Genetic predisposition and environmental factors, including the gut microbiota, have been suggested as major factors in the development and progression of atopic dermatitis. Hyperlipidemic human APOC1+/+ transgenic mice display many features of human atopic dermatitis, such as scaling, lichenification, excoriations, and pruritus, along with a disturbed skin barrier function. Cytokine analysis of serum shows an increase of various pro-inflammatory cytokines, including interleukin (IL)-12p40, IL-6, and IL-1α, but lower levels of interferon-γ. These mice also display aspects of colitis evident from macroscopic and histological abnormalities. Genome-wide transcriptome analysis of the intestine shows up-regulation of several genes associated with mast cells and eosinophils and this observation was confirmed by demonstrating increased numbers of IgE+ and FcRε+ mast cells in the colon and in the skin. Oral treatment with Lactobacillus plantarum NCIMB8826 resulted in decreased numbers of mast cells in the colon. Moreover, this L. plantarum strain ameliorated skin pathology, evident from improved skin barrier integrity, absence of skin thickening, and less excoriations. These results suggest that modulation of intestinal immune homeostasis contributes to the suppression of atopic dermatitis.
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Abrahamsson, T.R., Jakobsson, H.E., Andersson, A.F., Bjorksten, B., Engstrand, L. and Jenmalm, M.C., 2014. Low gut microbiota diversity in early infancy precedes asthma at school age. Clinical and Experimental Allergy 44: 842-850.
'Low gut microbiota diversity in early infancy precedes asthma at school age ' () 44 Clinical and Experimental Allergy : 842 -850.
Abt, M.C. and Artis, D., 2009. The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis. Current Opinion in Gastroenterology 25: 496-502.
'The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis ' () 25 Current Opinion in Gastroenterology : 496 -502.
Arisawa, T., Arisawa, S., Yokoi, T., Kuroda, M., Hirata, I. and Nakano, H., 2007. Endoscopic and histological features of the large intestine in patients with atopic dermatitis. Journal of Clinical Biochemistry and Nutrition 40: 24-30.
'Endoscopic and histological features of the large intestine in patients with atopic dermatitis ' () 40 Journal of Clinical Biochemistry and Nutrition : 24 -30.
Atarashi, K. and Honda, K., 2011. Microbiota in autoimmunity and tolerance. Current Opinion in Immunology 23: 761-768.
'Microbiota in autoimmunity and tolerance ' () 23 Current Opinion in Immunology : 761 -768.
Belkaid, Y. and Naik, S., 2013. Compartmentalized and systemic control of tissue immunity by commensals. Nature Immunology 14: 646-653.
'Compartmentalized and systemic control of tissue immunity by commensals ' () 14 Nature Immunology : 646 -653.
Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B.L., Skov, T., Paludan-Muller, G., Stokholm, J., Smith, B. and Krogfelt, K.A., 2011. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. Journal of Allergy and Clinical Immunology 128: 646-52.e1-5.
'Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age ' () 128 Journal of Allergy and Clinical Immunology .
Bottcher, M.F., Nordin, E.K., Sandin, A., Midtvedt, T. and Bjorksten, B., 2000. Microflora-associated characteristics in faeces from allergic and nonallergic infants. Clinical and Experimental Allergy 30: 1590-1596.
'Microflora-associated characteristics in faeces from allergic and nonallergic infants ' () 30 Clinical and Experimental Allergy : 1590 -1596.
Eichenfield, L.F., Tom, W.L., Chamlin, S.L., Feldman, S.R., Hanifin, J.M., Simpson, E.L., Berger, T.G., Bergman, J.N., Cohen, D.E., Cooper, K.D., Cordoro, K.M., Davis, D.M., Krol, A., Margolis, D.J., Paller, A.S., Schwarzenberger, K., Silverman, R.A., Williams, H.C., Elmets, C.A., Block, J., Harrod, C.G., Smith Begolka, W. and Sidbury, R., 2014. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. Journal of the American Academy of Dermatology 70: 338-351.
'Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis ' () 70 Journal of the American Academy of Dermatology : 338 -351.
Esparza-Gordillo, J., Weidinger, S., Folster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., Hubner, N., Wahn, U., Schreiber, S., Franke, A., Vogler, R., Heath, S., Baurecht, H., Novak, N., Rodriguez, E., Illig, T., Lee-Kirsch, M.A., Ciechanowicz, A., Kurek, M., Piskackova, T., Macek, M., Lee, Y.A. and Ruether, A., 2009. A common variant on chromosome 11q13 is associated with atopic dermatitis. Nature Genetics 41: 596-601.
'A common variant on chromosome 11q13 is associated with atopic dermatitis ' () 41 Nature Genetics : 596 -601.
