Age-induced apoptosis is believed to be caused by the imbalance between production of reactive oxygen species (ROS) and human body antioxidant defence. Regular aerobic treadmill-exercise has been suggested to enhance the antioxidant defence. This study aimed to investigate the effects of long-term treadmill exercise on age-related oxidative stress and the apoptosis of oligodendrocytes in the spinal cord of the rat. Sixty male rats were divided into six groups: three exercised groups, which underwent 6, 9 and 12 months of mild-to-moderate treadmill exercise and three non-exercised control groups. Spinal cord white or grey matter tissue sampling was done through mid-thoracic laminectomy. The malondialdehyde (MDA; indicator of oxidative stress) levels, the number of apoptotic oligodendrocytes and ultrastructural alterations were also evaluated. Our data showed that treadmill exercise resulted in decreased lipid peroxidation and the number of apoptotic oligodendrocytes in the spinal cord of rats, as compared to non-exercised animals. These results were confirmed by TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labelling) staining and electron microscope. This study suggests that the long-term treadmill exercise can affect oxidative stress and oligodendrocytes apoptosis in the spinal cord of aged rats and further studies are needed to validate these findings in humans.
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Bloomer, R.J., 2008. Effect of exercise on oxidative stress biomarkers. Advances in Clinical Chemistry 46: 1-50.
'Effect of exercise on oxidative stress biomarkers ' () 46 Advances in Clinical Chemistry : 1 -50 .
Brown, J., Cooper-Kuhn, C.M., Kempermann, G., Van Praag, H., Winkler, J., Gage, F.H. and Kuhn, H.G., 2003. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. European Journal of Neuroscience 17: 2042-2046.
'Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis ' () 17 European Journal of Neuroscience : 2042 -2046 .
Bullitt, E., Rahman, F.N., Smith, J.K., Kim, E., Zeng, D., Katz, L.M. and Marks, B.L., 2009. The effect of exercise on the cerebral vasculature of healthy aged subjects as visualized by MR angiography. American Journal of Neuroradiology 30: 1857-1863.
'The effect of exercise on the cerebral vasculature of healthy aged subjects as visualized by MR angiography ' () 30 American Journal of Neuroradiology : 1857 -1863 .
Chae, C.H. and Kim, H.T., 2009. Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats. Neurochemistry International 55: 208-213.
'Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats ' () 55 Neurochemistry International : 208 -213 .
Chaudhry, K., Rogers, R., Guo, M., Lai, Q., Goel, G., Liebelt, B., Ji, X., Curry, A., Carranza, A., Jimenez, D.F. and Ding, Y., 2010. Matrix metalloproteinase-9 (MMP-9) expression and extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation in exercise-reduced neuronal apoptosis after stroke. Neuroscience Letters 474: 109-114.
'Matrix metalloproteinase-9 (MMP-9) expression and extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation in exercise-reduced neuronal apoptosis after stroke ' () 474 Neuroscience Letters : 109 -114 .
Chakravarthy, M.V., Joyner, M.J. and Booth, F.W., 2002. An obligation for primary care physicians to prescribe physical activity to sedentary patients to reduce the risk of chronic health conditions. Mayo Clinic Proceedings 77: 165-173.
'An obligation for primary care physicians to prescribe physical activity to sedentary patients to reduce the risk of chronic health conditions ' () 77 Mayo Clinic Proceedings : 165 -173 .
Cobianchi, S., Marinelli, S., Florenzano, F., Pavone, F. and Luvisetto, S., 2010. Short-but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury. Neuroscience 168: 273-287.
'Short-but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury ' () 168 Neuroscience : 273 -287 .
Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F. and Loguercio, C., 2007. Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer 121: 2381-2386.
'Chronic inflammation and oxidative stress in human carcinogenesis ' () 121 International Journal of Cancer : 2381 -2386 .
Gilgun-Sherki, Y., Melamed, E. and Offen, D., 2004. The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. Journal of Neurology 251: 261-268.
'The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy ' () 251 Journal of Neurology : 261 -268 .
Gómez-Pinilla, F., Ying, Z., Opazo, P., Roy, R.R. and Edgerton, V.R., 2001. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. European Journal of Neuroscience 13: 1078-1084.
'Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle ' () 13 European Journal of Neuroscience : 1078 -1084 .
