This review reports the beneficial effects, observed in our clinical studies, of Bifidobacterium breve for premature infants, and children with cancers undergoing chemotherapy. To investigate the protective effects of B. breve (M-16V) as a probiotic on necrotizing enterocolitis (NEC) and infection in premature infants, we carried out a clinical study in 338 very low birth weight infants over a five-year period. These patients were supplemented with B. breve starting several hours after birth (Bifido group). 226 premature infants served as controls. Infants of the Bifido group were administered B. breve in a daily dose of 1Ã109 cells/day. The incidence of NEC was significantly reduced in the Bifido group (nil) compared with that in controls (6 cases, P<0.01). Infection also decreased significantly. Thus, administration of B. breve as a probiotic looks to be a very effective treatment for preventing NEC and infection in preterm infants. Mucositis, also referred to as mucosal barrier injury, is one of the most debilitating side effects of chemotherapy treatment. To evaluate the effects of the administration of B. breve (BBG-01, another strain than that used in the study of premature infants), a clinical study was performed to ascertain whether it attenuated intestinal mucositis in children with cancers on chemotherapy. A placebo-controlled trial was performed in patients with malignancies admitted for chemotherapy (n=42), who were randomised into two groups receiving probiotic or placebo. The frequency of fever and the use of intravenous antibiotics were significantly lower in the Bifido group than the placebo group. The B. breve administration enhanced the colonisation of anaerobes. Disruption of the intestinal microbiota after chemotherapy, such as the increase in the population levels of Enterobacteriaceae, was more pronounced in the placebo group. In conclusion, these data suggest that administration of B. breve is an effective approach to attenuating chemotherapy-induced mucositis in children with cancers. The study results strongly suggest that B. breve administration as a probiotic is an effective therapy for the prevention of NEC and infection in premature infants, and also a promising treatment for attenuating chemotherapy-induced mucositis in children with cancers.
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Bell, M.J., Feigin, R.D., Ternberg, J.L. and Brotherton, T., 1978. Evaluation of gastrointestinal microflora in necrotizing enterocolitis. Journal of Pediatrics 92: 589-592.
'Evaluation of gastrointestinal microflora in necrotizing enterocolitis ' () 92 Journal of Pediatrics : 589 -592.
Bellm, L.A., Epstein, J.B., Rose-Ped, A., Martin, P. and Fuchs, H.J., 2000. Patient reports of complications of bone marrow transplantation. Supportive Care in Cancer 8: 33-39.
'Patient reports of complications of bone marrow transplantation ' () 8 Supportive Care in Cancer : 33 -39.
Bennet, R., 1987. The faecal microflora of newborn infants during intensive care management and its relationship to neonatal septicemia. Thesis, Stockholm University, Stockholm, Sweden.
The faecal microflora of newborn infants during intensive care management and its relationship to neonatal septicemia
Benno, Y., Sawada, K. and Mitsuoka, T., 1984. The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiology and Immunology 28: 975-986.
'The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants ' () 28 Microbiology and Immunology : 975 -986.
Berg, R.D., 1999. Bacterial translocation from the gastrointestinal tract. Advances in Experimental Medicine and Biology 473: 11-30.
'Bacterial translocation from the gastrointestinal tract ' () 473 Advances in Experimental Medicine and Biology : 11 -30.
Bin-Num, A., Bromiker, R., Wilschanki, M., Kaplan, M., Rudensky, B., Caplan, M. and Hammerman, C., 2005. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. Journal of Pediatrics 147: 192-196.
'Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates ' () 147 Journal of Pediatrics : 192 -196.
Caplan, M.S. and Jilling, T., 2000. Neonatal necrotizing enterocolitis: possible role of probiotic supplementation. Journal of Pediatric Gastroenterology and Nutrition 30: s18-s22.
'Neonatal necrotizing enterocolitis: possible role of probiotic supplementation ' () 30 Journal of Pediatric Gastroenterology and Nutrition : s18 -s22.
Collier-Hyams, L.S. and Neish, A.S., 2005. Innate immune relationship between commensal flora and the mammalian intestinal epithelium. Cellular and Molecular Life Sciences 62: 1339-1348.
'Innate immune relationship between commensal flora and the mammalian intestinal epithelium ' () 62 Cellular and Molecular Life Sciences : 1339 -1348.
Distefano, G., Curreri, R., Betta, P., Romro, M.G. and Amato, M., 2004. Procalcitonin serum levels in perinatal bacterial and fungal infection of preterm infants. Acta Paediatrica 93: 216-219.
'Procalcitonin serum levels in perinatal bacterial and fungal infection of preterm infants ' () 93 Acta Paediatrica : 216 -219.
Fryklund, B., Tullus, K., Berglund, B. and Burman, L.G., 1992. Importance of the environment and the faecal flora of infants, nursing staff and parents as sources of gram-negative bacteria colonizing newborns in three neonatal wards. Infection 20: 253-257.
'Importance of the environment and the faecal flora of infants, nursing staff and parents as sources of gram-negative bacteria colonizing newborns in three neonatal wards ' () 20 Infection : 253 -257.