Finch, J., Munhutu, M.N. and Whitaker-Worth, D.L., 2010. Atopic dermatitis and nutrition. Clinics in Dermatology 28: 605-614.
'Atopic dermatitis and nutrition ' () 28 Clinics in Dermatology : 605 -614.
Gore, C., Munro, K., Lay, C., Bibiloni, R., Morris, J., Woodcock, A., Custovic, A. and Tannock, G.W., 2008. Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. Journal of Allergy and Clinical Immunology 121: 135-140.
'Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants ' () 121 Journal of Allergy and Clinical Immunology : 135 -140.
Gourbeyre, P., Denery, S. and Bodinier, M., 2011. Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions. Journal of Leukocyte Biology 89: 685-695.
'Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions ' () 89 Journal of Leukocyte Biology : 685 -695.
Hammer, B., Ashurst, P. and Naish, J., 1968. Diseases associated with ulcerative colitis and Crohn’s disease. Gut 9: 17-21.
'Diseases associated with ulcerative colitis and Crohn’s disease ' () 9 Gut : 17 -21.
Hanifin, J.M., 2009. Evolving concepts of pathogenesis in atopic dermatitis and other eczemas. Journal of Investigative Dermatology 129: 320-322.
'Evolving concepts of pathogenesis in atopic dermatitis and other eczemas ' () 129 Journal of Investigative Dermatology : 320 -322.
Iemoli, E., Trabattoni, D., Parisotto, S., Borgonovo, L., Toscano, M., Rizzardini, G., Clerici, M., Ricci, E., Fusi, A., De Vecchi, E., Piconi, S. and Drago, L., 2012. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. Journal of Clinical Gastroenterology 46 Suppl.: S33-S40.
'Probiotics reduce gut microbial translocation and improve adult atopic dermatitis ' () 46 Journal of Clinical Gastroenterology : S33 -S40.
Jong, M.C., Gijbels, M.J., Dahlmans, V.E., Gorp, P.J., Koopman, S.J., Ponec, M., Hofker, M.H. and Havekes, L.M., 1998. Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1. Journal of Clinical Investigation 101: 145-152.
'Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1 ' () 101 Journal of Clinical Investigation : 145 -152.
Juremalm, M. and Nilsson, G., 2005. Chemokine receptor expression by mast cells. Chemical Immunology and Allergy 87: 130-144.
'Chemokine receptor expression by mast cells ' () 87 Chemical Immunology and Allergy : 130 -144.
Kalliomaki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P. and Isolauri, E., 2001. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. The Lancet 357: 1076-1079.
'Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial ' () 357 The Lancet : 1076 -1079.
Kelly, D. and Mulder, I.E., 2012. Microbiome and immunological interactions. Nutrition Reviews 70 Suppl. 1: S18-S30.
'Microbiome and immunological interactions ' () 70 Nutrition Reviews : S18 -S30.
Kim, H.J., Kim, H.Y., Lee, S.Y., Seo, J.H., Lee, E. and Hong, S.J., 2013. Clinical efficacy and mechanism of probiotics in allergic diseases. Korean Journal of Pediatrics 56: 369-376.
'Clinical efficacy and mechanism of probiotics in allergic diseases ' () 56 Korean Journal of Pediatrics : 369 -376.
Kim, H.J., Kim, Y.J., Lee, S.H., Yu, J., Jeong, S.K. and Hong, S.J., 2014. Effects of Lactobacillus rhamnosus on allergic march model by suppressing Th2, Th17, and TSLP responses via CD4(+)CD25(+)Foxp3(+) Tregs. Clinical Immunology 153: 178-186.
'Effects of Lactobacillus rhamnosus on allergic march model by suppressing Th2, Th17, and TSLP responses via CD4(+)CD25(+)Foxp3(+) Tregs ' () 153 Clinical Immunology : 178 -186.
Kozyrskyj, A.L., Ernst, P. and Becker, A.B., 2007. Increased risk of childhood asthma from antibiotic use in early life. Chest 131: 1753-1759.
'Increased risk of childhood asthma from antibiotic use in early life ' () 131 Chest : 1753 -1759.
Kremer, B., Mariman, R., van Erk, M., Lagerweij, T. and Nagelkerken, L., 2012. Temporal colonic gene expression profiling in the recurrent colitis model identifies early and chronic inflammatory processes. PloS one 7: e50388.
'Temporal colonic gene expression profiling in the recurrent colitis model identifies early and chronic inflammatory processes ' () 7 PloS one : e50388.
Lees, C.W., Barrett, J.C., Parkes, M. and Satsangi, J., 2011b. New IBD genetics: common pathways with other diseases. Gut 60: 1739-1753.
'New IBD genetics: common pathways with other diseases ' () 60 Gut : 1739 -1753.
