Probiotics as a therapeutic strategy in obesity and overweight: a systematic review
äºBeneficial MicrobesSearch for other papers by X.M. Tomé-Castro in
Current site
Google Scholar
Research Group CYS, Faculty of Health Sciences, Jaume I University, Av. Sos Baynat, 12071 Castello de la Plana, Spain.
Search for other papers by M. Rodriguez-Arrastia in
Current site
Google Scholar
Health Research Centre, University of Almeria, Ctra. Sacramento s/n, 04120 Almeria, Spain.
Search for other papers by D. Cardona in
Current site
Google Scholar
Search for other papers by L. Rueda-Ruzafa in
Current site
Google Scholar
Search for other papers by G. Molina-Torres in
Current site
Google Scholar
Health Research Centre, University of Almeria, Ctra. Sacramento s/n, 04120 Almeria, Spain.
Research Group CTS-451 Health Sciences, University of Almeria, Ctra. Sacramento s/n, 04120 Almeria, Spain.
Search for other papers by P. Roman in
Current site
Google Scholar
Obesity and overweight are two of the most health challenges with an increasing prevalence in recent years, in which several complications have been identified to have a high impact in patientsâ health conditions. In this vein, an increasing interest in the gut microbiota has emerged as a target for therapeutic strategies in obesity and overweight due to its direct relation with the aforementioned health conditions and complications. Thus, the aim of this study was to evaluate the efficacy of probiotics as a therapeutic strategy in the management of obesity and overweight. A systematic review of randomised controlled trials was carried out in 6 databases until May 2019 to assess the use of probiotics in obesity and overweight patients. The Jadad Scale was used to assess the quality of the clinical trials. Twenty-three clinical trials published between 2000 and 2019 met the inclusion criteria. The role of probiotics in reducing body mass index and weight as well as changing the visceral abdominal fat area, waist and hip circumference were shown in 14 of 23 trials (60.87%); 14 trials (60.87%) showed changes on patientsâ fatty acids and biomarkers; and 4 trials (17.39%) studied the role of the gut microbiota in obese and overweight patients. Some probiotics strains are shown to be effective in reducing body mass index and hip circumference. This review provides evidence of successful results in weight loss using probiotic groups.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Abenavoli, L., Scarpellini, E., Colica, C., Boccuto, L., Salehi, B., Sharifi-Rad, J., Aiello, V., Romano, B., De Lorenzo, A., Izzo, A.A. and Capasso, R., 2019. Gut microbiota and obesity: a role for probiotics. Nutrients 11: 2690. https://doi.org/10.3390/nu11112690
-
Agerholm-Larsen, L., Raben, A., Haulrik, N., Hansen, A.S., Manders, M. and Astrup, A., 2000. Effect of 8-week intake of probiotic milk products on risk factors for cardiovascular diseases. European Journal of Clinical Nutrition 54: 288-297. https://doi.org/10.1038/sj.ejcn.1600937
-
Al-Muzafar, H.M. and Amin, K.A., 2017. Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers. BMC Complementary and Alternative Medicine 17: 43. https://doi.org/10.1186/s12906-016-1540-z
-
Aoun, A., Darwish, F. and Hamod, N., 2020. The influence of the gut microbiome on obesity in adults and the role of probiotics, prebiotics, and synbiotics for weight loss. Preventive Nutrition and Food Science 25: 113-123. https://doi.org/10.3746/pnf.2020.25.2.113
-
Azad, M.A.K., Sarker, M., Li, T. and Yin, J., 2018. Probiotic species in the modulation of gut microbiota: an overview. BioMed Research International 2018: 9478630. https://doi.org/10.1155/2018/9478630
-
Becattini, S., Taur, Y. and Pamer, E.G. 2016. Antibiotic-induced changes in the intestinal microbiota and disease. Trends in Molecular Medicine 22: 458-478. https://doi.org/10.1016/j.molmed.2016.04.003
-
Bernini, L.J., Simão, A.N.C., Alfieri, D.F., Lozovoy, M.A.B., Mari, N.L., de Souza, C. H.B., Dichi, I. and Costa, G.N., 2016. Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: a randomized trial. Effects of probiotics on metabolic syndrome. Nutrition 32: 716-719. https://doi.org/10.1016/j.nut.2015.11.001
