This study aimed to examine whether probiotics, which suppressed the differentiation of splenic T cells into type 2 helper T (Th2) cells and induced into regulatory T cells in vitro, alleviate allergic rhinitis (AR) and gut microbiota disturbance. We isolated Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 from human faecal microbiota and kimchi, respectively, and examined their effects on ovalbumin (OVA)-induced AR and gut microbiota disturbance in mice. Treatment with IM55, IM76, or their probiotic mixture (PM) significantly reduced OVA-induced allergic nasal symptoms and blood immunoglobulin E (IgE) levels in mice. These also reduced OVA-induced interleukin (IL)-4 and IL-5 levels in nasal tissues and bronchoalveolar lavage fluid (BALF) but increased OVA-suppressed IL-10 levels. Treatment with IM55, IM76, or PM reduced OVA-induced increase in the populations of mast cells, eosinophils, and Th2 cells and increased OVA-suppressed population of regulatory T cells in the BALF. Treatment with IM55, IM76, or PM also inhibited OVA-induced expression of IL-5 in lung and colon tissues and restored OVA-disturbed composition of gut microbiota Proteobacteria, Bacteroidetes, and Actinobacteria. These results suggest that IM55 and IM67 can alleviate AR by restoring Th2/Treg imbalance and gut microbiota disturbance.
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Amin, K., Janson, C. and Bystrom, J., 2016. Role of eosinophil granulocytes in allergic airway inflammation endotypes. Scandinavian Journal of Immunology 84: 75-85.
'Role of eosinophil granulocytes in allergic airway inflammation endotypes ' () 84 Scandinavian Journal of Immunology : 75 -85.
Anand, P., Singh, B., Jaggi, A.S. and Singh, N., 2012. Mast cells: an expanding pathophysiological role from allergy to other disorders. Naunyn Schmiedebergs Archives of Pharmacology 385: 657-670.
'Mast cells: an expanding pathophysiological role from allergy to other disorders ' () 385 Naunyn Schmiedebergs Archives of Pharmacology : 657 -670.
Baumann, R., Rabaszowski, M., Stenin, I., Tilgner, L., Scheckenbach, K., Wiltfang, J., Schipper, J., Chaker, A. and Wagenmann, M., 2013. Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge. American Journal of Rhinology and Allergy 27: 266-272.
'Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge ' () 27 American Journal of Rhinology and Allergy : 266 -272.
Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B.L., Skov, T., Paludan-Müller, G., Stokholm, J., Smith, B. and Krogfelt, K.A., 2011. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. Journal of Allergy and Clinical Immunology 128: 646-652.
'Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age ' () 128 Journal of Allergy and Clinical Immunology : 646 -652.
Blázquez, A.B. and Berin, M.C., 2017. Microbiome and food allergy. Translational Research 179: 199-203.
'Microbiome and food allergy ' () 179 Translational Research : 199 -203.
Broide, D.H., 2005. Allergic rhinitis: pathophysiology. Allergy and Asthma Proceedings 31: 370-374.
'Allergic rhinitis: pathophysiology ' () 31 Allergy and Asthma Proceedings : 370 -374.
Cook, P.R., 1998. Allergic rhinitis. Outcomes of immunotherapy on symptom control. Otolaryngologic Clinics of North America 31: 129-140.
'Allergic rhinitis. Outcomes of immunotherapy on symptom control ' () 31 Otolaryngologic Clinics of North America : 129 -140.
Dev, S., Mizuguchi, H., Das, A.K., Matsushita, C., Maeyama, K., Umehara, H., Kojima, J., Nishida, K., Takahashi, K. and Fukui, H., 2008. Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect. Journal of Pharmacological Sciences 107: 159-166.
'Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect ' () 107 Journal of Pharmacological Sciences : 159 -166.
Duncan, S.H. and Flint, H.J., 2013. Probiotics and prebiotics and health in ageing populations. Maturitas 75: 44-50.
'Probiotics and prebiotics and health in ageing populations ' () 75 Maturitas : 44 -50.
