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How do probiotics and prebiotics function at distant sites?

于Beneficial Microbes
著者:
G. Reid Lawson Health Research Institute, F3-106, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada.
Departments of Microbiology & Immunology and Surgery, The University of Western Ontario, London, Canada.

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T. Abrahamsson Department of Clinical and Experimental Medicine, Division of Paediatrics, Linköping University, Linköping, Sweden.

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M. Bailey Department of Pediatrics, Ohio State University, College of Medicine, Columbus, OH, USA.
Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA.

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L.B. Bindels Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Mounier 73, P.O. Box B1.73.11, 1200 Brussels, Belgium.

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R. Bubnov Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

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K. Ganguli Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children and Harvard Medical School, Charlestown, MA, 02114, USA.

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C. Martoni UAS Laboratories, 4027 Owl Creek Drive, Madison, WI 53718, USA.

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C. O’Neill Centre for Dermatology, Faculty of Biology Medicine and Health, The University of Manchester, UK.

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H.M. Savignac Former (during ISAPP): Clasado Research Services Ltd, Reading, United Kingdom; present: 4D Pharma PLC, Life Sciences Innovation Building, Cornhill Road, Aberdeen, AB25 2ZS, United Kingdom.

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C. Stanton APC Microbiome Institute, Biosciences Building, University College Cork, Ireland.

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N. Ship Bio-K+ Pharma Inc., 495 Boulevard Armand-Frappier, Laval QC, H7V 4B3 Canada.

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M. Surette Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton ON, L8S 4K1 Canada.

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K. Tuohy Nutrition and Nutrigenomics Unit, Department of Food Quality and Nutrition, Fondazione Edmund Mach, San Michele all’Adige, Trento, 38010, Italy.

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S. van Hemert Winclove Probiotics, Hulstweg 11, 1032 LB Amsterdam, the Netherlands.

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The realisation that microbes regarded as beneficial to the host can impart effects at sites distant from their habitat, has raised many possibilities for treatment of diseases. The objective of a workshop hosted in Turku, Finland, by the International Scientific Association for Probiotics and Prebiotics, was to assess the evidence for these effects and the extent to which early life microbiome programming influences how the gut microbiota communicates with distant sites. In addition, we examined how probiotics and prebiotics might affect the skin, airways, heart, brain and metabolism. The growing levels of scientific and clinical evidence showing how microbes influence the physiology of many body sites, leads us to call for more funding to advance a potentially exciting avenue for novel therapies for many chronic diseases.

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