Soon after birth, the human gastrointestinal tract quickly becomes colonised by a variety of bacterial species. Throughout life the gastrointestinal tract continues to serve as host to a complex society of nonpathological bacteria. Microorganisms, such as probiotics, have the potential to modulate mucosal immune response and reduce gastrointestinal inflammation caused by a variety of infectious and allergic events. The most widely studied genera of probiotics are lactobacilli and bifidobacteria. Lactobacillus rhamnosis strain ATC53103 (LGG) can replenish gut flora during infectious diarrhoeal episodes. This beneficial effect is carried over to traveller's diarrhoea and children experiencing antibiotic-associated diarrhoea. Furthermore, LGG can reduce the risk of respiratory tract infections in children attending daycares and hospitals. With allergic disease on the rise, probiotics have the potential to positively impact atopic dermatitis, asthma, and allergic rhinitis. LGG has been shown to decrease the severity and delay the onset of atopic dermatitis. Additionally, LGG is beneficial in the treatment of allergic colitis and necrotising entercolitis. Some strains of probiotics appear to be useful in the treatment and/or prevention of allergic disease, however, caution must be used when generalising the effectiveness of a specific strain of organism to other organisms and other disease states.
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Alfaleh, K. and Bassler, D., 2008. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database of Systematic Reviews 2008 (1): CD005496.
Baldassarre, M., Laforgia, N., Fanelli, M., Laneve, A., Grosso, R. and Lifschitz, C., 2010. Lactobacillus GG improves recovery in infants with blood in the stools and presumptive allergic colitis compared with extensively hydrolyzed formula alone. Journal of Pediatrics 156: 397-401.
'Lactobacillus GG improves recovery in infants with blood in the stools and presumptive allergic colitis compared with extensively hydrolyzed formula alone ' () 156 Journal of Pediatrics : 397 -401.
Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M. and Hammerman, C., 2005. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. Journal of Pediatrics 147: 192-196.
'Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates ' () 147 Journal of Pediatrics : 192 -196.
Boirivant, M. and Strober, W. 2007. The mechanism of action of probiotics. Current Opinion in Gastroenterology 23: 679-692.
'The mechanism of action of probiotics ' () 23 Current Opinion in Gastroenterology : 679 -692.
Bousvaros, A., Guandalini, S., Baldassano, R., Botelho, C., Evans, J., Ferry, G., Goldin, B., Hartigan, L., Kugathasan, S., Levy, J., Murray, K., Oliva-Hemker, M., Rosh, J., Tolia, V., Zholudev, A., Vanderhoof, J. and Hibberd, P., 2005. A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease. Inflammatory Bowel Diseases 11: 833-839.
'A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease ' () 11 Inflammatory Bowel Diseases : 833 -839.
Cary, V.A. and Boullata, J., 2010. What is the evidence for the use of probiotics in the treatment of inflammatory bowel disease? Journal of Clinical Nursing 19: 904-916.
'What is the evidence for the use of probiotics in the treatment of inflammatory bowel disease ' () 19 Journal of Clinical Nursing : 904 -916.
Costa-Ribeiro, H., Ribeiro, T., Mattos, A., Valois, S., Neri, D., Almeida, P., Cerqueira, C., Ramos, E., Young, R. and Vanderhoof, J., 2003. Limitations of probiotic therapy in acute, severe dehydrating diarrhea. Journal of Pediatric Gastroenterology and Nutrition 36: 112-115.
'Limitations of probiotic therapy in acute, severe dehydrating diarrhea ' () 36 Journal of Pediatric Gastroenterology and Nutrition : 112 -115.
Cox, M.J., Huang, Y.J., Fujimura, K.E., Liu, J.E., McKean, M., Boushey, H.A., Segal, M.R., Brodie, E.L., Cabana, M.D. and Lynch, S.V., 2010. Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome. PloS ONE 5: e8745.
Dobrogosz, W.J., Peacock, T.J. and Hassan, H.M., 2010. Evolution of the probiotic concept from conception to validation and acceptance in medical science. Advances in Applied Microbiology 72: 1-41.
'Evolution of the probiotic concept from conception to validation and acceptance in medical science ' () 72 Advances in Applied Microbiology : 1 -41.
Fuller, R., 1991. Probiotics in human medicine. Gut 32: 439-442.
'Probiotics in human medicine ' () 32 Gut : 439 -442.
