The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.
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Abdurasulova, I.N., Serdyuk, S.E. and Gmiro, V.E., 2007. Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis. Bulletin of Experimental Biology and Medicine 144: 217-220 (in Russian).
'Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis ' () 144 Bulletin of Experimental Biology and Medicine : 217 -220.
Abdurasulova, I.N. and Klimenko, V.M., 2011a. The role of immune and glial cells in the processes of neurodegeneration. Academic Medicine 11: 12-29 (in Russian).
'The role of immune and glial cells in the processes of neurodegeneration ' () 11 Academic Medicine : 12 -29.
Abdurasulova, I.N. and Klimenko, V.M., 2011b. Heterogeneity of the mechanisms of nerve cell damage in demyelinating autoimmune diseases of the CNS. Neuroscience and Behavior Physiology 41: 364-374.
'Heterogeneity of the mechanisms of nerve cell damage in demyelinating autoimmune diseases of the CNS ' () 41 Neuroscience and Behavior Physiology : 364 -374.
Abdurasulova, I.N., Tarasova, E.A., Matsulevich, A.V., Eliseev, A.V., Ermolenko, E.I., Suvorov, A.N. and Klimenko, V.M., 2015. Changes in the qualitative and quantitative composition of gut microbiota in rats during experimental allergic encephalomyelitis. Rossiiskii Fiziologicheskii Zhurnal Imeni im Sechenova 101: 1235-1249 (in Russian).
'Changes in the qualitative and quantitative composition of gut microbiota in rats during experimental allergic encephalomyelitis ' () 101 Rossiiskii Fiziologicheskii Zhurnal Imeni im Sechenova : 1235 -1249.
Aharoni, R., 2014. Immunomodulation neuroprotection and remyelination – the fundamenal therapeutic effects of glatiramer acetate: a critical review. Journal of Autoimmunity 54: 81-92.
'Immunomodulation neuroprotection and remyelination – the fundamenal therapeutic effects of glatiramer acetate: a critical review ' () 54 Journal of Autoimmunity : 81 -92.
Artemiadis, A.K., Anagnostouli, M.C. and Alexopoulos, E.C., 2011. Stress as a risk factor for multiple sclerosis onset or relapse: a systematic rewiew. Neuroepidemiology 36: 109-120.
'Stress as a risk factor for multiple sclerosis onset or relapse: a systematic rewiew ' () 36 Neuroepidemiology : 109 -120.
Ascherio, A. and Munger, K.L., 2007. Environmental risk factors for multiple sclerosis, part 1. The role of infection. Annals of Neurology 61: 288-299.
'Environmental risk factors for multiple sclerosis, part 1 ' () 61 Annals of Neurology : 288 -299.
Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., Ravid, R. and Rajewsky, K., 2000. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. Journal of Experimental Medicine 192: 393-404.
'Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction ' () 192 Journal of Experimental Medicine : 393 -404.
Bel’tiukov, P.P., Abdurasulova, I.N., Tarasova, E.A., Suvorov, A.N., Zakharova, E.T., Sokolov, A.V., Karpenko, M.N. and Ermolenko, E.I., 2009. Influence of probiotic Escherichia coli and enterococci on the immune system of healthy rats. Scientists note Saint-Petersburg State Medical University, Academy I.P. Pavlov 16(2): 54-58 (in Russian).
'Influence of probiotic Escherichia coli and enterococci on the immune system of healthy rats ' () 16 Scientists note Saint-Petersburg State Medical University, Academy I.P. Pavlov : 54 -58.
Benczur, M., Petranyl, G.G., Palffy, G., Varga, M., Talas, M., Kotsy, B., Földes, I. and Hollan, S.R., 1980. Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor. Clinical and Experimental Immunology 39: 657-662.
'Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor ' () 39 Clinical and Experimental Immunology : 657 -662.
Berer, K., Mues, M., Koutrolos, M., Al Rasbi, Z., Boziki, M., Johner, C., Wekerle, H. and Krishnamoorthy, G., 2011. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479: 538-541.
'Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination ' () 479 Nature : 538 -541.
Berer, K. and Krishnamoorthy, G., 2012. Commensal gut flora and brain autoimmunity: a love or hate affair? Acta Neuropathology 123: 639-651.
'Commensal gut flora and brain autoimmunity: a love or hate affair? ' () 123 Acta Neuropathology : 639 -651.
Beriou, G., Costantino, C.M., Ashley, C.W., Yang, L., Kuchroo, V.K., Baecher-Allan, C. and Hafler, D.A., 2009. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 113: 4240-4249.
'IL-17-producing human peripheral regulatory T cells retain suppressive function ' () 113 Blood : 4240 -4249.
Bhargava, P. and Mowry, E.M., 2014. Gut microbiom and multiple sclerosis. Current Neurology and Neuroscience Report 14: 492.
'Gut microbiom and multiple sclerosis ' () 14 Current Neurology and Neuroscience Report : 492.
Bitsch, A., Da Costa, C., Bunkowski, S., Weber, F., Rieckmann, P. and Brück, W., 1998. Identification of macrophage populations expressing tumor necrosis factor-alpha mRNA in acute multiple sclerosis. Acta Neuropathology 95: 373-377.
'Identification of macrophage populations expressing tumor necrosis factor-alpha mRNA in acute multiple sclerosis ' () 95 Acta Neuropathology : 373 -377.
Boster, A., Bartoszek, M.P., O’Connell, C., Pitt, D. and Racke, M., 2011. Efficacy, safety, and cost-effectiveness of glatiramer acetate in the treatment of relapsing-remitting multiple sclerosis. Therapeutic Advances in Neurological Disorders 4: 319-332.
'Efficacy, safety, and cost-effectiveness of glatiramer acetate in the treatment of relapsing-remitting multiple sclerosis ' () 4 Therapeutic Advances in Neurological Disorders : 319 -332.
Caporro, M., Disanto, G., Gobbi, C. and Zecca, C., 2014. Two decades of subcutaneous Glatiramer acetate injection: current role of the standard dose, and new high-dose low-frequency glatiramer acetate in relapsing-remitting multiple sclerosis treatment. Patient Prefer Adherence 8: 1123-1134.
'Two decades of subcutaneous Glatiramer acetate injection: current role of the standard dose, and new high-dose low-frequency glatiramer acetate in relapsing-remitting multiple sclerosis treatment ' () 8 Patient Prefer Adherence : 1123 -1134.
Comabella, M., Balashov, K., Issazadeh, S., Smith, D., Weiner, H.L. and Khoury, S.J., 1998. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. Journal of Clinical Investigation 102: 671-678.
'Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy ' () 102 Journal of Clinical Investigation : 671 -678.
Correale, J. and Villa, A., 2008. Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis. Journal of Neuroimmunology 195: 121-134.
'Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis ' () 195 Journal of Neuroimmunology : 121 -134.
Costantino, C.M., Baecher-Allan, C. and Hafler, D.A., 2008. Multiple sclerosis and regulatory T cells. Journal of Clinical Immunology 28: 697-706.
'Multiple sclerosis and regulatory T cells ' () 28 Journal of Clinical Immunology : 697 -706.
Del Prete, G., De Carli, M., Almerigogna, F., Giudizi, M.G., Biagiotti, R. and Romagnani, S., 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. Journal of Immunology 150: 353-360.
'Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production ' () 150 Journal of Immunology : 353 -360.
Demoulins, T., Gachelin, G., Bequet, D. and Dormont, D., 2003. A biased Vα24+ T-cell repertoire leads to circulating NKT-cell defects in a multiple sclerosis patient at the onset of his disease. Immunology Letters 90: 223-228.
'A biased Vα24+ T-cell repertoire leads to circulating NKT-cell defects in a multiple sclerosis patient at the onset of his disease ' () 90 Immunology Letters : 223 -228.