Durham, S.R., 1998. The inflammatory nature of allergic disease. Clinical and Experimental Allergy 28, Suppl. 6: 20-24.
'The inflammatory nature of allergic disease ' () 6 Clinical and Experimental Allergy : 20 -24.
Eifan, A.O. and Durham, S.R., 2016. Pathogenesis of rhinitis. Clinical and Experimental Allergy 46: 1139-1151.
'Pathogenesis of rhinitis ' () 46 Clinical and Experimental Allergy : 1139 -1151.
Enomoto, T., Sowa, M., Nishimori, K., Shimazu, S., Yoshida, A., Yamada, K., Furukawa, F., Nakagawa, T., Yanagisawa, N., Iwabuchi, N., Odamaki, T., Abe, F., Nakayama, J. and Xiao, J.Z., 2014. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergology International 63: 575-585.
'Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota ' () 63 Allergology International : 575 -585.
Forsberg, A., West, C.E., Prescott, S.L. and Jenmalm, M.C., 2016. Pre- and probiotics for allergy prevention: time to revisit recommendations? Clinical and Experimental Allergy 46: 1506-1521.
'Pre- and probiotics for allergy prevention: time to revisit recommendations? ' () 46 Clinical and Experimental Allergy : 1506 -1521.
Fu, L., Peng, J., Zhao, S., Zhang, Y., Su, X. and Wang, Y., 2017. Lactic acid bacteria-specific induction of CD4+Foxp3+ T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling. Scientific Reports 7: 1987.
'Lactic acid bacteria-specific induction of CD4+Foxp3+ T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling ' () 7 Scientific Reports : 1987.
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J.M., Topping, D.L., Suzuki, T., Taylor, T.D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M. and Ohno, H., 2011. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469: 543-547.
'Bifidobacteria can protect from enteropathogenic infection through production of acetate ' () 469 Nature : 543 -547.
Furrie, E., 2005. Probiotics and allergy. Proceedings of the Nutrition Society 64: 465-469.
'Probiotics and allergy ' () 64 Proceedings of the Nutrition Society : 465 -469.
Gu, Z.W., Wang, Y.X. and Cao, Z.W., 2017. Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model. Oncotarget 8: 14314-14324.
'Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model ' () 8 Oncotarget : 14314 -14324.
Han, J.L. and Lin, H.L., 2014. Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. World Journal of Gastroenterology 20: 17737-17745.
'Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective ' () 20 World Journal of Gastroenterology : 17737 -17745.
Hill, D.A., Siracusa, M.C., Abt, M.C., Kim, B.S., Kobuley, D., Kubo, M., Kambayashi, T., Larosa, D.F., Renner, E.D., Orange, J.S., Bushman, F.D. and Artis, D., 2012. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nature Medicine 18: 538-546.
'Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation ' () 18 Nature Medicine : 538 -546.
Hirsch, A.G., Pollak, J., Glass, T.A., Poulsen, M.N., Bailey-Davis, L., Mowery, J. and Schwartz, B.S., 2017. Early-life antibiotic use and subsequent diagnosis of food allergy and allergic diseases. Clinical and Experimental Allergy 47: 236-244.
'Early-life antibiotic use and subsequent diagnosis of food allergy and allergic diseases ' () 47 Clinical and Experimental Allergy : 236 -244.
Hougee, S., Vriesema, A.J., Wijering, S.C., Knippels, L.M., Folkerts, G., Nijkamp, F.P., Knol, J., and Garssen, J., 2010. Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study. International Archives of Allergy and Immunology 151: 107-117.
'Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study ' () 151 International Archives of Allergy and Immunology : 107 -117.
Ishida, Y., Nakamura, F., Kanzato, H., Sawada, D., Hirata, H., Nishimura, A., Kajimoto, O. and Fujiwara, S., 2005. Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study. Journal of Dairy Science 88: 527-533.
'Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study ' () 88 Journal of Dairy Science : 527 -533.
Ivory, K., Chambers, S.J., Pin, C., Prieto, E., Arqués, J.L. and Nicoletti, C., 2008. Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis. Clinical and Experimental Allergy 38: 1282-1289.
'Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis ' () 38 Clinical and Experimental Allergy : 1282 -1289.
Iwabuchi, N., Takahashi, N., Xiao, J.Z., Miyaji, K. and Iwatsuki, K., 2007. In vitro Th1 Cytokine-independent Th2 suppressive effects of bifidobacteria. Microbiology and Immunology 51: 649-660.
'In vitro Th1 Cytokine-independent Th2 suppressive effects of bifidobacteria ' () 51 Microbiology and Immunology : 649 -660.
Jeong, J.J., Kim, K.A., Hwang, Y.J., Han, M.J. and Kim, D.H., 2016. Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice. Beneficial Microbes 7: 707-718.
'Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice ' () 7 Beneficial Microbes : 707 -718.
Kang, H.J. and Im, S.H., 2015. Probiotics as an immune modulator. Journal of Nutritional Science and Vitaminology 61: 103-105.
'Probiotics as an immune modulator ' () 61 Journal of Nutritional Science and Vitaminology : 103 -105.
Kang, Y.B., Cai, Y. and Zhang, H., 2017. Gut microbiota and allergy/asthma: from pathogenesis to new therapeutic strategies. Allergologia et Immunopathologia 45: 305-309.
'Gut microbiota and allergy/asthma: from pathogenesis to new therapeutic strategies ' () 45 Allergologia et Immunopathologia : 305 -309.
Kim, J.H., Jeun, E.J., Hong, C.P., Kim, S.H., Jang, M.S., Lee, E.J., Moon, S.J., Yun, C.H., Im, S.H., Jeong, S.G., Park, B.Y., Kim, K.T., Seoh, J.Y., Kim, Y.K., Oh, S.J., Ham, J.S., Yang, B.G. and Jang, M.H., 2015. Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression. Journal of Allergy and Clinical Immunology 137: 507-516.
'Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression ' () 137 Journal of Allergy and Clinical Immunology : 507 -516.
Kimoto, H., Mizumachi, K., Okamoto, T. and Kurisaki, J., 2004. New Lactococcus strain with immunomodulatory activity: enhancement of Th1-type immune response. Microbiology and Immunology 48: 75-82.
'New Lactococcus strain with immunomodulatory activity: enhancement of Th1-type immune response ' () 48 Microbiology and Immunology : 75 -82.
Kulkarni, R., Behboudi, S. and Sharif, S., 2011. Insights into the role of Toll-like receptors in modulation of T cell responses. Cell and Tissue Research 343: 141-152.
'Insights into the role of Toll-like receptors in modulation of T cell responses ' () 343 Cell and Tissue Research : 141 -152.
Lim, S.M., Choi, H.S. and Kim, D.H., 2017. The mixture of Anemarrhena asphodeloides and Coptis chinensis attenuates high-fat diet-induced colitis in mice. American Journal of Chinese Medicine 45: 1033-1046.
'The mixture of Anemarrhena asphodeloides and Coptis chinensis attenuates high-fat diet-induced colitis in mice ' () 45 American Journal of Chinese Medicine : 1033 -1046.
Lim, S.M., Kang, G.D., Jeong, J.J., Choi, H.S. and Kim, D.H., 2016. Neomangiferin modulates the Th17/Treg balance and ameliorates colitis in mice. Phytomedicine 23: 131-140.
'Neomangiferin modulates the Th17/Treg balance and ameliorates colitis in mice ' () 23 Phytomedicine : 131 -140.
Liu, W., Deng, L., Chen, Y., Sun, C., Wang, J., Zhou, L., Li, H. and Luo, R., 2014. Anti-inflammatory effect of IL-37b in children with allergic rhinitis. Mediators of Inflammation 2014: 746846.
'Anti-inflammatory effect of IL-37b in children with allergic rhinitis ' () 2014 Mediators of Inflammation : 746846.
McKenzie, C., Tan, J., Macia, L. and Mackay, C.R., 2017. The nutrition-gut microbiome-physiology axis and allergic diseases. Immunological Reviews 278: 277-295.
