Recombinant lactic acid bacteria as delivery vectors of heterologous antigens: the future of vaccination?
In: Beneficial MicrobesSearch for other papers by A. Trombert in
Current site
Google Scholar
Lactic acid bacteria (LABs) are good candidates for the development of new oral vaccines and are attractive alternatives to attenuated pathogens. This review focuses on the use of wild-type and recombinant lactococci and lactobacilli with emphasis on their molecular design, immunomodulation and treatment of bacterial infections. The majority of studies related to recombinant LABs have focused on Lactococcus lactis, however, molecular tools have been successfully used for Lactobacillus spp. research. Recombinant lactobacilli and lactococci have several health benefits, such as immunomodulation, restoration of the microbiota, synthesis of antimicrobial substances and inhibition of virulence factors. In addition, protective immune responses that are well tolerated are induced by the expression of heterologous antigens from recombinant probiotics.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Abdul Mutalib, N.E., Met Isa, N., Alitheen, N.B., Song, A.A. and Rahim, R.A., 2014. IRES-incorporated lactococcal bicistronic vector for target gene expression in a eukaryotic system. Plasmid 73: 26-33.
'IRES-incorporated lactococcal bicistronic vector for target gene expression in a eukaryotic system ' () 73 Plasmid : 26 -33.
-
Ahmed, B., Loos, M., Vanrompay, D. and Cox, E., 2013. Mucosal priming of the murine immune system against enterohemorrhagic Escherichia coli O157:H7 using Lactococcus lactis expressing the type III secretion system protein EspB. Veterinary Immunology and Immunopathology 152: 141-145.
'Mucosal priming of the murine immune system against enterohemorrhagic Escherichia coli O157:H7 using Lactococcus lactis expressing the type III secretion system protein EspB ' () 152 Veterinary Immunology and Immunopathology : 141 -145.
-
Ahmed, B., Loos, M., Vanrompay, D. and Cox, E., 2014. Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization. Vaccine 32: 3909-3916.
'Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization ' () 32 Vaccine : 3909 -3916.
-
Asensi, G.F., De Sales, N.F., Dutra, F.F., Feijó, D.F., Bozza, M.T., Ulrich, R.G., Miyoshi, A., De Morais, K., Azevedo, V.A., Silva, J.T., Le Loir, Y. and Paschoalin, V.M., 2013. Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model. Microbial Cell Factories 12: 32.
'Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model ' () 12 Microbial Cell Factories : 32.
-
Audouy, S.A.L., Selm, S., Van Roosmalen, M.L., Post, E., Kanninga, R., Neef, J., Estevão, S., Nieuwenhuis, E.E.S., Adrian, P.V., Leenhouts, K. and Hermans, P.W.M., 2007. Development of lactococcal GEM-based pneumococcal vaccines. Vaccine 25: 2497-2506.
'Development of lactococcal GEM-based pneumococcal vaccines ' () 25 Vaccine : 2497 -2506.
-
Bambou, J.C., Giraud, A., Menard, S., Begue, B., Rakotobe, S., Heyman, M., Taddei, F., Cerf-Bensussan, N. and Gaboriau-Routhiau, V., 2004. In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain. Journal of Biological Chemistry 279: 42984-42992.
'In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain ' () 279 Journal of Biological Chemistry : 42984 -42992.
-
Benbouziane, B., Ribelles, P., Aubry, C., Martin, R., Kharrat, P., Riazi, A., Langella, P. and Bermúdez-Humarán, L.G., 2013. Development of a Stress-Inducible Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces. Journal of Biotechnology 168: 120-129.
'Development of a Stress-Inducible Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces ' () 168 Journal of Biotechnology : 120 -129.
-
Bermúdez-Humarán, L.G., 2009. Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins. Human Vaccines 5: 264-267.
'Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins ' () 5 Human Vaccines : 264 -267.
-
Bermúdez-Humarán, L.G., Aubry, C., Motta, J.P., Deraison, C., Steidler, L., Vergnolle, N., Chatel, J.M. and Langella, P., 2013. Engineering lactococci and lactobacilli for human health. Current opinion in Microbiology 16: 278-283.
'Engineering lactococci and lactobacilli for human health ' () 16 Current opinion in Microbiology : 278 -283.
-
Bermúdez-Humarán, L.G., Cortes-Perez, N.G., Le Loir, Y., Alcocer-González, J.M., Tamez-Guerra, R.S., De Oca-Luna, R.M. and Langella, P., 2004. An inducible surface presentation system improves celular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci. Journal of Medical Microbiology 53: 427-433.
