song, C., Li, T., Yu, C., Yao, T., Gao, H., Cao, S., Yi, X. and Chang, B., 2022. A cross-sectional comparative study on the effects of body mass index and exercise/sedentary on serum asprosin in male college students. PLoS ONE 17: e0265645.
-
Jiménez-Maldonado, A., Garcı́a-Suárez, P.C., Renterı́a, I., Moncada-Jiménez, J. and Plaisance, E.P., 2020. Impact of high-intensity interval training and sprint interval training on peripheral markers of glycemic control in metabolic syndrome and type 2 diabetes. Biochimica et Biophysica Acta – Molecular Basis of Disease 1866: 165820.
-
Jung, T.W., Kim, H.C., Kim, H.U., Park, T., Park, J., Kim, U., Kim, M.K. and Jeong, J.H., 2019. Asprosin attenuates insulin signaling pathway through PKCδ-activated ER stress and inflammation in skeletal muscle. Journal of Cellular Physiology 234: 20888-20899.
-
Kajimura, S., 2017. Advances in the understanding of adipose tissue biology. Nature Reviews Endocrinology 13: 69-70.
-
Khan, M.A.B., Hashim, M.J., King, J.K., Govender, R.D., Mustafa, H. and Al Kaabi, J., 2020. Epidemiology of type 2 diabetes – global burden of disease and forecasted trends. Journal of Epidemiology and Global Health 10: 107-111.
-
Ko, J.R., Seo, D.Y., Kim, T.N., Park, S.H., Kwak, H.B., Ko, K.S., Rhee, B.D. and Han, J., 2019. Aerobic exercise training decreases hepatic asprosin in diabetic rats. Journal of Clinical Medicine 8: 666. https://doi.org/10.3390/jcm8050666
-
Kocaman, N. and Kuloğlu, T., 2020. Expression of asprosin in rat hepatic, renal, heart, gastric, testicular and brain tissues and its changes in a streptozotocin-induced diabetes mellitus model. Tissue and Cell 66: 101397.
-
Kyrou, I., Mattu, H., Chatha, K. and Randeva, H., 2017. Fat hormones, adipokines. In: Schisler, J.C., Lang, C.H. and Willis, M.S. (eds.) Endocrinology of the Heart in Health and Disease. Integrated, Cellular, and Molecular Endocrinology of the Heart. Academic Press, Cambridge, MA, USA, pp. 167-205.
-
Lee, T., Yun, S., Jeong, J.H. and Jung, T.W., 2019. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation. Molecular and Cellular Endocrinology 486: 96-104.
-
Li, E., Shan, H., Chen, L., Long, A., Zhang, Y., Liu, Y., Jia, L., Wei, F., Han, J. and Li, T., 2019. OLFR734 mediates glucose metabolism as a receptor of asprosin. Cell Metabolism 30: 319-328.e318.
-
Liu, J.-X., Zhu, L., Li, P.-J., Li, N. and Xu, Y.-B., 2019. Effectiveness of high-intensity interval training on glycemic control and cardiorespiratory fitness in patients with type 2 diabetes: a systematic review and meta-analysis. Aging Clinical and Experimental Research 31: 575-593.
-
Madsen, S.M., Thorup, A.C., Bjerre, M. and Jeppesen, P.B., 2015. Does 8 weeks of strenuous bicycle exercise improve diabetes-related inflammatory cytokines and free fatty acids in type 2 diabetes patients and individuals at high-risk of metabolic syndrome? Archives of Physiology and Biochemistry 121: 129-138.
-
Man, A.W., Li, H. and Xia, N., 2020. Impact of lifestyles (diet and exercise) on vascular health: oxidative stress and endothelial function. Oxidative Medicine and Cellular Longevity 2020: 1496462.
-
Moradi, N., Fouani, F.Z., Vatannejad, A., Bakhti Arani, A., Shahrzad, S. and Fadaei, R., 2021. Serum levels of Asprosin in patients diagnosed with coronary artery disease (CAD): a case-control study. Lipids in Health and Disease 20: 88.
-
Naiemian, S., Naeemipour, M., Zarei, M., Lari Najafi, M., Gohari, A., Behroozikhah, M.R., Heydari, H. and Miri, M., 2020. Serum concentration of asprosin in new-onset type 2 diabetes. Diabetology and Metabolic Syndrome 12: 65.
-
Nakhaei, H., Mogharnasi, M. and Fanaei, H., 2019. Effect of swimming training on levels of asprosin, lipid profile, glucose and insulin resistance in rats with metabolic syndrome. Obesity Medicine 15: 100111.
-
Paes, L., Lima, D., Matsuura, C., de Souza, M.d.G., Cyrino, F., Barbosa, C., Ferrão, F., Bottino, D., Bouskela, E. and Farinatti, P., 2020. Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats. PLoS ONE 15: e0218228.
-
Powers, S.K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M.P. and Hyatt, H., 2020. Exercise-induced oxidative stress: Friend or foe? Journal of Sport and Health Science 9: 415-425.
-
Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P.K., Del Solar, M., Zhu, B. and York, B., 2016. Asprosin, a fasting-induced glucogenic protein hormone. Cell 165: 566-579.