'The nutrition-gut microbiome-physiology axis and allergic diseases ' () 278 Immunological Reviews : 277 -295.
Melli, L.C., Do Carmo-Rodrigues, M.S., Araújo-Filho, H.B., Solé, D. and De Morais, M.B., 2016. Intestinal microbiota and allergic diseases: a systematic review. Allergologia et Immunopathologia 44: 177-188.
'Intestinal microbiota and allergic diseases: a systematic review ' () 44 Allergologia et Immunopathologia : 177 -188.
Miraglia del Giudice, M., Indolfi, C., Capasso, M., Maiello, N., Decimo, F. and Ciprandi, G., 2017. Bifidobacterium mixture (B. longum BB536, B. infantis M-63, B. breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma. Italian Journal of Pediatrics 43: 25.
'Bifidobacterium mixture (B. longum BB536, B. infantis M-63, B. breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma ' () 43 Italian Journal of Pediatrics : 25.
Miyoshi, J. and Chang, E.B., 2017 The gut microbiota and inflammatory bowel diseases. Translational Research 179: 38-48.
'The gut microbiota and inflammatory bowel diseases ' () 179 Translational Research : 38 -48.
Morita, H., He, F., Kawase, M., Kubota, A., Kurizaki, J. and Salminen, S., 2006. Preliminary human study for possible alteration of serum immunoglobulin E production in perennial allergic rhinitis with fermented milk prepared with Lactobacillus gasseri TMC0356. Microbiology and Immunology 50: 701-706.
'Preliminary human study for possible alteration of serum immunoglobulin E production in perennial allergic rhinitis with fermented milk prepared with Lactobacillus gasseri TMC0356 ' () 50 Microbiology and Immunology : 701 -706.
Nathan, R.A., 2014. The rhinitis control assessment test: implications for the present and future. Current Opinion in Allergy and Clinical Immunology 14: 13-19.
'The rhinitis control assessment test: implications for the present and future ' () 14 Current Opinion in Allergy and Clinical Immunology : 13 -19.
Nogueira, J.C. and Gonçalves, M.C., 2011. Probiotics in allergic rhinitis. Brazilian Journal of Otorhinolaryngology 77: 129-134.
'Probiotics in allergic rhinitis ' () 77 Brazilian Journal of Otorhinolaryngology : 129 -134.
Odamaki, T., Xiao, J.Z., Iwabuchi, N., Sakamoto, M., Takahashi, N., Kondo, S., Miyaji, K., Iwatsuki, K., Togashi, H., Enomoto, T. and Benno, Y., 2007a. Influence of Bifidobacterium longum BB536 intake on faecal microbiota in individuals with Japanese cedar pollinosis during the pollen season. Journal of Medical Microbiology 56: 1301-1308.
'Influence of Bifidobacterium longum BB536 intake on faecal microbiota in individuals with Japanese cedar pollinosis during the pollen season ' () 56 Journal of Medical Microbiology : 1301 -1308.
Odamaki, T., Xiao, J.Z., Iwabuchi, N., Sakamoto, M., Takahashi, N., Kondo, S., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, T. and Benno, Y., 2007b. Fluctuation of fecal microbiota in individuals with Japanese cedar pollinosis during the pollen season and influence of probiotic intake. Journal of Investigational Allergology and Clinical Immunology 17: 92-100.
'Fluctuation of fecal microbiota in individuals with Japanese cedar pollinosis during the pollen season and influence of probiotic intake ' () 17 Journal of Investigational Allergology and Clinical Immunology : 92 -100.
Oh, H.A., Seo, J.Y., Jeong, H.J. and Kim, H.M., 2013. Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice. Immunopharmacology and Immunotoxicology 35: 678-686.
'Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice ' () 35 Immunopharmacology and Immunotoxicology : 678 -686.
Ouwehand, A.C., Isolauri, E., He, F., Hashimoto, H., Benno, Y. and Salminen, S., 2001. Differences in Bifidobacterium flora composition in allergic and healthy infants. Journal of Allergy and Clinical Immunology 108: 144-145.
