Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice
In: Beneficial MicrobesSchool of Integrative and Global Majors, University of Tsukuba, 305-8577 Tsukuba, Japan.
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School of Integrative and Global Majors, University of Tsukuba, 305-8577 Tsukuba, Japan.
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, 080-8555 Obihiro, Japan.
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Lactobacillus plantarum Shinshu N-07 (N07) and Lactobacillus curvatus #4G2 (#4G2) were isolated from fermented Brassica rapa L. and selected as promising probiotics with anti-adiposity activities based on in vitro assays. The anti-adiposity effects of these two strains were investigated using a diet-induced obesity animal model. Epididymal adipose tissue weight and adipocyte area were significantly lower and serum triglycerides and glucose tended to be lower in mice fed the high-fat diet supplemented with N07 compared with those fed the unsupplemented high-fat diet. Strain N07 suppressed hepatic steatosis, with accompanying downregulation of lipogenic genes in the liver. Expression of inflammatory cytokines and macrophage infiltration markers tended to be suppressed by N07 supplementation. Upregulation of uncoupling protein-1 in epididymal adipose tissue by N07 suggested that the transformation of white adipose tissue to brown might have been induced. Intestinal microbiota analysis revealed that a decrease in abundance of family S24-7 (phylum Bacteroidetes) following ingestion of the high-fat diet was partly recovered by supplementation with N07. Changes in those parameters were not observed in mice fed the high-fat diet supplemented with strain #4G2, suggesting strain specificities. Thus, N07 is a potential probiotic strain that could be used to develop functional foods that attenuate visceral fat accumulation after an appropriate human intervention trial.
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Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J., 1990. Basic local alignment search tool. Journal of Molecular Biology 215: 403-410. https://doi.org/10.1016/S0022-2836(05)80360-2
-
Begley, M., Gahan, C.G.M. and Hill, C., 2005. The interaction between bacteria and bile. FEMS Microbiology Reviews 29: 625-651.
'The interaction between bacteria and bile ' () 29 FEMS Microbiology Reviews : 625 -651.
-
Berthier, F. and Ehrlich, S.D., 1999. Genetic diversity within Lactobacillus sakei and Lactobacillus curvatus and design of PCR primers for its detection using randomly amplified polymorphic DNA. International Journal of Systematic Bacteriology 49: 997-1007.
'Genetic diversity within Lactobacillus sakei and Lactobacillus curvatus and design of PCR primers for its detection using randomly amplified polymorphic DNA ' () 49 International Journal of Systematic Bacteriology : 997 -1007.
-
Callahan, B.J., McMurdie, P.J., Rosen, M.J., Han, A.W., Johnson, A.J.A. and Holmes, S.P., 2016. DADA2: high-resolution sample inference from Illumina amplicon data. Nature Methods 13: 581-583.
'DADA2: high-resolution sample inference from Illumina amplicon data ' () 13 Nature Methods : 581 -583.
-
Campbell, C.L., Yu, R., Li, F., Zhou, Q., Chen, D., Qi, C., Yin, Y. and Sun, J., 2019. Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 12: 97-107.
'Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice ' () 12 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy : 97 -107.
-
Chen, L., Xu, Y., Chen, X., Fang, C., Zhao, L. and Chen, F., 2017. The maturing development of gut microbiota in commercial piglets during the weaning transition. Frontiers in Microbiology 8: 1-13.
'The maturing development of gut microbiota in commercial piglets during the weaning transition ' () 8 Frontiers in Microbiology : 1 -13.
-
Cumbie, C.B. and Hermayer, L.K., 2008. Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications. Vascular Health and Risk Management 55: 823-832.
'Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications ' () 55 Vascular Health and Risk Management : 823 -832.
-
DeSantis, T.Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E.L., Keller, K., Huber, T., Dalevi, D., Hu, P. and Andersen, G.L., 2006. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Applied and Environmental Microbiology 72: 5069-5072. https://doi.org/10.1128/AEM.03006-05
-
De Smet, I., De Boever, P. and Verstraete, W., 1998. Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity. British Journal of Nutrition 79: 185-194. https://doi.org/10.1079/bjn19980030
-
Di Cagno, R., Coda, R., De Angelis, M. and Gobbetti, M., 2013. Exploitation of vegetables and fruits through lactic acid fermentation. Food Microbiology 33: 1-10.