'An inducible surface presentation system improves celular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci ' () 53 Journal of Medical Microbiology : 427 -433.
-
Bermúdez-Humarán, L.G., Langella, P., Commissaire, J., Gilbert, S., Le Loir, Y., L'Haridon, R. and Corthier, G., 2003. Controlled intra- or extracellular production of staphylococcal nuclease and ovine omega interferon in Lactococcus lactis. FEMS Microbiology Letters 224: 307-313.
'Controlled intra- or extracellular production of staphylococcal nuclease and ovine omega interferon in Lactococcus lactis ' () 224 FEMS Microbiology Letters : 307 -313.
-
Besselink, M.G., Van Santvoort, H.C., Buskens, E., Boermeester, M.A., Van Goor, H., Timmerman, H.M., Nieuwenhuijs, V.B., Bollen, T.L., Van Ramshorst, B., Witteman, B.J., Rosman, C., Ploeg, R.J., Brink, M.A., Schaapherder, A.F., Dejong, C.H., Wahab, P.J., Van Laarhoven, C.J., Van der Harst, E., Van Eijck, C.H., Cuesta, M.A., Akkermans, L.M., Gooszen, H.G. and the Dutch Acute Pancreatitis Study Group, 2008. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. The Lancet 371: 651-659.
'Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial ' () 371 The Lancet : 651 -659.
-
Bolken, T. C., Franke, C. A., Jones, K.F., Bell, R.H., Swanson, R.M., King, D.S., Fischetti, V.A. and Hruby, D.E., 2002. Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors. Infection and Immunity 70: 2487-2491.
'Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors ' () 70 Infection and Immunity : 2487 -2491.
-
Bosma, T., Kanninga, R., Neef, J., Audouy, S.A.L., Van Roosmalen, M.L. Steen, A., Buist, G., Kok, J., Kuipers, O.P, Robillard, G. and Leenhouts, K., 2006. Novel surface display system for proteins on non-genetically modified gram-positive bacteria. Applied and Environmental Microbiology 72: 880-889.
'Novel surface display system for proteins on non-genetically modified gram-positive bacteria ' () 72 Applied and Environmental Microbiology : 880 -889.
-
Braat, H., Rottiers, P., Hommes, D.W., Huyghebaert, N., Remaut, E., Remon, J.P., Van Deventer, S.J., Neirynck, S., Peppelenbosch, M.P. and Steidler, L., 2006. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clinical Gastroenterology and Hepatology 4: 754-759.
'A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease ' () 4 Clinical Gastroenterology and Hepatology : 754 -759.
-
Buccato, S., Maione, D., Rinaudo, C.D., Volpini, G., Taddei, A.R., Rosini, R., Telford, J.L., Grandi, G. and Margarit, I., 2006. Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease. Journal of Infectious Diseases 194: 331-340.
'Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease ' () 194 Journal of Infectious Diseases : 331 -340.
-
Caluwaerts, S., Vandenbroucke, K., Steidler, L., Neirynck, Vanhoenacker, P., Corveleyn, S., Watkins, B., Sonis, S., Coulie, B. and Rottiers, P., 2010. AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncology 46: 564-570.
'AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis ' () 46 Oral Oncology : 564 -570.
-
Cauchard, S., Bermúdez-Humarán, L.G., Blugeon, S., Laugier, C., Langella, P. and Cauchard, J., 2011. Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection. Vaccine 30: 95-102.
'Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection ' () 30 Vaccine : 95 -102.
-
Charlier, C., Cretenet, M., Even, S. and Le Loir, Y., 2008. Interactions between Staphylococcus aureus and lactic acid bacteria: an old story with new perspectives. International Journal of Food Microbiology 131: 30-39.
'Interactions between Staphylococcus aureus and lactic acid bacteria: an old story with new perspectives ' () 131 International Journal of Food Microbiology : 30 -39.
-
Chen, S., Zhang, R., Duan, G. and Shi, J., 2011. Food-grade expression of Helicobacter pylori ureB subunit in Lactococcus lactis and its immunoreactivity. Current Microbiology 62: 1726-1731.
'Food-grade expression of Helicobacter pylori ureB subunit in Lactococcus lactis and its immunoreactivity ' () 62 Current Microbiology : 1726 -1731.
-
Chong, C., Bost, K.L. and Clements, J.D., 1996. Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infection and Immunity 64: 1154-1160.
'Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. ' () 64 Infection and Immunity : 1154 -1160.
-
Czerkinsky, C. and Holmgren, J., 2012. Mucosal delivery routes for optimal immunization: targeting immunity to the right tissues. Current Topics in Microbiology and Immunology 354: 1-18.
