Lactobacillus-produced exopolysaccharides and their potential health benefits: a review
äºBeneficial MicrobesCentre for Liver Research, School of Immunity and Infection, University of Birmingham, B15 2TT Birmingham, United Kingdom
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Lactic acid bacteria, such as those of the Lactobacillus genus, naturally reside within the microbiota of the human body and have long been used as starter cultures and probiotic enhancers in fermented foods, such as fermented drinks, yoghurts and cheeses. Many of the beneficial qualities of these bacteria have traditionally been associated with the bacteria themselves, however, a recent spate of studies have demonstrated a wide variety of biological effects exhibited by lactobacilli-produced exopolysaccharides which could, theoretically, confer a range of local and systemic health benefits upon the host. In this review, we discuss the production of exopolysaccharides within the Lactobacillus genus and explore their potential as beneficial bioactive compounds.
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-
Ai, L., Zhang, H., Guo, B., Chen, W., Wu, Z. and Wu, Y., 2008. Preparation, partial characterization and bioactivity of exopolysaccharides from Lactobacillus casei LC2W. Carbohydrate Polymers 74: 353-357.
'Preparation, partial characterization and bioactivity of exopolysaccharides from Lactobacillus casei LC2W ' () 74 Carbohydrate Polymers : 353 -357.
-
Akira, S., Uematsu, S. and Takeuchi, H., 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
'Pathogen recognition and innate immunity ' () 124 Cell : 783 -801.
-
Anwar, M.A., Kralj, S., Piqué, A.V., Leemhuis, H., van der Maarel, M.J.E.C. and Dijkhuizen, L., 2010. Inulin and levan synthesis by probiotic Lactobacillus gasseri strains: characterization of three novel fructansucrase enzymes and their fructan products. Microbiology 156: 1264-1274.
'Inulin and levan synthesis by probiotic Lactobacillus gasseri strains: characterization of three novel fructansucrase enzymes and their fructan products ' () 156 Microbiology : 1264 -1274.
-
à rsköld, E., Svensson, M., Grage, H., Roos, S., Rådström, P. and van Niel, E.W.J., 2007. Environmental influences on exopolysaccharide formation in Lactobacillus reuteri ATCC 55730. International Journal of Food Microbiology 116: 159-167.
'Environmental influences on exopolysaccharide formation in Lactobacillus reuteri ATCC 55730 ' () 116 International Journal of Food Microbiology : 159 -167.
-
Badel, S., Bernardi, T. and Michaud, P., 2010. New perspectives for lactobacilli exopolysaccharides. Biotechnology Advances 29: 54-66.
'New perspectives for lactobacilli exopolysaccharides ' () 29 Biotechnology Advances : 54 -66.
-
Behare, P.V., Singh, R., Nagpal, R. and Rao, K.H., 2013. Exopolysaccharides producing Lactobacillus fermentum strain for enhancing rheological and sensory attributes of low-fat dahi. Journal of Food Science and Technology 50: 1228-1232.
'Exopolysaccharides producing Lactobacillus fermentum strain for enhancing rheological and sensory attributes of low-fat dahi ' () 50 Journal of Food Science and Technology : 1228 -1232.
-
Bello, F.D., Walter, J., Hertel, C. and Hammes, W.P., 2001. In vitro study of prebiotic properties of levan-type exopolysaccharides from lactobacilli and non-digestible carbohydrates using denaturing gradient gel electrophoresis. Systematic and Applied Microbiology 24: 232-237.
'In vitro study of prebiotic properties of levan-type exopolysaccharides from lactobacilli and non-digestible carbohydrates using denaturing gradient gel electrophoresis ' () 24 Systematic and Applied Microbiology : 232 -237.
-
Bentley, S.D., Aanensen, D.M., Mavroidi, A., Saunders, D., Rabbinowitsch, E., Collins, M., Donohoe, K., Harris, D., Murphy, L. and Quail, M.A., 2006. Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes. PLoS Genetics 2: e31.
'Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes ' () 2 PLoS Genetics : e31.
-
Bernardeau, M., Guguen, M. and Vernoux, J.P., 2006. Beneficial lactobacilli in food and feed: long-term use, biodiversity and proposals for specific and realistic safety assessments. FEMS Microbiology Reviews 30: 487-513.
'Beneficial lactobacilli in food and feed: long-term use, biodiversity and proposals for specific and realistic safety assessments ' () 30 FEMS Microbiology Reviews : 487 -513.
-
Bhaskaracharya, R.K. and Shah, N.P., 2000. Texture characteristics and microstructure of skim milk mozzarella cheeses made using exopolysaccharide or non-exopolysaccharide producing starter cultures. Australian Journal of Dairy Technology 55: 132-138.
'Texture characteristics and microstructure of skim milk mozzarella cheeses made using exopolysaccharide or non-exopolysaccharide producing starter cultures ' () 55 Australian Journal of Dairy Technology : 132 -138.
-
Bleau, C., Monges, A., Rashidan, K., Laverdure, J.-P., Lacroix, M., Van Calsteren, M.-R., Millette, M., Savard, R. and Lamontagne, L., 2010. Intermediate chains of exopolysaccharides from Lactobacillus rhamnosus RW-9595M increase IL-10 production by macrophages. Journal of Applied Microbiology 108: 666-675.
'Intermediate chains of exopolysaccharides from Lactobacillus rhamnosus RW-9595M increase IL-10 production by macrophages ' () 108 Journal of Applied Microbiology : 666 -675.
-
Blum, S., Haller, D., Pfeifer, A. and Schiffrin, E.J., 2002. Probiotics and immune response. Clinical Reviews in Allergy and Immunology 22: 287-309.
'Probiotics and immune response ' () 22 Clinical Reviews in Allergy and Immunology : 287 -309.
-
Boels, I.C., van Kranenburg, R., Hugenholtz, J., Kleerebezem, M. and de Vos, W.M., 2001. Sugar catabolism and its impact on the biosynthesis and engineering of exopolysaccharide production in lactic acid bacteria. International Dairy Journal 11: 723-732.
'Sugar catabolism and its impact on the biosynthesis and engineering of exopolysaccharide production in lactic acid bacteria ' () 11 International Dairy Journal : 723 -732.
-
Byeon, S.E., Lee, J., Lee, E., Lee, S.Y., Hong, E.K., Kim, Y.E. and Cho, J.Y., 2009. Functional activation of macrophages, monocytes and splenic lymphocytes by polysaccharide fraction from Tricholoma matsutake. Archives of Pharmacal Research 32: 1565-1572.
'Functional activation of macrophages, monocytes and splenic lymphocytes by polysaccharide fraction from Tricholoma matsutake ' () 32 Archives of Pharmacal Research : 1565 -1572.
-
Cerning, J., Renard, C.M.G.C., Thibault, J.F., Bouillanne, C., Landon, M., Desmazeaud, M. and Topisirovic, L., 1994. Carbon source requirements for exopolysaccharide production by Lactobacillus casei CG11 and partial structure analysis of the polymer. Applied and Environmental Microbiology 60: 3914-3919.
'Carbon source requirements for exopolysaccharide production by Lactobacillus casei CG11 and partial structure analysis of the polymer ' () 60 Applied and Environmental Microbiology : 3914 -3919.
-
Chabot, S., Yu, H.-L., De Leseleuc, L., Cloutier, D., Van Calsteren, M.-R., Lessard, M., Roy, D., Lacroix, M. and Oth, D., 2001. Exopolysaccharides from Lactobacillus rhamnosus RW-9595M stimulate TNF, IL-6 and IL-12 in human and mouse cultured immunocompetent cells, and IFN-γ in mouse splenocytes. Lait 81: 683-697.
'Exopolysaccharides from Lactobacillus rhamnosus RW-9595M stimulate TNF, IL-6 and IL-12 in human and mouse cultured immunocompetent cells, and IFN-γ in mouse splenocytes ' () 81 Lait : 683 -697.
-
Charalampopoulos, D. and Rastall, R.A., 2012. Prebiotics in foods. Current Opinion in Biotechnology 23: 187-191.
'Prebiotics in foods ' () 23 Current Opinion in Biotechnology : 187 -191.
