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Effects of Traditional Asian Diet on dietary fibre requirement, gut microbiome composition, and faecal and urine metabolomes in healthy Asian women: a pilot study
in Beneficial MicrobesSchool of Health Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia
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Abstract
The Traditional Asian Diet (TAD) is characterised by high dietary fibre and functional foods. This study investigated TAD’s effects on meeting fibre requirements, gut microbiome, and faecal and urine metabolomes. A four-week randomised controlled trial was conducted among healthy Asian women allocated into the TAD group (n = 11) following a newly developed TAD program and the control group (n = 11). Assessments included dietary intake, gut health (symptoms, faecal form, frequency), serum fatty acids binding protein-2 (FABP-2) levels, faecal microbiome via 16s rRNA sequencing, and faecal and urine metabolites which were analysed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR), respectively. The TAD group showed significant increases in dietary fibre (
Clinical trial registration: NCT04885959, clinicaltrials.gov
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Abe, S., Zhang, S., Tomata, Y., Tsuduki, T., Sugawara, Y. and Tsuji, I., 2020. Japanese diet and survival time: the Ohsaki Cohort 1994 study. Clinical Nutrition 39(1): 298-303. https://doi.org/10.1016/j.clnu.2019.02.010
-
Ardani, L.R., Marlida, Y., Zain, M., Jamsari, J. and Fassah, D.M., 2023. Lactic acid bacteria and yeast strains isolated from fermented fish (budu) identified as candidate ruminant probiotics based on in vitro rumen fermentation characteristics. Veterinary World 16(2): 395. https://doi.org/10.14202/VETWORLD.2023.395-402
-
Barnett, D., Arts, I. and Penders, J., 2021. microViz: an R package for microbiome data visualisation and statistics. Journal of Open Source Software 6(63): 3201. https://doi.org/10.21105/joss.03201
-
Baxter, N.T., Schmidt, A.W., Venkataraman, A., Kim, K.S., Waldron, C. and Schmidt, T.M., 2019. Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibres. mBio 10(1): 1-13. https://doi.org/10.1128/mBio.02566-18
-
Bonazzi, E., Bretin, A., Vigué, L., Hao, F., Patterson, A.D., Gewirtz, A.T. and Chassaing, B., 2024. Individualised microbiotas dictate the impact of dietary fibre on colitis sensitivity. Microbiome 12(1): 1-14. https://doi.org/10.1186/s40168-023-01724-6
-
Callahan, B.J., McMurdie, P.J., Rosen, M.J., Han, A.W., Johnson, A.J.A. and Holmes, S.P., 2016. DADA2: high-resolution sample inference from Illumina amplicon data. Nature Methods 13(7): 581-583. https://doi.org/10.1038/nmeth.3869
-
Chan, R.S.M., Yu, B.W.M., Leung, J., Lee, J.S.W., Auyeung, T.W., Kwok, T. and Woo, J., 2019. How dietary patterns are related to inflammaging and mortality in community-dwelling older Chinese adults in Hong Kong – a prospective analysis. The Journal of Nutrition, Health & Aging 23(2): 181-194. https://doi.org/10.1007/s12603-018-1143-0
-
Chen, T., Long, W., Zhang, C., Liu, S., Zhao, L. and Hamaker, B.R., 2017. Fibre-utilising capacity varies in Prevotella – versus Bacteroides-dominated gut microbiota. Scientific Reports 7(1): 1-7. https://doi.org/10.1038/s41598-017-02995-4
-
Christensen, L., Vuholm, S., Roager, H.M., Nielsen, D.S., Krych, L., Kristensen, M., Astrup, A. and Hjorth, M.F., 2019. Prevotella abundance predicts weight loss success in healthy, overweight adults consuming a whole-grain diet ad libitum: a post hoc analysis of a 6-Wk randomised controlled trial. The Journal of Nutrition 149(12): 2174-2181. https://doi.org/10.1093/jn/nxz198
