Mind the gut: probiotics in paediatric neurogastroenterology
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The gut-brain axis has recently emerged as a key modulator of human health and the intestinal microbiome has a well-recognised pivotal role in this strong connection. The aim of this narrative review is to update and summarise the effect and clinical applicability of probiotics in paediatric neurogastroenterology. The Cochrane Database and PubMed were searched using keywords relating to different subtypes of functional gastrointestinal disorders (FGIDs) and their symptoms, those relating to the CNS and related neurological or behavioural dysfunction as well as ‘probiotic’ OR ’probiotics’. Included papers were limited to those including children (aged 0-18 years) and using English language. Although significant effects of specific strains have been reported in infants with FGIDs, heterogeneity amongst the studies (different products and concentrations used and FGID subtypes), has limited the ability to draw an overall conclusion on the clinical value of probiotics. According to different meta-analyses of randomised controlled trials, the use of Lactobacillus reuteri (DSM 17938) was associated with a significant decrease in average crying time in infantile colic. There is moderate evidence for this strain and LGG and limited evidence (based on one study each) for the beneficial effect of VSL#3 and a three-strain bifidobacteria mix in abdominal pain FGIDs, particularly in the irritable bowel disease subgroup of children, but not in functional dyspepsia. There is currently no clear evidence of positive effects of oral probiotics in autistic spectrum disorder. Efficacy and safety of other strains or beneficial effects in other conditions still need to be proven, as probiotic properties are strain-specific, and data cannot be extrapolated to other brain-gut or mood diseases or to other probiotics of the same or different species. To transform the use of probiotics from a tempting suggestion to a promising treatment modality in neurogastroenterological disorders more accurate differentiation of the efficacy-proven strains, clarification of dose, duration, and outcome and a careful selection of the target patients are still necessary.
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-
Adams, J.B., Johansen, L.J., Powell, L.D., Quig, D. and Rubin, R.A., 2011. Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity. BMC Gastroenterology 11: 22.
'Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity ' () 11 BMC Gastroenterology : 22.
-
Akar, M., Eras, Z., Oncel, M.Y., Arayici, S., Guzoglu, N., Canpolat, F.E., Uras, N. and Oguz, S.S., 2017. Impact of oral probiotics on neurodevelopmental outcomes in preterm infants. Journal of Maternal-Fetal and Neonatal Medicine 30: 411-415.
'Impact of oral probiotics on neurodevelopmental outcomes in preterm infants ' () 30 Journal of Maternal-Fetal and Neonatal Medicine : 411 -415.
-
Allen, A.P., Hutch, W., Borre, Y.E., Kennedy, P.J., Temko, A., Boylan, G., Murphy, E., Cryan, J.F., Dinan, T.G. and Clarke, G., 2016. Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Translational Psychiatry 6: 939.
'Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers ' () 6 Translational Psychiatry : 939.
-
Bailey, M.T., Lubach, G.R. and Coe, C.L., 2004. Prenatal stress alters bacterial colonization of the gut in infant monkeys. Journal of Pediatric Gastroenterology and Nutrition 38: 414-421.
'Prenatal stress alters bacterial colonization of the gut in infant monkeys ' () 38 Journal of Pediatric Gastroenterology and Nutrition : 414 -421.
-
Banaszkiewicz, A. and Szajewska, H., 2005. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial. Journal of Pediatrics 146: 364-369.
'Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial ' () 146 Journal of Pediatrics : 364 -369.
-
Bausserman, M. and Michail, S., 2005. The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. Journal of Pediatrics 147: 197-201.
'The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial ' () 147 Journal of Pediatrics : 197 -201.
-
Bercik, P., Collins, S.M. and Verdu, E.F., 2012. Microbes and the gut-brain axis. Neurogastroenterology and Motility 24: 405-413.
'Microbes and the gut-brain axis ' () 24 Neurogastroenterology and Motility : 405 -413.
-
Bercik, P., Park, A.J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P.A., Fahnestock, M., Moine, D., Berger, B., Huizinga, J.D., Kunze, W., McLean, P.G., Bergonzelli, G.E., Collins, S.M. and Verdu, E.F., 2011. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterology Motility 23: 1132-1139.
'The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication ' () 23 Neurogastroenterology Motility : 1132 -1139.
-
Boyle, R.J., Robins-Browne, R.M. and Tang, M.L., 2006. Probiotic use in clinical practice: what are the risks? American Journal of Clinical Nutrition 83: 1256-1264.
'Probiotic use in clinical practice: what are the risks? ' () 83 American Journal of Clinical Nutrition : 1256 -1264.
-
Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E., Savignac, H.M., Dinan, T.G., Bienenstock, J. and Cryan, J.F., 2011. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences of the USA 108: 16050-16055.
'Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve ' () 108 Proceedings of the National Academy of Sciences of the USA : 16050 -16055.
-
Bu, L.-N., Chang, M.-H., Ni, Y.-H., Chen, H.L. and Cheng, C.C., 2007. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatric International 49: 485-490.
'Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation ' () 49 Pediatric International : 485 -490.
-
Cerdó, T., Ruíz, A., Suárez, A. and Campoy, C., 2017. Probiotic, prebiotic, and brain development. Nutrients 9: 1247-1266.
'Probiotic, prebiotic, and brain development ' () 9 Nutrients : 1247 -1266.
-
Chau, K., Lau, E., Greenberg, S., Jacobson, S., Yazdani-Brojeni, P., Verma, N. and Koren, G., 2015. Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. Journal of Pediatrics 166: 74-78.
'Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938 ' () 166 Journal of Pediatrics : 74 -78.
-
Coccorullo, P., Strisciuglio, C., Martinelli, M., Miele, E., Greco, L. and Staiano, A., 2010. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a doubleblind, randomized, placebo-controlled study. Journal of Pediatrics 157: 598-602.
'Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a doubleblind, randomized, placebo-controlled study ' () 157 Journal of Pediatrics : 598 -602.
-
Collins, S.M. and Bercik, P., 2009. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136: 2003-2014.
'The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease ' () 136 Gastroenterology : 2003 -2014.
-
Cryan, J.F. and Dinan, T.G., 2012. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience 13: 701-712.
'Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour ' () 13 Nature Reviews Neuroscience : 701 -712.
-
DeWeerth, C., Fuentes, S., Puylaert, P. and De Vos, W.M.,. 2013. Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics 131: 550-558.
'Intestinal microbiota of infants with colic: development and specific signatures ' () 131 Pediatrics : 550 -558.
-
Dinan, T.G., Stanton, C. and Cryan, J.F., 2013. Psychobiotics: a novel class of psychotropic. Biological Psychiatry 74: 720-726.
'Psychobiotics: a novel class of psychotropic ' () 74 Biological Psychiatry : 720 -726.
-
Distrutti, E., O’Reilly, J.A., McDonald, C., Cipriani, S., Renga, B., Lynch, M.A. and Fiorucci, S., 2014. Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP. PLoS ONE 9: e106503.
'Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP ' () 9 PLoS ONE : e106503.
-
Drossman, D.A., 2006. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130: 1377-1390.
'The functional gastrointestinal disorders and the Rome III process ' () 130 Gastroenterology : 1377 -1390.
-
Eftekhari, K., Vahedi, Z., Kamali Aghdam, M. and Diaz, D.N., 2015. A randomized double-blind placebo-controlled trial of Lactobacillus reuteri for chronic functional abdominal pain in children. Iranian Journal of Pediatrics 25: e2616.
'A randomized double-blind placebo-controlled trial of Lactobacillus reuteri for chronic functional abdominal pain in children ' () 25 Iranian Journal of Pediatrics : e2616.
-
Finegold, S.M., Dowd, S.E., Gontcharova, V., Liu, C., Henley, K.E., Wolcott, R.D.,Youn, E., Summanen, P.H., Granpeesheh, D., Dixon, D., Liu, M., Molitoris, D.R. and Green 3rd, J.A., 2010. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe 16: 444-453.
'Pyrosequencing study of fecal microflora of autistic and control children ' () 16 Anaerobe : 444 -453.
-
Finniss, D.G., Kaptchuk, T.J., Miller, F. and Benedetti, F., 2010. Biological, clinical, and ethical advances of placebo effects. The Lancet 375: 686-695.
'Biological, clinical, and ethical advances of placebo effects ' () 375 The Lancet : 686 -695.
-
Firmansyah, A., Dwipoerwantoro, P.G., Kadim, M., Alatas, S., Conus, N., Lestarina, L., Bouisset, F. and Steenhout, P., 2011. Improved growth of toddlers fed a milk containing synbiotics. Asia Pacific Journal of Clinical Nutrition 20: 69-76.
'Improved growth of toddlers fed a milk containing synbiotics ' () 20 Asia Pacific Journal of Clinical Nutrition : 69 -76.
-
Foster, J.A., Rinaman, L. and Cryan, J.F., 2017. Stress and the gut-brain axis: regulation by the microbiome. Neurobiology of Stress 7: 124-136.
'Stress and the gut-brain axis: regulation by the microbiome ' () 7 Neurobiology of Stress : 124 -136.
-
Francavilla, R., Miniello, V., Magistà, A.M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., Indrio, F. and Cavallo, L., 2010. A randomized controlled trial of Lactobacillus GG in children with functional abdominal pain. Pediatrics 126: e1445-1452.
'A randomized controlled trial of Lactobacillus GG in children with functional abdominal pain ' () 126 Pediatrics : e1445 -1452.
-
Furness, J.B., 2012. The enteric nervous system and neurogastroenterology. Nature Reviews Gastroenterology and Hepatology 9: 286-294.
'The enteric nervous system and neurogastroenterology ' () 9 Nature Reviews Gastroenterology and Hepatology : 286 -294.
-
Gareau, M.G., 2014. Microbiota-gut-brain axis and cognitive function. Advances in Experimental Medicine and Biology 817: 357-371.
'Microbiota-gut-brain axis and cognitive function ' () 817 Advances in Experimental Medicine and Biology : 357 -371.
-
Gareau, M.G., Wine, E., Rodrigues, D.M., Cho, J.H., Whary, M.T., Philpott, D.J., Macqueen, G. and Sherman, P.M., 2011. Bacterial infection causes stress-induced memory dysfunction in mice. Gut 60: 307-317.
'Bacterial infection causes stress-induced memory dysfunction in mice ' () 60 Gut : 307 -317.
-
Gawronska, A., Dziechciarz, P., Horvath, A. and Szajewska, H., 2007. A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Alimentary Pharmacology and Therapeutics 25: 177-184.
'A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children ' () 25 Alimentary Pharmacology and Therapeutics : 177 -184.
-
Giannetti, E. and Staiano, A.M., 2016. Probiotics for irritable bowel syndrome: clinical data in children. Journal of Pediatric Gastroenterology and Nutrition 63 (Suppl. 1): S25-S26.