-
Choi, S.S., Kim, Y., Han, K.S., You, S., Oh, S. and Kim, S.H., 2006. Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro. Letters in Applied Microbiology 42: 452-458.
'Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro ' () 42 Letters in Applied Microbiology : 452 -458.
-
Ciszek-Lenda, M., Nowak, B., Oeróttek, M., Górska-FrÄ czek, S., Gamian, A. and Marcinkiewicz, J., 2012. Immunosuppressive effect of systemic administration of Lactobacillus rhamnosus KL37C-derived exopolysaccharide on the OVA-specific humoral response. Central European Journal of Immunology 37: 338-344.
'Immunosuppressive effect of systemic administration of Lactobacillus rhamnosus KL37C-derived exopolysaccharide on the OVA-specific humoral response ' () 37 Central European Journal of Immunology : 338 -344.
-
Ciszek-Lenda, M., Nowak, B., Srottek, M., Gamian, A. and Marcinkiewicz, J., 2011a. Immunoregulatory potential of exopolysaccharide from Lactobacillus rhamnosus KL37. Effects on the production of inflammatory mediators by mouse macrophages. International Journal of Experimental Pathology 92: 382-391.
'Immunoregulatory potential of exopolysaccharide from Lactobacillus rhamnosus KL37. Effects on the production of inflammatory mediators by mouse macrophages ' () 92 International Journal of Experimental Pathology : 382 -391.
-
Ciszek-Lenda, M., Nowak, B., Srottek, M., Walczewska, M., Gorska-Fraczek, S., Gamian, A. and Marcinkiewicz, J., 2013. Further studies on immunomodulatory effects of exopolysaccharide isolated from Lactobacillus rhamnosus KL37C. Central European Journal of Immunology 38: 289-298.
'Further studies on immunomodulatory effects of exopolysaccharide isolated from Lactobacillus rhamnosus KL37C ' () 38 Central European Journal of Immunology : 289 -298.
-
Ciszek-Lenda, M., Strus, M., Górska-FrÄ czek, S., Targosz-Korecka, M., Åróttek, M., Heczko, P.B., Gamian, A., SzymoÅski, M. and Marcinkiewicz, J., 2011b. Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides. Central-European Journal of Immunology 36: 121-129.
'Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides ' () 36 Central-European Journal of Immunology : 121 -129.
-
Das, D., Baruah, R. and Goyal, A., 2014. A food additive with prebiotic properties of an α-D-glucan from Lactobacillus plantarum DM5. International Journal of Biological Macromolecules 69: 20-26.
'A food additive with prebiotic properties of an α-D-glucan from Lactobacillus plantarum DM5 ' () 69 International Journal of Biological Macromolecules : 20 -26.
-
De Vuyst, L. and Degeest, B., 1999. Heteropolysaccharides from lactic acid bacteria. FEMS Microbiology Reviews 23: 153-177.
'Heteropolysaccharides from lactic acid bacteria ' () 23 FEMS Microbiology Reviews : 153 -177.
-
Degeest, B., Janssens, B. and De Vuyst, L., 2001. Exopolysaccharide (EPS) biosynthesis by Lactobacillus sakei 0-1: production kinetics, enzyme activities and EPS yields. Journal of Applied Microbiology 91: 470-477.
'Exopolysaccharide (EPS) biosynthesis by Lactobacillus sakei 0-1: production kinetics, enzyme activities and EPS yields ' () 91 Journal of Applied Microbiology : 470 -477.
-
Dertli, E., Colquhoun, I.J., Gunning, A.P., Bongaerts, R.J., Le Gall, G., Bonev, B.B., Mayer, M.J. and Narbad, A., 2013. Structure and biosynthesis of two exopolysaccharides produced by Lactobacillus johnsonii FI9785. Journal of Biological Chemistry 288: 31938-31951.
'Structure and biosynthesis of two exopolysaccharides produced by Lactobacillus johnsonii FI9785 ' () 288 Journal of Biological Chemistry : 31938 -31951.
-
Donnarumma, G., Molinaro, A., Cimini, D., De Castro, C., Valli, V., De Gregorio, V., De Rosa, M. and Schiraldi, C., 2014. Lactobacillus crispatus L1: high cell density cultivation and exopolysaccharide structure characterization to highlight potentially beneficial effects against vaginal pathogens. BMC Microbiology 14: 137.
'Lactobacillus crispatus L1: high cell density cultivation and exopolysaccharide structure characterization to highlight potentially beneficial effects against vaginal pathogens ' () 14 BMC Microbiology : 137.
-
Donot, F., Fontana, A., Baccou, J.C. and Schorr-Galindo, S., 2012. Microbial exopolysaccharides: Main examples of synthesis, excretion, genetics and extraction. Carbohydrate Polymers 87: 951-962.
'Microbial exopolysaccharides: Main examples of synthesis, excretion, genetics and extraction ' () 87 Carbohydrate Polymers : 951 -962.
-
Dueñas-Chasco, M.T., RodrÃguez-Carvajal, M.A., Tejero-Mateo, P., Espartero, J.L., Irastorza-Iribas, A. and Gil-Serrano, A.M., 1998. Structural analysis of the exopolysaccharides produced by Lactobacillus spp. G-77. Carbohydrate Research 307: 125-133.
'Structural analysis of the exopolysaccharides produced by Lactobacillus spp. G-77 ' () 307 Carbohydrate Research : 125 -133.
-
Durlu-Ozkaya, F., Aslim, B. and Ozkaya, M.T., 2007. Effect of exopolysaccharides (EPSs) produced by Lactobacillus delbrueckii subsp. bulgaricus strains to bacteriophage and nisin sensitivity of the bacteria. Lebensmittel-Wissenschaft und -Technologie 40: 564-568.
'Effect of exopolysaccharides (EPSs) produced by Lactobacillus delbrueckii subsp. bulgaricus strains to bacteriophage and nisin sensitivity of the bacteria ' () 40 Lebensmittel-Wissenschaft und -Technologie : 564 -568.
-
European Food Satefty Authority (EFSA), 2007. Opinion of the Scientific Committee on a request from EFSA on the introduction of a Qualified Presumption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA. EFSA Journal 587: 1-16.
'Opinion of the Scientific Committee on a request from EFSA on the introduction of a Qualified Presumption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA. ' () 587 EFSA Journal : 1 -16.
-
El-Gizawy, S.A., Barakat, S., Sharaf, O.M., El-Shafei, K., Fathy, F.A. and El-Sayed, H.S., 2013. Effect of growth conditions on the production of exopolysaccharides by microencapsulated Lactobacillus bulgaricus and use it to improve quality of Kareish cheese. Journal of Applied Sciences Research 9: 1097-1109.
'Effect of growth conditions on the production of exopolysaccharides by microencapsulated Lactobacillus bulgaricus and use it to improve quality of Kareish cheese ' () 9 Journal of Applied Sciences Research : 1097 -1109.
-
Epstein, F.H. and Ross, R., 1999. Atherosclerosis â an inflammatory disease. New England Journal of Medicine 340: 115-126.
'Atherosclerosis â an inflammatory disease ' () 340 New England Journal of Medicine : 115 -126.
-
Faber, E.J., Kamerling, J.P. and Vliegenthart, J.F.G., 2001. Structure of the extracellular polysaccharide produced by Lactobacillus delbrueckii subsp bulgaricus 291. Carbohydrate Research 331: 183-194.
'Structure of the extracellular polysaccharide produced by Lactobacillus delbrueckii subsp bulgaricus 291 ' () 331 Carbohydrate Research : 183 -194.
-
Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO), 2002. Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. Available at: ftp://ftp.fao.org/es/esn/food/wgreport2.pdf.
'Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food ', ().
-
Feng, M., Chen, X., Li, C., Nurgul, R. and Dong, M., 2012. Isolation and Identification of an Exopolysaccharide-producing lactic acid bacterium strain from Chinese Paocai and biosorption of Pb (II) by its exopolysaccharide. Journal of Food Science 77: T111-T117.
'Isolation and Identification of an Exopolysaccharide-producing lactic acid bacterium strain from Chinese Paocai and biosorption of Pb (II) by its exopolysaccharide ' () 77 Journal of Food Science : T111 -T117.