-
Borgeraas, H., Johnson, L.K., Skattebu, J., Hertel, J.K. and Hjelmesæth, J., 2018. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews 19: 219-232. https://doi.org/10.1111/obr.12626
-
Brahe, L.K., Astrup, A. and Larsen, L.H., 2016. Can we prevent obesity-related metabolic diseases by dietary modulation of the gut microbiota? Advances in Nutrition 7:, 90-101. https://doi.org/10.3945/an.115.010587
-
Castaner, O., Goday, A., Park, Y.M., Lee, S.H., Magkos, F., Shiow, S.A.T.E. and Schröder, H., 2018. The gut microbiome profile in obesity: a systematic review. International Journal of Endocrinology 2018: 4095789. https://doi.org/10.1155/2018/4095789
-
Cerdó, T., GarcÃa-Santos, J.A., Bermúdez, M. and Campoy, C., 2019. The role of probiotics and prebiotics in the prevention and treatment of obesity. Nutrients 11: 635. https://doi.org/10.3390/nu11030635
-
Chung, H.J., Yu, J.G., Lee, I.A., Liu, M.J., Shen, Y.F., Sharma, S.P., Jamal, M.A.H.M., Yoo, J.H., Kim, H.J. and Hong, S.T., 2016. Intestinal removal of free fatty acids from hosts by Lactobacilli for the treatment of obesity. FEBS Open Bio 6: 64-76. https://doi.org/10.1002/2211-5463.12024
-
Crovesy, L., Masterson, D. and Rosado, E.L., 2020. Profile of the gut microbiota of adults with obesity: a systematic review. European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-020-0607-6
-
Culpepper, T., Rowe, C.C., Rusch, C.T., Burns, A.M., Federico, A.P., Girard, S.A., Tompkins, T.A., Nieves, C., Dennis-Wall, J.C., Christman, M.C. and Langkamp-Henken, B., 2019. Three probiotic strains exert different effects on plasma bile acid profiles in healthy obese adults: Randomised, double-blind placebo-controlled crossover study. Beneficial Microbes 10: 497-509. https://doi.org/10.3920/BM2018.0151
-
Dahiya, D.K., Renuka, Puniya, M., Shandilya, U.K., Dhewa, T., Kumar, N., Kumar, S., Puniya, A.K. and Shukla, P., 2017. Gut microbiota modulation and its relationship with obesity using prebiotic fibers and probiotics: a review. Frontiers in Microbiology 8: 563. https://doi.org/10.3389/fmicb.2017.00563
-
De Groot, P.F., Frissen, M.N., De Clercq, N.C. and Nieuwdorp, M., 2017. Fecal microbiota transplantation in metabolic syndrome: History, present and future. Gut Microbes 8: 253-267. https://doi.org/10.1080/19490976.2017.1293224
-
Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N.M., de Barsy, M., Loumaye, A., Hermans, M.P., Thissen, J.P., De Vos, W.M. and Cani, P.D., 2019. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine 25: 1096-1103. https://doi.org/10.1038/s41591-019-0495-2
-
Ejtahed, H.S., Angoorani, P., Soroush, A.R., Atlasi, R., Hasani-Ranjbar, S., Mortazavian, A.M. and Larijani, B., 2019. Probiotics supplementation for the obesity management: a systematic review of animal studies and clinical trials. Journal of Functional Foods 52: 228-242. https://doi.org/10.1016/j.jff.2018.10.039
-
Falalyeyeva, T.M., Leschenko, I.V, Beregova, T.V., Lazarenko, L.M., Savchuk, O.M., Sichel, L.M., Tsyryuk, O.I., Vovk, T.B. and Spivak, M.Y., 2017. Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity. Fiziolohichnyi Zhurnal 63: 17-25. https://doi.org/10.15407/fz63.01.017
-
Fayfman, M., Flint, K. and Srinivasan, S., 2019. Obesity, motility, diet, and intestinal microbiota-connecting the dots. Current Gastroenterology Reports 21: 15. https://doi.org/10.1007/s11894-019-0680-y
-
Ferrarese, R., Ceresola, E.R., Preti, A. and Canducci, F., 2018. Probiotics, prebiotics and synbiotics for weight loss and metabolic syndrome in the microbiome era. European Review for Medical and Pharmacological Sciences 22: 7588-7605. https://doi.org/10.26355/eurrev_201811_16301
-
Flint, H.J., Scott, K.P., Duncan, S.H., Louis, P. and Forano, E., 2012. Microbial degradation of complex carbohydrates in the gut. Gut Microbes 3: 289-306. https://doi.org/10.4161/gmic.19897
-
Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO), 2001. Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Available at: http://tinyurl.com/8bccc3r.