Grüber, C., Wendt, M., Sulser, C., Lau, S., Kulig, M., Wahn, U., Werfel, T. and Niggemann, B., 2007. Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy. Allergy 62: 1270-1276.
'Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy ' () 62 Allergy : 1270 -1276.
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J.H., Poussa, T., Näse, L., Saxelin, M. and Korpela, R., 2001. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322: 1327-1331.
'Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial ' () 322 BMJ : 1327 -1331.
Helin, T., Haahtela, S. and Haahtela, T., 2002. No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATTCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study. Allergy 57: 243-246.
'No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATTCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study ' () 57 Allergy : 243 -246.
Hilton, E., Kolakowski, P., Singer, C. and Smith, M., 1997. Efficacy of Lactobacillus GG as a diarrheal preventive in travelers. Journal of Travel Medicine 4: 41-43.
'Efficacy of Lactobacillus GG as a diarrheal preventive in travelers ' () 4 Journal of Travel Medicine : 41 -43.
Hojsak, I., Abdović, S., Szajewska, H., Milošecić, M., Krznarić, Ž. and Kolaćek, S., 2010a. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics 125: e1171-e1177.
'Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections ' () 125 Pediatrics : e1171 -e1177.
Hojsak, I., Snovak, N., Abdović, S., Szajewska, H., Mišak, Z. and Kolaček, S., 2010b. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition 29: 312-316.
'Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial ' () 29 Clinical Nutrition : 312 -316.
Horii, K., Simon, S., Liu, D. and Sharma, V., 2007. Atopic dermatitis in children in the United States, 1997-2004: visit trends, patient and provider characteristics, and prescribing patterns. Pediatrics 120: e527-e534.
'Atopic dermatitis in children in the United States, 1997-2004: visit trends, patient and provider characteristics, and prescribing patterns ' () 120 Pediatrics : e527 -e534.
Hörmannsperger, G. and Haller, D., 2010. Molecular crosstalk of probiotic bacteria with the intestinal immune system: clinical relevance in the context of inflammatory bowel disease. International Journal of Medical Microbiology 300: 63-73.
International Study of Asthma and Allergies in Childhood Steering Committee (ISAAC), 1998. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczems: ISAAC. The Lancet 351: 1225-1232.
Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P. and Koivula, T., 1991. A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children. Pediatrics 88: 90-97.
'A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children ' () 88 Pediatrics : 90 -97.
Isolauri, E., Arvola, T., Sütas, Y., Moilanen, E. and Salminen, S., 2000. Probiotics in the management of atopic eczema. Clinical and Experimental Allergy 30: 1604-1610.
'Probiotics in the management of atopic eczema ' () 30 Clinical and Experimental Allergy : 1604 -1610.
Jung, L., 1999. Lactobacillus GG augments the immune response to typhoid vaccination: a double-blind, placebo-controlled study. FASEB Journal 13: A872.
'Lactobacillus GG augments the immune response to typhoid vaccination: a double-blind, placebo-controlled study ' () 13 FASEB Journal : A872.
Kaila, M., Isolauri, E., Soppi, E, Virtanen, E., Laine, S. and Arvilommi, H., 1992. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatric Research 32: 141-144.
'Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain ' () 32 Pediatric Research : 141 -144.
Kalliomäki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P. and Isolauri, E., 2001. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. The Lancet 357: 1076-1079.
'Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial ' () 357 The Lancet : 1076 -1079.
Krämer, U., Heinrich, J., Wjst, M. and Wichmann, H., 1999. Age of entry to day nursery and allergy in later childhood. The Lancet 353: 450-454.
'Age of entry to day nursery and allergy in later childhood ' () 353 The Lancet : 450 -454.
Kukkonen, K., Savilahti, E., Haahtela, T., Juntunen-Backman, K., Korpela, R., Poussa, T., Tuure, T. and Kuitunen, M., 2007. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. Journal of Allergy and Clinical Immunology 119: 192-198.
'Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial ' () 119 Journal of Allergy and Clinical Immunology : 192 -198.
Lee, J., Seto, D. and Bielory, L., 2008. Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. Journal of Allergy and Clinical Immunology 121: 116-121.
'Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis ' () 121 Journal of Allergy and Clinical Immunology : 116 -121.