-
Fooks, L.J., Fuller, R. and Gibson, G.R., 1999. Prebiotics, probiotics and human gut microbiology. International Dairy Journal 9: 53-61.
'Prebiotics, probiotics and human gut microbiology ' () 9 International Dairy Journal : 53 -61.
-
Freitas, F., Alves, V.D. and Reis, M.A.M., 2011. Advances in bacterial exopolysaccharides: from production to biotechnological applications. Trends in Biotechnology 29: 388-398.
'Advances in bacterial exopolysaccharides: from production to biotechnological applications ' () 29 Trends in Biotechnology : 388 -398.
-
Fukushima, Y., Kawata, Y., Hara, H., Terada, A. and Mitsuoka, T., 1998. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. International Journal of Food Microbiology 42: 39-44.
'Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children ' () 42 International Journal of Food Microbiology : 39 -44.
-
Gelderblom, H., Verweij, J., Nooter, K. and Sparreboom, A., 2001. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. European Journal of Cancer 37: 1590-1598.
'Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation ' () 37 European Journal of Cancer : 1590 -1598.
-
Gibson, G.R., Beatty, E.R., Wang, X. and Cummings, J.H., 1995. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108: 975-982.
'Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin ' () 108 Gastroenterology : 975 -982.
-
Gibson, G.R. and Roberfroid, M.B., 1995. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. Journal of Nutrition 125: 1401-1412.
'Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics ' () 125 Journal of Nutrition : 1401 -1412.
-
Gill, H.S., Rutherfurd, K.J. and Cross, M.L., 2001. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. Journal of Clinical Immunology 21: 264-271.
'Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes ' () 21 Journal of Clinical Immunology : 264 -271.
-
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M. and Campieri, M., 2000. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 119: 305-309.
'Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial ' () 119 Gastroenterology : 305 -309.
-
Gomes, A.M.P. and Malcata, F.X., 1999. Bifidobacterium spp. and Lactobacillus acidophilus: biological, biochemical, technological and therapeutical properties relevant for use as probiotics. Trends in Food Science and Technology 10: 139-157.
'Bifidobacterium spp. and Lactobacillus acidophilus: biological, biochemical, technological and therapeutical properties relevant for use as probiotics ' () 10 Trends in Food Science and Technology : 139 -157.
-
Górska-FrÄ czek, S., Sandström, C., Kenne, L., PaÅciak, M., Brzozowska, E., Strus, M., Heczko, P. and Gamian, A., 2013. The structure and immunoreactivity of exopolysaccharide isolated from Lactobacillus johnsonii strain 151. Carbohydrate Research 378: 148-153.
'The structure and immunoreactivity of exopolysaccharide isolated from Lactobacillus johnsonii strain 151 ' () 378 Carbohydrate Research : 148 -153.
-
Grobben, G.J., Smith, M.R., Sikkema, J. and De Bont, J.A.M., 1996. Influence of fructose and glucose on the production of exopolysaccharides and the activities of enzymes involved in the sugar metabolism and the synthesis of sugar nucleotides in Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772. Applied Microbiology and Biotechnology 46: 279-284.
'Influence of fructose and glucose on the production of exopolysaccharides and the activities of enzymes involved in the sugar metabolism and the synthesis of sugar nucleotides in Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772 ' () 46 Applied Microbiology and Biotechnology : 279 -284.
-
Harding, L.P., Marshall, V.M., Elvin, M., Gu, Y. and Laws, A.P., 2003. Structural characterisation of a perdeuteriomethylated exopolysaccharide by NMR spectroscopy: characterisation of the novel exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus EU23. Carbohydrate Research 338: 61-67.
'Structural characterisation of a perdeuteriomethylated exopolysaccharide by NMR spectroscopy: characterisation of the novel exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus EU23 ' () 338 Carbohydrate Research : 61 -67.
-
Harding, L.P., Marshall, V.M., Hernandez, Y., Gu, Y., Maqsood, M., McLay, N. and Laws, A.P., 2005. Structural characterisation of a highly branched exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus NCFB2074. Carbohydrate Research 340: 1107-1111.
'Structural characterisation of a highly branched exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus NCFB2074 ' () 340 Carbohydrate Research : 1107 -1111.
-
Hidalgo-Cantabrana, C., López, P., Gueimonde, M., de los Reyes-Gavilán, C.G., Suárez, A., Margolles, A. and Ruas-Madiedo, P., 2012. Immune modulation capability of exopolysaccharides synthesised by lactic acid bacteria and bifidobacteria. Probiotics and Antimicrobial Proteins 4: 227-237.
'Immune modulation capability of exopolysaccharides synthesised by lactic acid bacteria and bifidobacteria ' () 4 Probiotics and Antimicrobial Proteins : 227 -237.
-
Hidalgo-Cantabrana, C., Sánchez, B., Milani, C., Ventura, M., Margolles, A. and Ruas-Madiedo, P., 2014. Genomic overview and biological functions of exopolysaccharide biosynthesis in Bifidobacterium spp. Applied and Environmental Microbiology 80: 9-18.
'Genomic overview and biological functions of exopolysaccharide biosynthesis in Bifidobacterium spp ' () 80 Applied and Environmental Microbiology : 9 -18.
-
Hill, C., Guarner, F., Reid, G., Gibson, G.R., Merenstein, D.J., Pot, B., Morelli, L., Canani, B.R., Flint, H.J. and Salminen, S., 2014. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology and Hepatology 11: 506-514.
'The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic ' () 11 Nature Reviews Gastroenterology and Hepatology : 506 -514.
-
Hongpattarakere, T., Cherntong, N., Wichienchot, S., Kolida, S. and Rastall, R.A., 2012. In vitro prebiotic evaluation of exopolysaccharides produced by marine isolated lactic acid bacteria. Carbohydrate Polymers 87: 846-852.
'In vitro prebiotic evaluation of exopolysaccharides produced by marine isolated lactic acid bacteria ' () 87 Carbohydrate Polymers : 846 -852.
-
Horn, N., Wegmann, U., Dertli, E., Mulholland, F., Collins, S.R.A., Waldron, K.W., Bongaerts, R.J., Mayer, M.J. and Narbad, A., 2013. Spontaneous mutation reveals influence of exopolysaccharide on Lactobacillus johnsonii surface characteristics. PloS one 8: e59957.
'Spontaneous mutation reveals influence of exopolysaccharide on Lactobacillus johnsonii surface characteristics ' () 8 PloS one : e59957.
-
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S., 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. Journal of Immunology 162: 3749-3752.
'Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product ' () 162 Journal of Immunology : 3749 -3752.
-
Ibarburu, I., Aznar, R., ElizaquÃvel, P., GarcÃa-Quintáns, N., López, P., Munduate, A., Irastorza, A. and Dueñas, M. T., 2010. A real-time PCR assay for detection and quantification of 2-branched (1,3)-β-d-glucan producing lactic acid bacteria in cider. International Journal of Food Microbiology 143: 26-31.
'A real-time PCR assay for detection and quantification of 2-branched (1,3)-β-d-glucan producing lactic acid bacteria in cider ' () 143 International Journal of Food Microbiology : 26 -31.
-
Ismail, B. and Nampoothiri, K.M., 2013. Exposition of antitumour activity of a chemically characterized exopolysaccharide from a probiotic Lactobacillus plantarum MTCC 9510. Biologia 68: 1041-1047.
'Exposition of antitumour activity of a chemically characterized exopolysaccharide from a probiotic Lactobacillus plantarum MTCC 9510 ' () 68 Biologia : 1041 -1047.
-
Järup, L., 2003. Hazards of heavy metal contamination. British Medical Bulletin 68: 167-182.
'Hazards of heavy metal contamination ' () 68 British Medical Bulletin : 167 -182.
-
Jenner, P., 2003. Oxidative stress in Parkinsonâs disease. Annals of Neurology 53: S26-S38.
'Oxidative stress in Parkinsonâs disease ' () 53 Annals of Neurology : S26 -S38.
-
Jolly, L. and Stingele, F., 2001. Molecular organization and functionality of exopolysaccharide gene clusters in lactic acid bacteria. International Dairy Journal 11: 733-745.