-
Gérard, P., 2016. Gut microbiota and obesity. Cellular and Molecular Life Sciences 73: 147-162. https://doi.org/10.1007/s00018-015-2061-5
-
Gomes, A.C., Hoffmann, C. and Mota, J.F., 2018. The human gut microbiota: metabolism and perspective in obesity. Gut Microbes 9: 308-325. https://doi.org/10.1080/19490976.2018.1465157
-
Hadi, A., Alizadeh, K., Hajianfar, H., Mohammadi, H. and Miraghajani, M., 2018. Efficacy of synbiotic supplementation in obesity treatment: a systematic review and meta-analysis of clinical trials. Critical Reviews in Food Science and Nutrition, in press. https://doi.org/10.1080/10408398.2018.1545218
-
Hampl, S. and Campbell, A., 2015. Recognizing obesity and its complications: the story of score 1 for Health. NASN School Nurse 30: 46-52. https://doi.org/10.1177/1942602X14559749
-
Heiss, C.N. and Olofsson, L.E., 2019. The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system. Journal of Neuroendocrinology 31: e12684. https://doi.org/10.1111/jne.12684
-
Hibberd, A.A., Yde, C.C., Ziegler, M.L., Honoré, A.H., Saarinen, M.T., Lahtinen, S., Stahl, B., Jensen, H.M. and Stenman, L.K., 2019. Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults. Beneficial Microbes 10: 121-135. https://doi.org/10.3920/BM2018.0028
-
Higashikawa, F., Noda, M., Awaya, T., Danshiitsoodol, N., Matoba, Y., Kumagai, T. and Sugiyama, M., 2016. Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Clinical Nutrition 70: 582-587. https://doi.org/10.1038/ejcn.2016.17
-
Huang, C.H., Ho, C.Y., Chen, C.T., Hsu, H.F. and Lin, Y.H., 2019. Probiotic BSH activity and anti-obesity potential of Lactobacillus plantarum strain TCI378 isolated from Korean Kimchi. Preventive Nutrition and Food Science 24: 434-441. https://doi.org/10.3746/pnf.2019.24.4.434
-
Hulston, C.J., Churnside, A.A. and Venables, M.C., 2015. Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects. British Journal of Nutrition 113: 596-602. https://doi.org/10.1017/S0007114514004097
-
Ianiro, G., Tilg, H. and Gasbarrini, A., 2016. Antibiotics as deep modulators of gut microbiota: between good and evil. Gut 65: 1906-1915. https://doi.org/10.1136/gutjnl-2016-312297
-
Ivey, K.L., Hodgson, J.M., Kerr, D.A., Lewis, J.R., Thompson, P.L. and Prince, R.L., 2014. The effects of probiotic bacteria on glycaemic control in overweight men and women: a randomised controlled trial. European Journal of Clinical Nutrition 68: 447-452. https://doi.org/10.1038/ejcn.2013.294
-
Jadad, A.R., Moore, R.A., Carroll, D., Jenkinson, C., Reynolds, D.J., Gavaghan, D.J. and McQuay, H.J., 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clinical Trials 17: 1-12. https://doi.org/10.1016/0197-2456(95)00134-4
-
Jung, S.P., Lee, K.M., Kang, J.H., Yun, I.S., Park, H.O., Moon, Y. and Kim, J.Y., 2013. Effect of Lactobacillus gasseri BNR17 on overweight and obese adults: a randomized, double-blind clinical trial. Korean Journal of Family Medicine 34: 80-89. https://doi.org/10.4082/kjfm.2013.34.2.80
-
Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M. and Tsuchida, T., 2010. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. European Journal of Clinical Nutrition 64: 636-643. https://doi.org/10.1038/ejcn.2010.19
-
Kadooka, Y., Sato, M., Ogawa, A., Miyoshi, M., Uenishi, H., Ogawa, H., Ikuyama, K., Kagoshima, M. and Tsuchida, T., 2013. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. British Journal of Nutrition 110: 1696-1703. https://doi.org/10.1017/S0007114513001037
-
