The development of probiotic treatment in obesity: a review
In: Beneficial MicrobesSearch for other papers by M.C. Mekkes in
Current site
Google Scholar
Search for other papers by T.C. Weenen in
Current site
Google Scholar
Search for other papers by R.J. Brummer in
Current site
Google Scholar
Search for other papers by E. Claassen in
Current site
Google Scholar
Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity. Such treatment might consist of altering the composition of the microbial communities of an obese individual by administration of beneficial microorganisms, commonly known as probiotics. Here, we intend to contribute to the developmental process of probiotic treatment of human obesity. The aim is to review the evidence regarding the potential effect of probiotic strains on reduction of weight and body fat. A literature study was conducted focusing on clinical trials that examined the effect of specific microorganisms on body weight control. Analysis of the eligible articles pointed out that Lactobacillus gasseri SBT 2055, Lactobacillus rhamnosus ATCC 53103, and the combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12 may reduce adiposity, body weight, and weight gain. This suggests that these microbial strains can be applied in the treatment of obesity. Furthermore, short chain fatty acid production and low grade inflammation were found as the underlying mechanisms of action that influence metabolism and affect body weight. These findings might contribute to the development of probiotic treatment of obesity. Further research should be directed to the most effective combination and dosage rate of probiotic microorganisms.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Amar, J., Burcelin, R., Ruidavets, J.B., Cani, P.D., Fauvel, J., Alessi, M.C., Chamontin, B. and Ferriéres, J., 2008. Energy intake is associated with endotoxemia in apparently healthy men. American Journal of Clinical Nutrition 87: 1219-1223.
'Energy intake is associated with endotoxemia in apparently healthy men ' () 87 American Journal of Clinical Nutrition : 1219 -1223.
-
Bäckhed, F., Ding, H., Wang, T., Hooper, L.V., Koh, G.Y., Nagy, A., Semenkovich, C.F. and Gordon, J.I., 2004. The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the USA 101: 15718-15723.
'The gut microbiota as an environmental factor that regulates fat storage ' () 101 Proceedings of the National Academy of Sciences of the USA : 15718 -15723.
-
Bäckhed, F., Ley, R.E., Sonnenburg, J.L., Peterson, D.A. and Gordon, J.I., 2005. Host-bacterial mutualism in the human intestine. Science 307: 1915-1920.
'Host-bacterial mutualism in the human intestine ' () 307 Science : 1915 -1920.
-
Bukowska, H., Pieczul-Mróz, J., Jastrzebska, M., Chełstowski, K. and Naruszewicz, M., 1998. Decrease in fibrinogen and LDL-cholesterol levels upon supplementation of diet with Lactobacillus plantarum in subjects with moderately elevated cholesterol. Atherosclerosis 137: 437-438.
'Decrease in fibrinogen and LDL-cholesterol levels upon supplementation of diet with Lactobacillus plantarum in subjects with moderately elevated cholesterol ' () 137 Atherosclerosis : 437 -438.
-
Caesar, R., Fåk, F. and Bäckhed, F., 2010. Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. Journal of Internal Medicine 268: 320-328.
'Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism ' () 268 Journal of Internal Medicine : 320 -328.
-
Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A.M., Fava, F., Tuohy, K.M., Chabo, C., Waget, A., Delmée, E., Cousin, B., Sulpice, T., Chamontin, B., Ferrières, J., Tanti, J.F., Gibson, G.R., Casteilla, L., Delzenne, N.M., Alessi, M.C. and Burcelin, R., 2007. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56: 1761-1772.
'Metabolic endotoxemia initiates obesity and insulin resistance ' () 56 Diabetes : 1761 -1772.
-
Cani, P.D. and Delzenne, N.M., 2011. The gut microbiome as therapeutic target. Pharmacology and Therapeutics 130: 202-212.
'The gut microbiome as therapeutic target ' () 130 Pharmacology and Therapeutics : 202 -212.