'Mucosal delivery routes for optimal immunization: targeting immunity to the right tissues ' () 354 Current Topics in Microbiology and Immunology : 1 -18.
-
Daniel, C., Roussel, Y., Kleerebezem, M. and Pot, B., 2011. Recombinant lactic acid bacteria as mucosal biotherapeutic agents. Trends in Biotechnology 29: 499-508.
'Recombinant lactic acid bacteria as mucosal biotherapeutic agents ' () 29 Trends in Biotechnology : 499 -508.
-
De Azevedo, M., Karczewski, J., Lefévre, F., Azevedo, V., Miyoshi, A., Wells, J.M., Langella, P. and Chatel, J.M., 2012. In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A. BMC Microbiology 12: 299.
'In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A ' () 12 BMC Microbiology : 299.
-
De Ruyter, P.G., Kuipers, O.P. and De Vos, W.M., 1996a. Controlled gene expression system for Lactococcus lactis with the food-grade inducer nisin. Applied and Environmental Microbiology 62: 3662-3667.
'Controlled gene expression system for Lactococcus lactis with the food-grade inducer nisin ' () 62 Applied and Environmental Microbiology : 3662 -3667.
-
De Ruyter, P.G., Kuipers, O.P., Beerthuyzen, M.M., Van Alen-Boerrigter, I. and De Vos, W.M., 1996b. Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis. Journal of Bacteriology 178: 3434-3439.
'Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis ' () 178 Journal of Bacteriology : 3434 -3439.
-
De Ruyter, P.G., Kuipers, O.P., Meijer, W.C. and De Vos, W.M., 1997. Food-grade controlled lysis of Lactococcus lactis for accelerated cheese ripening. Nature Biotechnology 15: 976-979.
'Food-grade controlled lysis of Lactococcus lactis for accelerated cheese ripening ' () 15 Nature Biotechnology : 976 -979.
-
Del Rio, B., Dattwyler, R.J., Aroso, M., Neves, V., Meirelles, L., Seegers, J.F. and Gomes-Solecki, M., 2008. Oral immunization with recombinant Lactobacillus plantarum induces a protective immune response in mice with Lyme disease. Clinical and Vaccine Immunology 15: 1429-1435.
'Oral immunization with recombinant Lactobacillus plantarum induces a protective immune response in mice with Lyme disease ' () 15 Clinical and Vaccine Immunology : 1429 -1435.
-
Del Rio, B., Seegers, J.F. and Gomes-Solecki, M., 2010. Immune response to Lactobacillus plantarum expressing Borrelia burgdorferi OspA is modulated by the lipid modification of the antigen. PLoS One 5: e11199.
'Immune response to Lactobacillus plantarum expressing Borrelia burgdorferi OspA is modulated by the lipid modification of the antigen ' () 5 PLoS One : e11199.
-
Didari, T., Solki, S., Mozaffari, S., Nikfar, S. and Abdollahi, M., 2014. A systematic review of the safety of probiotics. Expert Opinion on Drug Safety 13: 227-239.
'A systematic review of the safety of probiotics ' () 13 Expert Opinion on Drug Safety : 227 -239.
-
Douillard, F.P., Mahony, J., Campanacci, V., Cambillau, C. and Van Sinderen, D., 2011. Construction of two Lactococcus lactis expression vectors combining the Gateway and the NIsin controlled expression systems. Plasmid 66: 129-135.
'Construction of two Lactococcus lactis expression vectors combining the Gateway and the NIsin controlled expression systems ' () 66 Plasmid : 129 -135.
-
Duong, T., Miller, M.J., Barrangou, R., Azcarate-Peril, M.A. and Klaenhammer, T.R., 2011. Construction of vectors for inducible and constitutive gene expression in Lactobacillus. Microbial Biotechnology 4: 357-367.
'Construction of vectors for inducible and constitutive gene expression in Lactobacillus ' () 4 Microbial Biotechnology : 357 -367.
-
Enouf, V., Langella, P., Commissaire, J., Cohen, J. and Corthier, G., 2001. Bovine rotavirus nonstructural protein 4 produced by Lactococcus lactis is antigenic and immunogenic. Applied and Environmental Microbiology 67: 1423-1428.
'Bovine rotavirus nonstructural protein 4 produced by Lactococcus lactis is antigenic and immunogenic ' () 67 Applied and Environmental Microbiology : 1423 -1428.
-
Esteban, L.E., Temprana, C.F., Argüelles, M.H., Glikmann, G. and Castello, A.A., 2013. Antigenicity and immunogenicity of rotavirus VP6 protein expressed on the surface of Lactococcus lactis. BioMed Research International 2013: 298598.
