Comparison of interleukin-6, oxidant and antioxidant levels in the kidneys of the trained and untrained rats following exhaustive exercise
In: Comparative Exercise PhysiologySearch for other papers by E.M. Ersever in
Current site
Google Scholar
Search for other papers by A. Aral in
Current site
Google Scholar
Search for other papers by T. Goktas in
Current site
Google Scholar
Search for other papers by L. Pınar in
Current site
Google Scholar
In this study, the cytokine response (interleukin-6; IL-6), free oxygen radicals which are claimed to be responsible for the damage in the kidney tissue of exercise-trained rats and untrained-rats, and antioxidant levels were investigated after being forced to an exhausting run. Forty male Wistar albino rats were assigned to the following groups: sedentary controls (C); untrained animals that acutely completed the exhaustive exercise and were sacrificed immediately after exhaustion (UT-i) or 1 day after exhaustion (UT-1); and long-term trained animals that completed the exhaustive exercise and were sacrificed immediately after exhaustion (T-i) or 1 day after exhaustion (T-1). In UT-i and 1 day after exhaustion (T-1) groups, total oxidant status levels were increased compared to controls (P<0.05). IL-6, which is reported to have an anti-inflammatory effect in exercise, did not increase in untrained group immediately, but started to increase 1 day after exhaustion compared to controls. IL-6 levels were significantly increased in the T-i and T-1 groups compared to the control and UT-i groups (P<0.05). The level of total antioxidant status did not show a significant increase in the UT-i group but started to rise after exhaustion the T-1 group. IL-6 levels were significantly increased in the T-i and T-1 groups compared to the control, UT-i, and UT-1 groups (P<0.05). As a result, while oxidant stress and antioxidant mechanism increased immediately in the trained group, IL-6 increased significantly immediately and 1 day later. In the untrained group, however, an increase was observed in oxidant stress, antioxidant mechanism, and IL-6 levels after 1 day.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Alpay, B., Hazar, S., Güzel, N.A., Gönenç, A., Gökdemir, K. and Gürsoy, R., 2007. Acute effect of wrestling competition on oxidative stress and total antioxidant capacity. Journal of Physical Education and Sport Sciences 9: 2-7.
'Acute effect of wrestling competition on oxidative stress and total antioxidant capacity ' () 9 Journal of Physical Education and Sport Sciences : 2 -7.
-
Barreto, D.V., Barreto, F.C., Liabeuf, S., Temmar, M., Lemke, H.D., Tribouilloy, C. and Choukroun, G., 2010. Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. Kidney International 53: 550-556. https://doi.org/10.1038/ki.2009.503.
-
Belviranli, M., Okudan, N., Revan, S., Balci, S. and Gokbel, H. 2016. Repeated supramaximal exercise-induced oxidative stress: effect of β-alanine plus creatine supplementation Asian Journal Sports Medicine 7: e26843. https://doi.org/10.5812/asjsm.26843
-
Chowdhury, S., Schulz, L., Palmisano, B., Singh, P., Berger, J.M., Yadav, V.K. and Karsenty, G., 2020. Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts. Journal of Clinical Investigation 130: 2888-2902.
'Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts ' () 130 Journal of Clinical Investigation : 2888 -2902.
-
Christian, P. and Fische, M., 2006. Interleukin-6 in acute exercise and training: what is the biological relevance? Exercise Immunology Review 12: 6-33.
'Interleukin-6 in acute exercise and training: what is the biological relevance? ' () 12 Exercise Immunology Review : 6 -33.
-
Deveden, E.T., Pinar, L., Göktaş, E., Özer, Ç. and Erdoğan, D., 2013. After an exhaustive exercise the most prominent muscle damage occurs a day later. Journal of Physical Medicine and Rehabilitation Sciences 16: e3.
'After an exhaustive exercise the most prominent muscle damage occurs a day later ' () 16 Journal of Physical Medicine and Rehabilitation Sciences : e3.
-
Erel, O., 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry 37: 277-285.
'A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation ' () 37 Clinical Biochemistry : 277 -285.
-
Fadıl, O., 2007. Exercise physiology. Journal of General Medicine 16: 1-7.
'Exercise physiology ' () 16 Journal of General Medicine : 1 -7.
-
Fischer, C.P., 2006. Interleukin-6 in acute exercise and training: what is the biological relevance? Exercise Immunology Review 12: 6-33.
'Interleukin-6 in acute exercise and training: what is the biological relevance? ' () 12 Exercise Immunology Review : 6 -33.
-
Flynn, G., McFarlin, B. and Markofski, M., 2007. The anti-inflammatory actions of exercise training. American Journal of Lifestyle Medicine 13: 220-235
'The anti-inflammatory actions of exercise training ' () 13 American Journal of Lifestyle Medicine : 220 -235.
-
Gomez-Cabrera, M.C., Domenech, E. and Viña, J., 2008. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radical Biology and Medicine 44: 126-131.
'Moderate exercise is an antioxidant: upregulation of antioxidant genes by training ' () 44 Free Radical Biology and Medicine : 126 -131.