-
Cani, P.D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard A, Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D.M., Muccioli, G.G. and Delzenne, N.M., 2009. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP- 2-driven improvement of gut permeability. Gut 58: 1091-1103.
'Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP- 2-driven improvement of gut permeability ' () 58 Gut : 1091 -1103.
-
Cole, J.R., Chai, B., Farris, R.J., Wang, Q., Kulam, S.A., McGarrell, D.M., Garrity, G.M. and Tiedje, J.M., 2005. The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis. Nucleic Acids Research 33: D294-D296.
'The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis ' () 33 Nucleic Acids Research : D294 -D296.
-
Delzenne, N.M. and Cani, P.D., 2008. Gut microflora is a key player in host energy homeostasis. Medicine Sciences 24: 505-510.
'Gut microflora is a key player in host energy homeostasis ' () 24 Medicine Sciences : 505 -510.
-
Elli, M., Colombo, O. and Tagliabue, A., 2010. A common core microbiota between obese individuals and their lean relatives? Evaluation of the predisposition to obesity on the basis of the fecal microflora profile. Medical Hypotheses 75: 350-352.
'A common core microbiota between obese individuals and their lean relatives? Evaluation of the predisposition to obesity on the basis of the fecal microflora profile ' () 75 Medical Hypotheses : 350 -352.
-
Finucane, M.M., Stevens, G.A., Cowan, M.J., Danaei, G., Lin, J.K., Paciorek, C.J., Singh, G.M., Gutierrez, H.R., Lu, Y., Bahalim, A.N., Farzadfar, F., Riley, L.M. and Ezzati, M. for the Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group, 2011. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 91 million participants. The Lancet 377: 557-567.
-
Fleming, S.E., Fitch, M.D., DeVries, S., Liu, M.L. and Kight, C., 1991. Nutrient utilization by cells isolated from rat jejunum, cecum and colon. Journal of Nutrition 121: 869-878.
'Nutrient utilization by cells isolated from rat jejunum, cecum and colon ' () 121 Journal of Nutrition : 869 -878.
-
Geurts, L., Neyrinck, A.M., Delzenne, N.M., Knauf, C. and Cani, P.D., 2013. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Beneficial Microbes, in press. DOI: http://dx.doi.org/10.3920/BM2012.0065.
-
Hooper, L.V., Midtvedt, T. and Gordon, J.I., 2002. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annual Review of Nutrition 22: 283-307.
'How host-microbial interactions shape the nutrient environment of the mammalian intestine ' () 22 Annual Review of Nutrition : 283 -307.
-
International Association for the Study of Obesity (IASO), 2012. Global overweight and obesity in adults; overweight and obesity in adults from selected countries around the world. Available at: http://www.iaso.org/resources/obesity-data-portal/resources/charts/2/. http://www.iaso.org/resources/obesity-data-portal/resources/charts/2/
-
Ilmonen, J., Isolauri, E., Poussa, T. and Laitinen, K., 2011. Impact of dietary counselling and probiotic intervention on maternal anthropometric measurements during and after pregnancy: a randomized placebo-controlled trial. Clinical Nutrition 30: 156-164.
'Impact of dietary counselling and probiotic intervention on maternal anthropometric measurements during and after pregnancy: a randomized placebo-controlled trial ' () 30 Clinical Nutrition : 156 -164.
-
Jia, W., Li, H., Zhao, L. and Nicholson, J.K., 2008. Gut microbiota: a potential new territory for drug targeting. Nature Reviews Drug Discovery 7: 123-129.
'Gut microbiota: a potential new territory for drug targeting ' () 7 Nature Reviews Drug Discovery : 123 -129.
-
Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M. and Tsuchida, T., 2010. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. European Journal of Clinical Nutrition 64: 636-643.
'Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial ' () 64 European Journal of Clinical Nutrition : 636 -643.