'Antigenicity and immunogenicity of rotavirus VP6 protein expressed on the surface of Lactococcus lactis ' () 2013 BioMed Research International : 298598.
-
Gasson, M.J., 1983. Genetic transfer systems in lactic acid bacteria. Antonie Van Leeuwenhoek 49: 275-282.
'Genetic transfer systems in lactic acid bacteria ' () 49 Antonie Van Leeuwenhoek : 275 -282.
-
Geller, B.L., Ivey, R.G., Trempy, J.E. and Hettinger-Smith, B., 1993. Cloning of a chromosomal gene required for pahge infection of Lactococcus lactis subsp. lactis C2. Journal of Bacteriology 175: 5510-5519.
'Cloning of a chromosomal gene required for pahge infection of Lactococcus lactis subsp. lactis C2 ' () 175 Journal of Bacteriology : 5510 -5519.
-
Geller, B.L., Wade, N., Gilberts, T.D., Hruby, D.E., Johanson, R. and Topisirovic, L., 2001. Surface expression of the conserved C repeat region of streptococcal M6 protein within the Pip bacteriophage receptor of Lactococcus lactis. Applied of Environmental Microbiology 67: 5370-5376.
'Surface expression of the conserved C repeat region of streptococcal M6 protein within the Pip bacteriophage receptor of Lactococcus lactis ' () 67 Applied of Environmental Microbiology : 5370 -5376.
-
Guimarães, V.D., Innocentin, S., Lefèvre, F., Azevedo, V., Wal, J.M., Langella, P. and Chatel, J.M., 2006. Applied of Environmental Microbiology 72: 7091-7097.
() 72 Applied of Environmental Microbiology : 7091 -7097.
-
Jiang, X., Yu, M., Qiao, X., Liu, M., Tang, L., Jiang, Y., Cui, W. and Li, Y., 2014. Up-regulation of MDP and tufsin gene expression in Th1 and Th17 cells as an adjuvant for an oral Lactobacillus casei vaccine against anti-transmissible gastroenteritis virus. Applied Microbiology and Biotechnology 7, in press. DOI: http://dx.doi.org/10.1007/s00253-014-5893-2.
-
Kajikawa, A. and Igimi, S., 2010. Innate and acquired immune responses induced by recombinant Lactobacillus casei displaying flagellin-fusion antigen on the cell-surface. Vaccine 28: 3409-3415.
'Innate and acquired immune responses induced by recombinant Lactobacillus casei displaying flagellin-fusion antigen on the cell-surface ' () 28 Vaccine : 3409 -3415.
-
Kajikawa, A., Nordone, S.K., Zhang, L., Stoeker, L.L., LaVoy, A.S., Klaenhammer, T.R. and Dean, G.A., 2011. Dissimilar properties of two recombinant Lactobacillus acidophilus strains displaying Salmonella FliC with different anchoring motifs. Applied and Environmental Microbiology 77: 6587-6596.
'Dissimilar properties of two recombinant Lactobacillus acidophilus strains displaying Salmonella FliC with different anchoring motifs ' () 77 Applied and Environmental Microbiology : 6587 -6596.
-
Kajikawa, A., Zhang, L., Long, J., Nordone, S., Stoeker, L., LaVoy, A., Bumgardner, S., Klaenhammer, T. and Dean, G., 2012. Construction and immunological evaluation of dual cell surface display of HIV-1 gag and Salmonella enterica serovar Typhimurium FliC in Lactobacillus acidophilus for vaccine delivery. Clinical and Vaccine Immunology 19: 1374-1381.
'Construction and immunological evaluation of dual cell surface display of HIV-1 gag and Salmonella enterica serovar Typhimurium FliC in Lactobacillus acidophilus for vaccine delivery ' () 19 Clinical and Vaccine Immunology : 1374 -1381.
-
Kleerebezem, M., Beerthuyzen, M.M., Vaughan, E.E., De Vos, W.M. and Kuipers, O.P., 1997. Controlled gene expression systems for lactic acid bacteria: transferable nisin-inducible expression cassettes for Lactococcus, Leuconostoc, and Lactobacillus spp. Applied and Environmental Microbiology 63: 4581-4584.
'Controlled gene expression systems for lactic acid bacteria: transferable nisin-inducible expression cassettes for Lactococcus, Leuconostoc, and Lactobacillus spp ' () 63 Applied and Environmental Microbiology : 4581 -4584.