Ermolenko, E., Gromova, L., Borshev, Y., Voeikova, A., Karaseva, A., Ermolenko, K., Gruzdkov, A. and Suvorov, A., 2013. Influence of different probiotic lactic acid bacteria on microbiota and metabolism of rats with dysbiosis. Bioscience of Microbiota, Food and Health 32(2): 41-49.
'Influence of different probiotic lactic acid bacteria on microbiota and metabolism of rats with dysbiosis ' () 32 Bioscience of Microbiota, Food and Health : 41 -49.
Feuerer, M., Hill, J.A., Mathis, D. and Benoist, C., 2009. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Natural Immunology 10: 689-695.
'Foxp3+ regulatory T cells: differentiation, specification, subphenotypes ' () 10 Natural Immunology : 689 -695.
Fillatreau, S., Sweenie, C.H., McGeachy, M.J., Gray, D. and Anderton, S.M., 2002. B cells regulate autoimmunity by provision of IL-10. Natural Immunology 3: 944-950.
'B cells regulate autoimmunity by provision of IL-10 ' () 3 Natural Immunology : 944 -950.
Ganina, K.K., Dugina, Y.L., Zhavbert, E.S., Ertuzun, I.A., Epstein, O.I. and Abdurasulova, I.N., 2015. Release-active antibodies to S100 protein are able to improve the experimental allergic encephalomyelitis. Zh Nevrol Psikhiatr im SS Korsakova 115(6): 78-82 (in Russian).
'Release-active antibodies to S100 protein are able to improve the experimental allergic encephalomyelitis ' () 115 Zh Nevrol Psikhiatr im SS Korsakova : 78 -82.
Gimenez, M.A., Sim, J.E. and Russell, J.H., 2004. TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation. Journal of Neuroimmunology 151: 116-125.
'TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation ' () 151 Journal of Neuroimmunology : 116 -125.
Gironi, M., Borgiani, B., Mariani, E., Cursano, C., Mendozzi, L., Cavarretta, R., Saresella, M., Clerici, M., Comi, G., Rovaris, M. and Furlan, R., 2014. Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment. Journal of Immunology Research 2014: 961863.
'Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment ' () 2014 Journal of Immunology Research : 961863.
Gol-Ara, M., Jadidi-Niaragh, F., Sadria, R., Azizi, G. and Mirshafiey, A., 2012. The role of different subset of regulatory T cells in immunopathogenesis of rheumatoid arthritis. Arthritis 2012: 805875.
'The role of different subset of regulatory T cells in immunopathogenesis of rheumatoid arthritis ' () 2012 Arthritis : 805875.
Gold, R., Linington, C. and Lassmann, H., 2006. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129: 1953-1971.
'Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research ' () 129 Brain : 1953 -1971.
Gray, E., Thomas, T.L., Betmouni, S., Scolding, N. and Love, S., 2008. Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathology 18: 86-95.
'Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis ' () 18 Brain Pathology : 86 -95.
Halpern, R., Agarwal, S., Dembek, C., Borton, L. and Lopez-Bresnahan, M., 2011. Comparison of adherence and persistence among multiple sclerosis patients treated with disease-modifying therapies: a retrospective administrative claims analysis. Patient Prefer Adherence 5: 73-84.
'Comparison of adherence and persistence among multiple sclerosis patients treated with disease-modifying therapies: a retrospective administrative claims analysis ' () 5 Patient Prefer Adherence : 73 -84.
Hauser, S.L., Waubant, E., Arnold, D.L, Vollmer, T., Antel, J., Fox, R.J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., Langer-Gould, A. and Smith, C.H., 2008. HERMES trial group. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. New England Journal of Medicine 358: 676-688.
'HERMES trial group. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis ' () 358 New England Journal of Medicine : 676 -688.
Johnson, K.P., Brooks, B.R., Cohen, J.A., Ford, C.C., Goldstein, J., Lisak, R.P., Myers, L.W., Panitch, H.S., Rose, J.W. and Schiffer, R.B., 1995. Copolymer 1 reduces relapse rate and improves disability in relapse ingremitting multiple sclerosis: results of a phase III multicenter, double-blind, placebo-controlled trial. The Copolimer 1 Multiple Sclerosis Study Group. Neurology 45: 1268-1276.