Karl, J.P., Margolis, L.M., Madslien, E.H., Murphy, N.E., Castellani, J.W., Gundersen, Y., Hoke, A.V., Levangie, M.W., Kumar, R., Chakraborty, N., Gautam, A., Hammamieh, R., Martini, S., Montain, S.J. and Pasiakos, S.M., 2017. Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. American Journal of Physiology â Gastrointestinal and Liver Physiology 312: G559-G571. https://doi.org/10.1152/ajpgi.00066.2017
-
Kim, J., Yun, J.M., Kim, M.K., Kwon, O. and Cho, B., 2018. Lactobacillus gasseri BNR17 supplementation reduces the visceral fat accumulation and waist circumference in obese adults: a randomized, double-blind, placebo-controlled trial. Journal of Medicinal Food 21: 454-461. https://doi.org/10.1089/jmf.2017.3937
-
King, R.J. and Ajjan, R.A., 2016. Vascular risk in obesity: facts, misconceptions and the unknown. Diabetes and Vascular Disease Research 14: 2-13. https://doi.org/10.1177/1479164116675488
-
Koutnikova, H., Genser, B., Monteiro-Sepulveda, M., Faurie, J.M., Rizkalla, S., Schrezenmeir, J. and Clément, K., 2019. Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials. BMJ Open 9: e017995. https://doi.org/10.1136/bmjopen-2017-017995
-
Leber, B., Tripolt, N. J., Blattl, D., Eder, M., Wascher, T. C., Pieber, T. R., Stauber, R., Sourij, H., Oettl, K. and Stadlbauer, V., 2012. The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study. European Journal of Clinical Nutrition 66: 1110-1115. https://doi.org/10.1038/ejcn.2012.103
-
Lee, S.J., Bose, S., Seo, J.G., Chung, W.S., Lim, C.Y. and Kim, H., 2014. The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: a randomized double-blind controlled clinical trial. Clinical Nutrition 33: 973-981. https://doi.org/10.1016/j.clnu.2013.12.006
-
Li, J., Lin, S., Vanhoutte, P.M., Woo, C.W. and Xu, A., 2016. Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in apoe-/-mice. Circulation 133: 2434-2446. https://doi.org/10.1161/CIRCULATIONAHA.115.019645
-
López-Moreno, A., Suárez, A., Avanzi, C., Monteoliva-Sánchez, M. and Aguilera, M., 2020. Probiotic strains and intervention total doses for modulating obesity-related microbiota dysbiosis: a systematic review and meta-analysis. Nutrients 12: 1921. https://doi.org/10.3390/nu12071921
-
Madjd, A., Taylor, M.A., Mousavi, N., Delavari, A., Malekzadeh, R., Macdonald, I.A. and Farshchi, H.R., 2016. Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: a randomized controlled trial. American Journal of Clinical Nutrition 103: 323-329. https://doi.org/10.3945/ajcn.115.120170
-
Maldonado-Galdeano, C., Cazorla, S.I., Lemme-Dumit, J.M., Vélez, E. and Perdigón, G., 2019. Beneficial effects of probiotic consumption on the immune system. Annals of Nutrition and Metabolism 74: 115-124. https://doi.org/10.1159/000496426
-
Maruvada, P., Leone, V., Kaplan, L.M. and Chang, E.B., 2017. The human microbiome and obesity: moving beyond associations. Cell Host and Microbe 22: 589-599. https://doi.org/10.1016/j.chom.2017.10.005
-
Mitev, K. and Taleski, V., 2019. Association between the gut microbiota and obesity. Open Access Macedonian Journal of Medical Sciences 7: 2050-2056. https://doi.org/10.3889/oamjms.2019.586
-
Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G. and Altman, D., 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine 6: e1000097. https://doi.org/10.1371/journal.pmed.1000097
-