-
Krüger, C., Hu, Y., Pan, Q., Marcotte, H., Hultberg, A., Delwar, D., Van Dalen, P.J., Pouwels, P.H., Leer, R.J., Kelly, G.C., Van Dollenweerd, C., Ma, J.K. and Hammarström, L., 2002. In situ delivery of passive immunity by lactobacilli producing single-chain antibodies. Nature of Biotechnology 20: 702-706.
'In situ delivery of passive immunity by lactobacilli producing single-chain antibodies ' () 20 Nature of Biotechnology : 702 -706.
-
Kuipers, O.P., De Ruyter, P., Kleerebezem, M. and De Vos, W.M., 1998. Quorum sensing-controlled gene expression in lactic acid bacteria. Journal of Biotechnology 64: 15-21.
'Quorum sensing-controlled gene expression in lactic acid bacteria ' () 64 Journal of Biotechnology : 15 -21.
-
Kukowska-Kaszuba, M., Dzierzbicka, K., Serocki, M. and Skladanowski, A., 2011. Solid phase synthesis and biological activity of tuftsin conjugates. Journal of Medicinal Chemistry 54: 2447-2454.
'Solid phase synthesis and biological activity of tuftsin conjugates ' () 54 Journal of Medicinal Chemistry : 2447 -2454.
-
Land, M.H., Rouster-Stevens, K., Woods, C.R., Cannon, M.L., Cnota, J. and Shetty, A.K., 2005. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 115: 178-181.
'Lactobacillus sepsis associated with probiotic therapy ' () 115 Pediatrics : 178 -181.
-
Langella, P. and Le Loir, Y., 1999. Heterologous protein secretion in Lactococcus lactis: a novel antigen delivery system. Brazilian Journal of Medical and Biological Research 32: 191-198.
'Heterologous protein secretion in Lactococcus lactis: a novel antigen delivery system ' () 32 Brazilian Journal of Medical and Biological Research : 191 -198.
-
Lei, H., Peng, X., Shu, H. and Zhao, D., 2014. Intranasal immunization with live recombinant Lactococcus lactis combined with heat-labile toxin B subunit protects chickens from highly pathogenic influenza H5N1 virus. Journal of Medical Virology, in press. DOI: http://dx.doi.org/10.1002/jmv.23983.
-
Lei, H., Xu, Y., Chen, J., Wei, X. and Lam, D.M., 2010. Immunoprotection against influenza H5N1 virus by oral administration of enteric-coated recombinant Lactococcus lactis mini-capsules. Virology 407: 319-324.
'Immunoprotection against influenza H5N1 virus by oral administration of enteric-coated recombinant Lactococcus lactis mini-capsules ' () 407 Virology : 319 -324.
-
Limaye, S.A., Haddad, R.I., Sonis, S.T., Colevas, A.D., Brennan, M.T., Hu, K.S. and Murphy, B.A., 2013. Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy. Cancer 119: 4268-4276.
'Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy ' () 119 Cancer : 4268 -4276.
-
Liu, S., Li, Y., Xu, Z. and Wang, Y., 2010. Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunization. Veterinary Research Communications 34: 491-502.
'Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunization ' () 34 Veterinary Research Communications : 491 -502.
-
Maidin, M.S., Song, A.A., Jalilsood, T., Sieo, C.C., Yusoff, K. and Rahim, R.A., 2014. Construction of a novel inducible expression vector for Lactococcus lactis M4 and Lactobacillus plantarum Pa21. Plasmid 74: 32-38.
'Construction of a novel inducible expression vector for Lactococcus lactis M4 and Lactobacillus plantarum Pa21 ' () 74 Plasmid : 32 -38.
-
Martín, R., Chain, F., Migue, S., Natividad, J.M., Sokol, H., Verdu, E.F., Langella, P. and Bermúdez-Humarán, L.G., 2014. Effects in the use of a genetically engineered strain of Lactococcus lactis delivering in situ IL-10 as a therapy to treat low-grade colon inflammation. Human Vaccines and Immunotherapeutics 10(6).
'Effects in the use of a genetically engineered strain of Lactococcus lactis delivering in situ IL-10 as a therapy to treat low-grade colon inflammation ' () 10 Human Vaccines and Immunotherapeutics : .
-
Mierau, I. and Kleerebezem, M., 2005. 10 years of the nisin-controlled gene expression system (NICE) in Lactococcus lactis. Applied and Environmental Microbiology 68: 705-717.
'10 years of the nisin-controlled gene expression system (NICE) in Lactococcus lactis ' () 68 Applied and Environmental Microbiology : 705 -717.