'Copolymer 1 reduces relapse rate and improves disability in relapse ingremitting multiple sclerosis: results of a phase III multicenter, double-blind, placebo-controlled trial. The Copolimer 1 Multiple Sclerosis Study Group ' () 45 Neurology : 1268 -1276.
Kakalacheva, K., Münz, C. and Lünemann, J.D., 2011. Viral triggers of multiple sclerosis. Biochimica et Biophysica Acta 1812: 132-140.
'Viral triggers of multiple sclerosis ' () 1812 Biochimica et Biophysica Acta : 132 -140.
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B. and Prat, A., 2007. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Medicine 13: 1173-1175.
'Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation ' () 13 Nature Medicine : 1173 -1175.
Kobayashi, T., Kato, I., Nanno, M., Shida, K., Shibuya, K., Matsuoka, Y. and Onoue, M., 2010. Oral administration of probiotic bacteria, Lactobacillus casei and Bifidobacterium breve, does not exacerbate neurological symptoms in experimental autoimmune encephalomyelitis. Immunopharmacolofy and Immunotoxicology 32: 116-124.
'Oral administration of probiotic bacteria, Lactobacillus casei and Bifidobacterium breve, does not exacerbate neurological symptoms in experimental autoimmune encephalomyelitis ' () 32 Immunopharmacolofy and Immunotoxicology : 116 -124.
Kuenz, B., Lutterotti, A., Ehling, R., Gneiss, C., Haemmerle, M., Rainer, C., Deisenhammer, F., Schocke, M., Berger, T. and Reindl, M., 2008. Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis. PLoS One 3: e2559.
'Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis ' () 3 PLoS One : e2559.
Kwon, H.K., Kim, G.C., Kim, Y., Hwang, W., Jash, A., Sahoo, A., Kim, J.E., Nam, J.H. and Im, S.H., 2013. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clinical Immunology 146: 217-227.
'Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response ' () 146 Clinical Immunology : 217 -227.
Lassmann, H., Van Horssen, J. and Mahad, D., 2012. Progressive multiple sclerosis: pathology and pathogenesis. Nature Reviews Neurology 8: 647-656.
'Progressive multiple sclerosis: pathology and pathogenesis ' () 8 Nature Reviews Neurology : 647 -656.
Lalive, P.H., Neuhaus, O., Benkhoucha, M., Burger, D., Hohfeld, R., Zamvil, S.S. and Weber, M.S., 2011. Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanisms of action. CNS Drugs 25: 401-414.
'Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanisms of action ' () 25 CNS Drugs : 401 -414.
Lauer, K., 2014. Notes on the epidemiology of multiple sclerosis, with special reference to dietary habits. International Journal of Molecular Science 15: 3533-3545.
'Notes on the epidemiology of multiple sclerosis, with special reference to dietary habits ' () 15 International Journal of Molecular Science : 3533 -3545.
Lavasani, S., Dzhambazov, B., Nouri, M., Fak, F., Buske, S., Molin, G., Thoriacius, H., Alenfall, J., Jepperson, B. and Weström, B., 2010. A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. Plos One 5: e9009.
'A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells ' () 5 Plos One : e9009.
Lee, Y.K., Menezes, J.S., Umesaki, Y. and Mazmanian, S.K., 2011. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the USA 108 (Suppl. 1): 4615-4622.
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis 4615 4622
Levinthal, D.J., Rahman, A., Nusrat, S., O’Leary, M., Heyman, R. and Bielefeldt, K., 2013. Adding to the burden: gastrointestinal symptoms and syndromes in multiple sclerosis. Multiple Sclerosis International 2013: 319201.
'Adding to the burden: gastrointestinal symptoms and syndromes in multiple sclerosis ' () 2013 Multiple Sclerosis International : 319201.
Libbey, J.E. and Fujinami, R.S., 2010. Potential triggers of MS. Results and Problems in Cell Differentiation 51: 24-42.