Jung, S.Y., Kim, D.Y., Yune, T.Y., Shin, D.H., Baek, S.B. and Kim, C.J., 2014. Treadmill exercise reduces spinal cord injury induced apoptosis by activating the PI3K/Akt pathway in rats. Experimental and Therapeutic Medicine 7: 587-593.
'Treadmill exercise reduces spinal cord injury induced apoptosis by activating the PI3K/Akt pathway in rats ' () 7 Experimental and Therapeutic Medicine : 587 -593 .
Kim, D.H., Ko, I.G., Kim, B.K., Kim, T.W., Kim, S.E., Shin, M.S., Kim, C.J., Kim, H., Kim, K.M. and Baek, S.S., 2010a. Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis. Physiology and Behavior 101: 660-665.
'Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis ' () 101 Physiology and Behavior : 660 -665 .
Kim, S.E., Ko, I.G., Kim, B.K., Shin, M.S., Cho, S., Kim, C.J., Kim, S.H., Baek, S.S., Lee, E.K. and Jee, Y.S., 2010b. Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Experimental Gerontology 45: 357-365.
'Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus ' () 45 Experimental Gerontology : 357 -365 .
Liu, G., Keeler, B.E., Zhukareva, V. and Houlé, J.D., 2010. Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats. Experimental Neurology 226: 200-206.
'Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats ' () 226 Experimental Neurology : 200 -206 .
Mattson, M.P., 2000. Apoptosis in neurodegenerative disorders. Nature Reviews Molecular Cell Biology 1: 120-130.
'Apoptosis in neurodegenerative disorders ' () 1 Nature Reviews Molecular Cell Biology : 120 -130 .
Mattson, M.P. and Magnus, T., 2006. Ageing and neuronal vulnerability. Nature Reviews Neuroscience 7:278-294.
'Ageing and neuronal vulnerability ' () 7 Nature Reviews Neuroscience : 278 -294 .
Qiao, D., Hou, L. and Liu, X., 2006. Influence of intermittent anaerobic exercise on mouse physical endurance and antioxidant components. British Journal of Sports Medicine 40: 214-218.
'Influence of intermittent anaerobic exercise on mouse physical endurance and antioxidant components ' () 40 British Journal of Sports Medicine : 214 -218 .
Reynolds, A., Laurie, C., Mosley, R.L. and Gendelman, H.E., 2007. Oxidative stress and the pathogenesis of neurodegenerative disorders. International Review of Neurobiology 82: 297-325.
'Oxidative stress and the pathogenesis of neurodegenerative disorders ' () 82 International Review of Neurobiology : 297 -325 .
Romano, A.D., Serviddio, G., De Matthaeis, A., Bellanti, F. and Vendemiale, G., 2010. Oxidative stress and aging. Journal of Nephrology 23: S29-S36.
'Oxidative stress and aging ' () 23 Journal of Nephrology : S29 -S36 .
Shokouhi, G., Tubbs, R.S., Shoja, M.M., Roshangar, L., Mesgari, M., Ghorbanihaghjo, A., Ahmadi, N., Sheikhzadeh, F. and Rad, J.S., 2008. The effects of aerobic exercise training on the age-related lipid peroxidation, Schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats. Life Sciences 82: 840-846.
'The effects of aerobic exercise training on the age-related lipid peroxidation, Schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats ' () 82 Life Sciences : 840 -846 .
Sczesny-Kaiser, M., Kowalewski, R., Schildhauer, T.A., Aach, M., Jansen, O., Grasmücke, D., Güttsches, A.K., Vorgerd, M. and Tegenthoff, M., 2017. Treadmill training with HAL exoskeleton—a novel approach for symptomatic therapy in patients with limb-girdle muscular dystrophy – preliminary study. Frontiers in Neuroscience 11: 449.
'Treadmill training with HAL exoskeleton—a novel approach for symptomatic therapy in patients with limb-girdle muscular dystrophy – preliminary study ' () 11 Frontiers in Neuroscience : 449 .
Skup, M., Dwornik, A., Macias, M., Sulejczak, D., Wiater, M. and Czarkowska-Bauch, J., 2002. Long-term locomotor training up-regulates TrkBFL receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord. Experimental Neurology 176: 289-307.
'Long-term locomotor training up-regulates TrkBFL receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord ' () 176 Experimental Neurology : 289 -307 .