'Probiotics for irritable bowel syndrome: clinical data in children ' () 63 Journal of Pediatric Gastroenterology and Nutrition : S25 -S26.
-
Giannetti, E., De’angelis, G., Turco, R., Campanozzi, A., Pensabene, L., Salvatore, S., De Seta, F. and Staiano, A., 2014. Subtypes of irritable bowel syndrome in children: prevalence at diagnosis and at follow-up. Journal of Pediatrics 164: 1099-1103.
'Subtypes of irritable bowel syndrome in children: prevalence at diagnosis and at follow-up ' () 164 Journal of Pediatrics : 1099 -1103.
-
Giannetti, E., Maglione, M., Alessandrella, A., Strisciuglio, C., De Giovanni, D., Campanozzi, A., Miele, E. and Staiano, A., 2017. A mixture of 3 bifidobacteria decreases abdominal pain and improves the quality of life in children with irritable bowel syndrome. a multicenter, randomized, double-blind, placebo-controlled, crossover trial. Journal of Clinical Gastroenterology 51: e5-e10.
'A mixture of 3 bifidobacteria decreases abdominal pain and improves the quality of life in children with irritable bowel syndrome ' () 51 Journal of Clinical Gastroenterology : e5 -e10.
-
Grossi, E., Melli, S., Dunca, D. and Terruzzi, V., 2016. Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics. SAGE Open Medical Case Reports 4: 2050313X16666231.
'Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics ' () 4 SAGE Open Medical Case Reports .
-
Guandalini, S., Magazzu, G., Chiaro, A., La Balestra, V., Di Nardo, G., Gopalan, S., Sibal, A., Romano, C., Canani, R.B., Lionetti, P. and Setty, M., 2010. VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study. Journal Pediatric Gastroenterology and Nutrition 51: 24-30.
'VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study ' () 51 Journal Pediatric Gastroenterology and Nutrition : 24 -30.
-
Guerra, P.V.P., Lima, L.N., Souza, T.C., Mazochi, V., Penna, F.J., Silva, A.M., Nicoli, J.R. and Guimarães, E.V., 2011. Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial. World Journal of Gastroenterology 17: 3916-3921.
'Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial ' () 17 World Journal of Gastroenterology : 3916 -3921.
-
Gulewitsch, M.D., Enck, P., Schwille-Kiuntke, J. Weimer, K. and Schlarb, A.A., 2013. Rome III criteria in parents’ hands: pain-related functional gastrointestinal disorders in community children and associations with somatic complaints and mental health. European Journal of Gastroenterology and Hepatology 25: 1223-1229.
'Rome III criteria in parents’ hands: pain-related functional gastrointestinal disorders in community children and associations with somatic complaints and mental health ' () 25 European Journal of Gastroenterology and Hepatology : 1223 -1229.
-
Halvorson, H.A., Schlett, C.D. and Riddle, M.S., 2006. Postinfectious irritable bowel syndrome – a meta-analysis. American Journal of Gastroenterology 101: 1894-1899.
'Postinfectious irritable bowel syndrome – a meta-analysis ' () 101 American Journal of Gastroenterology : 1894 -1899.
-
Horvath, A., Dziechciarz, P. and Szajewska, H., 2011. Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain related functional gastrointestinal disorders in childhood. Alimentary Pharmacololy and Therapeutics 33: 1302-1310.
'Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain related functional gastrointestinal disorders in childhood ' () 33 Alimentary Pharmacololy and Therapeutics : 1302 -1310.
-
Hsiao, E.Y., McBride, S.W., Hsien, S., Sharon, G., Hyde, E.R., McCue, T., Codelli, J.A., Chow, J., Reisman, S.E., Petrosino, J.F., Patterson, P.H. and Mazmanian, S.K., 2013. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155: 1451-1463.
'Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders ' () 155 Cell : 1451 -1463.
-
Hubbard, C.S., Becerra, L., Heinz, N., Ludwick, A., Rasooly, T., Wu, R., Johnson, A., Schechter, N.L., Borsook, D. and Nurko, S., 2016. Abdominal pain, the adolescent and altered brain structure and function. PLoS ONE 11: e0156545.
'Abdominal pain, the adolescent and altered brain structure and function ' () 11 PLoS ONE : e0156545.
-
Hyams, J.S., Di Lorenzo, C., Saps, M., Shulman, R.J., Staiano, A. and Van Tilburg, M., 2016. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 150: 1456-1468.
'Childhood functional gastrointestinal disorders: child/adolescent ' () 150 Gastroenterology : 1456 -1468.
-
Indrio, F., Di Mauro, A., Riezzo, G., Civardi, E., Intini, C., Corvaglia, L., Ballardini, E., Bisceglia, M., Cinquetti, M., Brazzoduro, E., Del Vecchio, A., Tafuri, S. and Francavilla, R., 2014. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatrics 168: 228-233.
'Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial ' () 168 JAMA Pediatrics : 228 -233.
-
Indrio, F., Riezzo, G., Raimondi, F., Bisceglia, M., Filannino, A., Cavallo, L. and Francavilla, R., 2011. Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants. European Journal of Clinical Investigation 41: 417-422.
'Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants ' () 41 European Journal of Clinical Investigation : 417 -422.
-
Jadresin, O., Hojsak, I., Misak, Z., Kekez, A.J., Trbojevic, T., Ivkovic, L. and Kolacek, S., 2017. Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain in children: RCT study. Journal of Pediatric Gastroenterology and Nutrition 64: 925-929.
'Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain in children: RCT study ' () 64 Journal of Pediatric Gastroenterology and Nutrition : 925 -929.
-
Kałuzna-Czaplinska, J. and Błaszczyk, S., 2012. The level of arabinitol in autistic children after probiotic therapy. Nutrition 28: 124-126.
'The level of arabinitol in autistic children after probiotic therapy ' () 28 Nutrition : 124 -126.
-
Kassinen, A., Krogius-Kurikka, L., Makivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J. and Palva, A., 2007. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 133: 24-33.
'The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects ' () 133 Gastroenterology : 24 -33.
-
Kato-Kataoka, A., Nishida, K., Takada, M., Suda, K., Kawai, M., Shimizu, K., Kushiro, A., Hoshi, R., Watanabe, O., Igarashi, T., Miyazaki, K., Kuwano, Y. and Rokutan, K., 2016. Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress. Beneficial Microbes 7: 153-156.
'Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress ' () 7 Beneficial Microbes : 153 -156.
-
Kelly, J.R., Borre, Y., C.O.B., Patterson, E., El Aidy, S., Deane, J., Kennedy, P.J., Beers, S., Scott, K., Moloney, G., Hoban, A.E., Scott, L., Fitzgerald, P., Ross, P., Stanton, C., Clarke, G., Cryan, J.F. and Dinan, T.G., 2016. Transferring the blues: depressionassociated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research 82: 109-118.
'Transferring the blues: depressionassociated gut microbiota induces neurobehavioural changes in the rat ' () 82 Journal of Psychiatric Research : 109 -118.
-
Kianifar, H., Ahanchian, H., Grover, Z., Jafari, S., Noorbakhsh, Z., Khakshour, A., Sedaghat, M. and Kiani, M., 2014. Synbiotic in the management of infantile colic: a randomised controlled trial. Journal of Paediatric and Child Health 50: 801-805.
'Synbiotic in the management of infantile colic: a randomised controlled trial ' () 50 Journal of Paediatric and Child Health : 801 -805.
-
Koppen, I.J.N., Benninga, M. and Tabbers, M.M., 2016b. Is there a role for pre-, pro- and synbiotics in the treatment of functional constipation in children? A systematic review. Journal Pediatric Gastroenterology and Nutrition 63 (Suppl. 1): S27-S35.
'Is there a role for pre-, pro- and synbiotics in the treatment of functional constipation in children? ' () 63 Journal Pediatric Gastroenterology and Nutrition : S27 -S35.
-
Koppen, I.J.N., Di Lorenzo, C., Saps, M., Dinning, P.G., Yacob, D., Levitt, M.A. and Benninga, M.A., 2016 a. Childhood constipation: finally something is moving! Expert Review Gastroenterology and Hepatology 10: 141-155.
'Childhood constipation: finally something is moving! ' () 10 Expert Review Gastroenterology and Hepatology : 141 -155.
-
Korterink, J., Devanarayana, N.M., Rajindrajith, S., Vlieger, A. and Benninga, M.A., 2015. Childhood functional abdominal pain: mechanisms and management. Nature Reviews Gastroenterology and Hepatology 12: 159-171.
'Childhood functional abdominal pain: mechanisms and management ' () 12 Nature Reviews Gastroenterology and Hepatology : 159 -171.
-
Korterink, J.J., Ockeloen, L., Benninga, M.A., Tabbers, M.M., Hilbink, M. and Deckers-Kocken, J.M., 2014. Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta analysis. Acta Paediatrica 103: 365-372.
'Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta analysis ' () 103 Acta Paediatrica : 365 -372.
-
LeCouffe, N.E., Westerbeek, E.A., Van Schie, P.E., Schaaf, V.A., Lafeber, H.N. and Van Elburg, R.M., 2014. Neurodevelopmental outcome during the first year of life in preterm infants after supplementation of a prebiotic mixture in the neonatal period: a follow-up study. Neuropediatrics 45: 022-029.
'Neurodevelopmental outcome during the first year of life in preterm infants after supplementation of a prebiotic mixture in the neonatal period: a follow-up study ' () 45 Neuropediatrics : 022 -029.
-
Li, L., Su, Q., Xie, B., Duan, L., Zhao, W., Hu, D., Wu, R. and Liu, H., 2016. Gut microbes in correlation with mood: case study in a closed experimental human life support system. Neurogastroenterololy and Motility 28: 1233-1240.
'Gut microbes in correlation with mood: case study in a closed experimental human life support system ' () 28 Neurogastroenterololy and Motility : 1233 -1240.
-
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y. and Jin, F., 2015. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience 310: 561-577.
'Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress ' () 310 Neuroscience : 561 -577.
-
Maragkoudaki, M., Chouliaras, G., Orel, R., Horvath, A., Szajewska, H. and Pappadopoulou, A., 2017: Lactobacillus reuteri DSM 17938 and a placebo both significantly reduced symptoms in children with functional abdominal pain. Acta Paediatrica 106: 1857-1862.
'Lactobacillus reuteri DSM 17938 and a placebo both significantly reduced symptoms in children with functional abdominal pain ' () 106 Acta Paediatrica : 1857 -1862.
-
Messaoudi, M., Violle, N., Bisson, J.F., Desor, D., Javelot, H. and Rougeot, C., 2011a. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes 2: 256-261.
'Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers ' () 2 Gut Microbes : 256 -261.
