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Probiotics and respiratory and gastrointestinal tract infections in Finnish military conscripts â a randomised placebo-controlled double-blinded study
in Beneficial MicrobesFaculty of Medicine, Otorhinolaryngology, University of Helsinki and University Central Hospital, Haartmaninkatu 4, P.O. Box 220, 00029 HUS, Helsinki, Finland
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Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Unioninkatu 22, 00130 Helsinki, Finland
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Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland
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Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, 00014 Helsinki, Finland
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Military conscripts are susceptible to respiratory and gastrointestinal tract infections. In previous studies probiotics have shown potency to reduce upper respiratory and gastrointestinal infections. The aim was to study whether probiotic intervention has an impact on seasonal occurrence of upper respiratory and gastrointestinal infections in two different conscript groups. In a randomised, double-blinded, placebo controlled study (https://clinicaltrials.gov NCT01651195), a total of 983 healthy adults were enrolled from two intakes of conscripts. Conscripts were randomised to receive either a probiotic combination of Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis ssp. lactis BB12 (BB12) or a control chewing tablet twice daily for 150 days (recruits) or for 90 days (reserve officer candidates). Clinical examinations were carried out and daily symptom diaries were collected. Outcome measures were the number of days with respiratory and gastrointestinal symptoms and symptom incidence, number and duration of infection episodes, number of antibiotic treatments received and number of days out of service because of the infection. Statistically no significant differences were found between the intervention groups either in the risk of symptom incidence or duration. However, probiotic intervention was associated with reduction of specific respiratory infection symptoms in military recruits, but not in reserve officer candidates. Probiotics did not significantly reduce overall respiratory and gastrointestinal infection morbidity.
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Guarino, A., Vecchio, A.L. and Canani, R.B., 2009. Probiotics as prevention and treatment for diarrhea. Current Opinion in Gastroenterology 25: 18-23.
'Probiotics as prevention and treatment for diarrhea ' () 25 Current Opinion in Gastroenterology : 18 -23.
-
Hao, Q., Dong, B.R. and Wu, T., 2015. Probiotics for preventing acute upper respiratory tract infections. Cochrane database of systematic reviews 2015: CD006895.
'Probiotics for preventing acute upper respiratory tract infections ' () 2015 Cochrane database of systematic reviews : CD006895.
-
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J.H., Poussa, T., Näse, L., Saxelin, M. and Korpela, R., 2001. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. British Medical Journal 322: 1327-1329.
'Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial ' () 322 British Medical Journal : 1327 -1329.
-
Hojsak, I., Snovak, N., Abdovic, S., Szajewska, H., Misak, Z. and Kolacek, S., 2010. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition 29: 312-316.
'Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial ' () 29 Clinical Nutrition : 312 -316.
-
Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO), 2002. Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. Available at: http://tinyurl.com/ou88oa2.
-
Juvonen, R., Bloigu, A., Peitso, A., Silvennoinen-Kassinen, S., Saikku, P., Leinonen, M. and Harju, T., 2008. Risk factors for acute respiratory tract illness in military conscripts. Respirology 13: 575-580.
'Risk factors for acute respiratory tract illness in military conscripts ' () 13 Respirology : 575 -580.
-
Kumpu, M., Kekkonen, R., Kautiainen, H., Järvenpää, S., Kristo, A., Huovinen, P., Pitkäranta, A., Korpela, R. and Hatakka, K., 2012. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. European Journal of Clinical nutrition 66: 1020-1023.
'Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial ' () 66 European Journal of Clinical nutrition : 1020 -1023.
-
Lehtoranta, L., Kalima, K., He, L., Lappalainen, M., Roivainen, M., Närkiö, M., Mäkelä, M., Siitonen, S., Korpela, R. and Pitkäranta, A., 2014. Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland. Journal of Clinical Virology 60: 276-81.
'Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland ' () 60 Journal of Clinical Virology : 276 -81.
-
Liu, S., Hu, P., Du, X., Zhou, T. and Pei, X., 2013. Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: a meta-analysis of randomized, placebo-controlled trials. Indian Pediatrics 50: 377-381.
'Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: a meta-analysis of randomized, placebo-controlled trials ' () 50 Indian Pediatrics : 377 -381.
-
Luoto, R., Ruuskanen, O., Waris, M., Kalliomäki, M., Salminen, S. and Isolauri, E., 2013. Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: a randomized, placebo-controlled trial. Journal of Allergy and Clinical Immunology 133: 405-413.
'Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: a randomized, placebo-controlled trial ' () 133 Journal of Allergy and Clinical Immunology : 405 -413.
-
Mäkelä, M.J., Puhakka, T., Ruuskanen, O., Leinonen, M., Saikku, P., Kimpimäki, M., Blomqvist, S., Hyypiä, T. and Arstila, P., 1998. Viruses and bacteria in the etiology of the common cold. Journal of Clinical Microbiology 36: 539-542.
'Viruses and bacteria in the etiology of the common cold ' () 36 Journal of Clinical Microbiology : 539 -542.