'Molecular organization and functionality of exopolysaccharide gene clusters in lactic acid bacteria ' () 11 International Dairy Journal : 733 -745.
-
Kahl, R. and Kappus, H., 1993. [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E]. Zeitschrift fur Lebensmittel-untersuchung und-forschung 196: 329-338.
'Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E ' () 196 Zeitschrift fur Lebensmittel-untersuchung und-forschung : 329 -338.
-
Kandler, O. and Weiss, N., 1986. Regular, nonsporing gram-positive rods. Bergeyâs Manual of Systematic Bacteriology 2: 1208-1234.
'Regular, nonsporing gram-positive rods ' () 2 Bergeyâs Manual of Systematic Bacteriology : 1208 -1234.
-
Kim, Y., Oh, S., Yun, H.S. and Kim, S.H., 2010. Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. Letters in Applied Microbiology 51: 123-130.
'Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells ' () 51 Letters in Applied Microbiology : 123 -130.
-
Kimura, K., McCartney, A.L., McConnell, M.A. and Tannock, G.W., 1997. Analysis of fecal populations of bifidobacteria and lactobacilli and investigation of the immunological responses of their human hosts to the predominant strains. Applied and Environmental Microbiology 63: 3394-3398.
'Analysis of fecal populations of bifidobacteria and lactobacilli and investigation of the immunological responses of their human hosts to the predominant strains ' () 63 Applied and Environmental Microbiology : 3394 -3398.
-
Kitazawa, H., Harata, T., Uemura, J., Saito, T., Kaneko, T. and Itoh, T., 1998. Phosphate group requirement for mitogenic activation of lymphocytes by an extracellular phosphopolysaccharide from Lactobacillus delbrueckii ssp. bulgaricus. International Journal of Food Microbiology 40: 169-175.
'Phosphate group requirement for mitogenic activation of lymphocytes by an extracellular phosphopolysaccharide from Lactobacillus delbrueckii ssp. bulgaricus ' () 40 International Journal of Food Microbiology : 169 -175.
-
Klingberg, T.D., Pedersen, M.H., Cencic, A. and Budde, B.B., 2005. Application of measurements of transepithelial electrical resistance of intestinal epithelial cell monolayers to evaluate probiotic activity. Applied and Environmental Microbiology 71: 7528-7530.
'Application of measurements of transepithelial electrical resistance of intestinal epithelial cell monolayers to evaluate probiotic activity ' () 71 Applied and Environmental Microbiology : 7528 -7530.
-
Kojic, M., Vujcic, M., Banina, A., Cocconcelli, P., Cerning, J. and Topisirovic, L., 1992. Analysis of exopolysaccharide production by Lactobacillus casei CG11, isolated from cheese. Applied and Environmental Microbiology 58: 4086-4088.
'Analysis of exopolysaccharide production by Lactobacillus casei CG11, isolated from cheese ' () 58 Applied and Environmental Microbiology : 4086 -4088.
-
Kooiman, P., 1968. The chemical structure of kefiran, the water-soluble polysaccharide of the kefir grain. Carbohydrate Research 7: 200-211.
'The chemical structure of kefiran, the water-soluble polysaccharide of the kefir grain ' () 7 Carbohydrate Research : 200 -211.
-
Korakli, M., Gänzle, M.G. and Vogel, R.F., 2002. Metabolism by bifidobacteria and lactic acid bacteria of polysaccharides from wheat and rye, and exopolysaccharides produced by Lactobacillus sanfranciscensis. Journal of Applied Microbiology 92: 958-965.
'Metabolism by bifidobacteria and lactic acid bacteria of polysaccharides from wheat and rye, and exopolysaccharides produced by Lactobacillus sanfranciscensis ' () 92 Journal of Applied Microbiology : 958 -965.
-
Korakli, M. and Vogel, R.F., 2006. Structure/function relationship of homopolysaccharide producing glycansucrases and therapeutic potential of their synthesised glycans. Applied Microbiology and Biotechnology 71: 790-803.
'Structure/function relationship of homopolysaccharide producing glycansucrases and therapeutic potential of their synthesised glycans ' () 71 Applied Microbiology and Biotechnology : 790 -803.
-
Kralj, S., Stripling, E., Sanders, P., Van Geel-Schutten, G.H. and Dijkhuizen, L., 2005. Highly hydrolytic reuteransucrase from probiotic Lactobacillus reuteri strain ATCC 55730. Applied and Environmental Microbiology 71: 3942-3950.
'Highly hydrolytic reuteransucrase from probiotic Lactobacillus reuteri strain ATCC 55730 ' () 71 Applied and Environmental Microbiology : 3942 -3950.
-
Kralj, S., Van Geel-Schutten, G.H., Dondorff, M.M.G., Kirsanovs, S., Van Der Maarel, M.J.E.C. and Dijkhuizen, L., 2004. Glucan synthesis in the genus Lactobacillus: isolation and characterization of glucansucrase genes, enzymes and glucan products from six different strains. Microbiology 150: 3681-3690.
'Glucan synthesis in the genus Lactobacillus: isolation and characterization of glucansucrase genes, enzymes and glucan products from six different strains ' () 150 Microbiology : 3681 -3690.
-
Landersjö, C., Yang, Z., Huttunen, E. and Widmalm, G., 2002. Structural studies of the exopolysaccharide produced by Lactobacillus rhamnosus strain GG (ATCC 53103). Biomacromolecules 3: 880-884.
'Structural studies of the exopolysaccharide produced by Lactobacillus rhamnosus strain GG (ATCC 53103) ' () 3 Biomacromolecules : 880 -884.
-
Laws, A.P., Chadha, M.J., Chacon-Romero, M., Marshall, V.M. and Maqsood, M., 2008. Determination of the structure and molecular weights of the exopolysaccharide produced by Lactobacillus acidophilus 5e2 when grown on different carbon feeds. Carbohydrate Research 343: 301-307.
'Determination of the structure and molecular weights of the exopolysaccharide produced by Lactobacillus acidophilus 5e2 when grown on different carbon feeds ' () 343 Carbohydrate Research : 301 -307.
-
Laws, A.P., Gu, Y. and Marshall, V., 2001. Biosynthesis, characterisation, and design of bacterial exopolysaccharides from lactic acid bacteria. Biotechnology Advances 19: 597-625.
'Biosynthesis, characterisation, and design of bacterial exopolysaccharides from lactic acid bacteria ' () 19 Biotechnology Advances : 597 -625.
-
Lebeer, S., Claes, I., Tytgat, G.N.J., Verhoeven, T.L.A., Marien, E., Von Ossowski, I., Reunanen, J., Palva, A., De Vos, W.M., De Keersmaecker, S.C.J. and Vanderleyden, J., 2012. Functional analysis of Lactobacillus rhamnosus GG pili in relation to adhesion and immunomodulatory interactions with intestinal epithelial cells. Applied and Environmental Microbiology 78: 185-193.
'Functional analysis of Lactobacillus rhamnosus GG pili in relation to adhesion and immunomodulatory interactions with intestinal epithelial cells ' () 78 Applied and Environmental Microbiology : 185 -193.
-
Lebeer, S., Claes, I.J.J., Verhoeven, T.L.A., Vanderleyden, J. and De Keersmaecker, S.C.J., 2011. Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine. Microbial Biotechnology 4: 368-374.
'Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine ' () 4 Microbial Biotechnology : 368 -374.
-
Lebeer, S., Vanderleyden, J. and De Keersmaecker, S.C.J., 2008. Genes and molecules of lactobacilli supporting probiotic action. Microbiology and Molecular Biology Reviews 72: 728-764.
'Genes and molecules of lactobacilli supporting probiotic action ' () 72 Microbiology and Molecular Biology Reviews : 728 -764.
-
Lebeer, S., Verhoeven, T.L.A., Francius, G., Schoofs, G., Lambrichts, I., Dufrêne, Y., Vanderleyden, J. and De Keersmaecker, S.C.J., 2009. Identification of a gene cluster for the biosynthesis of a long, galactose-rich exopolysaccharide in Lactobacillus rhamnosus GG and functional analysis of the priming glycosyltransferase. Applied and Environmental Microbiology 75: 3554-3563.