Smith, K.J., Kapoor, R. and Felts, P.A., 1999. Demyelination: the role of reactive oxygen and nitrogen species. Brain Pathology 9: 69-92.
'Demyelination: the role of reactive oxygen and nitrogen species ' () 9 Brain Pathology : 69 -92 .
Stephan, J.S. and Sleiman, S.F., 2019. Exercise factors as potential mediators of cognitive rehabilitation following traumatic brain injury. Current Opinion in Neurology 32: 808-814.
'Exercise factors as potential mediators of cognitive rehabilitation following traumatic brain injury ' () 32 Current Opinion in Neurology : 808 -814 .
Stubbs, B. and Schuch, F., 2019. Physical activity and exercise as a treatment of depression: evidence and neurobiological mechanism. In: Quevedo, J., Carvalho, A.F. and Zarate, C.A. Neurobiology of depression. Academic Press, Cambridge, MA, USA, pp. 293-299.
'Physical activity and exercise as a treatment of depression: evidence and neurobiological mechanism ', () 293 -299 .
Swain, R.A., Harris, A.B., Wiener, E.C., Dutka, M.V., Morris, H.D., Theien, B.E., Konda, S., Engberg, K., Lauterbur, P.C. and Greenough, W.T., 2003. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience 117: 1037-1046.
'Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat ' () 117 Neuroscience : 1037 -1046 .
Ullmann, G., Li, Y., Ray, M.A. and Lee, S.T., 2020. Study protocol of a randomized intervention study to explore effects of a pure physical training and a mind-body exercise on cognitive executive function in independent living adults age 65-85. Aging Clinical and Experimental Research 2020. https://doi.org/10.1007/s40520-020-01633-w.
Vaanholt, L.M., Speakman, J.R., Garland Jr, T., Lobley, G.E. and Visser, G.H., 2008. Protein synthesis and antioxidant capacity in aging mice: effects of long-term voluntary exercise. Physiological and Biochemical Zoology 81: 148-157.
'Protein synthesis and antioxidant capacity in aging mice: effects of long-term voluntary exercise ' () 81 Physiological and Biochemical Zoology : 148 -157 .
Warburton, D.E., Charlesworth, S., Ivey, A., Nettlefold, L. and Bredin, S.S., 2010. A systematic review of the evidence for Canada’s Physical Activity Guidelines for Adults. International Journal of Behavioral Nutrition and Physical Activity 7: 39.
'A systematic review of the evidence for Canada’s Physical Activity Guidelines for Adults ' () 7 International Journal of Behavioral Nutrition and Physical Activity : 39 .
Wei, Y.H., Lu, C.Y., Wei, C.Y., Ma, Y.S. and Lee, H.C., 2001. Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system. Chinese Journal of Physiology 44: 1-12.
'Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system ' () 44 Chinese Journal of Physiology : 1 -12 .
White, L.J. and Castellano, V., 2008. Exercise and brain health – implications for multiple sclerosis. Sports Medicine 38: 91-100.
'Exercise and brain health – implications for multiple sclerosis ' () 38 Sports Medicine : 91 -100 .
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 226 | 122 | 33 |
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Age-induced apoptosis is believed to be caused by the imbalance between production of reactive oxygen species (ROS) and human body antioxidant defence. Regular aerobic treadmill-exercise has been suggested to enhance the antioxidant defence. This study aimed to investigate the effects of long-term treadmill exercise on age-related oxidative stress and the apoptosis of oligodendrocytes in the spinal cord of the rat. Sixty male rats were divided into six groups: three exercised groups, which underwent 6, 9 and 12 months of mild-to-moderate treadmill exercise and three non-exercised control groups. Spinal cord white or grey matter tissue sampling was done through mid-thoracic laminectomy. The malondialdehyde (MDA; indicator of oxidative stress) levels, the number of apoptotic oligodendrocytes and ultrastructural alterations were also evaluated. Our data showed that treadmill exercise resulted in decreased lipid peroxidation and the number of apoptotic oligodendrocytes in the spinal cord of rats, as compared to non-exercised animals. These results were confirmed by TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labelling) staining and electron microscope. This study suggests that the long-term treadmill exercise can affect oxidative stress and oligodendrocytes apoptosis in the spinal cord of aged rats and further studies are needed to validate these findings in humans.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 226 | 122 | 33 |
| Full Text Views | 20 | 1 | 0 |
| PDF Views & Downloads | 27 | 1 | 1 |