-
Scheja, L. and Heeren, J., 2019. The endocrine function of adipose tissues in health and cardiometabolic disease. Nature Reviews Endocrinology 15: 507-524.
-
Shabir, K., Brown, J.E., Afzal, I., Gharanei, S., Weickert, M.O., Barber, T.M., Kyrou, I. and Randeva, H.S., 2021. Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence. Cytokine and Growth Factor Reviews 60: 120-132.
-
Sharma, S., Bhattarai, S., Ara, H., Sun, G., St Clair, D.K., Bhuiyan, M.S., Kevil, C., Watts, M.N., Dominic, P. and Shimizu, T., 2020. SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy. Redox Biology 37: 101740.
-
Srinivasan, K., Viswanad, B., Asrat, L., Kaul, C. and Ramarao, P., 2005. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacological Research 52: 313-320.
-
Suryanegara, J., Cassidy, S., Ninkovic, V., Popovic, D., Grbovic, M., Okwose, N., Trenell, M.I., MacGowan, G.G. and Jakovljevic, D.G., 2019. High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. Acta Diabetologica 56: 321-329.
-
Thyfault, J.P. and Bergouignan, A., 2020. Exercise and metabolic health: beyond skeletal muscle. Diabetologia 63: 1464-1474.
-
Ugur, K. and Aydin, S., 2019. Saliva and blood asprosin hormone concentration associated with obesity. International Journal of Endocrinology 2019: 2521096.
-
Wang, X.-L., Wang, J.-X., Chen, J.-L., Hao, W.-Y., Xu, W.-Z., Xu, Z.-Q., Jiang, Y.-T., Luo, P.-Q., Chen, Q. and Li, Y.-H., 2022. Asprosin in the paraventricular nucleus induces sympathetic activation and pressor responses via cAMP-dependent ROS production. International Journal of Molecular Sciences 23: 12595.
-
Wen, M.-S., Wang, C.-Y., Yeh, J.-K., Chen, C.-C., Tsai, M.-L., Ho, M.-Y., Hung, K.-C. and Hsieh, I.-C., 2020. The role of asprosin in patients with dilated cardiomyopathy. BMC Cardiovascular Disorders 20: 402.
-
Wiecek, M., Szymura, J., Maciejczyk, M., Kantorowicz, M. and Szygula, Z., 2018. Acute anaerobic exercise affects the secretion of asprosin, irisin, and other cytokines – a comparison between sexes. Frontiers in Physiology 9: 423615.
-
Xu, Z., Sun, J., Tong, Q., Lin, Q., Qian, L., Park, Y. and Zheng, Y., 2016. The role of ERK1/2 in the development of diabetic cardiomyopathy. International Journal of Molecular Sciences 17: 2001.
-
Yan, Z. and Spaulding, H.R., 2020. Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise. Redox Biology 32: 101508.
-
Zhang, P., Li, T., Wu, X., Nice, E.C., Huang, C. and Zhang, Y., 2020a. Oxidative stress and diabetes: antioxidative strategies. Frontiers of Medicine 14: 583-600.
-
Zhang, X., Jiang, H., Ma, X. and Wu, H., 2020b. Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus. Journal of Diabetes Investigation 11: 349-355.
-
Zhang, Z., Tan, Y., Zhu, L., Zhang, B., Feng, P., Gao, E., Xu, C., Wang, X., Yi, W. and Sun, Y., 2019. Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway. Life Sciences 231: 116554.
-
Zhong, M., Tian, X., Sun, Q., Li, L., Lu, Y., Feng, Z., Gao, Y. and Li, S., 2023. Correlation of asprosin and Nrg-4 with type 2 diabetes mellitus complicated with coronary heart disease and the diagnostic value. BMC Endocrine Disorders 23: 61.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 496 | 87 | 20 |
| Full Text Views | 7 | 2 | 1 |
| PDF Views & Downloads | 9 | 6 | 4 |
The effect of high intensity interval training on asprosin and oxidative stress in the heart tissue of diabetic male rats
In: Comparative Exercise PhysiologySearch for other papers by M.R. Tabatabaei in
Current site
Google Scholar
PubMed
Search for other papers by M. Nikbakht in
Current site
Google Scholar
PubMed
Search for other papers by R. Ranjbar in
Current site
Google Scholar
PubMed
Search for other papers by F. Daryanoosh in
Current site
Google Scholar
PubMed
Search for other papers by M. Ghanbarzadeh in
Current site
Google Scholar
PubMed
Abstract
The release of adipokines from adipose tissue depots plays a crucial role in regulating metabolic homeostasis and several other physiological processes in cardiovascular diseases caused by diabetes. In this study, we investigated the effect of high-intensity interval training (HIIT) on asprosin and oxidative stress of heart tissue type 2 diabetic male rats. 24 male Sprague-Dawley rats were divided into four groups: control (C), control training (CT), diabetes (D), and diabetes training (DT). Diabetes was induced by a high-fat diet and low-dose streptozotocin injection. The training group performed 8-week HIIT program on the treadmill. Two-way ANOVA was used to analyse data (
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 496 | 87 | 20 |
| Full Text Views | 7 | 2 | 1 |
| PDF Views & Downloads | 9 | 6 | 4 |