Lin, H., Hsu, C.-H., Chen, H.-L., Chung, M.-Y., Hsu, J.-F., Lien, R.-I., Tsao, L.-Y., Chen, C.-H. and Su, B.-H., 2008. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics 122: 693-700.
'Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial ' () 122 Pediatrics : 693 -700.
Loftus, E.V., 2004. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126: 1504-1517.
'Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences ' () 126 Gastroenterology : 1504 -1517.
Mack, D., Michail, S., Wei, S., McDougall, L. and Hollingsworth, M., 1999. Probiotics inhibit enteropathogenic E. coli adherance in vitro by inducing intestinal mucin gene expression. American Journal of Physiology – Gastrointestinal and Liver Physiology 276: 941-950.
'Probiotics inhibit enteropathogenic E. coli adherance in vitro by inducing intestinal mucin gene expression ' () 276 American Journal of Physiology – Gastrointestinal and Liver Physiology : 941 -950.
Mack, D., Ahrne, S., Hyde, L., Wei, S. and Hollingsworth, M., 2003. Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut 52: 827-833.
'Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro ' () 52 Gut : 827 -833.
Majamaa, H. and Isolauri, E., 1997. Probiotics: a novel approach in the management of food allergy. Journal of Allergy and Clinical Immunology 99: 179-185.
'Probiotics: a novel approach in the management of food allergy ' () 99 Journal of Allergy and Clinical Immunology : 179 -185.
Mannino, D., Homa, D., Akinbami, L., Moorman, J., Gwynn, C. and Redd, S., 2002. Surveillance for asthma – United States, 1980-1999. MMWR Surveillance Summaries 51: 1-13.
'Surveillance for asthma – United States, 1980-1999 ' () 51 MMWR Surveillance Summaries : 1 -13.
Mattar, A., Teitelbaum, D., Drongowski, R., Yongyi, F., Harmon, C. and Coran, A., 2002. Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model. Pediatric Surgery International 18: 586-590.
'Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model ' () 18 Pediatric Surgery International : 586 -590.
Montgomery, S., Wakefield, A., Morris, D., Pounder, R. and Murch, S., 2000. The initial care of newborn infants and subsequent hay fever. Allergy 55: 916-922.
'The initial care of newborn infants and subsequent hay fever ' () 55 Allergy : 916 -922.
Ohland, C.L. and MacNaughton, W.K., 2010. Probiotic bacteria and intestinal epithelial barrier function. American Journal of Physiology – Gastrointestinal and Liver Physiology 298: G807-G819.
'Probiotic bacteria and intestinal epithelial barrier function ' () 298 American Journal of Physiology – Gastrointestinal and Liver Physiology : G807 -G819.
Pagnini, C., Saeed, R., Bamias, G., Arseneau, K.O., Pizarro, T.T. and Cominelli, F. 2010. Probiotics promote gut health through stimulation of epithelial innate immunity. Proceedings of the National Academy of Sciences of the USA 107: 454-459.
'Probiotics promote gut health through stimulation of epithelial innate immunity ' () 107 Proceedings of the National Academy of Sciences of the USA : 454 -459.
Pohjavuori, E., Viljanen, M., Korpela, R., Kuitunen, M., Tiittanen, M., Vaarala, O. and Savilahti, E., 2004. Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy. Journal of Allergy and Clinical Immunology 114: 131-136.
'Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy ' () 114 Journal of Allergy and Clinical Immunology : 131 -136.
Polz, M. and Jabloński, L., 1986. Nosocomial infection in children's hospital: a retrospective study. Journal of Hygiene, Epidemiology, Microbiology and Immunology 30: 149-153.
'Nosocomial infection in children's hospital: a retrospective study ' () 30 Journal of Hygiene, Epidemiology, Microbiology and Immunology : 149 -153.
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R., 2004. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229-241.
'Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis ' () 118 Cell : 229 -241.
Rautava, S., Kalliomäki, M. and Isolauri, E., 2002. Probiotics during pregnancy and breastfeeding might confer immunomodulatory protection against atopic disease in the infant. Journal of Allergy and Clinical Immunology 109: 119-121.
'Probiotics during pregnancy and breastfeeding might confer immunomodulatory protection against atopic disease in the infant ' () 109 Journal of Allergy and Clinical Immunology : 119 -121.
Rautava, S., Ruuskanen, O., Ouwehand, A., Salminen, S. and Isolauri, E., 2004. The hygiene hypothesis of atopic disease: an extended version. Journal of Pediatric Gastroenterology and Nutrition 38: 378-388.