-
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M. and Cazaubiel, J.-M., 2011b. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition 105: 755-764.
'Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects ' () 105 British Journal of Nutrition : 755 -764.
-
Mi, G.L., Zhao, L., Qiao, D.D., Kang, W.Q., Tang, M.Q. and Xu, J.K., 2015. Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial. Antonie van Leeuwenhoek 107: 1547-1553.
'Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial ' () 107 Antonie van Leeuwenhoek : 1547 -1553.
-
Navarro, F., Liu, Y. and Rhoads, J.M., 2016. Can probiotics benefit children with autism spectrum disorders? World Journal of Gastroenterology 22(46): 10093-10102.
'Can probiotics benefit children with autism spectrum disorders? ' () 22 World Journal of Gastroenterology : 10093 -10102.
-
Parracho, H.M., Bingham, M.O., Gibson, G.R. and McCartney, A.L., 2005. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology 54: 987-991.
'Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children ' () 54 Journal of Medical Microbiology : 987 -991.
-
Parracho, H.M., Gibson, G.R., Knott, F., Bosscher, D., Kleerebezem, M. and McCartney, A.L., 2010. A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders. International Journal of Probiotics and Prebiotics 5: 69-74.
'A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders ' () 5 International Journal of Probiotics and Prebiotics : 69 -74.
-
Pärtty, A., Kalliomäki, M., Wacklin, P., Salminen, S. and Isolauri, E., 2015b. A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatric Research 77: 823-828.
'A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial ' () 77 Pediatric Research : 823 -828.
-
Pärtty, A., Lehtonen, L., Kalliomaki, M., Salminen, S. and Isolauri, E., 2015a. Probiotic Lactobacillus rhamnosus GG therapy and microbiological programming in infantile colic: a randomized, controlled trial. Pediatric Research 78: 470-475.
'Probiotic Lactobacillus rhamnosus GG therapy and microbiological programming in infantile colic: a randomized, controlled trial ' () 78 Pediatric Research : 470 -475.
-
Pensabene, L., Talarico, V., Concolino, D., Ciliberto, D., Campanozzi, A., Gentile, T., Rutigliano, V., Salvatore, S., Staiano, A., Di Lorenzo, C. and Post-Infectious Functional Gastrointestinal Disorders Study Group of Italian Society for Pediatric Gastroenterology, Hepatology and Nutrition, 2015. Postinfectious functional gastrointestinal disorders in children: a multicenter prospective study. Journal of Pediatrics 166: 903-907.
'Postinfectious functional gastrointestinal disorders in children: a multicenter prospective study ' () 166 Journal of Pediatrics : 903 -907.
-
Pusponegoro, H.D., Ismael, S., Sastroasmoro, S., Firmansyah, A. and Vandenplas, Y., 2015. Maladaptive behavior and gastrointestinal disorders in children with autism spectrum disorder. Pediatric Gastroenterology, Hepatology and Nutrition 18: 230-237.
'Maladaptive behavior and gastrointestinal disorders in children with autism spectrum disorder ' () 18 Pediatric Gastroenterology, Hepatology and Nutrition : 230 -237.
-
Quigley, E.M.M. and Flourie, B., 2007. Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterology and Motility 19: 166-172.
'Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date ' () 19 Neurogastroenterology and Motility : 166 -172.
-
Rajilic-Stojanovic, M., Biagi, E., Heilig, H.G., Kajander, K., Kekkonen, R.A., Tims, S. and De Vos, W.M., 2011. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 141: 1792-1801.
'Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome ' () 141 Gastroenterology : 1792 -1801.
-
Romano, C., Ferrau, V., Cavataio, F., Iacono, G., Spina, M., Lionetti, E., Comisi, F., Famiani, A. and Comito, D., 2014. Lactobacillus reuteri in children with functional abdominal pain (FAP). Journal of Paediatrics and Child Health 50: E68-E71.
'Lactobacillus reuteri in children with functional abdominal pain (FAP) ' () 50 Journal of Paediatrics and Child Health : E68 -E71.
-
Roos, S., Dicksved, J., Tarasco, V., Locatelli, E., Ricceri, F., Grandin, U. and Savino, F., 2013. 454 pyrosequencing analysis on faecal samples from a randomized DBPC trial of colicky infants treated with Lactobacillus reuteri DSM 17938. PloS ONE 8: e56710.
'454 pyrosequencing analysis on faecal samples from a randomized DBPC trial of colicky infants treated with Lactobacillus reuteri DSM 17938 ' () 8 PloS ONE : e56710.
-
Rutten, J.M., Korterink, J.J., Venmans, L.M., Benninga, M.A. and Tabbers, M.M., 2015. Nonpharmacologic treatment of functional abdominal pain disorders: a systematic review. Pediatrics 135: 522-535.
'Nonpharmacologic treatment of functional abdominal pain disorders: a systematic review ' () 135 Pediatrics : 522 -535.
-
Sadeghzadeh, M., Rabieefar, A., Khoshnevisasl, P., Mousavinasab, N. and Eftekhari, K., 2014. The effect of probiotics on childhood constipation: a randomized controlled double blind clinical trial. International Journal of Pediatrics 937212.
'The effect of probiotics on childhood constipation: a randomized controlled double blind clinical trial ', in International Journal of Pediatrics 937212 , ().