'Exploitation of vegetables and fruits through lactic acid fermentation ' () 33 Food Microbiology : 1 -10.
-
Fuller R., 1989. Probiotics in man and animals. Journal of Applied Bacteriology 66: 365-378.
'Probiotics in man and animals ' () 66 Journal of Applied Bacteriology : 365 -378.
-
Fusco, V., Quero, G.M., Chieffi, D. and Franz, C.M.A.P., 2016. Identification of Lactobacillus brevis using a species-specific AFLP-derived marker. International Journal of Food Microbiology 232: 90-94.
'Identification of Lactobacillus brevis using a species-specific AFLP-derived marker ' () 232 International Journal of Food Microbiology : 90 -94.
-
Guo, L.D., Yang, L.J. and Huo, G.C., 2011. Cholesterol removal by Lactobacillus plantarum isolated from homemade fermented cream in inner Mongolia of China. Czech Journal of Food Sciences 29: 219-225.
'Cholesterol removal by Lactobacillus plantarum isolated from homemade fermented cream in inner Mongolia of China ' () 29 Czech Journal of Food Sciences : 219 -225.
-
Hamilton, M.K., Ronveaux, C.C., Rust, B.M., Newman, J.W., Hawley, M., Barile, D., Mills, D.A. and Raybould, H.E., 2017. Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice. American Journal of Physiology – Gastrointestinal and Liver Physiology 312: G474-G487. https://doi.org/10.1152/ajpgi.00427.2016.
-
Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L. and Wang, Z., 2013. Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. Journal of Dairy Science 96: 2746-2753. https://doi.org/10.3168/jds.2012-6123.
-
Joyce, S.A., MacSharry, J., Casey, P.G., Kinsella, M., Murphy, E.F., Shanahan, F., Hill, C. and Gahan, C.G.M., 2014. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proceedings of the National Academy of Sciences of the USA 111: 7421-7426. https://doi.org/10.1073/pnas.1323599111
-
Karnik, A.A., Fields, A.V. and Shannon, R.P., 2007. Diabetic cardiomyopathy. Current Hypertension Reports 9: 467-473.
'Diabetic cardiomyopathy ' () 9 Current Hypertension Reports : 467 -473.
-
Kennedy, R., Lappin, D.F., Dixon, P.M., Buijs, M.J., Zaura, E., Crielaard, W., O’Donnell, L., Bennett, D., Brandt, B.W. and Riggio, M.P., 2016. The microbiome associated with equine periodontitis and oral health. Veterinary Research 47: 49. https://doi.org/10.1186/s13567-016-0333-1
-
Kim, D.-H., Jeong, D., Kang, I.-B., Kim, H., Song, K.-Y. and Seo, K.-H., 2017. Dual function of Lactobacillus kefiri DH5 in preventing high-fat-diet-induced obesity: direct reduction of cholesterol and upregulation of PPAR-α in adipose tissue. Molecular Nutrition and Food Research 61: 1700252. https://doi.org/10.1002/mnfr.201700252
-
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M. and Glöckner, F.O., 2013. Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies. Nucleic Acids Research 41: 1-11.
'Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies ' () 41 Nucleic Acids Research : 1 -11.
-
Konopka, A., 2009. What is microbial community ecology. ISME Journal 3: 1223-1230.
'What is microbial community ecology ' () 3 ISME Journal : 1223 -1230.