-
Miyoshi, A., Jamet, E., Commissaire, J., Renault, P., Langella, P. and Azevedo, V., 2004. A xylose-inducible expression system for Lactococcus lactis. FEMS Microbiology Letters 239: 205-212.
'A xylose-inducible expression system for Lactococcus lactis ' () 239 FEMS Microbiology Letters : 205 -212.
-
O'Sullivan, D.J. and Klaenhammer, T.R., 1993. High- and low-copy-number Lactococcus shuttle cloning vectors with features for clone screening. Gene 137: 227-231.
'High- and low-copy-number Lactococcus shuttle cloning vectors with features for clone screening ' () 137 Gene : 227 -231.
-
Oliveira, M.L., Arêas, A.P., Campos, I.B., Monedero, V., Perez-Martínez, G., Miyaji, E.N., Leite, L.C., Aires, K.A. and Lee Ho, P., 2006. Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A. Microbes and Infection 8: 1016-1024.
'Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A ' () 8 Microbes and Infection : 1016 -1024.
-
Platteeuw, C., Van Alen-Boerrigter, I., Van Schalkwijk, S. and De Vos, W.M., 1996. Food-grade cloning and expression system for Lactococcus lactis. Applied and Environmental Microbiology 62: 1008-1013.
'Food-grade cloning and expression system for Lactococcus lactis ' () 62 Applied and Environmental Microbiology : 1008 -1013.
-
Pontes, D.S., De Azevedo, M.S., Chatel, J.M., Langella, P., Azevedo, V. and Miyoshi, A., 2011. Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems. Protein Expression and Purification 79: 165-175.
'Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems ' () 79 Protein Expression and Purification : 165 -175.
-
Pouwels, P.H., Leer, R.J. and Boersma, W.J., 1996. The potential of Lactobacillus as a carrier for oral immunization: development and preliminary characterization of vector systems for targeted delivery of antigens. Journal of Biotechnology 44: 183-192.
'The potential of Lactobacillus as a carrier for oral immunization: development and preliminary characterization of vector systems for targeted delivery of antigens ' () 44 Journal of Biotechnology : 183 -192.
-
Pouwels, P.H., Vriesema, A., Martinez, B., Tielen, F.J., Seegers, J.F., Leer, R.J., Jore, J. and Smit, E., 2001. Lactobacilli as vehicles for targeting antigens to mucosal tissues by surface exposition of foreign antigens. Methods in Enzimology 336: 369-389.
'Lactobacilli as vehicles for targeting antigens to mucosal tissues by surface exposition of foreign antigens ' () 336 Methods in Enzimology : 369 -389.
-
Quigley, B.R., Hatkoff, M., Thanassi, D.G., Ouattara, M., Eichenbaum, Z. and Scott, J.R., 2010. A foreign protein incorporated on the Tip of T3 pili in Lactococcus lactis elicits systemic and mucosal immunity. Infection and Immunity 78: 1294-1303.
'A foreign protein incorporated on the Tip of T3 pili in Lactococcus lactis elicits systemic and mucosal immunity ' () 78 Infection and Immunity : 1294 -1303.
-
Ribeiro, L.A., Azevedo, V., Le Loir, Y., Oliveira, S.C., Dieye, Y., Piard, J.C., Gruss, A. and Langella, P., 2002. Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grade live vaccines against brucellosis. Applied and Environmental Microbiology 68: 910-916.
'Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grade live vaccines against brucellosis ' () 68 Applied and Environmental Microbiology : 910 -916.
-
Robinson, K., Chamberlain, L.M., Lopez, M.C., Rush, C.M., Marcotte, H., Le Page, R.W. and Wells, J.M., 2004. Mucosal and cellular immune responses elicited by recombinant Lactococcus lactis strains expressing tetanus toxin fragment C. Infection and Immunity 72: 2753-2761.
'Mucosal and cellular immune responses elicited by recombinant Lactococcus lactis strains expressing tetanus toxin fragment C ' () 72 Infection and Immunity : 2753 -2761.
-
Sáez, D., Fernández, P., Rivera, A., Andrews, E. and Oñate, A., 2012. Oral immunization of mice with recombinant Lactococcus lactis expressing Cu,Zn superoxide dismutase of Brucella abortus triggers protective immunity. Vaccine 30: 1283-1290.
'Oral immunization of mice with recombinant Lactococcus lactis expressing Cu,Zn superoxide dismutase of Brucella abortus triggers protective immunity ' () 30 Vaccine : 1283 -1290.
-
Scavone, P., Miyoshi, A., Rial, A., Chabalgoity, A., Langella, P., Azevedo, V. and Zunino, P., 2007. Intranasal immunisation with recombinant Lactococcus lactis displaying either anchored or secreted forms of Proteus mirabilis MrpA fimbrial protein confers specific immune response and induces a significant reduction of kidney bacterial colonisation in mice. Microbes and Infection 9: 821-828.