'Identification of a gene cluster for the biosynthesis of a long, galactose-rich exopolysaccharide in Lactobacillus rhamnosus GG and functional analysis of the priming glycosyltransferase ' () 75 Applied and Environmental Microbiology : 3554 -3563.
-
Li, J.-Y., Jin, M.-M., Meng, J., Gao, S.-M. and Lu, R.-R., 2013. Exopolysaccharide from Lactobacillus planterum LP6: antioxidation and the effect on oxidative stress. Carbohydrate Polymers 98: 1147-1152.
'Exopolysaccharide from Lactobacillus planterum LP6: antioxidation and the effect on oxidative stress ' () 98 Carbohydrate Polymers : 1147 -1152.
-
Li, S., Zhao, Y., Zhang, L., Zhang, X., Huang, L., Li, D., Niu, C., Yang, Z. and Wang, Q., 2012. Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods. Food Chemistry 135: 1914-1919.
'Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods ' () 135 Food Chemistry : 1914 -1919.
-
Li, W., Ji, J., Chen, X., Jiang, M., Rui, X. and Dong, M., 2014. Structural elucidation and antioxidant activities of exopolysaccharides from Lactobacillus helveticus MB2-1. Carbohydrate Polymers 102: 351-359.
'Structural elucidation and antioxidant activities of exopolysaccharides from Lactobacillus helveticus MB2-1 ' () 102 Carbohydrate Polymers : 351 -359.
-
Lih-Brody, L., Powell, S.R., Collier, K.P., Reddy, G.M., Cerchia, R., Kahn, E., Weissman, G.S., Katz, S., Floyd, R.A. and McKinley, M.J., 1996. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Digestive Diseases and Sciences 41: 2078-2086.
'Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease ' () 41 Digestive Diseases and Sciences : 2078 -2086.
-
Lilly, D.M. and Stillwell, R.H., 1965. Probiotics: growth-promoting factors produced by microorganisms. Science 147: 747-748.
'Probiotics: growth-promoting factors produced by microorganisms ' () 147 Science : 747 -748.
-
Lin, M.-H., Yang, Y.-L., Chen, Y.-P., Hua, K.-F., Lu, C.-P., Sheu, F., Lin, G.-H., Tsay, S.-S., Liang, S.-M. and Wu, S.-H., 2011. A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2. Journal of Biological Chemistry 286: 17736-17745.
'A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2 ' () 286 Journal of Biological Chemistry : 17736 -17745.
-
Liu, C.-F., Tseng, K.-C., Chiang, S.-S., Lee, B.-H., Hsu, W.-H. and Pan, T.-M., 2011a. Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides. Journal of the Science of Food and Agriculture 91: 2284-2291.
'Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides ' () 91 Journal of the Science of Food and Agriculture : 2284 -2291.
-
Liu, C.-T., Chu, F.-J., Chou, C.C. and Yu, R.-C., 2011b. Antiproliferative and anticytotoxic effects of cell fractions and exopolysaccharides from Lactobacillus casei 01. Mutation Research 721: 157-162.
'Antiproliferative and anticytotoxic effects of cell fractions and exopolysaccharides from Lactobacillus casei 01 ' () 721 Mutation Research : 157 -162.
-
London, L.E.E., Price, N.P.J., Ryan, P., Wang, L., Auty, M.A.E., Fitzgerald, G.F., Stanton, C. and Ross, R.P., 2014. Characterization of a bovine isolate Lactobacillus mucosae DPC 6426 which produces an exopolysaccharide composed predominantly of mannose residues. Journal of Applied Microbiology 117: 509-517.
'Characterization of a bovine isolate Lactobacillus mucosae DPC 6426 which produces an exopolysaccharide composed predominantly of mannose residues ' () 117 Journal of Applied Microbiology : 509 -517.
-
Looijesteijn, P.J., Trapet, L., De Vries, E., Abee, T. and Hugenholtz, J., 2001. Physiological function of exopolysaccharides produced by Lactococcus lactis. International Journal of Food Microbiology 64: 71-80.
'Physiological function of exopolysaccharides produced by Lactococcus lactis ' () 64 International Journal of Food Microbiology : 71 -80.
-
Lynch, K.M., McSweeney, P.L.H., Arendt, E.K., Uniacke-Lowe, T., Galle, S. and Coffey, A., 2014. Isolation and characterisation of exopolysaccharide-producing Weissella and Lactobacillus and their application as adjunct cultures in Cheddar cheese. International Dairy Journal 34: 125-134.
'Isolation and characterisation of exopolysaccharide-producing Weissella and Lactobacillus and their application as adjunct cultures in Cheddar cheese ' () 34 International Dairy Journal : 125 -134.
-
Ma, B., Forney, L.J. and Ravel, J., 2012. The vaginal microbiome: rethinking health and diseases. Annual Review of Microbiology 66: 371.
'The vaginal microbiome: rethinking health and diseases ' () 66 Annual Review of Microbiology : 371.
-
Maeda, H., Zhu, X., Suzuki, S., Suzuki, K. and Kitamura, S., 2004. Structural characterization and biological activities of an exopolysaccharide kefiran produced by Lactobacillus kefiranofaciens WT-2BT. Journal of Agricultural and Food Chemistry 52: 5533-5538.
'Structural characterization and biological activities of an exopolysaccharide kefiran produced by Lactobacillus kefiranofaciens WT-2BT ' () 52 Journal of Agricultural and Food Chemistry : 5533 -5538.
-
Markesbery, W.R., 1997. Oxidative stress hypothesis in Alzheimerâs disease. Free Radical Biology and Medicine 23: 134-147.
'Oxidative stress hypothesis in Alzheimerâs disease ' () 23 Free Radical Biology and Medicine : 134 -147.
-
Marshall, V.M. and Rawson, H.L., 1999. Effects of exopolysaccharide-producing strains of thermophilic lactic acid bacteria on the texture of stirred yoghurt. International Journal of Food Science and Technology 34: 137-143.
'Effects of exopolysaccharide-producing strains of thermophilic lactic acid bacteria on the texture of stirred yoghurt ' () 34 International Journal of Food Science and Technology : 137 -143.
-
Marshall, V.M., Laws, A.P., Gu, Y., Levander, F., Rådström, P., De Vuyst, L., Degeest, B., Vaningelgem, F., Dunn, H. and Elvin, M., 2001. Exopolysaccharide-producing strains of thermophilic lactic acid bacteria cluster into groups according to their EPS structure. Letters in Applied Microbiology 32: 433-437.
'Exopolysaccharide-producing strains of thermophilic lactic acid bacteria cluster into groups according to their EPS structure ' () 32 Letters in Applied Microbiology : 433 -437.
-
Matés, J.M., 2000. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153: 83-104.
'Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology ' () 153 Toxicology : 83 -104.
-
Mende, S., Krzyzanowski, L., Weber, J., Jaros, D. and Rohm, H., 2012. Growth and exopolysaccharide yield of Lactobacillus delbrueckii ssp. bulgaricus DSM 20081 in batch and continuous bioreactor experiments at constant pH. Journal of Bioscience and Bioengineering 113: 185-191.
'Growth and exopolysaccharide yield of Lactobacillus delbrueckii ssp. bulgaricus DSM 20081 in batch and continuous bioreactor experiments at constant pH ' () 113 Journal of Bioscience and Bioengineering : 185 -191.
-
Miao, M., Ma, Y., Jiang, B., Huang, C., Li, X., Cui, S.W. and Zhang, T., 2014. Structural investigation of a neutral extracellular glucan from Lactobacillus reuteri SK24. 003. Carbohydrate Polymers 106: 384-392.
'Structural investigation of a neutral extracellular glucan from Lactobacillus reuteri SK24. 003 ' () 106 Carbohydrate Polymers : 384 -392.
-
Mohan, R., Koebnick, C., Schildt, J., Mueller, M., Radke, M. and Blaut, M., 2008. Effects of Bifidobacterium lactis Bb12 supplementation on body weight, fecal pH, acetate, lactate, calprotectin, and IgA in preterm infants. Pediatric Research 64: 418-422.
