Effect of eight weeks of combined exercise and omega-3 supplementation on the levels of inflammatory and anti-inflammatory cytokines in elderly women
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Abstract
Exercise training and omega-3 supplementation are known to have anti-inflammatory effects; however, the simultaneous effect of exercise training and omega-3 supplementation has received little attention so far. The present study aimed to investigate the effect of combined training (resistance endurance) and omega-3 supplementation on the levels of inflammatory and anti-inflammatory cytokines in older women. The 40 participating older adults, with an average age of 66.7 ± 4.13 years, were randomly assigned to four groups: placebo, omega-3, training and training + omega-3. Combined exercise training (consisted of 30 mins running with 40-70% of reserve heart rate and resistance training included ten exercises, two sets, and each set consisted of 18-20 repetitions) performed for eight weeks and three sessions per week. Omega-3 supplementation was 2,000 mg daily (two 1000 mg capsules, one in the morning and one at night). Blood sampling was performed in pre and post-test (48 h after the last training session and omega-3 supplementation) stages, and interleukin (IL)-6, tumour necrosis factor (TNF)-α, and IL-10 levels were measured by ELISA. The dependent t-test results (pre- and post-test) indicated that there was a statistically significant difference (decrease) in HOMA-IR index, body fat percentage, body mass index, IL-6, and TNF-α in training and training + omega-3 groups, post-exercise (
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Alizaei Yousefabadi, H., Niyazi, A., Alaee, S., Fathi, M. and Mohammad Rahimi, G.R., 2021. Anti-inflammatory effects of exercise on metabolic syndrome patients: a systematic review and meta-analysis. Biological Research for Nursing 23: 280-292.
-
Bagavandoss, P., Kunkel, S. and Wiggins, R., 1988. Tumor necrosis factor-α (TNF-α) production and localization of macrophages and T lymphocytes in the rabbit corpus luteum. Endocrinology 122: 1185-1187.
-
Banitalebi, E., Mardanpour Shahrekordi, Z., Kazemi, A.R., Bagheri, L., Amani Shalamzari, S. and Faramarzi, M., 2016. Comparing the effects of eight weeks of combined training (endurance and resistance) in different orders on inflammatory factors and adipokines among elderly females. Women’s Health Bulletin 3: 1-10.
-
Bradding, P., Mediwake, R., Feather, I., Madden, J., Church, M., Holgate, S. and Howarth, P., 1995. TNF α is localized to nasal mucosal mast cells and is released in acute allergic rhinitis. Clinical and Experimental Allergy 25: 406-415.
-
Cadore, E.L., Izquierdo, M., Pinto, S.S., Alberton, C.L., Pinto, R.S., Baroni, B.M., Vaz, M.A., Lanferdini, F.J., Radaelli, R. and González-Izal, M., 2013. Neuromuscular adaptations to concurrent training in the elderly: effects of intrasession exercise sequence. Age 35: 891-903.
-
Charles, B.A., Doumatey, A., Huang, H., Zhou, J., Chen, G., Shriner, D., Adeyemo, A. and Rotimi, C.N., 2011. The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans. Journal of Clinical Endocrinology and Metabolism 96: E2018-E2022.
-
Conroy, S.M., Courneya, K.S., Brenner, D.R., Shaw, E., O’Reilly, R., Yasui, Y., Woolcott, C.G. and Friedenreich, C.M., 2016. Impact of aerobic exercise on levels of IL-4 and IL-10: results from two randomized intervention trials. Cancer Medicine 5: 2385-2397.
-
Conti, P., Ronconi, G., Caraffa, A., Gallenga, C., Ross, R., Frydas, I. and Kritas, S., 2020. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. Journal of Biological Regulators and Homeostatic Agents 34: 327-331.
-
Egger, J., Bretscher, P., Freigang, S., Kopf, M. and Carreira, E.M., 2013. Synthesis of epoxyisoprostanes: effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12. Angewandte Chemie International Edition 52: 5382-5385.
-
Franceschi, C., Bonafè, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E. and De Benedictis, G., 2000. Inflamm-aging: an evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences 908: 244-254.
-
Fràter-Schröder, M., Risau, W., Hallmann, R., Gautschi, P. and Böhlen, P., 1987. Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proceedings of the National Academy of Sciences of the USA 84: 5277-5281.