'Differences in Bifidobacterium flora composition in allergic and healthy infants ' () 108 Journal of Allergy and Clinical Immunology : 144 -145.
Owen, J.L. and Mohamadzadeh, M., 2013. Microbial activation of gut dendritic cells and the control of mucosal immunity. Journal of Interferon and Cytokine Research 33: 619-631.
'Microbial activation of gut dendritic cells and the control of mucosal immunity ' () 33 Journal of Interferon and Cytokine Research : 619 -631.
Pawankar, R., 2005. Mast cells in allergic airway disease and chronic rhinosinusitis. Chemical Immunology and Allergy 87: 111-129.
'Mast cells in allergic airway disease and chronic rhinosinusitis ' () 87 Chemical Immunology and Allergy : 111 -129.
Ricketti, P.A., Alandijani, S., Lin, C.H. and Casale, T.B., 2017. Investigational new drugs for allergic rhinitis. Expert Opinion on Investigational Drugs 26: 279-292.
'Investigational new drugs for allergic rhinitis ' () 26 Expert Opinion on Investigational Drugs : 279 -292.
Rosenberg, H.F., Masterson, J.C. and Furuta, G.T., 2016. Eosinophils, probiotics, and the microbiome. Journal of Leukocyte Biology 100: 881-888.
'Eosinophils, probiotics, and the microbiome ' () 100 Journal of Leukocyte Biology : 881 -888.
Settipane, R.A. and Charnock, D.R., 2007. Epidemiology of rhinitis: allergic and nonallergic. Clinical Allergy and Immunology 19: 23-34.
'Epidemiology of rhinitis: allergic and nonallergic ' () 19 Clinical Allergy and Immunology : 23 -34.
Shreffler, W.G., 2006. Evaluation of basophil activation in food allergy: present and future applications. Current Opinion in Allergy and Clinical Immunology 6: 226-233.
'Evaluation of basophil activation in food allergy: present and future applications ' () 6 Current Opinion in Allergy and Clinical Immunology : 226 -233.
Skoner, D.P., 2001. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. Journal of Allergy and Clinical Immunology 108, Suppl. 1: S2-8.
'Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis ' () 1 Journal of Allergy and Clinical Immunology : S2 -8.
Stephani, J., Radulovic, K. and Niess, J.H., 2011. Gut microbiota, probiotics and inflammatory bowel disease. Archivum Immunologiae et Therapia Experimetntalis 59: 161-177.
'Gut microbiota, probiotics and inflammatory bowel disease ' () 59 Archivum Immunologiae et Therapia Experimetntalis : 161 -177.
Sunada, Y., Nakamura, S. and Kamei, C., 2007. Effects of Lactobacillus acidophilus strain L-55 on experimental allergic rhinitis in BALB/c mice. Biological and Pharmaceutical Bulletin 30: 2163-2166.
'Effects of Lactobacillus acidophilus strain L-55 on experimental allergic rhinitis in BALB/c mice ' () 30 Biological and Pharmaceutical Bulletin : 2163 -2166.
Thursby, E. and Juge, N., 2017. Introduction to the human gut microbiota. Biochemical Journal 474: 1823-1836.
'Introduction to the human gut microbiota ' () 474 Biochemical Journal : 1823 -1836.
Tobita, K., Yanaka, H. and Otani, H., 2010. Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice. Animal Science Journal 81: 699-705.
'Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitized BALB/c mice ' () 81 Animal Science Journal : 699 -705.
Tsunemine, S., Isa, Y., Ohno, H., Hagino, S., Yamamura, H., Mizutani, N. and Nabe, T., 2015. Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9-1 on Japanese cedar pollen-induced allergic nasal symptoms in guinea pigs. Microbiology and Immunology 59: 690-699.
'Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9-1 on Japanese cedar pollen-induced allergic nasal symptoms in guinea pigs ' () 59 Microbiology and Immunology : 690 -699.