-
Salvatore, S., Barberi, S., Borrelli, O. Castellazzi, A., Di Mauro, D., Di Mauro, G., Doria, M., Francavilla, R., Landi, M., Martelli, A., Miniello, V.L., Simeone, G., Verduci, E., Verga, C., Zanetti, M.A., Staiano, A. and SIPPS Working Group on FGIDs, 2016. Pharmacological interventions on early functional gastrointestinal disorders. Italian Journal of Pediatrics 42: 68.
'Pharmacological interventions on early functional gastrointestinal disorders ' () 42 Italian Journal of Pediatrics : 68.
-
Sandler, R.H., Finegold, S.M. and Bolte, E.R., 2000. Short-term benefit from oral vancomycin treatment of regressive-onset autism. Journal of Child Neurology 15: 429-435.
'Short-term benefit from oral vancomycin treatment of regressive-onset autism ' () 15 Journal of Child Neurology : 429 -435.
-
Santocchi, E., Guiducci, L., Fulceri, F., Billeci, L., Buzzigoli, E., Apicella, F., Calderoni, S., Grossi, E., Morales, M.A. and Muratori, F., 2016. Gut to brain interaction in autism spectrum disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters. BMC Psychiatry 16: 183.
'Gut to brain interaction in autism spectrum disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters ' () 16 BMC Psychiatry : 183.
-
Saps, M., Nichols-Vinueza, D.X., Rosen, J.M. and Velasco-Benitez, C.A., 2014. Prevalence of functional gastrointestinal disorders in Colombian school children. Journal of Pediatrics 164: 542-545
'Prevalence of functional gastrointestinal disorders in Colombian school children ' () 164 Journal of Pediatrics : 542 -545.
-
Saps, M., Pensabene, L., Di Martino, L., Staiano, A., Wechsler, J., Zheng, X. and Di Lorenzo, C., 2008. Post-infectious functional gastrointestinal disorders in children. Journal of Pediatrics 152: 812-816.
'Post-infectious functional gastrointestinal disorders in children ' () 152 Journal of Pediatrics : 812 -816.
-
Saps, M., Pensabene, L., Turco, R., Staiano, A., Cupuro, D. and Di Lorenzo, C., 2009. Rotavirus gastroenteritis: precursor of functional gastrointestinal disorders? Journal of Pediatric Gastroenterology and Nutrition 49: 580-583.
'Rotavirus gastroenteritis: precursor of functional gastrointestinal disorders? ' () 49 Journal of Pediatric Gastroenterology and Nutrition : 580 -583.
-
Sarkar, A., Lehto, S.M., Harty, S., Dinan, T.G., Cryan, J.F. and Burnet, P.W., 2016. Psychobiotics and the manipulation of bacteria-gut-brain signals. Trends in Neurosciences 39: 763-781.
'Psychobiotics and the manipulation of bacteria-gut-brain signals ' () 39 Trends in Neurosciences : 763 -781.
-
Saulnier, D.M., Riehle, K., Mistretta, T.A., Diaz, M.A., Mandal, D., Raza, S., Weidler, E.M., Qin, X., Coarfa, C., Milosavljevic, A., Petrosino, J.F., Highlander, S., Gibbs, R., Lynch, S.V., Shulman, R.J. and Versalovic, J., 2011. Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology 141: 1782-1791.
'Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome ' () 141 Gastroenterology : 1782 -1791.
-
Saulnier, D.M., Ringel, Y., Heyman, M.B., Foster, J.A., Bercik, P., Shulman, R.J., Versalovic, J., Verdu, E.F., Dinan, T.G., Hecht, G. and Guarner, F., 2013. The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes 4: 17-27.
'The intestinal microbiome, probiotics and prebiotics in neurogastroenterology ' () 4 Gut Microbes : 17 -27.
-
Savignac, H.M., Kiely, B., Dinan, T.G. and Cryan, J.F., 2014. Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterology and Motility 26: 1615-1627.
'Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice ' () 26 Neurogastroenterology and Motility : 1615 -1627.
-
Savignac, H.M., Tramullas, M., Kiely, B., Dinan, T.G. and Cryan, J.F., 2015. Bifidobacteria modulate cognitive processes in an anxious mouse strain. Behavioral Brain Research 287: 59-72.
'Bifidobacteria modulate cognitive processes in an anxious mouse strain ' () 287 Behavioral Brain Research : 59 -72.
-
Savino, F., Castagno, E., Bretto, R., Brondello, C., Palumeri, E. and Oggero, R., 2005. A prospective 10-year study on children who had severe infantile colic. Acta Paediatrica 94: 129-132.
'A prospective 10-year study on children who had severe infantile colic ' () 94 Acta Paediatrica : 129 -132.
-
Savino, F., Cordisco, L., Tarasco, V., Palumeri, E., Calabrese, R., Oggero, R., Roos, S. and Matteuzzi, D., 2010. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 126: 526-533.
'Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial ' () 126 Pediatrics : 526 -533.
-
Schwille-Kiuntke, J., Frick, J.S., Zanger, P. and Enck, P., 2011. Post-infectious irritable bowel syndrome – a review of the literature. Zeitschrift fur Gastroenterologie 49: 997-1003.
'Post-infectious irritable bowel syndrome – a review of the literature ' () 49 Zeitschrift fur Gastroenterologie : 997 -1003.
-
Sommer, F. and Bäckhed, F., 2013. The gut microbiota – masters of host development and physiology. Nature Reviews Microbiology 11: 227-238.
'The gut microbiota – masters of host development and physiology ' () 11 Nature Reviews Microbiology : 227 -238.