-
Lee, C.J., Sears, C.L. and Maruthur, N., 2020. Gut microbiome and its role in obesity and insulin resistance. Annals of the New York Academy of Sciences 1461: 37-52. https://doi.org/10.1111/nyas.14107
-
Liao, C.-C., Ou, T.-T., Wu, C.-H. and Wang, C.-J., 2013. Prevention of diet-induced hyperlipidemia and obesity by caffeic acid in C57BL/6 mice through regulation of hepatic lipogenesis gene expression. Journal of Agricultural and Food Chemistry 61: 11082-11088. https://doi.org/10.1021/jf4026647
-
Lim, S.-M., Jeong, J.-J., Woo, K.H., Han, M.J. and Kim, D.-H., 2016. Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression. Nutrition Research 36: 337-348. https://doi.org/10.1016/j.nutres.2015.12.001
-
Liong, M.T. and Shah, N.P., 2005. Acid and bile tolerance and cholesterol removal ability of lactobacilli strains. Journal of Dairy Science 88: 55-66. https://doi.org/10.3168/jds.S0022-0302(05)72662-X
-
Madani, G., Mirlohi, M., Yahay, M. and Hassanzadeh, A., 2013. How much in vitro cholesterol reducing activity of lactobacilli predicts their in vivo cholesterol function? International Journal of Preventive Medicine 4: 404-413.
'How much in vitro cholesterol reducing activity of lactobacilli predicts their in vivo cholesterol function? ' () 4 International Journal of Preventive Medicine : 404 -413.
-
Masood, M.I., Qadir, M.I., Shirazi, J.H. and Khan, I.U., 2011. Beneficial effects of lactic acid bacteria on human beings. Critical Reviews in Microbiology 37: 91-98. https://doi.org/10.3109/1040841X.2010.536522
-
McDonald, D., Price, M.N., Goodrich, J., Nawrocki, E.P., Desantis, T.Z., Probst, A., Andersen, G.L., Knight, R. and Hugenholtz, P., 2012. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea. ISME Journal 6: 610-618. https://doi.org/10.1038/ismej.2011.139
-
Million, M., Angelakis, E., Paul, M., Armougom, F., Leibovici, L. and Raoult, D., 2012. Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microbial Pathogenesis 53: 100-108. https://doi.org/10.1016/j.micpath.2012.05.007
-
Miyoshi, M., Ogawa, A., Higurashi, S. and Kadooka, Y., 2014. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice. European Journal of Nutrition 53: 599-606.
'Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice ' () 53 European Journal of Nutrition : 599 -606.
-
Ogita, T., Tanii, Y., Morita, H. and Tanabe, S., 2011. Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ. International Journal of Molecular Medicine 28: 817-822. https://doi.org/10.3892/ijmm.2011.755
-
Olefsky, J.M. and Glass, C.K., 2010. Macrophages, inflammation, and insulin resistance. Expert Opinion on Therapeutic Targets 19: 1-28. https://doi.org/10.1146/annurev-physiol-021909-135846
-
Orci, L., Cook, W.S., Ravazzola, M., Wang, M., Park, B.-H., Montesano, R. and Unger, R.H., 2004. Rapid transformation of white adipocytes into fat-oxidizing machines. Proceedings of the National Academy of Sciences of the USA 101: 2058-2063. https://doi.org/10.1073/pnas.0308258100
-
Ormerod, K.L., Wood, D.L.A., Lachner, N., Gellatly, S.L., Daly, J.N., Parsons, J.D., Dal’Molin, C.G.O., Palfreyman, R.W., Nielsen, L.K., Cooper, M.A., Morrison, M., Hansbro, P.M. and Hugenholtz, P., 2016. Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals. Microbiome 4: 36. https://doi.org/10.1186/s40168-016-0181-2
-
Park, S., Ji, Y., Jung, H.-Y., Park, H., Kang, J., Choi, S.-H., Shin, H., Hyun, C.-K., Kim, K.-T. and Holzapfel, W.H., 2017. Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model. Applied Microbiology and Biotechnology 101: 1605-1614. https://doi.org/10.1007/s00253-016-7953-2
-
Parvez, S., Malik, K.A., Ah Kang, S. and Kim, H.Y., 2006. Probiotics and their fermented food products are beneficial for health. Journal of Applied Microbiology 100: 1171-1185.
'Probiotics and their fermented food products are beneficial for health ' () 100 Journal of Applied Microbiology : 1171 -1185.
-
Reeves, P.G., Nielsen, F.H. and Fahey, G.C., 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123: 1939-1951.
'AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet ' () 123 Journal of Nutrition : 1939 -1951.