Fujii, T., Ohtsuka, Y., Lee, T., Kudo, T., Shoji, H., Sato, H., Nagata, S., Shimizu, T. and Yamashiro, Y., 2006. Bifidobacterium breve enhances TGF-β signaling by regulating Smad7 expression in preterm infants. Journal of Pediatric Gastroenterology and Nutrition 43: 83-88.
'Bifidobacterium breve enhances TGF-β signaling by regulating Smad7 expression in preterm infants ' () 43 Journal of Pediatric Gastroenterology and Nutrition : 83 -88.
Grönlund, M.M., Lehtonen, O.P., Eerola, E. and Kero, P., 1999. Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean delivery. Journal of Pediatric Gastroenterology and Nutrition 28: 19-25.
'Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean delivery ' () 28 Journal of Pediatric Gastroenterology and Nutrition : 19 -25.
Guthrie, S.O., Gordon, P.V., Thomas, V., Thorp, J.A., Peabody, J. and Clark, R.H., 2003. Necrotizing enterocolitis among neonates in the United States. Journal of Perinatology 23: 278-285.
'Necrotizing enterocolitis among neonates in the United States ' () 23 Journal of Perinatology : 278 -285.
Henry, M.C. and Lawrence Moss, R., 2005. Surgical therapy for necrotizing enterocolitis: bring evidence to the bedside. Seminars in Pediatric Surgery 14: 181-190.
'Surgical therapy for necrotizing enterocolitis: bring evidence to the bedside ' () 14 Seminars in Pediatric Surgery : 181 -190.
Hooper, L.V., Wong, M.H., Thelin, A., Hansson, L., Falk, P.G. and Gordon, J.I., 2001. Molecular analysis of commensal host-microbial relationship in the intestine. Science 291: 881-884.
'Molecular analysis of commensal host-microbial relationship in the intestine ' () 291 Science : 881 -884.
Kawamura, M. and Nishida, H., 1995. The usefulness of serial C-reactive protein measurement in managing managing neonatal infection. Acta Paediatrica 84: 10-13.
'The usefulness of serial C-reactive protein measurement in managing managing neonatal infection ' () 84 Acta Paediatrica : 10 -13.
Li, Y., Shimizu, T., Hosaka, A., Kaneko, N., Ohtsuka, Y. and Yamashiro, Y., 2004. Effect of Bifidobacterium breve supplementation on intestinal flora of low birth weight infants. Pediatrics International 46: 509-515
'Effect of Bifidobacterium breve supplementation on intestinal flora of low birth weight infants ' () 46 Pediatrics International : 509 -515.
Lin, H.C., Su, B.H., Chen, A.C., Lin, T.W., Tsai, C.H., Yeh, T.F. and Oh, W., 2005. Oral pobiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics 115: 1-4.
'Oral pobiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants ' () 115 Pediatrics : 1 -4.
Mata, L.J. and Urrutia, J.J., 1971. Intestinal colonization of breastfed children in rural area of low socio-economic level. Annals of the New York Academy of Sciences 176: 93-109.
'Intestinal colonization of breastfed children in rural area of low socio-economic level ' () 176 Annals of the New York Academy of Sciences : 93 -109.
McCracken, V.J. and Lorenz, R.G., 2001. The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota. Cellular Microbiology 3: 1-11.
'The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota ' () 3 Cellular Microbiology : 1 -11.
Nanthakumar, N.N., Fusunyan, R.D., Sanderson, I. and Walker, W.A., 2000. Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis. Proceedings of the National Academy of Sciences of the USA 97: 6043-6048.
'Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis ' () 97 Proceedings of the National Academy of Sciences of the USA : 6043 -6048.
Neish, A.S., 2004. Molecular aspects of intestinal epithelial cell-bacterial interactions that determine the development of intestinal inflammation. Inflammatory Bowel Diseases 10: 159-168.
'Molecular aspects of intestinal epithelial cell-bacterial interactions that determine the development of intestinal inflammation ' () 10 Inflammatory Bowel Diseases : 159 -168.
Petty, J.K. and Ziegler, M.M., 2005. Operative strategies from necrotizing enterocolitis: the prevention and treatment of short-bowel syndrome. Seminars in Pediatric Surgery 14: 191-198.
'Operative strategies from necrotizing enterocolitis: the prevention and treatment of short-bowel syndrome ' () 14 Seminars in Pediatric Surgery : 191 -198.
Salhab, W.A., Perlman, J.M., Silver, I. and Sue Broyles, R., 2004. Necrotizing enterocolitis and neurodevelopmental outcome in extremely low birth weight infants <1000g. Journal of Perinatology 24: 534-540.
'Necrotizing enterocolitis and neurodevelopmental outcome in extremely low birth weight infants 1000g ' () 24 Journal of Perinatology : 534 -540.
Satoh, Y., Shinohara, K., Umezaki, H., Shoji, H., Satoh, H., Ohtsuka, Y., Shiga, S., Nagata, S., Shimizu, T. and Yamashiro, Y., 2007. Bifidobacteria prevents necrotizing enterocolitis and infection in preterm infants. International Journal of Probiotics and Prebiotics 2: 149-154.
