Impact of ginger supplementation on serum PGE2, COX2, and IL-6 in response to exhaustive exercise in female taekwondo athletes
In: Comparative Exercise PhysiologySearch for other papers by S.Z. Karizak in
Current site
Google Scholar
Search for other papers by M. Shahnehzad in
Current site
Google Scholar
Search for other papers by A. Zar in
Current site
Google Scholar
Abstract
Inflammation and muscle soreness sometimes occur after high-intensity exercise in some athletes. This study aimed to determine the effect of a ginger supplement period on serum cyclooxygenase-2 (COX2), prostaglandin E2 (PGE2), and interleukin (IL)-6 in response to exhaustive exercise in female taekwondo athletes. In this semi-experimental study, 24 semi-professional female taekwondo athletes (mean age 19.75 ± 2.03 years, height 160 ± 6 cm, weight 53.99 ± 7.49 kg) were selected voluntarily. Subjects were randomly assigned to the ginger supplement + exhaustive (GE + EE) and exhaustive exercise (EE) groups. 24 doses of 2,000 mg of pure ginger supplement (3 days/week for 8 weeks) were taken in the morning and evening (4 capsules of 500 mg: 2 in the morning and 2 in the evening). Then Bruce’s test was performed as an exhaustive exercise. Blood samples were collected in two stages before and after the intervention, and serum levels of COX2, PGE2, and IL-6 were measured using the Elisa method. T-tests and analysis of variance with repeated measures were used to examine intra-group changes and compare between groups from pre-test to post-test using SPSS version 25 software. The results showed a significant increase in the level of serum COX2 (
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Adelizzi, R.A., 1999. COX-1 and COX-2 in health and disease. Journal of Osteopathic Medicine 99(Suppl): S7-S12.
-
Allen, J., Sun, Y. and Woods, J.A., 2015. Exercise and the regulation of inflammatory responses. In: Bouchard, C. (ed.) Progress in molecular biology and translational science. Academic Press, Cambridge, MA, USA, pp. 337-354.
-
Arcusa, R., Villaño, D., Marhuenda, J., Cano, M., Cerdà, B. and Zafrilla, P., 2022. Potential role of ginger (Zingiber officinale Roscoe) in the prevention of neurodegenerative diseases. Frontiers in Nutrition 9: 809621.
-
Azeez, T.B. and Lunghar, J., 2021. Antiinflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale). Inflammation and Natural Products 2021: 127-146).
-
Black, C.D. and O’Connor, P.J., 2008. Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. International Journal of Sports Nutrition and Exercise Metabolism 18: 653-664.
-
Black, C.D. and O’Connor, P.J., 2010. Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytotherapy Research 24: 1620-1626.
-
Black, C.D., Herring, M.P., Hurley, D.J. and O’Connor, P.J., 2010. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. Journal of Pain 11: 894-903.
-
Heavens, K.R., Szivak, T.K., Hooper, D.R., Dunn-Lewis, C., Comstock, B.A., Flanagan, S.D. and Kraemer, W.J., 2014. The effects of high-intensity short rest resistance exercise on muscle damage markers in men and women. Journal of Strength and Conditioning Research 28: 1041-1049.
-
Hoseinzadeh, K., Daryanoosh, F., Baghdasar, P.J. and Alizadeh, H., 2015. Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness. Medical Journal of the Islamic Republic of Iran 29: 261.
-
Jalali, M., Mahmoodi, M., Moosavian, S.P., Jalali, R., Ferns, G., Mosallanezhad, A. and Mosallanezhad, Z., 2020. The effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta-analysis of clinical trials. Phytotherapy Research 34: 1723-1733.
-
Kashef, A., Zare Karizak, S., Sadeghi Nikoo, A. and Kashef, M., 2021. Effect of single session of high-intensity interval exercise on some immune and inflammatory factors in male athletes and the risk of infection to coronavirus. Journal of Shahid Sadoughi University of Medical Sciences 28: 3326-3337.
-
Kazemi, F. and Khani Sanij, E., 2019. Response of pro-inflammatory cytokines, IL-6 and IL-8 to short-term supplementation with ginger and acute exhaustive exercise in male athletes. Research in Medicine 43: 222-227.
-
Li, C., Li, J., Jiang, F., Tzvetkov, N.T., Horbanczuk, J.O., Li, Y. and Wang, D., 2021. Vasculoprotective effects of ginger (Zingiber officinale Roscoe) and underlying molecular mechanisms. Food and Function 12: 1897-1913.