-
Spiller, R. and Lam, C., 2012. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome. Journal of Neurogastroenterology and Motility 18: 258-268.
'An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome ' () 18 Journal of Neurogastroenterology and Motility : 258 -268.
-
Srinivasjois, R., Rao, S. and Patole, S., 2015. Probiotic supplementation in children with autism spectrum disorder. Archives of Disease in Childhood 100: 505-506.
'Probiotic supplementation in children with autism spectrum disorder ' () 100 Archives of Disease in Childhood : 505 -506.
-
Steenbergen, L., Sellaro, R., Van Hemert, S., Bosch, J.A. and Colzato, L.S., 2015. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain, Behavior and Immunity 48: 258-264.
'A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood ' () 48 Brain, Behavior and Immunity : 258 -264.
-
Sung, V., Hiscock, H., Tang, M.L., Mensah, F.K., Nation, M.L., Satzke, C., Heine, R.G., Stock, A., Barr, R.G. and Wake, M., 2014. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomized trial. British Medical Journal 348: 2107.
'Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomized trial ' () 348 British Medical Journal : 2107.
-
Szajewska, H. and Dryl, R., 2016. Probiotics for the management of infantile colic. Journal of Pediatric Gastroenterology and Nutrition 63 (Suppl. 1): S22-S24.
'Probiotics for the management of infantile colic ' () 63 Journal of Pediatric Gastroenterology and Nutrition : S22 -S24.
-
Szajewska, H., Gyrczuk, E. and Horvath, A., 2013. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. Journal of Pediatrics 162: 257-262.
'Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial ' () 162 Journal of Pediatrics : 257 -262.
-
Tabbers, M.M., Chmielewska, A., Roseboom, M.G., Chmielewska, A., Roseboom, M.G., Crastes, N., Perrin, C., Reitsma, J.B., Norbruis, O., Szajewska, H. and Benninga, M.A., 2011. Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial. Pediatrics 127: e1392-1399.
'Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial ' () 127 Pediatrics : e1392 -1399.
-
Takada, M., Nishida, K., Kataoka-Kato, A., Gondo, Y., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Watanabe, O., Igarashi, T., Kuwano, Y., Miyazaki, K. and Rokutan, K., 2016. Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models. Neurogastroenterology and Motility 28: 1027-1036.
'Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models ' () 28 Neurogastroenterology and Motility : 1027 -1036.
-
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain-Raspaud, S., Trotin, B., Naliboff, B. and Mayer, E.A., 2013. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 144: 1394-1401.
'Consumption of fermented milk product with probiotic modulates brain activity ' () 144 Gastroenterology : 1394 -1401.
-
Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K. and Ostatnikova, D., 2015. Gastrointestinal microbiota in children with autism in Slovakia. Physiology and Behavior 138: 179-187.
'Gastrointestinal microbiota in children with autism in Slovakia ' () 138 Physiology and Behavior : 179 -187.
-
Urban´ska, M. and Szajewska, H., 2014. The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence. European Journal of Pediatrics 173: 1327-1337.
'The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence ' () 173 European Journal of Pediatrics : 1327 -1337.
-
Van den Berg, J.P., Westerbeek, E.A., Bröring-Starre, T., Garssen, J. and Van Elburg, R.M., 2016. Neurodevelopment of preterm infants at 24 months after neonatal supplementation of a prebiotic mix: a randomized trial. Journal Pediatric Gastroenterology and Nutrition 63: 270-276.
'Neurodevelopment of preterm infants at 24 months after neonatal supplementation of a prebiotic mix: a randomized trial ' () 63 Journal Pediatric Gastroenterology and Nutrition : 270 -276.
-
Van den Nieuwboer, M., Brummer, R.J., Guarner, F., Morelli, L., Cabana, M. and Claassen, E., 2015. Safety of probiotics and synbiotics in children under 18 years of age. Beneficial Microbes 6: 615-630.
'Safety of probiotics and synbiotics in children under 18 years of age ' () 6 Beneficial Microbes : 615 -630.
-
Van den Nieuwboer, M., Claassen, E., Morelli, L., Guarner, F. and Brummer, R.J., 2014. Probiotic and synbiotic safety in infants under two years of age. Beneficial Microbes 5: 45-60.
'Probiotic and synbiotic safety in infants under two years of age ' () 5 Beneficial Microbes : 45 -60.
-
Vandenplas, Y., Abkari, A., Bellaiche, M., Benninga, M., Chouraqui, J.P., Çokura, F., Harb, T., Hegar, B., Lifschitz, C., Ludwig, T., Miqdady, M., De Morais, M.B., Osatakul, S., Salvatore, S., Shamir, R., Staiano, A., Szajewska, H. and Thapar, N., 2015. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. Journal of Pediatric Gastroenterololy and Nutrition 61: 531-537.
'Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age ' () 61 Journal of Pediatric Gastroenterololy and Nutrition : 531 -537.
-
Verdu, E.F., 2009. Probiotics effects on gastrointestinal function: beyond the gut? Neurogastroenterology and Motility 21: 477-480.
'Probiotics effects on gastrointestinal function: beyond the gut? ' () 21 Neurogastroenterology and Motility : 477 -480.
-
Wager, T.D. and Atlas, L.Y., 2015. The neuroscience of placebo effects: connecting context, learning and health. Nature Review Neuroscience 16: 403-418.
'The neuroscience of placebo effects: connecting context, learning and health ' () 16 Nature Review Neuroscience : 403 -418.
