Save

Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats

in Beneficial Microbes
Autor:innen:
T. Wang Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China P.R.

Search for other papers by T. Wang in
Current site
Google Scholar
PubMed
Close
,
X. Hu Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China P.R.

Search for other papers by X. Hu in
Current site
Google Scholar
PubMed
Close
,
S. Liang Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China P.R.

Search for other papers by S. Liang in
Current site
Google Scholar
PubMed
Close
,
W. Li Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China P.R.

Search for other papers by W. Li in
Current site
Google Scholar
PubMed
Close
,
X. Wu Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China P.R.

Search for other papers by X. Wu in
Current site
Google Scholar
PubMed
Close
,
L. Wang Institute of Ageing Research, Hangzhou Normal University, Building D, Science and Technology Park, 1378 Wenyi West Road, Hangzhou, Zhejiang 311121, China P.R.

Search for other papers by L. Wang in
Current site
Google Scholar
PubMed
Close
, und
F. Jin Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China P.R.

Search for other papers by F. Jin in
Current site
Google Scholar
PubMed
Close
Zitierung herunterladen Berechtigungen erhalten

Optionen für den Zugriff

Nutzen Sie bitte eine der untenstehenden Zugriffsmöglichkeiten, um den vollständigen Artikel zu lesen.

Institutszugang

Melden Sie sich mit Open Athens, Shibboleth oder Ihren institutionellen Anmeldedaten an.

Über Institut einloggen

Kauf

Sofortzugang erwerben (PDF-Download und unbegrenzter Online-Zugang):

36,93 €

Weitere Zugriffsmöglichkeiten

Auf DeepDyve mieten
Token einlösen

Gut microbiota play a vital role in maintaining the health of the host. Many factors affect gut microbiota; application of broad range antibiotics disturb microbiota, while probiotic application protects the microbiota. To investigate how probiotics alter the physiological and psychological changes induced by antibiotics, we tested the performance of ampicillin-treated rats in the presence or absence of Lactobacillus fermentum strain NS9, in elevated plus maze and Morris water maze. The results showed that NS9 normalised the composition of gut microbiota and alleviated the ampicillin-induced inflammation in the colon. The levels of the mineralocorticoid and N-methyl-D-aspartate receptors were also elevated in the hippocampus of the ampillicin+NS9 treated group. NS9 administration also reduced the anxiety-like behaviour and alleviated the ampicillin-induced impairment in memory retention. These findings suggest that NS9 is beneficial to the host, because it restores the physiological and psychological abnormalities induced by ampicillin. Our results highlight how gut contents regulate the brain, and shed light on the clinical applications of probiotics to treat the side effect of antibiotics and mental disorders.

Kennzahlen

Insgesamt Letzte 365 Tage In den letzten 30 Tagen
Aufrufe von Kurzbeschreibungen 1334 412 45
Gesamttextansichten 130 40 2
PDF-Downloads 63 11 4