Nakamura, F., Ishida, Y., Aihara, K., Sawada, D., Ashida, N., Sugawara, T., Aoki, Y., Takehara, I., Takano, K. and Fujiwara, S., 2016. Effect of fragmented Lactobacillus amylovorus CP1563 on lipid metabolism in overweight and mildly obese individuals: a randomized controlled trial. Microbial Ecology in Health and Disease 27: 30312. https://doi.org/10.3402/mehd.v27.30312
-
NCD Risk Factor Collaboration, 2017. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The Lancet 390: 2627-2642. https://doi.org/10.1016/S0140-6736(17)32129-3
-
Noh, K., Kang, Y.R., Nepal, M.R., Shakya, R., Kang, M.J., Kang, W., Lee, S., Jeong, H.G. and Jeong, T.C., 2017. Impact of gut microbiota on drug metabolism: an update for safe and effective use of drugs. Archives of Pharmacal Research 40: 1345-1355. https://doi.org/10.1007/s12272-017-0986-y
-
Novotny-Núñez, I., Maldonado-Galdeano, C., de Moreno de LeBlanc, A. and Perdigón, G., 2015. Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model. Nutrition 31: 1000-1007. https://doi.org/10.1016/j.nut.2015.02.006
-
Obata, Y. and Pachnis, V., 2016. The effect of microbiota and the immune system on the development and organization of the enteric nervous system. Gastroenterology 151: 836-844. https://doi.org/10.1053/j.gastro.2016.07.044
-
Ogawa, A., Kadooka, Y., Kato, K., Shirouchi, B. and Sato, M., 2014. Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects. Lipids in Health and Disease 13: 36. https://doi.org/10.1186/1476-511X-13-36
-
Osterberg, K.L., Boutagy, N.E., McMillan, R.P., Stevens, J.R., Frisard, M.I., Kavanaugh, J.W., Davy, B.M., Davy, K.P. and Hulver, M.W., 2015. Probiotic supplementation attenuates increases in body mass and fat mass during high-fat diet in healthy young adults. Obesity 23: 2364-2370. https://doi.org/10.1002/oby.21230
-
Paramsothy, S., Paramsothy, R., Rubin, D.T., Kamm, M.A., Kaakoush, N.O., Mitchell, H.M. and Castaño-RodrÃguez, N., 2017. Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis. Journal of Crohnâs and Colitis 11: 1180-1199. https://doi.org/10.1093/ecco-jcc/jjx063
-
Park, S.S., Lee, Y.J., Kang, H., Yang, G., Hong, E.J., Lim, J.Y., Oh, S. and Kim, E., 2019. Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARγ signaling. Scientific Reports 9: 20152. https://doi.org/10.1038/s41598-019-56817-w
-
Pedret, A., Valls, R.M., Calderón-Pérez, L., Llauradó, E., Companys, J., Pla-Pagà , L., Moragas, A., MartÃn-Luján, F., Ortega, Y., Giralt, M., Caimari, A., Chenoll, E., Genovés, S., Martorell, P., Codoñer, F.M., Ramón, D., Arola, L. and Solà , R., 2019. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. International Journal of Obesity 43: 1863-1868. https://doi.org/10.1038/s41366-018-0220-0
-
Prados-Bo, A., Gómez-MartÃnez, S., Nova, E. and Marcos, A., 2015. El papel de los probióticos en el manejo de la obesidad. Nutricion Hospitalaria 31: 10-18. https://doi.org/10.3305/nh.2015.31.sup1.8702
-
RamÃrez-Pérez, O., Cruz-Ramón, V., Chinchilla-López, P. and Méndez-Sánchez, N., 2017. The role of the gut microbiota in bile acid metabolism. Annals of Hepatology 16: S21-s26. https://doi.org/10.5604/01.3001.0010.5494
-
Rizzetto, L., Fava, F., Tuohy, K.M. and Selmi, C., 2018. Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex. Journal of Autoimmunity 92: 12-34. https://doi.org/10.1016/j.jaut.2018.05.008
-
Rouxinol-Dias, A.L., Pinto, A.R., Janeiro, C., Rodrigues, D., Moreira, M., Dias, J. and Pereira, P., 2016. Probiotics for the control of obesity â its effect on weight change. Porto Biomedical Journal 1: 12-24. https://doi.org/10.1016/j.pbj.2016.03.005
-