-
Dixon, P., 2003. Computer program review VEGAN, a package of R functions for community ecology. Journal of Vegetation Science 14(6): 927-930. http://doi.wiley.com/10.1111/j.1654-1103.2002.tb02049.x
-
Dwiyanto, J., Hussain, M.H., Reidpath, D., Ong, K.S., Qasim, A., Lee, S.W.H., Lee, S.M., Foo, S.C., Chong, C.W. and Rahman, S., 2021. Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country. Scientific Reports 11(1): 1-10. https://doi.org/10.1038/s41598-021-82311-3
-
Galena, A.E., Chai, J., Zhang, J., Bednarzyk, M., Perez, D., Ochrietor, J.D., Jahan-Mihan, A. and Arikawa, A.Y., 2022. The effects of fermented vegetable consumption on the composition of the intestinal microbiota and levels of inflammatory markers in women: a pilot and feasibility study. PLoS ONE 17(10). https://doi.org/10.1371/JOURNAL.PONE.0275275
-
Godny, L., Reshef, L., Sharar Fischler, T., Elial-Fatal, S., Pfeffer-Gik, T., Raykhel, B., Rabinowitz, K., Levi-Barda, A., Perets, T.T., Barkan, R., Goren, I., Ollech, J.E., Yanai, H., Gophna, U. and Dotan, I., 2022. Increasing adherence to the Mediterranean diet and lifestyle is associated with reduced fecal calprotectin and intra-individual changes in microbial composition of healthy subjects. Gut Microbes 14(1): 1-14. https://doi.org/10.1080/19490976.2022.2120749
-
Hall, D.A., Voigt, R.M., Cantu-Jungles, T.M., Hamaker, B., Engen, P.A., Shaikh, M., Raeisi, S., Green, S.J., Naqib, A., Forsyth, C.B., Chen, T., Manfready, R., Ouyang, B., Rasmussen, H.E., Sedghi, S. and Goetz, C.G., 2023. An open label, non-randomised study assessing a prebiotic fi ber intervention in a small cohort of Parkinson’s disease participants. Nature Communications 14(926): 1-14. https://doi.org/10.1038/s41467-023-36497-x
-
Harmayani, E., Anal, A.K., Wichienchot, S., Bhat, R., Gardjito, M., Santoso, U., Siripongvutikorn, S., Puripaatanavong, J. and Payyappallimana, U., 2019. Healthy food traditions of Asia: exploratory case studies from Indonesia, Thailand, Malaysia, and Nepal. Journal of Ethnic Foods 6(1): 1-18. https://doi.org/10.1186/s42779-019-0002-x
-
Heo, G.Y., Koh, H.B., Kim, H.J., Kim, K.W., Jung, C.Y., Kim, H.W., Chang, T.I., Park, J.T., Yoo, T.-H., Kang, S.-W. and Han, S.H., 2023. Association of plant protein intake with risk of incident CKD: a UK biobank study. American Journal of Kidney Diseases 82(6): 687-697. https://doi.org/10.1053/j.ajkd.2023.05.007
-
Ismail, I.H., Lay, C., Majid, N.H.A., Lee, W.S., Lee, B.W., Abdul Latiff, A.H., Tina Tan, H.T., Knol, J. and Lee, Y.Y., 2020. Dietary patterns in childhood and their effect on gut microbiota – an Asian perspective on atopy risk. Journal of Allergy and Clinical Immunology 146(5): 1005-1007. https://doi.org/10.1016/j.jaci.2020.05.057
-
Kim, K.A., Jeong, J.J., Yoo, S.Y. and Kim, D.H., 2016. Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice. BMC Microbiology 16(1): 1-9. https://doi.org/10.1186/s12866-016-0625-7
-
Kim, S.H., Ko, J. and Kwon, D.Y., 2023. Jang, Korean fermented soybean product, the result of endeavors of ancients for the best taste of Korean diet. Journal of Ethnic Foods 10(1). https://doi.org/10.1186/s42779-023-00183-6
-
Kisuse, J., La-Ongkham, O., Nakphaichit, M., Therdtatha, P., Momoda, R., Tanaka, M., Fukuda, S., Popluechai, S., Kespechara, K., Sonomoto, K., Lee, Y.K., Nitisinprasert, S. and Nakayama, J., 2018. Urban diets linked to gut microbiome and metabolome alterations in children: a comparative cross-sectional study in Thailand. Frontiers in Microbiology 9(JUN): 1-16. https://doi.org/10.3389/fmicb.2018.01345