-
Friedenreich, C.M., O’Reilly, R., Shaw, E., Stanczyk, F.Z., Yasui, Y., Brenner, D.R. and Courneya, K.S., 2016. Inflammatory marker changes in postmenopausal women after a year-long exercise intervention comparing high versus moderate volumes exercise dose and inflammation in postmenopausal women. Cancer Prevention Research 9: 196-203.
-
Gleeson, M., Bishop, N.C., Stensel, D.J., Lindley, M.R., Mastana, S.S. and Nimmo, M.A., 2011. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Reviews Immunology 11: 607-615.
-
Greene, M.A. and Loeser, R.F., 2015. Aging-related inflammation in osteoarthritis. Osteoarthritis and Cartilage 23: 1966-1971.
-
Gremeaux, V., Gayda, M., Lepers, R., Sosner, P., Juneau, M. and Nigam, A., 2012. Exercise and longevity. Maturitas 73: 312-317.
-
Haron, N., 2023. Molecular mechanism of stevioside on TNF-a-induced insulin resistance in 3T3-L1 adipocytes by integration of metabolomics, protein and gene expression, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor, Malaysia.
-
Huang, W.-Y., Wang, J., Liu, Y.-M., Zheng, Q.-S. and Li, C.-Y., 2014. Inhibitory effect of malvidin on TNF-α-induced inflammatory response in endothelial cells. European Journal of Pharmacology 723: 67-72.
-
Ihalainen, J.K., Hackney, A. and Taipale, R., 2019. Changes in inflammation markers after a 10-week high-intensity combined strength and endurance training block in women: the effect of hormonal contraceptive use. Journal of Science and Medicine in Sport 22: 1044-1048.
-
Ilie, O., Iordan, D.-A., Codreanu, C.M., Matei, D. and Galaction, A.-I., 2021. Anti-inflammatory effects of exercise training. A systematic review. Balneo and PRM Research Journal 12: 418-425.
-
Lawless, C., Wang, C., Jurk, D., Merz, A., von Zglinicki, T. and Passos, J.F., 2010. Quantitative assessment of markers for cell senescence. Experimental Gerontology 45: 772-778.
-
Lee, J.S., Kim, C.G., Seo, T.B., Kim, H.G. and Yoon, S.J., 2015. Effects of 8-week combined training on body composition, isokinetic strength, and cardiovascular disease risk factors in older women. Aging Clinical and Experimental Research 27: 179-186.
-
Liu, Z.-G., 2005. Molecular mechanism of TNF signaling and beyond. Cell Research 15: 24.
-
Matthews, D., Hosker, J., Rudenski, A., Naylor, B., Treacher, D. and Turner, R.C., 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
-
Mogharnasi, M., Azadmanesh, M. and Mousa Zadeh, H., 2013. The effects of aerobic training and omega-3 fatty acid supplement on sICAM-1 in old males. Journal of Sport Biosciences 1: 125-138.
-
Park, S.-M., Kwak, Y.-S. and Ji, J.-G., 2015. The effects of combined exercise on health-related fitness, endotoxin, and immune function of postmenopausal women with abdominal obesity. Journal of Immunology Research 2015: 830567.
-
Pedersen, B.K., 2009. The diseasome of physical inactivity – and the role of myokines in muscle-fat cross talk. Journal of Physiology 587: 5559-5568.
-
Pedersen, B.K., 2017. Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. European Journal of Clinical Investigation 47: 600-611.
-
Rangel-Huerta, O.D., Aguilera, C.M., Mesa, M.D. and Gil, A., 2012. Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials. British Journal of Nutrition 107: S159-S170.
-
Ringleb, M., Javelle, F., Haunhorst, S., Bloch, W., Fennen, L., Baumgart, S., Drube, S., Reuken, P.A., Pletz, M.W. and Wagner, H., 2023. Acute resistance exercise-induced changes in IL-6, IL-10, and IL-1ra in healthy adults: a systematic review and meta-analysis. medRxiv: 2023.2005.2010.23289790 (unpeerreviewed preprint).
-
Rong, Y.-D., Bian, A.-L., Hu, H.-Y., Ma, Y. and Zhou, X.-Z., 2018. Study on relationship between elderly sarcopenia and inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10. BMC Geriatrics 18: 1-6.