'Bifidobacteria prevents necrotizing enterocolitis and infection in preterm infants ' () 2 International Journal of Probiotics and Prebiotics : 149 -154.
Schimpff, S.C., Young, V.M., Green, W.H., Vermeulen, G.D., Moody, M.R. and Wiernik, P.H., 1972. Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Annals of Internal Medicine 77: 707-714.
'Origin of infection in acute nonlymphocytic leukemia ' () 77 Significance of hospital acquisition of potential pathogens. Annals of Internal Medicine : 707 -714.
Sonis, S.T., 2004. The pathobiology of mucositis. Nature Reviews Cancer 4: 277-284.
'The pathobiology of mucositis ' () 4 Nature Reviews Cancer : 277 -284.
Stark, P.L. and Lee, A., 1981. The microbial ecology of the large bowel of breast-fed and formula-fed infants during the first year of life. Journal of Medical Microbiology 15: 198-203.
'The microbial ecology of the large bowel of breast-fed and formula-fed infants during the first year of life ' () 15 Journal of Medical Microbiology : 198 -203.
Stoll, B.J., Gordon, T., Korones, S.B., Shankaran, S., Tyson, J.E., Bauer, C.R., Fanaroff, A.A., Lemons, J.A., Donovan, E.F., Oh, W., Stevenson, D.K., Ehrenkranz, R.A., Papile, L.A., Verter, J. and Wright, L.L., 1996. Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. Journal of Pediatrics 129: 72-80.
'Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network ' () 129 Journal of Pediatrics : 72 -80.
Van Vliet, M.J., Tissing, W.J., Dun, C.A., Meessen, N.E., Kamps, W.A., De Bont, E.S. and Harmsen, H.J., 2009. Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut. Clinical Infectious Diseases 49: 262-270.
'Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut ' () 49 Clinical Infectious Diseases : 262 -270.
Wada, M., Nagata, S., Saito, M., Shimizu, T., Yamashiro, Y., Matsuki, T., Asahara, T. and Nomoto, K., 2009. Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies. Supportive Care in Cancer 18: 751-759.
'Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies ' () 18 Supportive Care in Cancer : 751 -759.
Wang, C., Shoji, H., Sato, H., Nagata, S., Ohtsuka, Y., Shimizu, T. and Yamashiro, Y., 2007. Effects of oral administration of Bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants. Journal of Pediatric Gastroenterology and Nutrition 44: 252-257.
'Effects of oral administration of Bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants ' () 44 Journal of Pediatric Gastroenterology and Nutrition : 252 -257.
Yoshioka, H., Iseki, K. and Fujita, J., 1983. Development and differences of intestinal flora in the neonatal period in breastfed and bottlefed infants. Pediatrics 72: 317-321.
'Development and differences of intestinal flora in the neonatal period in breastfed and bottlefed infants ' () 72 Pediatrics : 317 -321.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 485 | 180 | 18 |
| å ¨ææµè§æ¬¡æ° | 32 | 6 | 0 |
| PDFä¸è½½æ¬¡æ° | 27 | 5 | 0 |
This review reports the beneficial effects, observed in our clinical studies, of Bifidobacterium breve for premature infants, and children with cancers undergoing chemotherapy. To investigate the protective effects of B. breve (M-16V) as a probiotic on necrotizing enterocolitis (NEC) and infection in premature infants, we carried out a clinical study in 338 very low birth weight infants over a five-year period. These patients were supplemented with B. breve starting several hours after birth (Bifido group). 226 premature infants served as controls. Infants of the Bifido group were administered B. breve in a daily dose of 1Ã109 cells/day. The incidence of NEC was significantly reduced in the Bifido group (nil) compared with that in controls (6 cases, P<0.01). Infection also decreased significantly. Thus, administration of B. breve as a probiotic looks to be a very effective treatment for preventing NEC and infection in preterm infants. Mucositis, also referred to as mucosal barrier injury, is one of the most debilitating side effects of chemotherapy treatment. To evaluate the effects of the administration of B. breve (BBG-01, another strain than that used in the study of premature infants), a clinical study was performed to ascertain whether it attenuated intestinal mucositis in children with cancers on chemotherapy. A placebo-controlled trial was performed in patients with malignancies admitted for chemotherapy (n=42), who were randomised into two groups receiving probiotic or placebo. The frequency of fever and the use of intravenous antibiotics were significantly lower in the Bifido group than the placebo group. The B. breve administration enhanced the colonisation of anaerobes. Disruption of the intestinal microbiota after chemotherapy, such as the increase in the population levels of Enterobacteriaceae, was more pronounced in the placebo group. In conclusion, these data suggest that administration of B. breve is an effective approach to attenuating chemotherapy-induced mucositis in children with cancers. The study results strongly suggest that B. breve administration as a probiotic is an effective therapy for the prevention of NEC and infection in premature infants, and also a promising treatment for attenuating chemotherapy-induced mucositis in children with cancers.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 485 | 180 | 18 |
| å ¨ææµè§æ¬¡æ° | 32 | 6 | 0 |
| PDFä¸è½½æ¬¡æ° | 27 | 5 | 0 |