-
Lapébie, P., Lombard, V., Drula, E., Terrapon, N. and Henrissat, B., 2019. Bacteroidetes use thousands of enzyme combinations to break down glycans. Nature Communications 10(1). https://doi.org/10.1038/s41467-019-10068-5
-
Law, C.W., Chen, Y., Shi, W. and Smyth, G.K., 2014. Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biology 15(2): 1-17. https://doi.org/10.1186/gb-2014-15-2-r29
-
Lee, J. and Kim, J., 2018. Association between dietary pattern and incidence of cholesterolemia in Korean adults: the Korean genome and epidemiology study. Nutrients 10(1). https://doi.org/10.3390/nu10010053
-
Lee, Y.Y., Hassan, S.A., Ismail, I.H., Chong, S.Y., Affendi, R., Ali, R., Lee, W.S. and Majid, N.A., 2017. Gut microbiota in early life and its in fl uence on health and disease: a position paper by the Malaysian working group on gastrointestinal health. Journal of Paediatrics and Child Health 53: 1152-1158. https://doi.org/10.1111/jpc.13640
-
Lessard-Lord, J., Roussel, C., Lupien-Meilleur, J., Généreux, P., Richard, V., Guay, V., Roy, D. and Desjardins, Y., 2024. Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect. NPJ Biofilms and Microbiomes 10(1). https://doi.org/10.1038/s41522-024-00493-w
-
Lewis, S.J. and Heaton, K.W., 1997. Stool form scale as a useful guide to intestinal transit time. Scandinavian Journal of Gastroenterology 32(9): 920-924. https://doi.org/10.3109/00365529709011203
-
Lin, D., Peters, B.A., Friedlander, C., Freiman, H.J., Goedert, J.J., Sinha, R., Miller, G., Bernstein, M.A., Hayes, R.B. and Ahn, J., 2018. Association of dietary fibre intake and gut microbiota in adults. British Journal of Nutrition 120(9): 1014-1022. https://doi.org/10.1017/S0007114518002465
-
Liu, H., Liao, C., Wu, L., Tang, J., Chen, J., Lei, C., Zheng, L., Zhang, C., Liu, Y.Y., Xavier, J. and Dai, L., 2022. Ecological dynamics of the gut microbiome in response to dietary fibre. The ISME Journal 16(8): 2040-2055. https://doi.org/10.1038/s41396-022-01253-4
-
Love, M.I., Huber, W. and Anders, S., 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology 15(12): 1-21. https://doi.org/10.1186/s13059-014-0550-8
-
MacDonald, A., Van Wegberg, A.M.J., Ahring, K., Beblo, S., Bélanger-Quintana, A., Burlina, A., Campistol, J., Coşkun, T., Feillet, F., Giżewska, M., Huijbregts, S.C., Leuzzi, V., Maillot, F., Muntau, A.C., Rocha, J.C., Rocha, J.C., Romani, C., Trefz, F. and Van Spronsen, F.J., 2020. PKU dietary handbook to accompany PKU guidelines. Orphanet Journal of Rare Diseases 15(1): 1-21. https://doi.org/10.1186/s13023-020-01391-y
-
Mitchell, S.C., Zhang, A.Q. and Smith, R.L., 2008. Dimethylamine and diet. Food and Chemical Toxicology 46(5): 1734-1738. https://doi.org/10.1016/j.fct.2008.01.010
-
Nakayama, J., Watanabe, K., Jiang, J., Matsuda, K., Chao, S.H., Haryono, P., La-Ongkham, O., Sarwoko, M.A., Sujaya, I.N., Zhao, L., Chen, K.T., Chen, Y.P., Chiu, H.H., Hidaka, T., Huang, N.X., Kiyohara, C., Kurakawa, T., Sakamoto, N., Sonomoto, K., Tashiro, K., Tsuji, H., Chen, M.J., Leelavatcharamas, V., Liao, C.C., Nitisinprasert, S., Rahayu, E.S., Ren, F.Z., Tsai, Y.C. and Lee, Y.K., 2015. Diversity in gut bacterial community of school-age children in Asia. Scientific Reports 5: 1-12. https://doi.org/10.1038/srep08397
-
Nogal, A., Valdes, A.M. and Menni, C., 2021. The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. Gut Microbes 13(1): 1-24. https://doi.org/10.1080/19490976.2021.1897212
-
Oliver, A., Chase, A.B., Weihe, C., Orchanian, S.B., Riedel, S.F., Hendrickson, C.L., Lay, M., Sewall, J.M., Martiny, J.B.H. and Whiteson, K., 2021. High-fibre, whole-food dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids. mSystems 6(2). https://doi.org/10.1128/msystems.00115-21