'Potential triggers of MS ' () 51 Results and Problems in Cell Differentiation : 24 -42.
Lock, C., Oksenberg, J. and Steinman, L., 1999. The role of TNFα and lymphotoxin in demyelinating disease. Annals of the Rheumatic Diseases 58 (Suppl. I): I121-I128.
'The role of TNFα and lymphotoxin in demyelinating disease ' () 58 Annals of the Rheumatic Diseases : I121 -I128.
Mars, L.T., Laloux, V., Goude, K., Desbois, S., Saoudi, A., Van Kaer, L., Lassmann, H., Herbelin, A., Lehuen, A. and Liblau, R.S., 2002. Cutting edge: Vα14-Jα281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. Journal of Immunology 168: 6007-6011.
'Cutting edge: Vα14-Jα281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice ' () 168 Journal of Immunology : 6007 -6011.
Matute, C., Alberdi, E., Domercq, M., Sanchez-Gomez, M.V., Perez-Samartin, A. and Rodriguez-Antiguedad, A., 2007. Excitotoxic damage to white matter. Journal of Anatomy 210: 693-702.
'Excitotoxic damage to white matter ' () 210 Journal of Anatomy : 693 -702.
Noseworthy, J.H., Lucchinetti, C., Rodriguez, M. and Weinshenker, B.G., 2000. Multiple sclerosis. New England Journal of Medicine 343: 938-952.
'Multiple sclerosis ' () 343 New England Journal of Medicine : 938 -952.
Ochoa-Reparaz, J. and Kasper, L.H., 2014. Gut microbiome as the risk factors in central nervous system autoimmunity. FEBS Letters 588: 4214-4222.
'Gut microbiome as the risk factors in central nervous system autoimmunity ' () 588 FEBS Letters : 4214 -4222.
Ochoa-Reparaz, J., Mielcarz, D.W., Ditrio, L.E., Burroughs, A.R., Foureau, D.M., Haque-Begum, S. and Kasper, L.H., 2009. Role of gut commensal microbiota in the development of experimental autoimmune encephalomyelitis. Journal of Immunology 183: 6041-6050.
'Role of gut commensal microbiota in the development of experimental autoimmune encephalomyelitis ' () 183 Journal of Immunology : 6041 -6050.
O’Gorman, C., Lucas, R. and Taylor, B., 2012. Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms. International Journal of Molecular Science 13: 11718-11752.
'Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms ' () 13 International Journal of Molecular Science : 11718 -11752.
Poser, C.M., 2006. The multiple sclerosis trait and the development of multiple sclerosis: genetic vulnerability and environmental effect. Clinical Neurology and Neurosurgery 108: 227-233.
'The multiple sclerosis trait and the development of multiple sclerosis: genetic vulnerability and environmental effect ' () 108 Clinical Neurology and Neurosurgery : 227 -233.
Preziosi, G., Raptis, D.A., Raeburn, A., Thiruppathy, K., Panicker, J. and Emmanuel, A., 2013. Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease. European Journal of Gastroenterology and Hepatology 25: 1044-1050.
'Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease ' () 25 European Journal of Gastroenterology and Hepatology : 1044 -1050.
Ries, S., Hilgenberg, E., Lampropoulou, V., Shen, P., Dang, V.D., Wilantri, S., Sakwa, I. and Fillatreau, S., 2014. B-type suppression: a role played by ‘regulatory B cells’ or ‘regulatory plasma cells’? European Journal of Immunology 44: 1251-1257.
'B-type suppression: a role played by ‘regulatory B cells’ or ‘regulatory plasma cells’? ' () 44 European Journal of Immunology : 1251 -1257.
Robinson, A.P., Harp, C.T., Noronha, A. and Miller, S.D., 2014. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handbook of Clinical Neurology 122: 173-189.
'The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment ' () 122 Handbook of Clinical Neurology : 173 -189.
Rumah, K.R., Linden, J., Fischetti, V.A. and Vartanian, T., 2013. Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One 8: e76359.
'Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease ' () 8 PLoS One : e76359.
Sawcer, S., Franklin, R. and Ban, M., 2014, Multiple sclerosis genetic. Lancet Neurology 13(7): 700-709.
'Multiple sclerosis genetic ' () 13 Lancet Neurology : 700 -709.
Simmons, S.B., Pierson, E.R., Lee, S.Y. and Goverman, J.M., 2013. Modeling the heterogeneity of multiple sclerosis in animals. Trends Immunology 34: 410-422.
'Modeling the heterogeneity of multiple sclerosis in animals ' () 34 Trends Immunology : 410 -422.
Smith, T., Hewson, A.K., Kingsley, C.I., Leonard, J.P. and Cuzner, M.L., 1997. Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat. American Journal of Pathology 150: 1909-1917.
'Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat ' () 150 American Journal of Pathology : 1909 -1917.
Sospedra, M. and Martin, R., 2005. Immunology of multiple sclerosis. Annual Review of Immunology 23: 683-747.
'Immunology of multiple sclerosis ' () 23 Annual Review of Immunology : 683 -747.
Steiner, I., Nisipianu, P. and Wirguin, I., 2001. Infection and the etiology and pathogenesis of multiple sclerosis. Current Neurological and Neuroscience Report 1: 271-276.
'Infection and the etiology and pathogenesis of multiple sclerosis ' () 1 Current Neurological and Neuroscience Report : 271 -276.
Suvorov, A.N., Zaharenko, S.M. and Alekhina, G.G., 2003. Энтерококки как пробиотики выбора. Clinical Nutrition 1: 26-29 (in Russian).
'Энтерококки как пробиотики выбора ' () 1 Clinical Nutrition : 26 -29.
Takata, K., Kinoshita, M., Okuno, T., Moriya, M., Kohda, T., Honorat, J.A., Sugimoto, T., Kumanogoh, A., Kayama, H., Takeda, K., Sakoda, S. and Nakatsuji, Y., 2011. The lactic acid bacterium Pediococcus acidilactici supresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells. PLoS One 6: e27644.
'The lactic acid bacterium Pediococcus acidilactici supresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells ' () 6 PLoS One : e27644.
Tarasova, E., Yermolenko, E., Donets, V., Sundukova, Z., Bochkareva, A., Borschev, I., Suvorova, M., Ilyasov, I., Simanenkov, V. and Suvorov, A., 2010. The influence of probiotic enetrococci on the microbiota and cytokines expression in rats with dysbiosis induced by antibiotics. Beneficial Microbes 1: 265-270.
'The influence of probiotic enetrococci on the microbiota and cytokines expression in rats with dysbiosis induced by antibiotics ' () 1 Beneficial Microbes : 265 -270.
Vartanian, T., Li, Y., Zhao, M. and Stefansson, K., 1995. Interferon-gamma-induced oligodendrocyte cell death: implication for the pathogenesis of multiple sclerosis. Molecular Medicine 1: 732-743.
'Interferon-gamma-induced oligodendrocyte cell death: implication for the pathogenesis of multiple sclerosis ' () 1 Molecular Medicine : 732 -743.
Westall, F.C., 2006. Molecular mimicry revisited: gut bacteria and multiple sclerosis. Journal of Clinical Microbiology 44: 2099-2104.
'Molecular mimicry revisited: gut bacteria and multiple sclerosis ' () 44 Journal of Clinical Microbiology : 2099 -2104.
Ziemssen, T., Neuhaus, O. and Hohlfeld, R., 2001. Risk-benefit assessment of glatiramer acetate in multiple sclerosis. Drug Safety 24: 979-990.
'Risk-benefit assessment of glatiramer acetate in multiple sclerosis ' () 24 Drug Safety : 979 -990.
| All Time | Past 365 days | Past 30 Days | |
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The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 402 | 129 | 16 |
| Full Text Views | 56 | 16 | 0 |
| PDF Views & Downloads | 14 | 1 | 0 |