-
Greene, E.C., 1963. Anatomy of the rat. Hafner Publishing Company, New York, NY, USA, pp. 195-209.
'Anatomy of the rat ', () 195 -209.
-
Greene, E.L. and Paller, M.S., 1991. Oxygen free radicals in acute renal failure. Mineral and Electrolyte Metabolism 17: 124-132.
'Oxygen free radicals in acute renal failure ' () 17 Mineral and Electrolyte Metabolism : 124 -132.
-
Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Müller-Newen, G. and Schaper, F., 2003. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochemical Journal 18: 1-20.
'Principles of interleukin (IL)-6-type cytokine signalling and its regulation ' () 18 Biochemical Journal : 1 -20.
-
Higashi, Y., Kimura, M., Noma, K., Hara, K. and Nakagawa, K., 2003. Effect of different intensities of exercise on endothelium dependent vasodilation on humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation 108: 530-535.
'Effect of different intensities of exercise on endothelium dependent vasodilation on humans: role of endothelium-dependent nitric oxide and oxidative stress ' () 108 Circulation : 530 -535.
-
Holick, C.N., Giovannucci, E.L., Stampfer, M.J. and Michaud, D.S., 2006. Prospective study of body mass index, height, physical activity and incidence of bladder cancer in US men and women. International Journal of Cancer 120: 140-146.
'Prospective study of body mass index, height, physical activity and incidence of bladder cancer in US men and women ' () 120 International Journal of Cancer : 140 -146.
-
Jaworski, Z., 2014. Oxidant-antioxidant status in the blood of horses with symptomatic recurrent airway obstruction (RAO). Journal Veterinary International Medicine 14: 1845-1852.
'Oxidant-antioxidant status in the blood of horses with symptomatic recurrent airway obstruction (RAO) ' () 14 Journal Veterinary International Medicine : 1845 -1852.
-
Ji, L., Stratman, F.W. and Lardy, H.A., 1998. Antioxidant enzyme systems in rat liver and skeletal muscle. Influences of selenium deficiency, chronic training, and acute exercise. Archives of Biochemistry and Biophysics 35: 150-160.
'Antioxidant enzyme systems in rat liver and skeletal muscle ' () 35 Archives of Biochemistry and Biophysics : 150 -160.
-
Karaman, E. F., Ariman, I. and Ozden, S., 2020. Responses of oxidative stress and inflammatory cytokines after zearalenone exposure in human kidney cells. World Mycotoxin Journal 13: 411-421. https://doi.org/10.3920/WMJ2019.2512
-
Kocturk, S., Kayatekin, B.M., Resmi, H., Açıkgöz, O., Kaynak, C. and Ozer E., 2008. The apoptotic response to strenuous exercise of the gastrocnemius and soleus muscle fibers in rats. European Journal of Applied Physiology 102: 515-524.
'The apoptotic response to strenuous exercise of the gastrocnemius and soleus muscle fibers in rats ' () 102 European Journal of Applied Physiology : 515 -524.
-
Lopez-Torres, M., Gredilla, R., Sanz, A. and Barja, G., 2002. Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Radical Biology Medicine 32: 882-889.
'Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria ' () 32 Free Radical Biology Medicine : 882 -889.
-
Makhloufi, C., Crescence, L., Darbousset, R., McKay, N., Massy, Z.A., Dubois, C. and Poitevin, S., 2020. Assessment of thrombotic and bleeding tendency in two mouse models of chronic kidney disease: Adenine-diet and 5/6th nephrectomy. TH Open 4: e66-e76. https://doi.org/10.1055/s-0040-1705138
-
Margarıtıs, I., Tessıer, F., Rıchard, M.J. and Marconnet, P., 1997. No evidence of oxidative stress after a triathlon race in highly trained competitors. International Journal Sports Medicine 18: 186-190.
'No evidence of oxidative stress after a triathlon race in highly trained competitors ' () 18 International Journal Sports Medicine : 186 -190.
-
Morillas, R., Villegas, G., Lopez, M., Vidal, G., Zafrilla, P., 2006. Effect of polyphenolic antioxidants on exercise-induced oxidative stress. Clinical Nutrition 25: 20-26. https://doi.org/10.1016/2005.11.007
-
Nechemia-Arbely, Y., Barkan, D., Pizov, G., Shriki, A., Rose-John, S., Galun, E. and Axelrod, J.H., 2008. IL-6/IL-6R axis plays a critical role in acute kidney injury. Journal of the American Society of Nephrology 19: 1106-1115.
'IL-6/IL-6R axis plays a critical role in acute kidney injury ' () 19 Journal of the American Society of Nephrology : 1106 -1115.
-
Oh-Ishi, S., Kizaki, T., Okawara, T., Sakurai, T., Izawa, T. and Nagata, N., 1997. Endurance training improves the resistance of rat diaphragm to exercise-induced oxidative stress. American Journal of Respiratory and Critical Care Medicine 156: 79-85.
'Endurance training improves the resistance of rat diaphragm to exercise-induced oxidative stress ' () 156 American Journal of Respiratory and Critical Care Medicine : 79 -85.
