Heat-killed Lactobacillus gasseri can enhance immunity in the elderly in a double-blind, placebo-controlled clinical study
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This double-blind, placebo-controlled clinical trial was conducted to test whether Lactobacillus gasseri TMC0356 (TMC0356) can modify the immune response in the elderly. Heat-killed TMC0356 or placebo was orally administered to 28 healthy subjects aged 50-70 years old for 4 weeks at a dosage of 1.0×109 cfu/day. Peripheral blood mononuclear cells (PBMCs) were collected from the subjects before and after the study completion, together with general health and blood examination records. Isolated PBMCs were examined for the number of T cells, CD8+CD28+ cells, native T cells, B cells, natural killer (NK) cells and the ratios of CD4/CD8 T cells and native/memory T cells. NK cell activation and concanavalin A-induced lymphocyte transformation of the isolated PBMCs were also examined. The number of CD8+ T cells significantly increased in the subjects after TMC0356 oral administration (P<0.05). Furthermore, the population of CD8+CD28+ T cells and the amount of lymphocyte transformation both significantly decreased in PBMCs from the placebo group (P<0.05). However, such changes were not observed in the subjects exposed to TMC0356. These results suggest that TMC0356 can increase the number of CD8+ T cells and reduce CD28 expression loss in CD8+ T cells of the elderly. The effect of TMC0356 on immune responses in the elderly may enhance their natural defence mechanisms against pathogenic infections.
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Heat-killed Lactobacillus gasseri can enhance immunity in the elderly in a double-blind, placebo-controlled clinical study
In: Beneficial MicrobesSearch for other papers by K. Miyazawa in
Current site
Google Scholar
PubMed
Search for other papers by M. Kawase in
Current site
Google Scholar
PubMed
Search for other papers by A. Kubota in
Current site
Google Scholar
PubMed
Search for other papers by K. Yoda in
Current site
Google Scholar
PubMed
Search for other papers by G. Harata in
Current site
Google Scholar
PubMed
Search for other papers by M. Hosoda in
Current site
Google Scholar
PubMed
Search for other papers by F. He in
Current site
Google Scholar
PubMed
This double-blind, placebo-controlled clinical trial was conducted to test whether Lactobacillus gasseri TMC0356 (TMC0356) can modify the immune response in the elderly. Heat-killed TMC0356 or placebo was orally administered to 28 healthy subjects aged 50-70 years old for 4 weeks at a dosage of 1.0×109 cfu/day. Peripheral blood mononuclear cells (PBMCs) were collected from the subjects before and after the study completion, together with general health and blood examination records. Isolated PBMCs were examined for the number of T cells, CD8+CD28+ cells, native T cells, B cells, natural killer (NK) cells and the ratios of CD4/CD8 T cells and native/memory T cells. NK cell activation and concanavalin A-induced lymphocyte transformation of the isolated PBMCs were also examined. The number of CD8+ T cells significantly increased in the subjects after TMC0356 oral administration (P<0.05). Furthermore, the population of CD8+CD28+ T cells and the amount of lymphocyte transformation both significantly decreased in PBMCs from the placebo group (P<0.05). However, such changes were not observed in the subjects exposed to TMC0356. These results suggest that TMC0356 can increase the number of CD8+ T cells and reduce CD28 expression loss in CD8+ T cells of the elderly. The effect of TMC0356 on immune responses in the elderly may enhance their natural defence mechanisms against pathogenic infections.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 969 | 329 | 23 |
| Full Text Views | 58 | 14 | 0 |
| PDF Views & Downloads | 47 | 13 | 0 |