-
Pagliai, G., Russo, E., Niccolai, E., Dinu, M., Di, V., Alessandro, P., Bartolucci, G., Baldi, S., Menicatti, M., Giusti, B., Marcucci, R., Rossolini, G.M., Casini, A., Sofi, F. and Amedei, A., 2020. Influence of a 3 – month low – calorie Mediterranean diet compared to the vegetarian diet on human gut microbiota and SCFA: the CARDIVEG study. European Journal of Nutrition 59(5): 2011-2024. https://doi.org/10.1007/s00394-019-02050-0
-
Pasolli, E., Asnicar, F., Manara, S., Zolfo, M., Karcher, N., Armanini, F., Beghini, F., Manghi, P., Tett, A., Ghensi, P., Collado, M.C., Rice, B.L., DuLong, C., Morgan, X.C., Golden, C.D., Quince, C., Huttenhower, C. and Segata, N., 2019. Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle. Cell 176(3): 649-662.e20. https://doi.org/10.1016/j.cell.2019.01.001
-
Pasolli, E., De Filippis, F., Mauriello, I.E., Cumbo, F., Walsh, A.M., Leech, J., Cotter, P.D., Segata, N. and Ercolini, D., 2020. Large-scale genome-wide analysis links lactic acid bacteria from food with the gut microbiome. Nature Communications 11(1): 1-12. https://doi.org/10.1038/s41467-020-16438-8
-
Qiao, S., Liu, C.S.-J.C., Li, C., Cas, S., Wang, T., Huanqin, C., Cas, D., Kai, W., Li, B., Li, H., Liu, C.S.-J.C. and Liu, H., 2022. Gut Parabacteroides merdae protects against cardiovascular damage by increasing commensal bacteria-driven branched-chain amino acid catabolism. Nature Metabolism 4: 1271-1286. https://www.researchsquare.com/article/rs-1127540/latest.pdf
-
Rahayu, E.S., Utami, T., Mariyatun, M., Hasan, P.N., Kamil, R.Z., Setyawan, R.H., Pamungkaningtyas, F.H., Harahap, I.A., Wiryohanjoyo, D.V., Pramesi, P.C., Cahyanto, M.N., Sujaya, I.N. and Juffrie, M., 2019. Gut microbiota profile in healthy Indonesians. World Journal of Gastroenterology 25(12): 1478-1491. https://doi.org/10.3748/wjg.v25.i12.1478
-
Ren, Y., Wu, J., Wang, Y., Zhang, L., Ren, J., Zhang, Z., Chen, B., Zhang, K., Zhu, B., Liu, W., Li, S. and Li, X., 2023. Lifestyle patterns influence the composition of the gut microbiome in a healthy Chinese population. Scientific Reports 13(1): 1-16. https://doi.org/10.1038/s41598-023-41532-4
-
Rusch, C., Beke, M., Tucciarone, L., Nieves, C., Ukhanova, M., Tagliamonte, M.S., Mai, V., Suh, J.H., Wang, Y., Chiu, S., Patel, B., Ramirez-Zamora, A. and Langkamp-Henken, B., 2021. Mediterranean diet adherence in people with Parkinson’s disease reduces constipation symptoms and changes fecal microbiota after a 5-week single-arm pilot study. Frontiers in Neurology 12. https://doi.org/10.3389/FNEUR.2021.794640/FULL
-
Sahran, N.-F., Lee, Y.Y., Ismail, I.H., Taib, F. and Hoo, P.S., 2021. Development and validity of a Traditional Asian Diet instructional booklet. Journal of Gastroenterology and Hepatology: 74-283. https://doi.org/https://doi.org/101111/jgh.15607
-
Shi, Z. and Ganji, V., 2020. Dietary patterns and cardiovascular disease risk among Chinese adults: a prospective cohort study. European Journal of Clinical Nutrition 74(12): 1725-1735. https://doi.org/10.1038/s41430-020-0668-6
-
Tett, A., Pasolli, E., Masetti, G., Ercolini, D. and Segata, N., 2021. Prevotella diversity, niches and interactions with the human host. Nature Reviews Microbiology 19(9): 585-599. https://doi.org/10.1038/s41579-021-00559-y
-
Thévenot, E.A., Roux, A., Xu, Y., Ezan, E. and Junot, C., 2015. Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. Journal of Proteome Research 14(8): 3322-3335. https://doi.org/10.1021/acs.jproteome.5b00354
-