-
Russo, L. and Lumeng, C.N., 2018. Properties and functions of adipose tissue macrophages in obesity. Immunology 155: 407-417.
'Properties and functions of adipose tissue macrophages in obesity ' () 155 Immunology : 407 -417.
-
Sandagdorj, B., Hamajima, C., Kawahara, T., Watanabe, J. and Tanaka, S., 2019. Characterization of microbiota that influence immunomodulatory effects of fermented Brassica rapa L. Microbes and Environments 34: 206-214. https://doi.org/10.1264/jsme2.ME19003
-
Sanz, Y., Santacruz, A. and Gauffin, P., 2010. Gut microbiota, obesity and metabolic disorders. Proceedings of the Nutrition Society 69: 434-441.
'Gut microbiota, obesity and metabolic disorders ' () 69 Proceedings of the Nutrition Society : 434 -441.
-
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W.S. and Huttenhower, C., 2011. Metagenomic biomarker discovery and explanation. Genome Biology 12: R60. https://doi.org/10.1186/gb-2011-12-6-r60
-
Serino, M., Luche, E., Gres, S., Baylac, A., Bergé, M., Cenac, C., Waget, A., Klopp, P., Iacovoni, J., Klopp, C., Mariette, J., Bouchez, O., Lluch, J., Ouarné, F., Monsan, P., Valet, P., Roques, C., Amar, J., Bouloumié, A., Théodorou, V. and Burcelin, R., 2012. Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut 61: 543-553.
'Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota ' () 61 Gut : 543 -553.
-
Taguchi, H., Senoura, T., Hamada, S., Matsui, H., Kobayashi, Y., Watanabe, J., Wasaki, J. and Ito, S., 2008. Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiology Letters 287: 34-40. https://doi.org/10.1111/j.1574-6968.2008.01281.x
-
Tanaka, S., Yamamoto, K., Yamada, K., Furuya, K. and Uyeno, Y., 2016. Relationship of enhanced butyrate production by colonic butyrate-producing bacteria and immunomodulatory effects in normal mice fed insoluble fraction of Brassica rapa L. Applied and Environmental Microbiology 82: 2693-2699. https://doi.org/10.1128/AEM.03343-15
-
Tomaro-Duchesneau, C., Jones, M.L., Shah, D., Jain, P., Saha, S. and Prakash, S., 2014. Cholesterol assimilation by Lactobacillus probiotic bacteria: an in vitro investigation. BioMed Research International 2014: 380316. https://doi.org/10.1155/2014/380316
-
Tomaro-Duchesneau, C., Saha, S., Malhotra, M., Jones, M.L., Rodes, L. and Prakash, S., 2015. Lactobacillus fermentum NCIMB 5221 and NCIMB 2797 as cholesterol-lowering probiotic biotherapeutics: in vitro analysis. Beneficial Microbes 6: 861-869.
'Lactobacillus fermentum NCIMB 5221 and NCIMB 2797 as cholesterol-lowering probiotic biotherapeutics: in vitro analysis ' () 6 Beneficial Microbes : 861 -869.
-
Torriani, S., Felis, E.G. and Dellaglio, F., 2001. Differentiation of Lactobacillus plantarum, L. pentosus, and L. paraplantarum by recA gene sequence analysis and multiplex PCR assay with recA gene-derived primers. Applied and Environmental Microbiology 67: 3450-3454.
'Differentiation of Lactobacillus plantarum, L. pentosus, and L. paraplantarum by recA gene sequence analysis and multiplex PCR assay with recA gene-derived primers ' () 67 Applied and Environmental Microbiology : 3450 -3454.
-
Verwaerde, C., Delanoye, A., Macia, L., Tailleux, A. and Wolowczuk, I., 2006. Influence of high-fat feeding on both naive and antigen-experienced T-cell immune response in DO10.11 mice. Scandinavian Journal of Immunology 64: 457-466.
'Influence of high-fat feeding on both naive and antigen-experienced T-cell immune response in DO10.11 mice ' () 64 Scandinavian Journal of Immunology : 457 -466.
