Bacillus coagulans and its applications in medicine
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Bacillus coagulans is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Additionally, toxicological experiments and a large number of clinical observations have showed that B. coagulans is safe and has no effect of mutagenicity, teratogenicity or genotoxicity. This review summarises the latest advances associated with B. coagulans, from its biological features, probable action mechanisms, toxicity, and medical applications.
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Fitzpatrick, L.R., Small, J.S., Greene, W.H., Karpa, K.D. and Keller, D., 2011. Bacillus coagulans GBI-30 (BC30) improves indices of Clostridium difficile-induced colitis in mice. Gut Pathogens 3: 16. DOI: https://doi.org/10.1186/1757-4749-3-16
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Wu, T., Zhang, Y., Lv, Y., Li, P., Yi, D., Wang, L., Zhao, D., Chen, H., Gong, J. and Hou, Y., 2018. Beneficial impact and molecular mechanism of Bacillus coagulans on piglets’ intestine. International Journal of Molecular Sciences 19: 2084. DOI: https://doi.org/10.3390/ijms19072084
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| All Time | Past 365 days | Past 30 Days | |
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| Abstract Views | 4453 | 1112 | 81 |
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Bacillus coagulans and its applications in medicine
In: Beneficial MicrobesSearch for other papers by Y. Mu in
Current site
Google Scholar
PubMed
Search for other papers by Y. Cong in
Current site
Google Scholar
PubMed
Bacillus coagulans is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Additionally, toxicological experiments and a large number of clinical observations have showed that B. coagulans is safe and has no effect of mutagenicity, teratogenicity or genotoxicity. This review summarises the latest advances associated with B. coagulans, from its biological features, probable action mechanisms, toxicity, and medical applications.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4453 | 1112 | 81 |
| Full Text Views | 75 | 19 | 2 |
| PDF Views & Downloads | 134 | 40 | 3 |