Mariman, R., Kremer, B., van Erk, M., Lagerweij, T., Koning, F. and Nagelkerke, L., 2012. Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics. Inflammatory Bowel Diseases 18: 1424-1433.
'Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics ' () 18 Inflammatory Bowel Diseases : 1424 -1433.
Mariman, R., Tielen, F., Koning, F. and Nagelkerken, L., 2015. The probiotic mixture VSL#3 Has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/6 Mice. Journal of Nutrition 145: 1354-1361.
'The probiotic mixture VSL#3 Has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/6 Mice ' () 145 Journal of Nutrition : 1354 -1361.
Matsuda, A., Tanaka, A., Pan, W., Okamoto, N., Oida, K., Kingyo, N., Amagai, Y., Xia, Y., Jang, H., Nishikawa, S., Kajiwara, N., Ahn, G., Ohmori, K. and Matsuda, H., 2012. Supplementation of the fermented soy product ImmuBalance effectively reduces itching behavior of atopic NC/Tnd mice. Journal of Dermatological Science 67: 130-139.
'Supplementation of the fermented soy product ImmuBalance effectively reduces itching behavior of atopic NC/Tnd mice ' () 67 Journal of Dermatological Science : 130 -139.
Mills, C.D., Kincaid, K., Alt, J.M., Heilman, M.J. and Hill, A.M., 2000. M-1/M-2 macrophages and the Th1/Th2 paradigm. Journal of Immunology 164: 6166-6173.
'M-1/M-2 macrophages and the Th1/Th2 paradigm ' () 164 Journal of Immunology : 6166 -6173.
Nagelkerke, L., Verzaal, P., Lagerweij, T., Persoon-Deen, C., Berbee, J.F., Prens, E.P., Havekes, L.M. and Oranje, A.P., 2008. Development of atopic dermatitis in mice transgenic for human apolipoprotein C1. Journal of Investigative Dermatology 128: 1165-1172.
'Development of atopic dermatitis in mice transgenic for human apolipoprotein C1 ' () 128 Journal of Investigative Dermatology : 1165 -1172.
Niwa, Y., Sumi, H. and Akamatsu, H., 2004. An association between ulcerative colitis and atopic dermatitis, diseases of impaired superficial barriers. Journal of Investigative Dermatology 123: 999-1000.
'An association between ulcerative colitis and atopic dermatitis, diseases of impaired superficial barriers ' () 123 Journal of Investigative Dermatology : 999 -1000.
Oranje, A.P., Verbeek, R., Verzaal, P., Haspels, I., Prens, E. and Nagelkerke, L., 2009. Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. British Journal of Dermatology 160: 54-61.
'Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis ' () 160 British Journal of Dermatology : 54 -61.
Ozdemir, O., 2010. Any benefits of probiotics in allergic disorders? Allergy and Asthma Proceedings 31: 103-111.
'Any benefits of probiotics in allergic disorders? ' () 31 Allergy and Asthma Proceedings : 103 -111.
Penders, J., Stobberingh, E.E., Van den Brandt, P.A. and Thijs, C., 2007. The role of the intestinal microbiota in the development of atopic disorders. Allergy 62: 1223-1236.
'The role of the intestinal microbiota in the development of atopic disorders ' () 62 Allergy : 1223 -1236.
Pike, M.G., Heddle, R.J., Boulton, P., Turner, M.W. and Atherton, D.J., 1986. Increased intestinal permeability in atopic eczema. Journal of Investigative Dermatology 86: 101-104.
'Increased intestinal permeability in atopic eczema ' () 86 Journal of Investigative Dermatology : 101 -104.
Psarros, M., Heber, S., Sick, M., Thoppae, G., Harshman, K. and Sick, B., 2005. RACE: remote analysis computation for gene expression data. Nucleic Acids Research 33: W638-43.
'RACE: remote analysis computation for gene expression data ' () 33 Nucleic Acids Research : W638 -43.
Pugh, S.M., Rhodes, J., Mayberry, J.F., Roberts, D.L., Heatley, R.V. and Newcombe, R.G., 1979. Atopic disease in ulcerative colitis and Crohn’s disease. Clinical Allergy 9: 221-223.
'Atopic disease in ulcerative colitis and Crohn’s disease ' () 9 Clinical Allergy : 221 -223.
Rautava, S., Ruuskanen, O., Ouwehand, A., Salminen, S. and Isolauri, E., 2004. The hygiene hypothesis of atopic disease--an extended version. Journal of Pediatric Gastroenterology and Nutrition 38: 378-388.
'The hygiene hypothesis of atopic disease--an extended version ' () 38 Journal of Pediatric Gastroenterology and Nutrition : 378 -388.
Romagnani, S., 2004. The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology 112: 352-363.
