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Effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in mice

In: Beneficial Microbes
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T. Satoh Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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M. Murata Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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N. Iwabuchi Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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T. Odamaki Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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H. Wakabayashi Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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K. Yamauchi Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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F. Abe Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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J.Z. Xiao Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan

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Probiotics have been shown to have a preventative effect on skin photoaging induced by short term UV irradiation, however, the underlying mechanisms and the effect of probiotics on skin photoaging induced by chronic UV irradiation remain unclear. In this study, we investigated the effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in hairless mice. Mice were irradiated with UVB three times weekly and orally administered B. breve B-3 (2×109 cfu/mouse /day) for 7 weeks. Nonirradiated mice and UVB-irradiated mice without probiotic treatment were used as controls. B. breve B-3 significantly suppressed the changes of transepidermal water loss, skin hydration, epidermal thickening and attenuated the damage to the tight junction structure and basement membrane induced by chronic UVB irradiation. Administration of B. breve B-3 tended to suppress the UV-induced interleukin-1β production in skin (P=0.09). These results suggest that B. breve B-3 could potentially be used to prevent photoaging induced by chronic UV irradiation.

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