Probiotic and prebiotic interventions for non-alcoholic fatty liver disease: a systematic review and network meta-analysis
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Many studies have associated altered intestinal bacterial communities and non-alcoholic fatty liver disease, but the putative effects are inconclusive. The purpose of this network meta-analysis (NMA) was to evaluate the effects of probiotics, prebiotics, and synbiotics on non-alcoholic fatty liver disease through randomised intervention trials. Literature searches were performed until March 2020. For each outcome, a random NMA was performed, the surface under the cumulative ranking curve (SUCRA) was determined. A total of 22 randomised trials comparing prebiotic, probiotic, and synbiotic treatments included 1301 participants. Considering all seven results (aspartate aminotransferase, alanine aminotransferase, body mass index, weight, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) together, the highest SUCRA values are probiotics (94%), synbiotics (61%) and prebiotics (56%), respectively. NMA results provide evidence that probiotics, prebiotics, and synbiotics can alleviate non-alcoholic fatty liver disease. However, due to the lack of high-quality randomised trials, this research also has some limitations.
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| All Time | Past 365 days | Past 30 Days | |
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Probiotic and prebiotic interventions for non-alcoholic fatty liver disease: a systematic review and network meta-analysis
In: Beneficial MicrobesSearch for other papers by H. Jin in
Current site
Google Scholar
PubMed
Search for other papers by X. Xu in
Current site
Google Scholar
PubMed
Search for other papers by B. Pang in
Current site
Google Scholar
PubMed
Search for other papers by R. Yang in
Current site
Google Scholar
PubMed
School of Hospitality Management, Guilin Tourism University, 26 Liangfeng Road, Yanshan District, Guilin City, Guangxi Province 541006, China P.R.
Search for other papers by H. Sun in
Current site
Google Scholar
PubMed
Search for other papers by C. Jiang in
Current site
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PubMed
Search for other papers by D. Shao in
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PubMed
Search for other papers by J. Shi in
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PubMed
Many studies have associated altered intestinal bacterial communities and non-alcoholic fatty liver disease, but the putative effects are inconclusive. The purpose of this network meta-analysis (NMA) was to evaluate the effects of probiotics, prebiotics, and synbiotics on non-alcoholic fatty liver disease through randomised intervention trials. Literature searches were performed until March 2020. For each outcome, a random NMA was performed, the surface under the cumulative ranking curve (SUCRA) was determined. A total of 22 randomised trials comparing prebiotic, probiotic, and synbiotic treatments included 1301 participants. Considering all seven results (aspartate aminotransferase, alanine aminotransferase, body mass index, weight, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) together, the highest SUCRA values are probiotics (94%), synbiotics (61%) and prebiotics (56%), respectively. NMA results provide evidence that probiotics, prebiotics, and synbiotics can alleviate non-alcoholic fatty liver disease. However, due to the lack of high-quality randomised trials, this research also has some limitations.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1226 | 411 | 29 |
| Full Text Views | 22 | 8 | 0 |
| PDF Views & Downloads | 42 | 19 | 0 |