-
Waters, A.M., Schilpzand, E., Bell, C., Walker, L.S. and Baber, K., 2013. Functional gastrointestinal symptoms in children with anxiety disorders. Journal of Abnormal Child Psychology 41: 151-163.
'Functional gastrointestinal symptoms in children with anxiety disorders ' () 41 Journal of Abnormal Child Psychology : 151 -163.
-
Weizman, Z., Abu-Abed, J. and Binsztok, M., 2016. Lactobacillus reuteri DSM17938 for the management of functional abdominal pain in childhood: a randomized, double-blind, placebo-controlled trial. Journal of Pediatrics 174: 160-164.
'Lactobacillus reuteri DSM17938 for the management of functional abdominal pain in childhood: a randomized, double-blind, placebo-controlled trial ' () 174 Journal of Pediatrics : 160 -164.
-
West, C., Wu, R.Y., Wong, A., Stanisz, A.M., Yan, R., Min, K.K., Pasyk, M., McVey Neufeld, K.A., Karamat, M.I., Foster, J.A., Bienenstock, J., Forsythe, P. and Kunze, W.A., 2017. Lactobacillus rhamnosus strain JB-1 reverses restraint stress-induced gut dysmotility. Neurogastroenterology and Motilility 29: e12903.
'Lactobacillus rhamnosus strain JB-1 reverses restraint stress-induced gut dysmotility ' () 29 Neurogastroenterology and Motilility : e12903.
-
West, R., Roberts, E. and Sichel, L.S., 2013. Improvements in gastrointestinal symptoms among children with autism spectrum disorder receiving the DelproVR probiotic and immunomodulatory formulation. Journal of Probiotics and Health 1: 2.
'Improvements in gastrointestinal symptoms among children with autism spectrum disorder receiving the DelproVR probiotic and immunomodulatory formulation ' () 1 Journal of Probiotics and Health : 2.
-
Williams, B.L., Hornig, M., Parekh, T. and Lipkin, W.I., 2012. Application of novel PCR-based methods for detection, quantitation and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio 3: e00261-11.
'Application of novel PCR-based methods for detection, quantitation and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances ' () 3 MBio : e00261 -11.
-
Wojtyniak, K., Horvath, A., Dziechciarz, P. and Szajewska, H., 2017. Lactobacillus casei rhamnosus Lcr35 in the management of functional constipation in children: a randomized trial. Journal of Pediatrics 184: 101-105.e101.
'Lactobacillus casei rhamnosus Lcr35 in the management of functional constipation in children: a randomized trial ' () 184 Journal of Pediatrics : 101 -105.e101.
-
World Health Organisation (WHO), 2013. Meeting report: autism spectrum disorders and other developmental disorders. From raising awareness to building capacity. WHO, Geneva, Switzerland. Available at: http://apps.who.int/iris/handle/10665/103312.
-
Xu, M., Wang, J., Wang, N., Sun, F., Wang, L. and Liu, X.-H., 2015. The efficacy and safety of the probiotic bacterium Lactobacillus reuteri DSM 17938 for infantile colic: a meta-analysis of randomized controlled trials. PLoS ONE 10: e0141445.
'The efficacy and safety of the probiotic bacterium Lactobacillus reuteri DSM 17938 for infantile colic: a meta-analysis of randomized controlled trials ' () 10 PLoS ONE : e0141445.
-
Zhu, L., Liu, W., Alkhouri, R., Baker, R.D., Bard, J.E., Quigley, E.M. and Baker, S.S., 2014. Structural changes in the gut microbiome of constipated patients. Physiological Genomics 46: 679-686.
'Structural changes in the gut microbiome of constipated patients ' () 46 Physiological Genomics : 679 -686.
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Mind the gut: probiotics in paediatric neurogastroenterology
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The gut-brain axis has recently emerged as a key modulator of human health and the intestinal microbiome has a well-recognised pivotal role in this strong connection. The aim of this narrative review is to update and summarise the effect and clinical applicability of probiotics in paediatric neurogastroenterology. The Cochrane Database and PubMed were searched using keywords relating to different subtypes of functional gastrointestinal disorders (FGIDs) and their symptoms, those relating to the CNS and related neurological or behavioural dysfunction as well as ‘probiotic’ OR ’probiotics’. Included papers were limited to those including children (aged 0-18 years) and using English language. Although significant effects of specific strains have been reported in infants with FGIDs, heterogeneity amongst the studies (different products and concentrations used and FGID subtypes), has limited the ability to draw an overall conclusion on the clinical value of probiotics. According to different meta-analyses of randomised controlled trials, the use of Lactobacillus reuteri (DSM 17938) was associated with a significant decrease in average crying time in infantile colic. There is moderate evidence for this strain and LGG and limited evidence (based on one study each) for the beneficial effect of VSL#3 and a three-strain bifidobacteria mix in abdominal pain FGIDs, particularly in the irritable bowel disease subgroup of children, but not in functional dyspepsia. There is currently no clear evidence of positive effects of oral probiotics in autistic spectrum disorder. Efficacy and safety of other strains or beneficial effects in other conditions still need to be proven, as probiotic properties are strain-specific, and data cannot be extrapolated to other brain-gut or mood diseases or to other probiotics of the same or different species. To transform the use of probiotics from a tempting suggestion to a promising treatment modality in neurogastroenterological disorders more accurate differentiation of the efficacy-proven strains, clarification of dose, duration, and outcome and a careful selection of the target patients are still necessary.
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