-
Ley, R.E., Bäckhed, F., Turnbaugh, P., Lozupone, C.A., Knight, R.D. and Gordon, J.I., 2005. Obesity alters gut microbial ecology. Proceedings of the National Academy of Sciences of the USA 102: 11070-11075.
'Obesity alters gut microbial ecology ' () 102 Proceedings of the National Academy of Sciences of the USA : 11070 -11075.
-
Ley, R.E., Turnbaugh, P.J., Klein, S. and Gordon, J.I., 2006. Microbial ecology: human gut microbes associated with obesity. Nature 444: 1022-1023.
'Microbial ecology: human gut microbes associated with obesity ' () 444 Nature : 1022 -1023.
-
Luoto, R., Kalliomäki, M., Laitinen, K. and Isolauri, E., 2010. The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years. International Journal of Obesity 34: 1531-1537.
'The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years ' () 34 International Journal of Obesity : 1531 -1537.
-
Lyra, A., Lahtinen, S., Tiihonen, K. and Ouwehand, A.C., 2010. Intestinal microbiota and overweight. Beneficial Microbes 1: 407-421.
'Intestinal microbiota and overweight ' () 1 Beneficial Microbes : 407 -421.
-
Mehta, N.N., McGillicuddy, F.C., Anderson, P.D., Hinkle, C.C., Shah, R., Pruscino, L., Tabita-Martinez, J., Sellers, K.F., Rickels, M.R. and Reilly, M.P., 2010. Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes 59: 172-181.
'Experimental endotoxemia induces adipose inflammation and insulin resistance in humans ' () 59 Diabetes : 172 -181.
-
Mikirova, N.A., Casciari, J.J., Hunninghake, R.E. and Beezley, M.M., 2011. Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation. International Journal of Medical Sciences 8: 445-452.
'Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation ' () 8 International Journal of Medical Sciences : 445 -452.
-
Nadal, I., Santacruz, A., Marcos, A., Warnberg, J., Garagorri, M., Moreno, L.A., Martin-Matillas, M., Campoy, C., Martí, A., Moleres, A., Delgado, M., Veiga, O.L., García-Fuentes, M., Redondo, C.G. and Sanz, Y., 2009. Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents. International Journal of Obesity 33: 758-767.
'Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents ' () 33 International Journal of Obesity : 758 -767.
-
Prentice, A.M., 2006. The emerging epidemic of obesity in developing countries. International Journal of Epidemiology 35: 93-99.
'The emerging epidemic of obesity in developing countries ' () 35 International Journal of Epidemiology : 93 -99.
-
Reinhold, R., Von Schultzendorff, A. and Muller-Riemenschneider, F., 2011. Economic consequences of overweight and obesity in Asia-Pacific. European Journal of Integrative Medicine 3: 3-9.
'Economic consequences of overweight and obesity in Asia-Pacific ' () 3 European Journal of Integrative Medicine : 3 -9.
-
Roediger, W.E., 1980, Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21: 793-798.
'Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man ' () 21 Gut : 793 -798.
-
Santacruz, A., Marcos, A., Wärnberg, J., Martí, A., Martin-Matillas, M., Campoy, C., Moreno, L.A., Veiga, O., Redondo-Figuero, C., Garagorri, J.M., Azcona, C., Delgado, M., García-Fuentes, M., Collado, M.C. and Sanz, Y., 2009. Interplay between weight loss and gut microbiota composition in overweight adolescents. Obesity 17: 1906-1915.
'Interplay between weight loss and gut microbiota composition in overweight adolescents ' () 17 Obesity : 1906 -1915.
-
Sonnenburg, J.L., Xu, J., Leip, D.D., Chen, C.H., Westover, B.P., Weatherford, J., Buhler, J.D. and Gordon, J.I., 2005. Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science 307: 1955-1959.
'Glycan foraging in vivo by an intestine-adapted bacterial symbiont ' () 307 Science : 1955 -1959.
