Here, we aimed to explore the therapeutic effect of voluntary wheel running (VWR) in high-fat diet-fed rats on pulmonary tissue injury via the modulation of autophagic response. Thirty-two rats were allocated into four groups; normal diet (Control); VWR; high-fat-diet (HFD), and HFD + VWR. After three months, pathological effect of HFD on pulmonary tissue was investigated. The levels of tumour necrosis factor (TNF)-α were detected in the bronchoalveolar lavage fluid (BALF). We monitored the expression of interleukin (IL)-6 and autophagy-related genes in lung tissues. H&E staining showed pathological changes in HFD group coincided with the increase of TNF-α levels in the bronchoalveolar fluid compared to the normal rats. Our results showed the up-regulation of IL-6, becline-1, LC3 and P62 in the HFD group compared to the Control group. VWR inhibited HFD-induced changes and could decrease HFD-induced changes via the regulation of autophagy status.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
Ahmadi, M., Rahbarghazi, R. and Shahbazfar, A.-A., 2018. Monitoring IL-13 expression in relation to miRNA-155 and miRNA-133 changes following intra-tracheal administration of mesenchymal stem cells and conditioned media in ovalbumin sensitized rats. Thai Journal of Veterinary Medicine 48: 347-355.
'Monitoring IL-13 expression in relation to miRNA-155 and miRNA-133 changes following intra-tracheal administration of mesenchymal stem cells and conditioned media in ovalbumin sensitized rats ' () 48 Thai Journal of Veterinary Medicine : 347 -355.
Akhavanakbari, G., Babapour, B., Alipour, M.R., Keyhanmanesh, R., Ahmadi, M. and Aslani, M.R., 2019. Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats. Biofactors 45: 75-84.
'Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats ' () 45 Biofactors : 75 -84.
Aslani, M.R., Ghobadi, H., Panahpour, H., Ahmadi, M., Khaksar, M. and Heidarzadeh, M., 2020. Modification of lung endoplasmic reticulum genes expression and NF-kB protein levels in obese ovalbumin-sensitized male and female rats. Life Sciences 247: 117446.
'Modification of lung endoplasmic reticulum genes expression and NF-kB protein levels in obese ovalbumin-sensitized male and female rats ' () 247 Life Sciences : 117446.
Bayazidi, M.G., Rahbarghazi, R., Rezabakhsh, A., Rezaie, J., Hassanpour, M. and Ahmadi, M., 2022. Type 2 diabetes mellitus induced autophagic response within pulmonary tissue in the rat model. BioImpacts. https://doi.org/10.34172/bi.2022.22183
Birse, R.T., Choi, J., Reardon, K., Rodriguez, J., Graham, S., Diop, S., Ocorr, K., Bodmer, R. and Oldham, S., 2010. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metabolism 12: 533-544.
'High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila ' () 12 Cell Metabolism : 533 -544.
Brazzale, D.J., Pretto, J.J. and Schachter, L.M., 2015. Optimizing respiratory function assessments to elucidate the impact of obesity on respiratory health. Respirology 20: 715-721.
'Optimizing respiratory function assessments to elucidate the impact of obesity on respiratory health ' () 20 Respirology : 715 -721.
Che, Y., Wang, Z.P., Yuan, Y., Zhang, N., Jin, Y.G., Wan, C.X. and Tang, Q.Z., 2018. Role of autophagy in a model of obesity: a long-term high fat diet induces cardiac dysfunction. Molecular Medicine Reports 18: 3251-3261.
'Role of autophagy in a model of obesity: a long-term high fat diet induces cardiac dysfunction ' () 18 Molecular Medicine Reports : 3251 -3261.
Chooi, Y.C., Ding, C. and Magkos, F., 2019. The epidemiology of obesity. Metabolism 92: 6-10.
'The epidemiology of obesity ' () 92 Metabolism : 6 -10.
Deloux, R., Vitiello, D., Mougenot, N., Noirez, P., Li, Z., Mericskay, M., Ferry, A. and Agbulut, O., 2017. Voluntary exercise improves cardiac function and prevents cardiac remodeling in a mouse model of dilated cardiomyopathy. Frontiers in Physiology 8: 899.
'Voluntary exercise improves cardiac function and prevents cardiac remodeling in a mouse model of dilated cardiomyopathy ' () 8 Frontiers in Physiology : 899.