-
Liu, S.Z., Jemiolo, B., Lavin, K.M., Lester, B.E., Trappe, S.W. and Trappe, T.A., 2016. Prostaglandin E2/cyclooxygenase pathway in human skeletal muscle: influence of muscle fiber type and age. Journal of Applied Physiology 120: 546-551.
-
Mao, Q.Q., Xu, X.Y., Cao, S.Y., Gan, R.Y., Corke, H., Beta, T. and Li, H.B., 2019. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods 8: 185.
-
Mashhadi, N.S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L. and Mofid, M.R., 2013. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. International Journal of Preventive Medicine 4(Suppl. 1): S36.
-
Mbaveng, A.T. and Kuete, V., 2017. Syzygium aromaticum. In: Kuete, V. (ed.) Medicinal spices and vegetables from Africa – therapeutic potential against metabolic, inflammatory, infectious and systemic diseases. Elsevier, Amsterdam, the Netherlands, pp. 611-625.
-
Morvaridzadeh, M., Fazelian, S., Agah, S., Khazdouz, M., Rahimlou, M., Agh, F. and Heshmati, J., 2020. Effect of ginger (Zingiber officinale) on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Cytokine 135: 155224.
-
Rondanelli, M., Fossari, F., Vecchio, V., Gasparri, C., Peroni, G. and Spadaccini, D., 2020. Clinical trials on pain lowering effect of ginger: a narrative review. Phytotherapy Research 34: 2843-2856.
-
SalimiSafar, Z., 2021. Effect of 8 weeks HIIT with ginger supplementation on LDH, CK, IL-6, PGE2 in young female taekwondo athletes. MSc thesis in Shahid Rajaee University of Tehran, Iran.
-
Sathi, A.S., 2022. An overview of chemical constituents and biological activities of Zingiber officinale. International Journal of Herbal Medicine 10: 14-19.
-
Van Breemen, R.B., Tao, Y. and Li, W., 2011. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia 82: 38-43.
-
Wei, C.K., Tsai, Y.H., Korinek, M., Hung, P.H., El-Shazly, M., Cheng, Y.B. and Chang, F.R., 2017. 6-paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet-fed mice. International Journal of Molecular Sciences 18: 168.
-
Wilson, P.B., 2015. Ginger (Zingiber officinale) as an analgesic and ergogenic aid in sport: a systemic review. Journal of Strength and Conditioning Research 29: 2980-2995.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 900 | 197 | 37 |
| Full Text Views | 25 | 2 | 2 |
| PDF Views & Downloads | 58 | 5 | 5 |
Impact of ginger supplementation on serum PGE2, COX2, and IL-6 in response to exhaustive exercise in female taekwondo athletes
In: Comparative Exercise PhysiologySearch for other papers by S.Z. Karizak in
Current site
Google Scholar
PubMed
Search for other papers by M. Shahnehzad in
Current site
Google Scholar
PubMed
Search for other papers by A. Zar in
Current site
Google Scholar
PubMed
Abstract
Inflammation and muscle soreness sometimes occur after high-intensity exercise in some athletes. This study aimed to determine the effect of a ginger supplement period on serum cyclooxygenase-2 (COX2), prostaglandin E2 (PGE2), and interleukin (IL)-6 in response to exhaustive exercise in female taekwondo athletes. In this semi-experimental study, 24 semi-professional female taekwondo athletes (mean age 19.75 ± 2.03 years, height 160 ± 6 cm, weight 53.99 ± 7.49 kg) were selected voluntarily. Subjects were randomly assigned to the ginger supplement + exhaustive (GE + EE) and exhaustive exercise (EE) groups. 24 doses of 2,000 mg of pure ginger supplement (3 days/week for 8 weeks) were taken in the morning and evening (4 capsules of 500 mg: 2 in the morning and 2 in the evening). Then Bruce’s test was performed as an exhaustive exercise. Blood samples were collected in two stages before and after the intervention, and serum levels of COX2, PGE2, and IL-6 were measured using the Elisa method. T-tests and analysis of variance with repeated measures were used to examine intra-group changes and compare between groups from pre-test to post-test using SPSS version 25 software. The results showed a significant increase in the level of serum COX2 (
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 900 | 197 | 37 |
| Full Text Views | 25 | 2 | 2 |
| PDF Views & Downloads | 58 | 5 | 5 |