Turnbaugh, P.J., Hamady, M., Yatsunenko, T., Cantarel, B.L., Duncan, A., Ley, R.E., Sogin, M.L., Jones, W.J., Roe, B.A., Affourtit, J.P., Egholm, M., Henrissat, B., Heath, A.C., Knight, R. and Gordon, J.I., 2009. A core gut microbiome in obese and lean twins. Nature 457: 480-484.
'A core gut microbiome in obese and lean twins ' () 457 Nature : 480 -484.
Vrieze, A., Holleman, F., Zoetendal, E.G. De Vos, W.M., Hoekstra, J.B. and Nieuwdorp, M., 2010. The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia 53: 606-613.
'The environment within: how gut microbiota may influence metabolism and body composition ' () 53 Diabetologia : 606 -613.
Wang, M.F., Lin, H.C., Wang, Y.Y. and Hsu, C.H., 2004. Treatment of perennial allergic rhinitis with lactic acid bacteria. Pediatric Allergy and Immunology 15: 152-158.
'Treatment of perennial allergic rhinitis with lactic acid bacteria ' () 15 Pediatric Allergy and Immunology : 152 -158.
Wu, L.C and Zarrin, A.A., 2014. The production and regulation of IgE by the immune system. Nature Reviews Immunology 14: 247-259.
'The production and regulation of IgE by the immune system ' () 14 Nature Reviews Immunology : 247 -259.
Xiao, J.Z., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Togashi, K., Enomoto, K. and Enomoto, T., 2006. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clinical and Experimental Allergy 36: 1425-1435.
'Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial ' () 36 Clinical and Experimental Allergy : 1425 -1435.
Yang, G., Liu, Z.Q. and Yang, P.C., 2013. Treatment of allergic rhinitis with probiotics: an alternative approach. North American Journal of Medicine and Science 5: 465-468.
'Treatment of allergic rhinitis with probiotics: an alternative approach ' () 5 North American Journal of Medicine and Science : 465 -468.
Yu, J., Jang, S.O., Kim, B.J., Song, Y.H., Kwon, J.W., Kang, M.J., Choi, W.A., Jung, H.D. and Hong, S.J., 2010. The effects of Lactobacillus rhamnosus on the prevention of asthma in a murine model. Allergy, Asthma and Immunology Research 2: 199-205.
'The effects of Lactobacillus rhamnosus on the prevention of asthma in a murine model ' () 2 Allergy, Asthma and Immunology Research : 199 -205.
Zhu, J., 2015. T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine 75: 14-24.
'T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production ' () 75 Cytokine : 14 -24.
| All Time | Past 365 days | Past 30 Days | |
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This study aimed to examine whether probiotics, which suppressed the differentiation of splenic T cells into type 2 helper T (Th2) cells and induced into regulatory T cells in vitro, alleviate allergic rhinitis (AR) and gut microbiota disturbance. We isolated Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 from human faecal microbiota and kimchi, respectively, and examined their effects on ovalbumin (OVA)-induced AR and gut microbiota disturbance in mice. Treatment with IM55, IM76, or their probiotic mixture (PM) significantly reduced OVA-induced allergic nasal symptoms and blood immunoglobulin E (IgE) levels in mice. These also reduced OVA-induced interleukin (IL)-4 and IL-5 levels in nasal tissues and bronchoalveolar lavage fluid (BALF) but increased OVA-suppressed IL-10 levels. Treatment with IM55, IM76, or PM reduced OVA-induced increase in the populations of mast cells, eosinophils, and Th2 cells and increased OVA-suppressed population of regulatory T cells in the BALF. Treatment with IM55, IM76, or PM also inhibited OVA-induced expression of IL-5 in lung and colon tissues and restored OVA-disturbed composition of gut microbiota Proteobacteria, Bacteroidetes, and Actinobacteria. These results suggest that IM55 and IM67 can alleviate AR by restoring Th2/Treg imbalance and gut microbiota disturbance.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1022 | 279 | 21 |
| Full Text Views | 88 | 15 | 1 |
| PDF Views & Downloads | 160 | 26 | 3 |