Fricke, K., Vieira, M., Younas, H., Shin, M.-K., Bevans-Fonti, S., Berger, S., Lee, R., DâAlessio, F.R., Zhong, Q. and Nelson, A., 2018. High fat diet induces airway hyperresponsiveness in mice. Scientific Reports 8: 6404.
'High fat diet induces airway hyperresponsiveness in mice ' () 8 Scientific Reports : 6404.
Ghorbanzadeh, V., Mohammadi, M., Mohaddes, G., Dariushnejad, H., Chodari, L. and Mohammadi, S., 2016. Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats. Physiology International 103: 459-468.
'Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats ' () 103 Physiology International : 459 -468.
Ghyasi, R., Moslehi, A. and Naderi, R., 2019. Combination effect of voluntary exercise and Garlic (Allium sativum) on oxidative stress biomarkers and lipid profile in healthy rats. Pharmaceutical Sciences 25: 268-273.
'Combination effect of voluntary exercise and Garlic (Allium sativum) on oxidative stress biomarkers and lipid profile in healthy rats ' () 25 Pharmaceutical Sciences : 268 -273.
Guo, S., Huang, Y., Zhang, Y., Huang, H., Hong, S. and Liu, T., 2020. Impacts of exercise interventions on different diseases and organ functions in mice. Journal of Sport and Health Science 9: 53-73.
'Impacts of exercise interventions on different diseases and organ functions in mice ' () 9 Journal of Sport and Health Science : 53 -73.
Hassanpour, M., Rahbarghazi, R., Nouri, M., Aghamohammadzadeh, N., Safaei, N. and Ahmadi, M., 2019. Role of autophagy in atherosclerosis: foe or friend? Journal of Inflammation 16: 8.
'Role of autophagy in atherosclerosis: foe or friend? ' () 16 Journal of Inflammation : 8.
Keyhanmanesh, R., Rahbarghazi, R. and Ahmadi, M., 2018. Systemic transplantation of mesenchymal stem cells modulates endothelial cell adhesion molecules induced by ovalbumin in rat model of asthma. Inflammation 41: 2236-2245.
'Systemic transplantation of mesenchymal stem cells modulates endothelial cell adhesion molecules induced by ovalbumin in rat model of asthma ' () 41 Inflammation : 2236 -2245.
Lasker, S., Rahman, M.M., Parvez, F., Zamila, M., Miah, P., Nahar, K., Kabir, F., Sharmin, S.B., Subhan, N. and Ahsan, G.U., 2019. High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Scientific Reports 9: 20026.
'High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation ' () 9 Scientific Reports : 20026.
Lozano, I., Van der Werf, R., Bietiger, W., Seyfritz, E., Peronet, C., Pinget, M., Jeandidier, N., Maillard, E., Marchioni, E. and Sigrist, S., 2016. High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications. Nutrition & Metabolism 13: 15.
'High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications ' () 13 Nutrition & Metabolism : 15.
Mafort, T.T., Rufino, R., Costa, C.H. and Lopes, A.J., 2016. Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function. Multidisciplinary Respiratory Medicine 11: 28.
'Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function ' () 11 Multidisciplinary Respiratory Medicine : 28.
Naderi, R., Mohaddes, G., Mohammadi, M., Ghaznavi, R., Ghyasi, R. and Vatankhah, A.M., 2015. Voluntary exercise protects heart from oxidative stress in diabetic rats. Advanced Pharmaceutical Bulletin 5: 231.
'Voluntary exercise protects heart from oxidative stress in diabetic rats ' () 5 Advanced Pharmaceutical Bulletin : 231.
Namkoong, S., Cho, C.-S., Semple, I. and Lee, J.H., 2018. Autophagy dysregulation and obesity-associated pathologies. Molecules and Cells 41: 3.
'Autophagy dysregulation and obesity-associated pathologies ' () 41 Molecules and Cells : 3.
Oskuye, Z.Z., Bavil, F.M., Hamidian, G.R., Mehri, K., Qadiri, A., Ahmadi, M., Oghbaei, H., Vatankhah, A.M. and Keyhanmanesh, R., 2019. Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats. Iranian Journal of Basic Medical Sciences 22: 197.
'Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats ' () 22 Iranian Journal of Basic Medical Sciences : 197.
Rahbarghazi, R., Keyhanmanesh, R., Aslani, M.R., Hassanpour, M. and Ahmadi, M., 2019. Bone marrow mesenchymal stem cells and condition media diminish inflammatory adhesion molecules of pulmonary endothelial cells in an ovalbumin-induced asthmatic rat model. Microvascular Research 121: 63-70.
'Bone marrow mesenchymal stem cells and condition media diminish inflammatory adhesion molecules of pulmonary endothelial cells in an ovalbumin-induced asthmatic rat model ' () 121 Microvascular Research : 63 -70.
Tabish, S., 2017. Lifestyle diseases: consequences, characteristics, causes and control. Journal of Cardiology and Current Research 9: 00326.
'Lifestyle diseases: consequences, characteristics, causes and control ' () 9 Journal of Cardiology and Current Research : 00326.
Vega, C.C., Reyes-Castro, L.A., Bautista, C.J., Larrea, F., Nathanielsz, P.W. and Zambrano, E., 2015. Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism. International Journal of Obesity 39: 712-719.
'Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism ' () 39 International Journal of Obesity : 712 -719.
Wang, C., 2014. Obesity, inflammation, and lung injury (OILI): the good. Mediators of Inflammation 2014: 978463.
'Obesity, inflammation, and lung injury (OILI): the good ' () 2014 Mediators of Inflammation : 978463.
Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M.T.-H., Brickey, W.J. and Ting, J.P., 2011. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nature Immunology 12: 408-415.
'Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling ' () 12 Nature Immunology : 408 -415.
Yang, L., Li, P., Fu, S., Calay, E.S. and Hotamisligil, G.S., 2010. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell metabolism 11: 467-478.
'Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance ' () 11 Cell metabolism : 467 -478.
Zammit, C., Liddicoat, H., Moonsie, I. and Makker, H., 2010. Obesity and respiratory diseases. International Journal of General Medicine 3: 335.
'Obesity and respiratory diseases ' () 3 International Journal of General Medicine : 335.
Zarafshan, E., Rahbarghazi, R., Rezaie, J., Aslani, M.R., Saberianpour, S., Ahmadi, M. and Keyhanmanesh, R., 2020. Type 2 diabetes mellitus provokes rat immune cells recruitment into the pulmonary niche by up-regulation of endothelial adhesion molecules. Advanced Pharmaceutical Bulletin 12: 176-182.
'Type 2 diabetes mellitus provokes rat immune cells recruitment into the pulmonary niche by up-regulation of endothelial adhesion molecules ' () 12 Advanced Pharmaceutical Bulletin : 176 -182.
Zuo, A., Zhao, X., Li, T., Li, J., Lei, S., Chen, J., Xu, D., Song, C., Liu, T. and Li, C., 2020. CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway. Journal of Cellular and Molecular Medicine 24: 2635-2647.
'CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway ' () 24 Journal of Cellular and Molecular Medicine : 2635 -2647.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 333 | 75 | 9 |
| å ¨ææµè§æ¬¡æ° | 16 | 1 | 0 |
| PDFä¸è½½æ¬¡æ° | 15 | 0 | 0 |
Here, we aimed to explore the therapeutic effect of voluntary wheel running (VWR) in high-fat diet-fed rats on pulmonary tissue injury via the modulation of autophagic response. Thirty-two rats were allocated into four groups; normal diet (Control); VWR; high-fat-diet (HFD), and HFD + VWR. After three months, pathological effect of HFD on pulmonary tissue was investigated. The levels of tumour necrosis factor (TNF)-α were detected in the bronchoalveolar lavage fluid (BALF). We monitored the expression of interleukin (IL)-6 and autophagy-related genes in lung tissues. H&E staining showed pathological changes in HFD group coincided with the increase of TNF-α levels in the bronchoalveolar fluid compared to the normal rats. Our results showed the up-regulation of IL-6, becline-1, LC3 and P62 in the HFD group compared to the Control group. VWR inhibited HFD-induced changes and could decrease HFD-induced changes via the regulation of autophagy status.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 333 | 75 | 9 |
| å ¨ææµè§æ¬¡æ° | 16 | 1 | 0 |
| PDFä¸è½½æ¬¡æ° | 15 | 0 | 0 |