Tian, T., Zhang, X., Luo, T., Wang, D., Sun, Y. and Dai, J., 2021. Effects of short-term dietary fibre intervention on gut microbiota in young healthy people. Diabetes, Metabolic Syndrome and Obesity 14: 3507-3516. https://doi.org/10.2147/DMSO.S313385
-
Tu, C. and Benn, E.K.T., 2017. RRApp, a robust randomisation app, for clinical and translational research. Journal of Clinical and Translational Science 1(6): 323-327. https://doi.org/10.1017/cts.2017.310
-
Vangay, P., Johnson, A.J., Ward, T.L., Al-Ghalith, G.A., Shields-Cutler, R.R., Hillmann, B.M., Lucas, S.K., Beura, L.K., Thompson, E.A., Till, L.M., Batres, R., Paw, B., Pergament, S.L., Saenyakul, P., Xiong, M., Kim, A.D., Kim, G., Masopust, D., Martens, E.C., Angkurawaranon, C., McGready, R., Kashyap, P.C., Culhane-Pera, K.A. and Knights, D., 2018. US immigration westernises the human gut microbiome. Cell 175(4): 962-972.e10. https://doi.org/10.1016/j.cell.2018.10.029
-
Vukovic, V., Hantikainen, E., Raftopoulou, A., Gögele, M., Rainer, J., Domingues, F.S., Pramstaller, P.P., Garcia-Larsen, V. and Pattaro, C., 2023. Association of dietary proteins with serum creatinine and estimated glomerular filtration rate in a general population sample: the CHRIS study. Journal of Nephrology 36(1): 103-114. https://doi.org/10.1007/s40620-022-01409-7
-
Wells, J.M., Brummer, R.J., Derrien, M., MacDonald, T.T., Troost, F., Cani, P.D., Theodorou, V., Dekker, J., Méheust, A., De Vos, W.M., Mercenier, A., Nauta, A. and Garcia-Rodenas, C.L., 2017. Homeostasis of the gut barrier and potential biomarkers. American Journal of Physiology: Gastrointestinal and Liver Physiology 312(3): G171-G193. https://doi.org/10.1152/ajpgi.00048.2015
-
Whitehead, A.L., Julious, S.A., Cooper, C.L. and Campbell, M.J., 2016. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Statistical Methods in Medical Research 25(3): 1057-1073. https://doi.org/10.1177/0962280215588241
-
Wu, X., Unno, T., Kang, S. and Park, S., 2021. A Korean-style balanced diet has a potential connection with ruminococcaceae enterotype and reduction of metabolic syndrome incidence in Korean adults. Nutrients 13(2): 1-18. https://doi.org/10.3390/nu13020495
-
Yeoh, Y.K., Sun, Y., Ip, L.Y.T., Wang, L., Chan, F.K.L., Miao, Y. and Ng, S.C., 2022. Prevotella species in the human gut is primarily comprised of Prevotella copri, Prevotella stercorea and related lineages. Scientific Reports 12(1): 1-9. https://doi.org/10.1038/s41598-022-12721-4
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Effects of Traditional Asian Diet on dietary fibre requirement, gut microbiome composition, and faecal and urine metabolomes in healthy Asian women: a pilot study
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Abstract
The Traditional Asian Diet (TAD) is characterised by high dietary fibre and functional foods. This study investigated TAD’s effects on meeting fibre requirements, gut microbiome, and faecal and urine metabolomes. A four-week randomised controlled trial was conducted among healthy Asian women allocated into the TAD group (n = 11) following a newly developed TAD program and the control group (n = 11). Assessments included dietary intake, gut health (symptoms, faecal form, frequency), serum fatty acids binding protein-2 (FABP-2) levels, faecal microbiome via 16s rRNA sequencing, and faecal and urine metabolites which were analysed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR), respectively. The TAD group showed significant increases in dietary fibre (
Clinical trial registration: NCT04885959, clinicaltrials.gov
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