Sanchis-Chordà , J., Del Pulgar, E.M.G., Carrasco-Luna, J., BenÃtez-Páez, A., Sanz, Y. and Codoñer-Franch, P., 2018. Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children. European Journal of Nutrition, in press. https://doi.org/10.1007/s00394-018-1828-5
-
Sarao, L.K. and Arora, M., 2017. Probiotics, prebiotics, and microencapsulation: a review. Critical Reviews in Food Science and Nutrition 57: 344-371. https://doi.org/10.1080/10408398.2014.887055
-
Stenman, L.K., Lehtinen, M.J., Meland, N., Christensen, J.E., Yeung, N., Saarinen, M. T., Courtney, M., Burcelin, R., Lähdeaho, M.L., Linros, J., Apter, D., Scheinin, M., Kloster-Smerud, H., Rissanen, A. and Lahtinen, S., 2016. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults-randomized controlled trial. EBioMedicine 13: 190-200. https://doi.org/10.1016/j.ebiom.2016.10.036
-
Stone, P.W., 2002. Popping the (PICO) question in research and evidence-based practice. Applied Nursing Research 15: 197-198. https://doi.org/10.1053/apnr.2002.34181
-
Sun, Q., Zhang, S., Liu, X., Huo, Y., Su, B. and Li, X., 2020. Effects of a probiotic intervention on Escherichia coli and high-fat diet-induced intestinal microbiota imbalance. Applied Microbiology and Biotechnology 104: 1243-1257. https://doi.org/10.1007/s00253-019-10304-4
-
Suzumura, E.A., Bersch-Ferreira, Ã.C., Torreglosa, C.R., Da Silva, J.T., Coqueiro, A.Y., Kuntz, M.G.F., Chrispim, P.P., Weber, B. and Cavalcanti, A.B., 2019. Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: a systematic review and meta-analyses of randomized trials. Nutrition Reviews 77: 430-450. https://doi.org/10.1093/nutrit/nuz001
-
Takahashi, S., Anzawa, D., Takami, K., Ishizuka, A. and Mawatari, T., 2016. On visceral fat accumulation in healthy Japanese adults: a randomized controlled trial. Bioscience of Microbiota, Food and Health 35: 163-171.
'On visceral fat accumulation in healthy Japanese adults: a randomized controlled trial ' () 35 Bioscience of Microbiota, Food and Health : 163 -171.
-
Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R. and Gordon, J.I., 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444: 1027-1031. https://doi.org/10.1038/nature05414
-
Vallianou, N., Stratigou, T., Christodoulatos, G.S., Tsigalou, C. and Dalamaga, M., 2020. Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives. Current Obesity Reports, in press. https://doi.org/10.1007/s13679-020-00379-w
-
Wang, B.Z., Xin, S.S., Ding, L.N., Ding, W.Y., Hou, Y.L., Liu, C.Q. and Zhang, X.D., 2019. The Potential role of probiotics in controlling overweight/obesity and associated metabolic parameters in adults: a systematic review and meta-analysis. Evidence-based Complementary and Alternative Medicine 2019: 3862971. https://doi.org/10.1155/2019/3862971
-
World Health Organization (WHO) (2018. World Health Statistics 2018: monitoring health for the SDGs. World Health Organization, Geneva, Switzerland. Available at: https://tinyurl.com/yyjak7cw
-
Xu, Y., Wang, N., Tan, H.Y., Li, S., Zhang, C. and Feng, Y., 2020. Function of Akkermansia muciniphila in obesity: interactions with lipid metabolism, immune response and gut systems. Frontiers in Microbiology 11: 219. https://doi.org/10.3389/fmicb.2020.00219
-
Zarrati, M., Salehi, E., Mofid, V., Hossein Zadeh-Attar, M.J., Nourijelyani, K., Bidad, K. and Shidfar, F., 2013. Relationship between probiotic consumption and IL-10 and IL-17 secreted by PBMCs in overweight and obese people. Iranian Journal of Allergy, Asthma, and Immunology 12: 404-406.