'The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? ' () 112 Immunology : 352 -363.
Romagnani, S., 2006. Regulatory T cells: which role in the pathogenesis and treatment of allergic disorders? Allergy 61: 3-14.
'Regulatory T cells: which role in the pathogenesis and treatment of allergic disorders? ' () 61 Allergy : 3 -14.
Rook, G.A., 2012. Hygiene hypothesis and autoimmune diseases. Clinical Reviews in Allergy & Immunology 42: 5-15.
'Hygiene hypothesis and autoimmune diseases ' () 42 Clinical Reviews in Allergy & Immunology : 5 -15.
Rosenfeldt, V., Benfeldt, E., Valerius, N.H., Paerregaard, A. and Michaelsen, K.F., 2004. Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. Journal of Pediatrics 145: 612-616.
'Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis ' () 145 Journal of Pediatrics : 612 -616.
Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Folster-Holst, R., Rodriguez, E., Lee, Y.A., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nothen, M.M., Irvine, A.D., McLean, W.H., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N. and Weidinger, S., in press. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. Journal of Allergy and Clinical Immunology. doi: http://dx.doi.org/10.1016/j.jaci.2015.06.029.
Song, H., Yoo, Y., Hwang, J., Na, Y.C. and Kim, H.S., in press. Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. Journal of Allergy and Clinical Immunology. doi: http://dx.doi.org/10.1016/j.jaci.2015.08.021.
Strachan, D.P., 1989. Hay fever, hygiene, and household size. BMJ 299: 1259-1260.
'Hay fever, hygiene, and household size ' () 299 BMJ : 1259 -1260.
Sun, M., He, C., Cong, Y. and Liu, Z., 2015. Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunology 8: 969-978.
'Regulatory immune cells in regulation of intestinal inflammatory response to microbiota ' () 8 Mucosal Immunology : 969 -978.
Van der Aa, L.B., Heymans, H.S., Van Aalderen, W.M. and Sprikkelman, A.B., 2010. Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. Pediatric Allergy and Immunology 21: e355-e367.
'Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence ' () 21 Pediatric Allergy and Immunology : e355 -e367.
Van Vlijmen, B.J., Van den Maagdenberg, A.M., Gijbels, M.J., Van der Boom, H., HogenEsch, H., Frants, R.R., Hofker, M.H. and Havekes, L.M., 1994. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. Journal of Clinical Investigation 93: 1403-1410.
'Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice ' () 93 Journal of Clinical Investigation : 1403 -1410.
Von Mutius, E., 2007. Allergies, infections and the hygiene hypothesis – the epidemiological evidence. Immunobiology 212: 433-439.
'Allergies, infections and the hygiene hypothesis – the epidemiological evidence ' () 212 Immunobiology : 433 -439.
Wang, M., Karlsson, C., Olsson, C., Adlerberth, I., Wold, A.E., Strachan, D.P., Martricardi, P.M., Aberg, N., Perkin, M.R., Tripodi, S., Coates, A.R., Hesselmar, B., Saalman, R., Molin, G. and Ahrne, S., 2008. Reduced diversity in the early fecal microbiota of infants with atopic eczema. Journal of Allergy and Clinical Immunology 121: 129-134.
'Reduced diversity in the early fecal microbiota of infants with atopic eczema ' () 121 Journal of Allergy and Clinical Immunology : 129 -134.
| All Time | Past 365 days | Past 30 Days | |
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| Abstract Views | 514 | 129 | 37 |
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Genetic predisposition and environmental factors, including the gut microbiota, have been suggested as major factors in the development and progression of atopic dermatitis. Hyperlipidemic human APOC1+/+ transgenic mice display many features of human atopic dermatitis, such as scaling, lichenification, excoriations, and pruritus, along with a disturbed skin barrier function. Cytokine analysis of serum shows an increase of various pro-inflammatory cytokines, including interleukin (IL)-12p40, IL-6, and IL-1α, but lower levels of interferon-γ. These mice also display aspects of colitis evident from macroscopic and histological abnormalities. Genome-wide transcriptome analysis of the intestine shows up-regulation of several genes associated with mast cells and eosinophils and this observation was confirmed by demonstrating increased numbers of IgE+ and FcRε+ mast cells in the colon and in the skin. Oral treatment with Lactobacillus plantarum NCIMB8826 resulted in decreased numbers of mast cells in the colon. Moreover, this L. plantarum strain ameliorated skin pathology, evident from improved skin barrier integrity, absence of skin thickening, and less excoriations. These results suggest that modulation of intestinal immune homeostasis contributes to the suppression of atopic dermatitis.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 514 | 129 | 37 |
| Full Text Views | 18 | 0 | 0 |
| PDF Views & Downloads | 23 | 0 | 0 |