Our aim was to determine whether a fermented milk drink containing probiotics could improve the bowel habits of frail elderly individuals living in a nursing home. A total of 135 participants were enrolled in this pilot study. The bowel habits (stool quality and bowel movements) were recorded by nursing staff during a baseline period of 3 weeks. After this period participants received daily a fermented milk drink containing minimally 6.5×109 colony forming units of Lactobacillus casei Shirota (LcS) for 6 weeks. During this period, bowel habits were recorded and compared to baseline period. Forty-four participants (74-99 years old) were compliant and used for analysis. Consumption of fermented milk containing LcS significantly increased the percentage of ideal stool types per week (P<0.01), lowered the percentage of constipation stool types per week (P<0.01) and significantly lowered the percentage of diarrhoea stool types per week (P=0.016) as compared to the baseline period. The study product had no significant effect on bowel movements. During the study, no changes in laxative usage or adverse events associated with the study product were reported. Our results suggest that a fermented milk containing LcS significantly improves the bowel habits of frail elderly residents in a nursing home. These promising results should be further substantiated by a confirmatory study.
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Barat, I., Andreasen, F. and Damsgaard, E.M.S., 2000. The consumption of drugs by 75-year-old individuals living in their own homes. European Journal of Clinical Pharmacology 56: 501-509.
'The consumption of drugs by 75-year-old individuals living in their own homes ' () 56 European Journal of Clinical Pharmacology : 501 -509.
Biagi, E., Candela, M., Fairweather-Tait, S., Franceschi, C. and Brigidi, P., 2012. Ageing of the human metaorganism: the microbial counterpart. Age 34: 247-267.
'Ageing of the human metaorganism: the microbial counterpart ' () 34 Age : 247 -267.
Chmielewska, A. and Szajewska, H., 2010. Systematic review of randomised controlled trials: probiotics for functional constipation. World Journal of Gastroenterology 16: 69.
'Systematic review of randomised controlled trials: probiotics for functional constipation ' () 16 World Journal of Gastroenterology : 69.
Claassen, E., 2014. Cost-benefit relation of diet and probiotics in iatrogenic bowel irregularity (IBI). Frontiers in Pharmacology 5: 14.
'Cost-benefit relation of diet and probiotics in iatrogenic bowel irregularity (IBI) ' () 5 Frontiers in Pharmacology : 14.
Claesson, M.J., Jeffery, I.B., Conde, S., Power, S.E., O’Connor, E.M., Cusack, S., Harris, H.M.B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., Fitzgerald, G.F., Deane, J., O’Conner, M., Harnedy, N., O’Conner, K., O’Mahony, D., Van Sinderen, D., Wallace, M., Brennan, L., Stanton, C., Marchesi, J. R., Fitzgerald, A. P., Shanahan, F., Hill, C. and O’Toole, P.W., 2012. Gut microbiota composition correlates with diet and health in the elderly. Nature 488: 178-184.
'Gut microbiota composition correlates with diet and health in the elderly ' () 488 Nature : 178 -184.
Dong, H., Rowland, I., Thomas, L.V. and Yaqoob, P., 2013. Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers. European Journal of Nutrition 52: 1853-1863.
'Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers ' () 52 European Journal of Nutrition : 1853 -1863.
Drossman, D.A., Corazziari, E., Delvaux, M., Spiller, R.C., Talley, N.J., Thompson, W.G., Whitehead, W.E. (eds.), 2006. Rome III: The functional gastrointestinal disorders, 3rd edition. Degnon Associates, McLean, VA, USA.
'Rome III: The functional gastrointestinal disorders, 3rd edition', ().
Duncan, S.H. and Flint, H.J., 2013. Probiotics and prebiotics and health in ageing populations. Maturitas 75: 44-50.
'Probiotics and prebiotics and health in ageing populations ' () 75 Maturitas : 44 -50.
Floch, M.H., Walker, W.A., Madsen, K., Sanders, M.E., Macfarlane, G.T., Flint, H.J., Dieleman, L.A., Ringel, Y., Guandalini, S., Kelly, C.P. and Brandt, L.J., 2011. Recommendations for probiotic use – 2011 update. Journal of Clinical Gastroenterology 45: S168-S171.
'Recommendations for probiotic use – 2011 update ' () 45 Journal of Clinical Gastroenterology : S168 -S171.
Food and Agriculture Organization/World Health Organization (FAO/WHO), 2001. Report of a joint FAO/WHO Expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Córdoba, Argentina. October, 1-4, 2001. FAO, Rome, Italy. Available at: http://tinyurl.com/8bccc3r.
'Report of a joint FAO/WHO Expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. ', ().
Gandell, D., Straus, S.E., Bundookwala, M., Tsui, V. and Alibhai, S.M., 2013. Treatment of constipation in older people. Canadian Medical Association Journal 185: 663.
'Treatment of constipation in older people ' () 185 Canadian Medical Association Journal : 663.
Hell, M., Bernhofer, C., Stalzer, P., Kern, J.M. and Claassen, E., 2013. Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic. Beneficial Microbes 4: 39-51.
'Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic ' () 4 Beneficial Microbes : 39 -51.
Hempel, S., Newberry, S.J., Maher, A.R., Wang, Z., Miles, J.N., Shanman, R., Johnsen, B. and Shekelle, P.G., 2012. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. Journal of the American Medical Association 307: 1959-1969.
'Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis ' () 307 Journal of the American Medical Association : 1959 -1969.
Hill, C., Guarner, F., Reid, G., Gibson, G.R., Merenstein, D.J., Pot, B., Morelli, L., Canani, R. B., Flint, H.J., Salminen, S., Calder, P.C. and Sanders, M.E., 2014. Expert consensus document: the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology and Hepatology 11: 506-514.
'Expert consensus document: the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic ' () 11 Nature Reviews Gastroenterology and Hepatology : 506 -514.
Karlström, O., Fryklund, B., Tullus, K. and Burman, L.G., 1998. A prospective nationwide study of Clostridium difficile-associated diarrhea in Sweden. Clinical Infectious Diseases 26: 141-145.
'A prospective nationwide study of Clostridium difficile-associated diarrhea in Sweden ' () 26 Clinical Infectious Diseases : 141 -145.
Koebnick, C., Wagner, I., Leitzmann, P., Stern, U. and Zunft, H.F., 2003. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Canadian Journal of Gastroenterology 17: 655-660.
'Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation ' () 17 Canadian Journal of Gastroenterology : 655 -660.
Magrone, T. and Jirillo, E., 2013. The interaction between gut microbiota and age-related changes in immune function and inflammation. Immunity and Ageing 10: 31.
'The interaction between gut microbiota and age-related changes in immune function and inflammation ' () 10 Immunity and Ageing : 31.
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V.D., Sokol, H., Dore, J., Corthier, G. and Furet, J.P., 2009. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC microbiology 9: 123.
'The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age ' () 9 BMC microbiology : 123.
Matsumoto, K., Takada, T., Shimizu, K., Moriyama, K., Kawakami, K., Hirano, K., Kajimoto, O. and Nomoto, K., 2010. Effects of a probiotic fermented milk beverage containing Lactobacillus casei strain Shirota on defecation frequency, intestinal microbiota, and the intestinal environment of healthy individuals with soft stools. Journal of Bioscience and Bioengineering 110: 547-552.
'Effects of a probiotic fermented milk beverage containing Lactobacillus casei strain Shirota on defecation frequency, intestinal microbiota, and the intestinal environment of healthy individuals with soft stools ' () 110 Journal of Bioscience and Bioengineering : 547 -552.
Mazlyn, M.M., Nagarajah, L.H.L., Fatimah, A., Norimah, A.K. and Goh, K.L., 2013. Effects of a probiotic fermented milk on functional constipation: a randomized, double blind, placebo controlled study. Journal of Gastroenterology and Hepatology 28: 1141-1147.
'Effects of a probiotic fermented milk on functional constipation: a randomized, double blind, placebo controlled study ' () 28 Journal of Gastroenterology and Hepatology : 1141 -1147.
Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M.C., Clavel, T., Koebnick, C., Zunft, H.J.F., Doré, J. and Blaut, M., 2006. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Applied and Environmental Microbiology 72: 1027-1033.
'Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study ' () 72 Applied and Environmental Microbiology : 1027 -1033.
Nagata, S., Asahara, T., Ohta, T., Yamada, T., Kondo, S., Bian, L., Wang, C., Yamashiro, Y. and Nomoto, K., 2011. Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged. British Journal of Nutrition 106: 549-556.
'Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged ' () 106 British Journal of Nutrition : 549 -556.
Rao, S.S. and Go, J.T., 2010. Update on the management of constipation in the elderly: new treatment options. Clinical Interventions in Aging 5: 163.
'Update on the management of constipation in the elderly: new treatment options ' () 5 Clinical Interventions in Aging : 163.
Sakai, T., Makino, H., Ishikawa, E., Oishi, K. and Kushiro, A., 2011. Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population. International Journal of Food Sciences and Nutrition 62: 423-430.
'Fermented milk containing Lactobacillus casei strain Shirota reduces incidence of hard or lumpy stools in healthy population ' () 62 International Journal of Food Sciences and Nutrition : 423 -430.
Sekirov, I., Russell, S.L., Antunes, L.C.M. and Finlay, B.B., 2010. Gut microbiota in health and disease. Physiological Reviews 90: 859-904.
'Gut microbiota in health and disease ' () 90 Physiological Reviews : 859 -904.
Shioiri, T., Yahagi, K., Nakayama, S., Asahara, T., Yuki, N., Kawakami, K., Yamaoka, Y., Sakai, Y., Nomoto, K. and Totani, M., 2006. The effects of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota and transgalactosylated oligosaccharides on defecation frequency, intestinal microflora, organic acid concentrations, and putrefactive metabolites of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study. Bioscience and Microflora 25: 137-146.