-
R Core Team, 2014. A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available at: http://www.R-project.org/.
-
Rautava, S., Salminen, S. and Isolauri, E., 2009. Specific probiotics in reducing the risk of acute infections in infancy â a randomised, double-blind, placebo-controlled study. British Journal of Nutrition 101: 1722-1726.
'Specific probiotics in reducing the risk of acute infections in infancy â a randomised, double-blind, placebo-controlled study ' () 101 British Journal of Nutrition : 1722 -1726.
-
Reid, G., Jass, J., Sebulsky, M.T. and McCormick, J.K., 2003. Potential uses of probiotics in clinical practice. Clinical Microbiology Review 16: 658-672.
'Potential uses of probiotics in clinical practice ' () 16 Clinical Microbiology Review : 658 -672.
-
Smith, T.J., Rigassio-Radler, D., Denmark, R., Haley, T. and Touger-Decker, R., 2013. Effect of Lactobacillus rhamnosus LGG(R) and Bifidobacterium animalis ssp. lactis BB-12(R) on health-related quality of life in college students affected by upper respiratory infections. British Journal of Nutrition 109: 1999-2007.
'Effect of Lactobacillus rhamnosus LGG(R) and Bifidobacterium animalis ssp ' () 109 British Journal of Nutrition : 1999 -2007.
-
Taipale, T., Pienihakkinen, K., Isolauri, E., Larsen, C., Brockmann, E., Alanen, P., Jokela, J. and Soderling, E., 2011. Bifidobacterium animalis subsp lactis BB-12 in reducing the risk of infections in infancy. British Journal of Nutrition 105: 409-416.
'Bifidobacterium animalis subsp lactis BB-12 in reducing the risk of infections in infancy ' () 105 British Journal of Nutrition : 409 -416.
-
Tiollier, E., Chennaoui, M., Gomez-Merino, D., Drogou, C., Filaire, E. and Guezennec, C.Y., 2007. Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training. Military Medicine 172: 1006-1011.
'Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training ' () 172 Military Medicine : 1006 -1011.
-
Vartti, A., Mäkitie, I., Aro, A., Henriksson, M., Jormanainen, V. and Nikkari, S., 2009. Varusmiesten käsitykset ja tietämys influenssasta palveluksen alkuvaiheessa. Suomen Lääkärilehti 64: 3303.
'Varusmiesten käsitykset ja tietämys influenssasta palveluksen alkuvaiheessa ' () 64 Suomen Lääkärilehti : 3303.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 611 | 198 | 23 |
| Gesamttextansichten | 32 | 7 | 0 |
| PDF-Downloads | 40 | 14 | 0 |
Probiotics and respiratory and gastrointestinal tract infections in Finnish military conscripts â a randomised placebo-controlled double-blinded study
in Beneficial MicrobesFaculty of Medicine, Otorhinolaryngology, University of Helsinki and University Central Hospital, Haartmaninkatu 4, P.O. Box 220, 00029 HUS, Helsinki, Finland
Search for other papers by K. Kalima in
Current site
Google Scholar
PubMed
Search for other papers by L. Lehtoranta in
Current site
Google Scholar
PubMed
Search for other papers by L. He in
Current site
Google Scholar
PubMed
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Unioninkatu 22, 00130 Helsinki, Finland
Search for other papers by J. Pitkäniemi in
Current site
Google Scholar
PubMed
Search for other papers by R. Lundell in
Current site
Google Scholar
PubMed
Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland
Search for other papers by I. Julkunen in
Current site
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PubMed
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Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, 00014 Helsinki, Finland
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PubMed
Military conscripts are susceptible to respiratory and gastrointestinal tract infections. In previous studies probiotics have shown potency to reduce upper respiratory and gastrointestinal infections. The aim was to study whether probiotic intervention has an impact on seasonal occurrence of upper respiratory and gastrointestinal infections in two different conscript groups. In a randomised, double-blinded, placebo controlled study (https://clinicaltrials.gov NCT01651195), a total of 983 healthy adults were enrolled from two intakes of conscripts. Conscripts were randomised to receive either a probiotic combination of Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis ssp. lactis BB12 (BB12) or a control chewing tablet twice daily for 150 days (recruits) or for 90 days (reserve officer candidates). Clinical examinations were carried out and daily symptom diaries were collected. Outcome measures were the number of days with respiratory and gastrointestinal symptoms and symptom incidence, number and duration of infection episodes, number of antibiotic treatments received and number of days out of service because of the infection. Statistically no significant differences were found between the intervention groups either in the risk of symptom incidence or duration. However, probiotic intervention was associated with reduction of specific respiratory infection symptoms in military recruits, but not in reserve officer candidates. Probiotics did not significantly reduce overall respiratory and gastrointestinal infection morbidity.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 611 | 198 | 23 |
| Gesamttextansichten | 32 | 7 | 0 |
| PDF-Downloads | 40 | 14 | 0 |