-
Stein, C.J. and Colditz, G.A., 2004. The epidemic of obesity. The Journal of Clinical Endocrinology and Metabolism 89: 2522-2525.
'The epidemic of obesity ' () 89 The Journal of Clinical Endocrinology and Metabolism : 2522 -2525.
-
Stel, V.S., Jager, K.J., Zoccali, C., Wanner, C. and Dekker, F.W., 2007. The randomized clinical trial: an unbeatable standard in clinical research. Kidney International 72: 539-542.
'The randomized clinical trial: an unbeatable standard in clinical research ' () 72 Kidney International : 539 -542.
-
Tremaroli, V. and Bäckhed, F., 2012. Functional interactions between the gut microbiota and host metabolism. Nature 489: 242-249.
'Functional interactions between the gut microbiota and host metabolism ' () 489 Nature : 242 -249.
-
Turnbaugh, P.J., Hamady, M., Yatsunenko, T., Cantarel, B.L., Duncan, A., Ley, R.E., Sogin, M.L., Jones, W.J., Roe, B.A., Affourtit, J.P., Egholm, M., Henrissat, B., Heath, A.C., Knight, R. and Gordon, J.I., 2009. A core gut microbiome in obese and lean twins. Nature 457: 480-484.
'A core gut microbiome in obese and lean twins ' () 457 Nature : 480 -484.
-
Vrieze, A., Holleman, F., Zoetendal, E.G., De Vos, W.M., Hoekstra, J.B. and Nieuwdorp, M., 2010. The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia 53: 606-613.
'The environment within: how gut microbiota may influence metabolism and body composition ' () 53 Diabetologia : 606 -613.
-
World Health Organization (WHO), 2012. World health statistics 2012. World Health Organization, Geneva, Switzerland.
-
World Health Organization (WHO), 2011. Obesity and overweight. Fact sheet N311. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/. http://www.who.int/mediacentre/factsheets/fs311/en/
-
Zhang, H., DiBaise, J.K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M.D., Wing, R., Rittmann, B.E. and Krajmalnik-Brown, R., 2009. Human gut microbiota in obesity and after gastric bypass. Proceedings of the National Academy of Sciences of the USA 106: 2365-2370.
'Human gut microbiota in obesity and after gastric bypass ' () 106 Proceedings of the National Academy of Sciences of the USA : 2365 -2370.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1567 | 445 | 51 |
| Full Text Views | 87 | 50 | 1 |
| PDF Views & Downloads | 58 | 7 | 0 |
The development of probiotic treatment in obesity: a review
In: Beneficial MicrobesSearch for other papers by M.C. Mekkes in
Current site
Google Scholar
PubMed
Search for other papers by T.C. Weenen in
Current site
Google Scholar
PubMed
Search for other papers by R.J. Brummer in
Current site
Google Scholar
PubMed
Search for other papers by E. Claassen in
Current site
Google Scholar
PubMed
Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity. Such treatment might consist of altering the composition of the microbial communities of an obese individual by administration of beneficial microorganisms, commonly known as probiotics. Here, we intend to contribute to the developmental process of probiotic treatment of human obesity. The aim is to review the evidence regarding the potential effect of probiotic strains on reduction of weight and body fat. A literature study was conducted focusing on clinical trials that examined the effect of specific microorganisms on body weight control. Analysis of the eligible articles pointed out that Lactobacillus gasseri SBT 2055, Lactobacillus rhamnosus ATCC 53103, and the combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12 may reduce adiposity, body weight, and weight gain. This suggests that these microbial strains can be applied in the treatment of obesity. Furthermore, short chain fatty acid production and low grade inflammation were found as the underlying mechanisms of action that influence metabolism and affect body weight. These findings might contribute to the development of probiotic treatment of obesity. Further research should be directed to the most effective combination and dosage rate of probiotic microorganisms.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1567 | 445 | 51 |
| Full Text Views | 87 | 50 | 1 |
| PDF Views & Downloads | 58 | 7 | 0 |