-
Wagner, M., Samdal Steinskog, E.S. and Wiig, H., 2015. Adipose tissue macrophages: the inflammatory link between obesity and cancer? Expert Opinion on Therapeutic Targets 19: 527-538.
'Adipose tissue macrophages: the inflammatory link between obesity and cancer? ' () 19 Expert Opinion on Therapeutic Targets : 527 -538.
-
Wolowczuk, I., Verwaerde, C., Viltart, O., Delanoye, A., Delacre, M., Pot, B. and Grangette, C., 2008. Feeding our immune system: impact on metabolism. Clinical and Developmental Immunology 2008: 639803. https://doi.org/10.1155/2008/639803.
-
Wouters, D., Grosu-Tudor, S., Zamfir, M. and De Vuyst, L., 2013. Bacterial community dynamics, lactic acid bacteria species diversity and metabolite kinetics of traditional Romanian vegetable fermentations. Journal of the Science of Food and Agriculture 93: 749-760.
'Bacterial community dynamics, lactic acid bacteria species diversity and metabolite kinetics of traditional Romanian vegetable fermentations ' () 93 Journal of the Science of Food and Agriculture : 749 -760.
-
Wu, C.-C., Weng, W.-L., Lai, W.-L., Tsai, H.-P., Liu, W.-H., Lee, M.-H., Tsai, Y.-C., Wu, C.-C., Weng, W.-L., Lai, W.-L., Tsai, H.-P., Liu, W.-H., Lee, M.-H. and Tsai, Y.-C., 2015. Effect of Lactobacillus plantarum strain K21 on high-fat diet-fed obese mice. Evidence-Based Complementary and Alternative Medicine 2015: e391767.
'Effect of Lactobacillus plantarum strain K21 on high-fat diet-fed obese mice ' () 2015 Evidence-Based Complementary and Alternative Medicine : e391767.
-
Yamamoto, K., Furuya, K., Yamada, K., Takahashi, F., Hamajima, C. and Tanaka, S., 2018. Enhancement of natural killer activity and IFN-γ production in an IL-12-dependent manner by a Brassica rapa L. Bioscience, Biotechnology, and Biochemistry 82: 654-668. https://doi.org/10.1080/09168451.2017.1408396
-
Zhao, L., Zhang, Q., Ma, W., Tian, F., Shen, H. and Zhou, M., 2017. A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota. Food and Function 8: 4644-4656.
'A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota ' () 8 Food and Function : 4644 -4656.
Supplementary Materials
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Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice
In: Beneficial MicrobesSchool of Integrative and Global Majors, University of Tsukuba, 305-8577 Tsukuba, Japan.
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School of Integrative and Global Majors, University of Tsukuba, 305-8577 Tsukuba, Japan.
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, 080-8555 Obihiro, Japan.
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Lactobacillus plantarum Shinshu N-07 (N07) and Lactobacillus curvatus #4G2 (#4G2) were isolated from fermented Brassica rapa L. and selected as promising probiotics with anti-adiposity activities based on in vitro assays. The anti-adiposity effects of these two strains were investigated using a diet-induced obesity animal model. Epididymal adipose tissue weight and adipocyte area were significantly lower and serum triglycerides and glucose tended to be lower in mice fed the high-fat diet supplemented with N07 compared with those fed the unsupplemented high-fat diet. Strain N07 suppressed hepatic steatosis, with accompanying downregulation of lipogenic genes in the liver. Expression of inflammatory cytokines and macrophage infiltration markers tended to be suppressed by N07 supplementation. Upregulation of uncoupling protein-1 in epididymal adipose tissue by N07 suggested that the transformation of white adipose tissue to brown might have been induced. Intestinal microbiota analysis revealed that a decrease in abundance of family S24-7 (phylum Bacteroidetes) following ingestion of the high-fat diet was partly recovered by supplementation with N07. Changes in those parameters were not observed in mice fed the high-fat diet supplemented with strain #4G2, suggesting strain specificities. Thus, N07 is a potential probiotic strain that could be used to develop functional foods that attenuate visceral fat accumulation after an appropriate human intervention trial.
| All Time | Past 365 days | Past 30 Days | |
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