'Intranasal immunisation with recombinant Lactococcus lactis displaying either anchored or secreted forms of Proteus mirabilis MrpA fimbrial protein confers specific immune response and induces a significant reduction of kidney bacterial colonisation in mice ' () 9 Microbes and Infection : 821 -828.
-
Sleator, R.D. and Hill, C., 2006. Patho-biotechnology: using bad bugs to do good things. Current Opinion in Biotechnology 17: 211-216.
'Patho-biotechnology: using bad bugs to do good things ' () 17 Current Opinion in Biotechnology : 211 -216.
-
Steidler, L. and Rottiers, P., 2006. Therapeutic drug delivery by genetically modified Lactococcus lactis. Annual of the New York Academy of Sciences 1072: 176-186.
'Therapeutic drug delivery by genetically modified Lactococcus lactis ' () 1072 Annual of the New York Academy of Sciences : 176 -186.
-
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W. and Remaut, E., 2000. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289: 1352-1355.
'Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 ' () 289 Science : 1352 -1355.
-
Steidler, L., Rottiers, P. and Coulie, B., 2009. Actobiotics as a novel method for cytokine delivery. Annual of the New York Academy of Sciences 1182: 135-145.
'Actobiotics as a novel method for cytokine delivery ' () 1182 Annual of the New York Academy of Sciences : 135 -145.
-
Stoeker, L., Nordone, S., Gunderson, S., Zhang, L., Kajikawa, A., LaVoy, A., Miller, M., Klaenhammer, T.R. and Dean, G.A, 2011. Assessment of Lactobacillus gasseri as a candidate oral vaccine vector. Clinical and Vaccine Immunology 18: 1834-1844.
'Assessment of Lactobacillus gasseri as a candidate oral vaccine vector ' () 18 Clinical and Vaccine Immunology : 1834 -1844.
-
Van Roosmalen, M.L., Kanninga, R., El Khattabi, M., Neef, J., Audouy, S., Bosma, T., Kuipers, A., Post, E., Steen, A., Kok, J., Buist, G., Kuipers, O.P., Robillard, G. and Leenhouts, K., 2006. Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria. Methods 38: 144-149.
'Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria ' () 38 Methods : 144 -149.
-
Villena, J., Medina, M., Racedo, S. and Alvarez, S., 2010. Resistance of young mice to pneumococcal infection can be improved by oral vaccination with recombinant Lactococcus lactis. Journal of Microbiology, Immunology and Infection 43: 1-10.
'Resistance of young mice to pneumococcal infection can be improved by oral vaccination with recombinant Lactococcus lactis ' () 43 Journal of Microbiology, Immunology and Infection : 1 -10.
-
Wang, Z.H., Cao, X.H., Du, X.G., Feng, H.B., Di-Wang, He-Song and Zeng, X.Y., 2014a. Mucosal and systemic immunity in mice after intranasal immunization with recombinant Lactococcus lactis expressing ORF6 of PRRSV. Cellular Immunology 287: 69-73.
'Mucosal and systemic immunity in mice after intranasal immunization with recombinant Lactococcus lactis expressing ORF6 of PRRSV ' () 287 Cellular Immunology : 69 -73.
-
Wang, Z.H., Wang, Y.L. and Zeng, X.Y., 2014b. Construction and expression of a heterologous protein in Lactococcus lactis by using the nisin-controlled gene expression system: the case of the PRRSV ORF6 gene. Genetics and Molecular Research 13: 1088-1096.
'Construction and expression of a heterologous protein in Lactococcus lactis by using the nisin-controlled gene expression system: the case of the PRRSV ORF6 gene ' () 13 Genetics and Molecular Research : 1088 -1096.
-
Wardowska, A., Dzierzbicka, K., Menderska, A. and Trzonkoski, P., 2013. New conjugates of tuftsin and muramyl dipeptide as stimulators of dendritic cells. Protein and Peptide Letters 20: 200-204.
'New conjugates of tuftsin and muramyl dipeptide as stimulators of dendritic cells ' () 20 Protein and Peptide Letters : 200 -204.
-
Wells, J.M. and Mercenier, A. 2008. Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Nature Reviews Microbiology 6: 349-362.
'Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria ' () 6 Nature Reviews Microbiology : 349 -362.
-
Wells, J.M., Robinson, K., Chamberlain, L.M., Schofield, K.M. and Le Page, R.W., 1996. Lactic acid bacteria as vaccine delivery vehicles. Antoine Van Leeuwenhoek 70: 317-330.