-
Pedersen, B.K. and Febbraio, M., 2005. Muscle-derived interleukin-6: a possible link between skeletal muscle, adipose tissue, liver, and brain. Brain, Behaviour and Immunity 19: 371-376.
'Muscle-derived interleukin-6: a possible link between skeletal muscle, adipose tissue, liver, and brain ' () 19 Brain, Behaviour and Immunity : 371 -376.
-
Rosa Neto, J.C., Lira, F.S., Oyama, L.M., Zanchi, N.E., Yamashita, A.S., Batista, M.L. and Seelaender, M., 2009. Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats. European Journal of Applied Physiology 106: 697-704.
'Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats ' () 106 European Journal of Applied Physiology : 697 -704.
-
Sen, C.K., 1995. Oxidants and antioxidants in exercise. Journal of Applied Physiology 79: 675-686.
'Oxidants and antioxidants in exercise ' () 79 Journal of Applied Physiology : 675 -686.
-
Sónia, S., Pedro, G., Vanda, P., Elisabete, S., João, S., Bruno, I. and Joana, A., 2011. Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats. Journal Experimental Gerontology 46: 468-474.
'Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats ' () 46 Journal Experimental Gerontology : 468 -474.
-
Spier, S.A., Delp, M.D., Meininger, C.J., Donato, A.J., Ramsey, M.W. and Muller-Delp, J.M., 2004. Effects of aging and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles. Journal of Physiology 556: 947-958. https://doi.org/10.1113/2003.060301
-
Terblanche, S.E., 2000. The effects of exhaustive exercise on the activity levels of catalase in various tissues of male and female rats. Cell Biology International 23: 749-753.
'The effects of exhaustive exercise on the activity levels of catalase in various tissues of male and female rats ' () 23 Cell Biology International : 749 -753.
-
Urhausen, A. and Kindermann, W., 2002. Diagnosis of overtraining: what tools do we have? Sports Medicine 32: 95-102.
'Diagnosis of overtraining: what tools do we have? ' () 32 Sports Medicine : 95 -102.
-
Vollaard, N.B., Shearman, J.P. and Cooper, C.E., 2005. Exercise induced oxidative stress: myths, realities and physiological relevance. Sports Medicine 35: 1045-1062.
'Exercise induced oxidative stress: myths, realities and physiological relevance ' () 35 Sports Medicine : 1045 -1062.
-
Yalcın, A. and Gurel, A., 2021. Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model. Biotechnic and Histochemistry 96: 616-622.
'Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model ' () 96 Biotechnic and Histochemistry : 616 -622.
-
Zhang, J., Li, Y., Shan, K., Wang, L., Qiu, W., Lu, Y. and Wang, Y., 2014. Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation. FASEB Journal 28: 1511-1525.
'Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation ' () 28 FASEB Journal : 1511 -1525.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 278 | 62 | 10 |
| Full Text Views | 22 | 3 | 0 |
| PDF Views & Downloads | 25 | 4 | 0 |
Comparison of interleukin-6, oxidant and antioxidant levels in the kidneys of the trained and untrained rats following exhaustive exercise
In: Comparative Exercise PhysiologySearch for other papers by E.M. Ersever in
Current site
Google Scholar
PubMed
Search for other papers by A. Aral in
Current site
Google Scholar
PubMed
Search for other papers by T. Goktas in
Current site
Google Scholar
PubMed
Search for other papers by L. Pınar in
Current site
Google Scholar
PubMed
In this study, the cytokine response (interleukin-6; IL-6), free oxygen radicals which are claimed to be responsible for the damage in the kidney tissue of exercise-trained rats and untrained-rats, and antioxidant levels were investigated after being forced to an exhausting run. Forty male Wistar albino rats were assigned to the following groups: sedentary controls (C); untrained animals that acutely completed the exhaustive exercise and were sacrificed immediately after exhaustion (UT-i) or 1 day after exhaustion (UT-1); and long-term trained animals that completed the exhaustive exercise and were sacrificed immediately after exhaustion (T-i) or 1 day after exhaustion (T-1). In UT-i and 1 day after exhaustion (T-1) groups, total oxidant status levels were increased compared to controls (P<0.05). IL-6, which is reported to have an anti-inflammatory effect in exercise, did not increase in untrained group immediately, but started to increase 1 day after exhaustion compared to controls. IL-6 levels were significantly increased in the T-i and T-1 groups compared to the control and UT-i groups (P<0.05). The level of total antioxidant status did not show a significant increase in the UT-i group but started to rise after exhaustion the T-1 group. IL-6 levels were significantly increased in the T-i and T-1 groups compared to the control, UT-i, and UT-1 groups (P<0.05). As a result, while oxidant stress and antioxidant mechanism increased immediately in the trained group, IL-6 increased significantly immediately and 1 day later. In the untrained group, however, an increase was observed in oxidant stress, antioxidant mechanism, and IL-6 levels after 1 day.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 278 | 62 | 10 |
| Full Text Views | 22 | 3 | 0 |
| PDF Views & Downloads | 25 | 4 | 0 |
