Save

Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis

于Beneficial Microbes
著者:
X.-Y. Ang School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia

Search for other papers by X.-Y. Ang in
Current site
Google Scholar
PubMed
Close
,
N.S. Roslan School of Medical Sciences, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
Hospital Universiti Sains Malaysia (HUSM), Health Campus, 16150 Kelantan, Malaysia

Search for other papers by N.S. Roslan in
Current site
Google Scholar
PubMed
Close
,
N. Ahmad Kota Bharu Health Clinic, Ministry of Health Malaysia, 15200 Kelantan, Malaysia

Search for other papers by N. Ahmad in
Current site
Google Scholar
PubMed
Close
,
S.Mo. Yusof Kubang Kerian Health Clinic, Ministry of Health Malaysia, 16150 Kelantan, Malaysia

Search for other papers by S.Mo. Yusof in
Current site
Google Scholar
PubMed
Close
,
N. Abdullah Pengkalan Chepa Health Clinic, Ministry of Health Malaysia, 16100 Kelantan, Malaysia

Search for other papers by N. Abdullah in
Current site
Google Scholar
PubMed
Close
,
N.N. Nik Ab Rahman Wakaf Che Yeh Health Clinic, Ministry of Health Malaysia, 15100 Kelantan, Malaysia

Search for other papers by N.N. Nik Ab Rahman in
Current site
Google Scholar
PubMed
Close
,
J.-J. Woon Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Search for other papers by J.-J. Woon in
Current site
Google Scholar
PubMed
Close
,
C.S.-J. Teh Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Search for other papers by C.S.-J. Teh in
Current site
Google Scholar
PubMed
Close
,
S.D. Todorov ProBacLab, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, 05508-090, Brazil

Search for other papers by S.D. Todorov in
Current site
Google Scholar
PubMed
Close
,
G. Liu CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China P.R.
CAS-TWAS Centre of Excellence for Biotechnology, Beijing 100101, China P.R.

Search for other papers by G. Liu in
Current site
Google Scholar
PubMed
Close
, and
M.-T. Liong School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia
Renewable Biomass Transformation Cluster, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia

Search for other papers by M.-T. Liong in
Current site
Google Scholar
PubMed
Close
https://orcid.org/0000-0002-4471-8271
Download Citation 获得许可

Access options

Get access to the full article by using one of the access options below.

Institutional Login

Log in with Open Athens, Shibboleth, or your institutional credentials

Login with Institutional Access

Purchase

Buy instant access (PDF download and unlimited online access):

€36.93

Abstract

The development of probiotics has now included the areas along the gut-vaginal axis. We thus aimed to investigate the effects of lactobacilli probiotic to modulate and restore vaginal and gut microbiota of pregnant women with vaginal candidiasis (VC). A randomised, double-blind and placebo-controlled study was performed in 78 pregnant women with VC. Patients were randomised to either the probiotic (SynForU-HerCare) or placebo which were administered at baseline and continued for 8-weeks (two capsules/day of 9.5 log cfu/capsule). Microbiota profiles were assessed at time points of weeks-0, 4 and 8 for high vaginal swab and faecal samples. Shannon diversity index showed that after 8-weeks amid VC, a shift in microbial community compositional changes occurred in the high vaginal region at both genus (P=0.025) and species (P=0.044) levels, where the administration of probiotic prevented such a shift. These changes were mainly attributed to a decreased in abundance of Lactobacillus (P=0.042) accompanied by increased abundance of Prevotella (P=0.002) and Atopobium (P=0.002) in the placebo group while the probiotic group remained unchanged over time. The administration of probiotics also prevented a reduced abundance of faecal phylum Firmicutes after 8-weeks as seen in the placebo group (P<0.0001), which also showed reduction at subsequent taxonomic levels of class, family, genera and species. VC has not only altered the microbiota of vagina regions but also gut microbiota profiles, causing lessening of gut microbiota that are crucial for gut nutrient availability, protection and immunity. The administration of lactobacilli probiotics has prevented such a shift, leading to better modulated gut and vaginal microenvironment amid VC.

The study was registered at ClinicalTrials.gov: identifier number NCT03940612

内容统计数据

全部期间 过去一年 过去30天
摘要浏览次数 8422 1599 95
全文浏览次数 188 39 3
PDF下载次数 310 58 2