'Effects of Bifidobacterium lactis Bb12 supplementation on body weight, fecal pH, acetate, lactate, calprotectin, and IgA in preterm infants ' () 64 Pediatric Research : 418 -422.
-
Nikolic, M., López, P., Strahinic, I., Suárez, A., Kojic, M., Fernández-GarcÃa, M., Topisirovic, L., Golic, N. and Ruas-Madiedo, P., 2012. Characterisation of the exopolysaccharide (EPS)-producing Lactobacillus paraplantarum BGCG11 and its non-EPS producing derivative strains as potential probiotics. International Journal of Food Microbiology 158: 155-162.
'Characterisation of the exopolysaccharide (EPS)-producing Lactobacillus paraplantarum BGCG11 and its non-EPS producing derivative strains as potential probiotics ' () 158 International Journal of Food Microbiology : 155 -162.
-
Nissen, L., Chingwaru, W., Sgorbati, B., Biavati, B. and Cencic, A., 2009. Gut health promoting activity of new purative probiotic/protective Lactobacillus spp. strains: A functional study in the small intestinal cell model. International Journal of Food Microbiology 135: 288-294.
'Gut health promoting activity of new purative probiotic/protective Lactobacillus spp. strains: A functional study in the small intestinal cell model ' () 135 International Journal of Food Microbiology : 288 -294.
-
Nowak, B., Ciszek-Lenda, M., Åróttek, M., Gamian, A., Kontny, E., Górska-FrÄ czek, S. and Marcinkiewicz, J., 2012. Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice. Archivum Immunologiae et Therapiae Experimentalis 60: 211-220.
'Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice ' () 60 Archivum Immunologiae et Therapiae Experimentalis : 211 -220.
-
Parker, R.B., 1974. Probiotics, the other half of the antibiotic story. Animal Nutrition and Health 29: 4-8.
'Probiotics, the other half of the antibiotic story ' () 29 Animal Nutrition and Health : 4 -8.
-
Patel, A. and Prajapati, J.B., 2013. Food and health applications of exopolysaccharides produced by lactic acid bacteria. Advances in Dairy Research 1: 2.
'Food and health applications of exopolysaccharides produced by lactic acid bacteria ' () 1 Advances in Dairy Research : 2.
-
Pathmakanthan, S., 1999. Mucosally associated bacterial flora of the human colon: quantitative and species specific differences between normal and inflamed colonic biopsies. Microbial Ecology in Health and Disease 11: 169-174.
'Mucosally associated bacterial flora of the human colon: quantitative and species specific differences between normal and inflamed colonic biopsies ' () 11 Microbial Ecology in Health and Disease : 169 -174.
-
Patten, D.A. and Collett, A., 2013. Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota. Microbiology 159: 1535-1544.
'Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota ' () 159 Microbiology : 1535 -1544.
-
Patten, D.A., Leivers, S., Chadha, M.J., Maqsood, M., Humphreys, P.N., Laws, A.P. and Collett, A., 2014. The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2. Carbohydrate Research 384: 119-127.
'The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2 ' () 384 Carbohydrate Research : 119 -127.
-
Petry, S., Furlan, S., Crepeau, M.-J., Cerning, J. and Desmazeaud, M., 2000. Factors affecting exocellular polysaccharide production by Lactobacillus delbrueckii subsp. bulgaricus grown in a chemically defined medium. Applied and Environmental Microbiology 66: 3427-3431.
'Factors affecting exocellular polysaccharide production by Lactobacillus delbrueckii subsp. bulgaricus grown in a chemically defined medium ' () 66 Applied and Environmental Microbiology : 3427 -3431.
-
Pham, P.L., Dupont, I., Roy, D., Lapointe, G. and Cerning, J., 2000. Production of exopolysaccharide by Lactobacillus rhamnosus R and analysis of its enzymatic degradation during prolonged fermentation. Applied and Environmental Microbiology 66: 2302-2310.
'Production of exopolysaccharide by Lactobacillus rhamnosus R and analysis of its enzymatic degradation during prolonged fermentation ' () 66 Applied and Environmental Microbiology : 2302 -2310.
-
Picard, C., Fioramonti, J., Francois, A., Robinson, T., Neant, F. and Matuchansky, C., 2005. Review article: bifidobacteria as probiotic agents â physiological effects and clinical benefits. Alimentary Pharmacology and Therapeutics 22: 495-512.
'Review article: bifidobacteria as probiotic agents â physiological effects and clinical benefits ' () 22 Alimentary Pharmacology and Therapeutics : 495 -512.
-
Pidoux, M., De Ruiter, G.A., Brooker, B.E., Colquhoun, I.J. and Morris, V.J., 1990. Microscopic and chemical studies of a gelling polysaccharide from Lactobacillus hilgardii. Carbohydrate Polymers 13: 351-362.
'Microscopic and chemical studies of a gelling polysaccharide from Lactobacillus hilgardii ' () 13 Carbohydrate Polymers : 351 -362.
-
Polak-Berecka, M., Wasko, A., Szwajgier, D. and Chomaz, A., 2013. Bifidogenic and antioxidant activity of exopolysaccharides produced by Lactobacillus rhamnosus E/N cultivated on different carbon sources. Polish Journal of Microbiology 62: 181-189.
'Bifidogenic and antioxidant activity of exopolysaccharides produced by Lactobacillus rhamnosus E/N cultivated on different carbon sources ' () 62 Polish Journal of Microbiology : 181 -189.
-
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. and Beutler, B., 1998. Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282: 2085-2088.
'Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: Mutations in Tlr4 gene ' () 282 Science : 2085 -2088.
-
Postma, P.W., Lengeler, J.W. and Jacobson, G.R., 1993. Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteria. Microbiological Reviews 57: 543-594.
'Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteria ' () 57 Microbiological Reviews : 543 -594.
-
Poulsen, L.V., 1999. Microbial biofilm in food processing. Lebensmittel-Wissenschaft und Technologie 32: 321-326.
'Microbial biofilm in food processing ' () 32 Lebensmittel-Wissenschaft und Technologie : 321 -326.
-
Redondo-Lopez, V., Cook, R.L. and Sobel, J.D., 1990. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Review of Infectious Diseases 12: 856-872.
'Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora ' () 12 Review of Infectious Diseases : 856 -872.
-
Robijn, G.W., Gutiérrez Gallego, R., van den Berg, D.J.C., Haas, H., Kamerling, J.P. and Vliegenthart, J.F.G., 1996. Structural characterization of the exopolysaccharide produced by Lactobacillus acidophilus LMG9433. Carbohydrate Research 288: 203-218.
'Structural characterization of the exopolysaccharide produced by Lactobacillus acidophilus LMG9433 ' () 288 Carbohydrate Research : 203 -218.
-
Ruas-Madiedo, P., Gueimonde, M., De los Reyes-Gavilan, C.G. and Salminen, S., 2006. Effect of exopolysaccharide isolated from âViiliâ on the adhesion of probiotics and pathogens to intestinal mucus. Journal of Dairy Science 89: 2355-2358.
'Effect of exopolysaccharide isolated from âViiliâ on the adhesion of probiotics and pathogens to intestinal mucus ' () 89 Journal of Dairy Science : 2355 -2358.
-
Ruas-Madiedo, P., Hugenholtz, J. and Zoon, P., 2002. An overview of the functionality of exopolysaccharides produced by lactic acid bacteria. International Dairy Journal 12: 163-171.
'An overview of the functionality of exopolysaccharides produced by lactic acid bacteria ' () 12 International Dairy Journal : 163 -171.
-
Ruas-Madiedo, P., Medrano, M., Salazar, N., de los Reyes-Gavilan, C.G., Perez, P.F. and Abraham, A.G., 2010. Exopolysaccharides produced by Lactobacillus and Bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells. Journal of Applied Microbiology 109: 2079-2086.
'Exopolysaccharides produced by Lactobacillus and Bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells ' () 109 Journal of Applied Microbiology : 2079 -2086.
