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The impact of high-intensity interval training and alternate-day fasting on glucose metabolism in rats on a high-fat diet

In: Comparative Exercise Physiology
Authors:
H. Banitalebi Shahed University, Department of Exercise Physiology, Tehran, Iran

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E. Nasiri Shahed University, Faculty of Humanities, Department of Physical Education and Sport Sciences, Tehran, Iran

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B. Bazgir Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

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B. Abbasi Shahed University, Department of Exercise Physiology, Tehran, Iran

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A. Samadi Shahed University, Faculty of Humanities, Department of Physical Education and Sport Sciences, Tehran, Iran

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Abstract

The effect of lifestyle modifications in the form of exercise training and fasting intervention on glucose metabolism in subjects on a high-fat diet is not completely understood. The present study aimed to examine the effects of alternate-day fasting (ADF) and high-intensity interval training (HIIT) on serum levels of C-peptide, fructosamine, and glucose in rats under a high-fat diet. Twenty-eight male Wistar rats were initially fed a high-fat diet for 12 weeks, then randomised into the following four groups: HIIT, ADF, HIIT + ADF, and control (CON). The HIIT and ADF interventions were conducted 3 days per week for 6 weeks. The HIIT induced a significant reduction in serum fructosamine levels compared to other groups ( P < 0.05), as well as there was a significant reduction in serum glucose levels compared to the ADF and HIIT + ADF groups ( P < 0.05). ADF and HIIT + ADF did not cause any significant changes in fructosamine, glucose, and C-peptide serum levels compared to the CON group ( P > 0.05). In subjects under a high-fat diet, HIIT but not ADF or HIIT + ADF may be associated with favourable improvements in glucose metabolism markers.

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