-
Sanders, K.M., Stuart, A.L., Scott, D., Kotowicz, M.A. and Nicholson, G.C., 2015. Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial. International Journal of Endocrinology 2015: 210527.
-
Saremi, A., Shavandi, N. and Mohammadpour, K., 2015. Effects of 8 weeks aerobic training with omega-3 supplementation on inflammatory responses in type 2 diabetic patients. Payesh (Health Monitor) 14: 111-119.
-
Schroeder, E.C., Franke, W.D., Sharp, R.L. and Lee, D.-C., 2019. Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: a randomized controlled trial. PLoS ONE 14: e0210292.
-
Sillanpää, E., Laaksonen, D.E., Häkkinen, A., Karavirta, L., Jensen, B., Kraemer, W.J., Nyman, K. and Häkkinen, K., 2009. Body composition, fitness, and metabolic health during strength and endurance training and their combination in middle-aged and older women. European Journal of Applied Physiology 106: 285-296.
-
Tofighi, A. and Ghafari, G., 2013a. Effect of aerobic training with omega-3 consumption on soluble adhesion molecules in the obese women. Medical Journal of Tabriz University of Medical Sciences 36: 20-27.
-
Tofighi, A. and Ghafari, G., 2013b. Effects of regular aerobic training accompanied by omega-3 supplementation on soluble intercellular adhesion molecule-1 and lipid profiles of obese elderly women. Iranian Journal of Nutrition Sciences & Food Technology 8: 35-44.
-
Tortosa-Caparrós, E., Navas-Carrillo, D., Marı́n, F. and Orenes-Piñero, E., 2017. Anti-inflammatory effects of omega-3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome. Critical Reviews in Food Science and Nutrition 57: 3421-3429.
-
Wall, R., Ross, R.P., Fitzgerald, G.F. and Stanton, C., 2010. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutrition Reviews 68: 280-289.
-
Zhang, S.X., Liu, J., Jahanshahi, A.A., Nawaser, K., Yousefi, A., Li, J. and Sun, S., 2020. At the height of the storm: healthcare staff’s health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain, Behavior, and Immunity 87: 144-146.
-
Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A.M. and Giugliano, D., 2002. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 105: 804-809.
| All Time | Past 365 days | Past 30 Days | |
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Effect of eight weeks of combined exercise and omega-3 supplementation on the levels of inflammatory and anti-inflammatory cytokines in elderly women
In: Comparative Exercise PhysiologySearch for other papers by V. Sobhani in
Current site
Google Scholar
PubMed
Search for other papers by R. Shakibaei in
Current site
Google Scholar
PubMed
Search for other papers by M. Gholami in
Current site
Google Scholar
PubMed
Search for other papers by E. Arabzadeh in
Current site
Google Scholar
PubMed
Abstract
Exercise training and omega-3 supplementation are known to have anti-inflammatory effects; however, the simultaneous effect of exercise training and omega-3 supplementation has received little attention so far. The present study aimed to investigate the effect of combined training (resistance endurance) and omega-3 supplementation on the levels of inflammatory and anti-inflammatory cytokines in older women. The 40 participating older adults, with an average age of 66.7 ± 4.13 years, were randomly assigned to four groups: placebo, omega-3, training and training + omega-3. Combined exercise training (consisted of 30 mins running with 40-70% of reserve heart rate and resistance training included ten exercises, two sets, and each set consisted of 18-20 repetitions) performed for eight weeks and three sessions per week. Omega-3 supplementation was 2,000 mg daily (two 1000 mg capsules, one in the morning and one at night). Blood sampling was performed in pre and post-test (48 h after the last training session and omega-3 supplementation) stages, and interleukin (IL)-6, tumour necrosis factor (TNF)-α, and IL-10 levels were measured by ELISA. The dependent t-test results (pre- and post-test) indicated that there was a statistically significant difference (decrease) in HOMA-IR index, body fat percentage, body mass index, IL-6, and TNF-α in training and training + omega-3 groups, post-exercise (
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 850 | 210 | 5 |
| Full Text Views | 21 | 7 | 0 |
| PDF Views & Downloads | 44 | 14 | 0 |