-
Ruas-Madiedo, P., Moreno, J.A., Salazar, N., Delgado, S., Mayo, B., Margolles, A. and Clara, G., 2007. Screening of exopolysaccharide-producing Lactobacillus and Bifidobacterium strains isolated from the human intestinal microbiota. Applied and Environmental Microbiology 73: 4385-4388.
'Screening of exopolysaccharide-producing Lactobacillus and Bifidobacterium strains isolated from the human intestinal microbiota ' () 73 Applied and Environmental Microbiology : 4385 -4388.
-
Ruijssenaars, H.J., Stingele, F. and Hartmans, S., 2000. Biodegradibility of food-associated extracellular polysaccharides. Current Microbiology 40: 194-199.
'Biodegradibility of food-associated extracellular polysaccharides ' () 40 Current Microbiology : 194 -199.
-
Saito, M., Sakagami, H. and Fujisawa, S., 2003. Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Anticancer Research 23: 4693.
'Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) ' () 23 Anticancer Research : 4693.
-
Schlee, M., Harder, J., Köten, B., Stange, E.F., Wehkamp, J. and Fellermann, K., 2008. Probiotic lactobacilli and VSL# 3 induce enterocyte β-defensin 2. Clinical and Experimental Immunology 151: 528-535.
'Probiotic lactobacilli and VSL# 3 induce enterocyte β-defensin 2 ' () 151 Clinical and Experimental Immunology : 528 -535.
-
Schrezenmeir, J. and De Vrese, M., 2001. Probiotics, prebiotics, and synbiotics-approaching a definition. American Society for Clinical Nutrition 73: 361s-364s.
'Probiotics, prebiotics, and synbiotics-approaching a definition ' () 73 American Society for Clinical Nutrition : 361s -364s.
-
Sengül, N., Aslim, B., Uçar, G., Yücel, N., IÅik, S., Bozkurt, H., SakaoÄullari, Z. and Atalay, F., 2006. Effects of exopolysaccharide-producing probiotic strains on experimental colitis in rats. Diseases of the Colon and Rectum 49: 250-258.
'Effects of exopolysaccharide-producing probiotic strains on experimental colitis in rats ' () 49 Diseases of the Colon and Rectum : 250 -258.
-
Servin, A.L., 2004. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiology Reviews 28: 405-440.
'Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens ' () 28 FEMS Microbiology Reviews : 405 -440.
-
Sghir, A., Gramet, G., Suau, A., Rochet, V., Pochart, P. and Dore, J., 2000. Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization. Applied and Environmental Microbiology 66: 2263-2266.
'Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization ' () 66 Applied and Environmental Microbiology : 2263 -2266.
-
Shao, L., Wu, Z., Zhang, H., Chen, W., Ai, L. and Guo, B., 2014. Partial characterization and immunostimulatory activity of exopolysaccharides from Lactobacillus rhamnosus KF5. Carbohydrate Polymers 107: 51-56.
'Partial characterization and immunostimulatory activity of exopolysaccharides from Lactobacillus rhamnosus KF5 ' () 107 Carbohydrate Polymers : 51 -56.
-
Sies, H., 1997. Oxidative stress: oxidants and antioxidants. Experimental Physiology 82: 291-295.
'Oxidative stress: oxidants and antioxidants ' () 82 Experimental Physiology : 291 -295.
-
Slattery, L., OâCallaghan, J., Fitzgerald, G.F., Beresford, T. and Ross, R.P., 2010. Lactobacillus helveticus â a thermophilic dairy starter related to gut bacteria. Journal of Dairy Science 93: 4435-4454.
'Lactobacillus helveticus â a thermophilic dairy starter related to gut bacteria ' () 93 Journal of Dairy Science : 4435 -4454.
-
Stack, H.M., Kearney, N., Stanton, C., Fitzgerald, G.F. and Ross, R.P., 2010. Association of beta-glucan endogenous production with increased stress tolerance of intestinal lactobacilli. Applied and Environmental Microbiology 76: 500-507.
'Association of beta-glucan endogenous production with increased stress tolerance of intestinal lactobacilli ' () 76 Applied and Environmental Microbiology : 500 -507.
-
Stiles, M.E. and Holzapfel, W.H., 1997. Lactic acid bacteria of foods and their current taxonomy. International Journal of Food Microbiology 36: 1-29.
'Lactic acid bacteria of foods and their current taxonomy ' () 36 International Journal of Food Microbiology : 1 -29.
-
Surayot, U., Wang, J., Seesuriyachan, P., Kuntiya, A., Tabarsa, M., Lee, Y., Kim, J.-K., Park, W. and You, S., 2014. Exopolysaccharides from lactic acid bacteria: structural analysis, molecular weight effect on immunomodulation. International Journal of Biological Macromolecules 68: 233-240.
'Exopolysaccharides from lactic acid bacteria: structural analysis, molecular weight effect on immunomodulation ' () 68 International Journal of Biological Macromolecules : 233 -240.
-
Suresh Kumar, A., Mody, K. and Jha, B., 2007. Bacterial exopolysaccharides â a perception. Journal of Basic Microbiology 47: 103-117.
'Bacterial exopolysaccharides â a perception ' () 47 Journal of Basic Microbiology : 103 -117.
-
Sutherland, I.W., 2001. Biofilm exopolysaccharides: a strong and sticky framework. Microbiology 147: 3-9.
'Biofilm exopolysaccharides: a strong and sticky framework ' () 147 Microbiology : 3 -9.
-
Takeda, K., Kaisho, T. and Akira, S., 2003. Toll-like receptors. Annual Review of Immunology 21: 335-376.
'Toll-like receptors ' () 21 Annual Review of Immunology : 335 -376.
-
Takeda, K., Suzuki, T., Shimada, S.I., Shida, K., Nanno, M. and Okumura, K., 2006. Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota. Clinical and Experimental Immunology 146: 109-115.
'Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota ' () 146 Clinical and Experimental Immunology : 109 -115.
-
Tallon, R., Bressollier, P. and Urdaci, M.C., 2003. Isolation and characterization of two exopolysaccharides produced by Lactobacillus plantarum EP56. Research in Microbiology 154: 705-712.
'Isolation and characterization of two exopolysaccharides produced by Lactobacillus plantarum EP56 ' () 154 Research in Microbiology : 705 -712.
-
Tannock, G.W., Munro, K., Harmsen, H.J.M., Welling, G.W., Smart, J. and Gopal, P.K., 2000. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Applied and Environmental Microbiology 66: 2578-2588.
'Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20 ' () 66 Applied and Environmental Microbiology : 2578 -2588.
-
Tok, E. and Aslim, B., 2010. Cholesterol removal by some lactic acid bacteria that can be used as probiotic. Microbiology and Immunology 54: 257-264.
'Cholesterol removal by some lactic acid bacteria that can be used as probiotic ' () 54 Microbiology and Immunology : 257 -264.
-
Torino, M.I., Mozzi, F. and de Valdez, G.F., 2005. Exopolysaccharide biosynthesis by Lactobacillus helveticus ATCC 15807. Applied Microbiology and Biotechnology 68: 259-265.
'Exopolysaccharide biosynthesis by Lactobacillus helveticus ATCC 15807 ' () 68 Applied Microbiology and Biotechnology : 259 -265.
-
Tsuda, H. and Miyamoto, T., 2010. Production of exopolysaccahride by Lactobacillus plantarum and the prebiotic activity of the exopolysaccharide. Food Science and Technology Research 16: 87-92.
'Production of exopolysaccahride by Lactobacillus plantarum and the prebiotic activity of the exopolysaccharide ' () 16 Food Science and Technology Research : 87 -92.
-
Tsuda, H., Hara, K. and Miyamoto, T., 2008. Binding of mutagens to exopolysaccharide produced by Lactobacillus plantarum mutant strain 301102S. Journal of Dairy Science 91: 2960-2966.
'Binding of mutagens to exopolysaccharide produced by Lactobacillus plantarum mutant strain 301102S ' () 91 Journal of Dairy Science : 2960 -2966.
-
Turpin, W., Humblot, C., Thomas, M. and Guyot, J.-P., 2010. Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms. International Journal of Food Microbiology 143: 87-102.
'Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms ' () 143 International Journal of Food Microbiology : 87 -102.