'Relationship between probiotic consumption and IL-10 and IL-17 secreted by PBMCs in overweight and obese people ' () 12 Iranian Journal of Allergy, Asthma, and Immunology : 404 -406.
-
Zarrati, M., Salehi, E., Nourijelyani, K., Mofid, V., Zadeh, M.J.H., Najafi, F., Ghaflati, Z., Bidad, K., Chamari, M., Karimi, M. and Shidfar, F., 2014. Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet. Journal of the American College of Nutrition 33: 417-425. https://doi.org/10.1080/07315724.2013.874937
-
Zhai, S., Qin, S., Li, L., Zhu, L., Zou, Z. and Wang, L., 2019. Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice. FEMS Microbiology Letters 366: fnz153. https://doi.org/10.1093/femsle/fnz153
Supplementary Materials
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 5586 | 1321 | 50 |
| å ¨ææµè§æ¬¡æ° | 133 | 25 | 0 |
| PDFä¸è½½æ¬¡æ° | 199 | 31 | 0 |
Probiotics as a therapeutic strategy in obesity and overweight: a systematic review
äºBeneficial MicrobesSearch for other papers by X.M. Tomé-Castro in
Current site
Google Scholar
PubMed
Research Group CYS, Faculty of Health Sciences, Jaume I University, Av. Sos Baynat, 12071 Castello de la Plana, Spain.
Search for other papers by M. Rodriguez-Arrastia in
Current site
Google Scholar
PubMed
Health Research Centre, University of Almeria, Ctra. Sacramento s/n, 04120 Almeria, Spain.
Search for other papers by D. Cardona in
Current site
Google Scholar
PubMed
Search for other papers by L. Rueda-Ruzafa in
Current site
Google Scholar
PubMed
Search for other papers by G. Molina-Torres in
Current site
Google Scholar
PubMed
Health Research Centre, University of Almeria, Ctra. Sacramento s/n, 04120 Almeria, Spain.
Research Group CTS-451 Health Sciences, University of Almeria, Ctra. Sacramento s/n, 04120 Almeria, Spain.
Search for other papers by P. Roman in
Current site
Google Scholar
PubMed
Obesity and overweight are two of the most health challenges with an increasing prevalence in recent years, in which several complications have been identified to have a high impact in patientsâ health conditions. In this vein, an increasing interest in the gut microbiota has emerged as a target for therapeutic strategies in obesity and overweight due to its direct relation with the aforementioned health conditions and complications. Thus, the aim of this study was to evaluate the efficacy of probiotics as a therapeutic strategy in the management of obesity and overweight. A systematic review of randomised controlled trials was carried out in 6 databases until May 2019 to assess the use of probiotics in obesity and overweight patients. The Jadad Scale was used to assess the quality of the clinical trials. Twenty-three clinical trials published between 2000 and 2019 met the inclusion criteria. The role of probiotics in reducing body mass index and weight as well as changing the visceral abdominal fat area, waist and hip circumference were shown in 14 of 23 trials (60.87%); 14 trials (60.87%) showed changes on patientsâ fatty acids and biomarkers; and 4 trials (17.39%) studied the role of the gut microbiota in obese and overweight patients. Some probiotics strains are shown to be effective in reducing body mass index and hip circumference. This review provides evidence of successful results in weight loss using probiotic groups.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 5586 | 1321 | 50 |
| å ¨ææµè§æ¬¡æ° | 133 | 25 | 0 |
| PDFä¸è½½æ¬¡æ° | 199 | 31 | 0 |