'The hygiene hypothesis of atopic disease: an extended version ' () 38 Journal of Pediatric Gastroenterology and Nutrition : 378 -388.
Romagnani, S., 1994. Regulation of the development of type 2 T-helper cells in allergy. Current Opinion in Immunology 6: 838-846.
'Regulation of the development of type 2 T-helper cells in allergy ' () 6 Current Opinion in Immunology : 838 -846.
Rosenfeldt, V., Benfeldt, E., Valerius, N., Paerregaard, A. and Michaelsen, K., 2004. Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. Journal of Pediatrics 145: 612-616.
'Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis ' () 145 Journal of Pediatrics : 612 -616.
Saavedra, J., Bauman, N., Oung, I., Perman, J. and Yolken, R., 1994. Feeding Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. The Lancet 344: 1046-1049.
'Feeding Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus ' () 344 The Lancet : 1046 -1049.
Schultz, M., Göttl, C., Young, R., Iwen, P. and Vanderhoof, J., 2004. Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization. Journal of Pediatric Gastroenterology and Nutrition 38: 293-297.
'Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization ' () 38 Journal of Pediatric Gastroenterology and Nutrition : 293 -297.
Sly, R., 1999. Changing prevalence of allergic rhinitis and asthma. Annals of Allergy, Asthma and Immunology 82: 233-248; quiz 248-252.
Vanderhoof, J., Whitney, D., Antonson, D., Hanner, T., Lupo, J. and Young, R., 1999. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. Journal of Pediatrics 135: 564-568.
'Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children ' () 135 Journal of Pediatrics : 564 -568.
Walker-Smith, J. and Murch, S. (eds.), 1999. Diseases of the small intestine in childhood. Isis Medical Media, Oxford, UK.
Diseases of the small intestine in childhood
Welliver, R. and McLaughin, S., 1984. Unique epidemiology of nosocomial infection in children's hospital. American Journal of Diseases of Children 138: 131-135.
'Unique epidemiology of nosocomial infection in children's hospital ' () 138 American Journal of Diseases of Children : 131 -135.
Weston, S., Halbert, A., Richmond, P. and Prescott, S., 2005. Effects of probiotics on atopic dermatitis: a randomized controlled trial. Archives of Disease in Childhood 90: 892-897.
'Effects of probiotics on atopic dermatitis: a randomized controlled trial ' () 90 Archives of Disease in Childhood : 892 -897.
Wold, A., 1998. The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora? Allergy 53: S20-S25.
'The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora ' () 53 Allergy : S20 -S25.
Wolvers, D., Antoine, J.-M., Myllyluoma, E., Schrezenmeir, J., Szajewska, H. and Rijkers, G.T., 2010. Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics. Journal of Nutrition 140: 698S-712S.
'Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics ' () 140 Journal of Nutrition : 698S -712S.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 574 | 121 | 6 |
| Full Text Views | 21 | 0 | 0 |
| PDF Views & Downloads | 27 | 0 | 0 |
Soon after birth, the human gastrointestinal tract quickly becomes colonised by a variety of bacterial species. Throughout life the gastrointestinal tract continues to serve as host to a complex society of nonpathological bacteria. Microorganisms, such as probiotics, have the potential to modulate mucosal immune response and reduce gastrointestinal inflammation caused by a variety of infectious and allergic events. The most widely studied genera of probiotics are lactobacilli and bifidobacteria. Lactobacillus rhamnosis strain ATC53103 (LGG) can replenish gut flora during infectious diarrhoeal episodes. This beneficial effect is carried over to traveller's diarrhoea and children experiencing antibiotic-associated diarrhoea. Furthermore, LGG can reduce the risk of respiratory tract infections in children attending daycares and hospitals. With allergic disease on the rise, probiotics have the potential to positively impact atopic dermatitis, asthma, and allergic rhinitis. LGG has been shown to decrease the severity and delay the onset of atopic dermatitis. Additionally, LGG is beneficial in the treatment of allergic colitis and necrotising entercolitis. Some strains of probiotics appear to be useful in the treatment and/or prevention of allergic disease, however, caution must be used when generalising the effectiveness of a specific strain of organism to other organisms and other disease states.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 574 | 121 | 6 |
| Full Text Views | 21 | 0 | 0 |
| PDF Views & Downloads | 27 | 0 | 0 |