-
Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M.M. and Mazur, M., 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological Interactions 160: 1-40.
'Free radicals, metals and antioxidants in oxidative stress-induced cancer ' () 160 Chemico-biological Interactions : 1 -40.
-
Van Calsteren, M., Pau-Roblot, C., Bégin, A. and Roy, D., 2002. Structure determination of the exopolysaccharide produced by Lactobacillus rhamnosus strains RW-9595M and R. Biochemical Journal 363: 7-17.
'Structure determination of the exopolysaccharide produced by Lactobacillus rhamnosus strains RW-9595M and R ' () 363 Biochemical Journal : 7 -17.
-
Van Hijum, S.A.F.T., Bonting, K., Maarel, M.J.E.C. and Dijkhuizen, L., 2001. Purification of a novel fructosyltransferase from Lactobacillus reuteri strain 121 and characterization of the levan produced. FEMS Microbiology Letters 205: 323-328.
'Purification of a novel fructosyltransferase from Lactobacillus reuteri strain 121 and characterization of the levan produced ' () 205 FEMS Microbiology Letters : 323 -328.
-
Van Hijum, S.A.F.T., Kralj, S., Ozimek, L.K., Dijkhuizen, L. and Van Geel-Schutten, I.G.H., 2006. Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria. Microbiology and Molecular Biology Reviews 70: 157-176.
'Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria ' () 70 Microbiology and Molecular Biology Reviews : 157 -176.
-
Vanhaverbeke, C., Bosso, C., Colin-Morel, P., Gey, C., Gamar-Nourani, L., Blondeau, K., Simonet, J.-M. and Heyraud, A., 1998. Structure of an extracellular polysaccharide produced by Lactobacillus rhamnosus strain C83. Carbohydrate Research 314: 211-220.
'Structure of an extracellular polysaccharide produced by Lactobacillus rhamnosus strain C83 ' () 314 Carbohydrate Research : 211 -220.
-
Vinderola, G., Matar, C. and Perdigon, G., 2005. Role of intestinal epithelial cells in immune effects mediated by Gram-positive probiotic bacteria: Involvement of Toll-like receptors. Clinical and Diagnostic Laboratory Immunology 12: 1075-1084.
'Role of intestinal epithelial cells in immune effects mediated by Gram-positive probiotic bacteria: Involvement of Toll-like receptors ' () 12 Clinical and Diagnostic Laboratory Immunology : 1075 -1084.
-
Vinderola, G., Perdigon, G., Duarte, J., Fanrworth, E. and Matar, C., 2006. Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity. Cytokine 36: 254-260.
'Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity ' () 36 Cytokine : 254 -260.
-
Wachi, S., Kanmani, P., Tomosada, Y., Kobayashi, H., Yuri, T., Egusa, S., Shimazu, T., Suda, Y., Aso, H. and Sugawara, M., 2014. Lactobacillus delbruecki TUA4408L and its extracellular polysaccharides attenuate enterotoxigenic Escherichia coli-induced inflammatory response in porcine intestinal epitheliocytes via Toll-like receptor-2 and 4. Molecular Nutrition and Food Research doi: 10.1002/mnfr.201400218.
'Lactobacillus delbruecki TUA4408L and its extracellular polysaccharides attenuate enterotoxigenic Escherichia coli-induced inflammatory response in porcine intestinal epitheliocytes via Toll-like receptor-2 and 4 ', in Molecular Nutrition and Food Research , ().
-
Wang, K., Li, W., Rui, X., Chen, X., Jiang, M. and Dong, M., 2014. Characterization of a novel exopolysaccharide with antitumor activity from Lactobacillus plantarum 70810. International Journal of Biological Macromolecules 63: 133-139.
'Characterization of a novel exopolysaccharide with antitumor activity from Lactobacillus plantarum 70810 ' () 63 International Journal of Biological Macromolecules : 133 -139.
-
Watnick, P.I. and Kolter, R., 1999. Steps in the development of a Vibrio cholerae El Tor biofilm. Molecular Microbiology 34: 586-595.
'Steps in the development of a Vibrio cholerae El Tor biofilm ' () 34 Molecular Microbiology : 586 -595.
-
Wehkamp, J., Harder, J., Wehkamp, K., Wehkamp-von Meissner, B., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S. and Fellermann, K., 2004. NF-κB-and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infection and immunity 72: 5750-5758.
'NF-κB-and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium ' () 72 Infection and immunity : 5750 -5758.
-
Wells, J.M., 2011. Immunomodulatory mechanisms of lactobacilli. BMC Microbial Cell Factories 10: S17.
'Immunomodulatory mechanisms of lactobacilli ' () 10 BMC Microbial Cell Factories : S17.
-
Welman, A.D. and Maddox, I.S., 2003. Exopolysaccharides from lactic acid bacteria: perspectives and challenges. Trends in Biotechnology 21: 269-274.
'Exopolysaccharides from lactic acid bacteria: perspectives and challenges ' () 21 Trends in Biotechnology : 269 -274.
-
Wohlgemuth, S., Loh, G. and Blaut, M., 2010. Recent developments and perspectives in the investigation of probiotic effects. International Journal of Medical Microbiology 300: 3-10.
'Recent developments and perspectives in the investigation of probiotic effects ' () 300 International Journal of Medical Microbiology : 3 -10.
-
Yang, T., Wu, K., Wang, F., Liang, X., Liu, Q., Li, G. and Li, Q., 2014. Effect of exopolysaccharides from lactic acid bacteria on the texture and microstructure of buffalo yoghurt. International Dairy Journal 34: 252-256.
'Effect of exopolysaccharides from lactic acid bacteria on the texture and microstructure of buffalo yoghurt ' () 34 International Dairy Journal : 252 -256.
-
Zhang, L., Liu, C., Li, D., Zhao, Y., Zhang, X., Zeng, X., Yang, Z. and Li, S., 2013. Antioxidant activity of an exopolysaccharide isolated from Lactobacillus plantarum C88. International Journal of Biological Macromolecules 54: 270-275.
'Antioxidant activity of an exopolysaccharide isolated from Lactobacillus plantarum C88 ' () 54 International Journal of Biological Macromolecules : 270 -275.
-
Zhang, M., Liu, B., Zhang, Y., Wei, H., Lei, Y. and Zhao, L., 2007. Structural shifts of mucosa-associated lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis. Journal of Clinical Microbiology 45: 496-500.
'Structural shifts of mucosa-associated lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis ' () 45 Journal of Clinical Microbiology : 496 -500.
-
Zhang, Y., Du, R., Wang, L. and Zhang, H., 2010. The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats. European Food Research and Technology 231: 151-158.
'The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats ' () 231 European Food Research and Technology : 151 -158.
-
Zocco, M.A., Dal Verme, L.Z., Cremonini, F., Piscaglia, A.C., Nista, E.C., Candelli, M., Novi, M., Rigante, D., Cazzato, I.A. and Ojetti, V., 2006. Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis. Alimentary Pharmacology and Therapeutics 23: 1567-1574.
'Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis ' () 23 Alimentary Pharmacology and Therapeutics : 1567 -1574.
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Lactobacillus-produced exopolysaccharides and their potential health benefits: a review
äºBeneficial MicrobesCentre for Liver Research, School of Immunity and Infection, University of Birmingham, B15 2TT Birmingham, United Kingdom
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Lactic acid bacteria, such as those of the Lactobacillus genus, naturally reside within the microbiota of the human body and have long been used as starter cultures and probiotic enhancers in fermented foods, such as fermented drinks, yoghurts and cheeses. Many of the beneficial qualities of these bacteria have traditionally been associated with the bacteria themselves, however, a recent spate of studies have demonstrated a wide variety of biological effects exhibited by lactobacilli-produced exopolysaccharides which could, theoretically, confer a range of local and systemic health benefits upon the host. In this review, we discuss the production of exopolysaccharides within the Lactobacillus genus and explore their potential as beneficial bioactive compounds.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 997 | 401 | 26 |
| å ¨ææµè§æ¬¡æ° | 130 | 49 | 1 |
| PDFä¸è½½æ¬¡æ° | 55 | 21 | 2 |