'Lactic acid bacteria as vaccine delivery vehicles ' () 70 Antoine Van Leeuwenhoek : 317 -330.
-
Wen, L.J., Hou, X.L., Wang, G.H., Yu, L.Y., Wei, X.M., Liu, J.K., Liu, Q. and Wei, C.H., 2012. Immunization with recombinant Lactobacillus casei strains producing K99, K88 fimbrial protein protects mice against enterotoxigenic Escherichia coli. Vaccine 30: 3339-3349.
'Immunization with recombinant Lactobacillus casei strains producing K99, K88 fimbrial protein protects mice against enterotoxigenic Escherichia coli ' () 30 Vaccine : 3339 -3349.
-
Wirth, R., An, F.Y. and Clewell, D.B., 1986. Highly efficient protoplast transformation system from Streptococcus faecalis and a new Escherichia coli - S. faecalis shuttle vector. Journal of Bacteriology 165: 831-836.
'Highly efficient protoplast transformation system from Streptococcus faecalis and a new Escherichia coli - S. faecalis shuttle vector ' () 165 Journal of Bacteriology : 831 -836.
-
Wu, C.M., Lin, C.F., Chang, Y.C. and Chung, T.C., 2006. Construction and characterization of nisin-controlled expression vectors for use in Lactobacillus reuteri. Bioscience, Biotechnology, and Biochemistry 70: 757-767.
'Construction and characterization of nisin-controlled expression vectors for use in Lactobacillus reuteri ' () 70 Bioscience, Biotechnology, and Biochemistry : 757 -767.
-
Yang, X.Q., Zhao, Y.G., Chen, X.Q., Jiang, B. and Sun, D.Y., 2013. The protective effect of recombinant Lactococcus lactis oral vaccine on a Clostridium difficile-infected animal model. BMC Gastroenterology 13: 117.
'The protective effect of recombinant Lactococcus lactis oral vaccine on a Clostridium difficile-infected animal model ' () 13 BMC Gastroenterology : 117.
-
Zamri, H.F., Shamsudin, M.N., Rahim, R.A. and Neela, V., 2012. Oral vaccination with Lactococcus lactis expressing the Vibrio cholerae Wzm protein to enhance mucosal and systemic immunity. Vaccine 30: 3231-3238.
'Oral vaccination with Lactococcus lactis expressing the Vibrio cholerae Wzm protein to enhance mucosal and systemic immunity ' () 30 Vaccine : 3231 -3238.
-
Zárate, G. and Nader-Macias, M.E., 2007 Protective effect of vaginal Lactobacillus paracasei CRL 1289 against urogenital infection produced by Staphylococcus aureus in a mouse animal model. Infectious Diseases in Obstetrics and Gynecology 2007: 1-6.
'Protective effect of vaginal Lactobacillus paracasei CRL 1289 against urogenital infection produced by Staphylococcus aureus in a mouse animal model ' () 2007 Infectious Diseases in Obstetrics and Gynecology : 1 -6.
-
Zhou, X.X., Li, W.F., Ma, G.X. and Pan, Y.J., 2006. The nisi-controlled gene expression system: construction, application and improvements. Biotechnology Advances 24: 285-295.
'The nisi-controlled gene expression system: construction, application and improvements ' () 24 Biotechnology Advances : 285 -295.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 487 | 194 | 15 |
| Full Text Views | 8 | 0 | 0 |
| PDF Views & Downloads | 20 | 0 | 0 |
Recombinant lactic acid bacteria as delivery vectors of heterologous antigens: the future of vaccination?
In: Beneficial MicrobesSearch for other papers by A. Trombert in
Current site
Google Scholar
PubMed
Lactic acid bacteria (LABs) are good candidates for the development of new oral vaccines and are attractive alternatives to attenuated pathogens. This review focuses on the use of wild-type and recombinant lactococci and lactobacilli with emphasis on their molecular design, immunomodulation and treatment of bacterial infections. The majority of studies related to recombinant LABs have focused on Lactococcus lactis, however, molecular tools have been successfully used for Lactobacillus spp. research. Recombinant lactobacilli and lactococci have several health benefits, such as immunomodulation, restoration of the microbiota, synthesis of antimicrobial substances and inhibition of virulence factors. In addition, protective immune responses that are well tolerated are induced by the expression of heterologous antigens from recombinant probiotics.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 487 | 194 | 15 |
| Full Text Views | 8 | 0 | 0 |
| PDF Views & Downloads | 20 | 0 | 0 |