'The effects of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota and transgalactosylated oligosaccharides on defecation frequency, intestinal microflora, organic acid concentrations, and putrefactive metabolites of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study ' () 25 Bioscience and Microflora : 137 -146.
Sur, D., Manna, B., Niyogi, S. K., Ramamurthy, T., Palit, A., Nomoto, K., Takahashi, T., Shima, T., Tsuji, H., Kurakawa, T., Takeda, Y., Nair, G.B. and Bhattacharya, S.K., 2011. Role of probiotic in preventing acute diarrhoea in children: a community-based, randomized, double-blind placebo-controlled field trial in an urban slum. Epidemiology and Infection 139: 919-926.
'Role of probiotic in preventing acute diarrhoea in children: a community-based, randomized, double-blind placebo-controlled field trial in an urban slum ' () 139 Epidemiology and Infection : 919 -926.
Van den Nieuwboer, M., Brummer, R.J., Guarner, F., Morelli, L., Cabana, M. and Claassen, E., 2015. The administration of probiotics and synbiotics in immune compromised adults: is it safe? Beneficial Microbes 6: 3-17.
'The administration of probiotics and synbiotics in immune compromised adults: is it safe? ' () 6 Beneficial Microbes : 3 -17.
Van den Nieuwboer, M., Claassen, E., Morelli, L., Guarner, F. and Brummer, R.J., 2014. Probiotic and synbiotic safety in infants under two years of age. Beneficial Microbes 5: 45-60.
'Probiotic and synbiotic safety in infants under two years of age ' () 5 Beneficial Microbes : 45 -60.
Van Dessel, C., Flamaing, J. and Hiele, M., 2005. Acute infectious (not Clostridium difficile-associated) diarrhea in the elderly. Tijdschrift voor Gerontologie en Geriatrie 36: 209-212.
'Acute infectious (not Clostridium difficile-associated) diarrhea in the elderly ' () 36 Tijdschrift voor Gerontologie en Geriatrie : 209 -212.
Van Puyenbroeck, K., Hens, N., Coenen, S., Michiels, B., Beunckens, C., Molenberghs, G., Van Royen, P. and Verhoeven, V., 2012. Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents. American Journal of Clinical Nutrition 95: 1165-1171.
'Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents ' () 95 American Journal of Clinical Nutrition : 1165 -1171.
Van Tongeren, S.P., Slaets, J.P., Harmsen, H.J.M. and Welling, G.W., 2005. Fecal microbiota composition and frailty. Applied and Environmental Microbiology 71: 6438-6442.
'Fecal microbiota composition and frailty ' () 71 Applied and Environmental Microbiology : 6438 -6442.
Videlock, E.J. and Cremonini, F., 2012. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Alimentary Pharmacology & Therapeutics 35: 1355-1369.
'Meta-analysis: probiotics in antibiotic-associated diarrhoea ' () 35 Alimentary Pharmacology & Therapeutics : 1355 -1369.
Wong, S., Jamous, A., O’Driscoll, J., Sekhar, R., Weldon, M., Yau, C.Y., Hirani, S.P., Grimble, G. and Forbes, A., 2014. A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial. British Journal of Nutrition 111: 672-678.
'A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial ' () 111 British Journal of Nutrition : 672 -678.
Wright, K., Wright, H. and Murray, M., in press. Probiotic treatment for the prevention of antibiotic-associated diarrhoea in geriatric patients: a multicentre randomised controlled pilot study. Australasian Journal on Ageing. DOI: http://dx.doi.org/10.1111/ajag.12116.
'Probiotic treatment for the prevention of antibiotic-associated diarrhoea in geriatric patients: a multicentre randomised controlled pilot study ', in Australasian Journal on Ageing , ().
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 610 | 296 | 27 |
| Full Text Views | 17 | 4 | 0 |
| PDF Views & Downloads | 23 | 6 | 0 |
Our aim was to determine whether a fermented milk drink containing probiotics could improve the bowel habits of frail elderly individuals living in a nursing home. A total of 135 participants were enrolled in this pilot study. The bowel habits (stool quality and bowel movements) were recorded by nursing staff during a baseline period of 3 weeks. After this period participants received daily a fermented milk drink containing minimally 6.5×109 colony forming units of Lactobacillus casei Shirota (LcS) for 6 weeks. During this period, bowel habits were recorded and compared to baseline period. Forty-four participants (74-99 years old) were compliant and used for analysis. Consumption of fermented milk containing LcS significantly increased the percentage of ideal stool types per week (P<0.01), lowered the percentage of constipation stool types per week (P<0.01) and significantly lowered the percentage of diarrhoea stool types per week (P=0.016) as compared to the baseline period. The study product had no significant effect on bowel movements. During the study, no changes in laxative usage or adverse events associated with the study product were reported. Our results suggest that a fermented milk containing LcS significantly improves the bowel habits of frail elderly residents in a nursing home. These promising results should be further substantiated by a confirmatory study.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 610 | 296 | 27 |
| Full Text Views | 17 | 4 | 0 |
| PDF Views & Downloads | 23 | 6 | 0 |