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Homeostatic impact of indigenous microbiota and secretory immunity
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In the process of evolution, the mucosal immune system has generated two layers of anti-inflammatory defence: (1) immune exclusion performed by secretory IgA (and secretory IgM) antibodies to modulate or inhibit surface colonisation of microorganisms and dampen penetration of potentially dangerous antigens; and (2) suppressive mechanisms to avoid local and peripheral hypersensitivity to innocuous antigens, particularly food proteins and components of commensal bacteria. When induced via the gut, the latter phenomenon is called 'oral tolerance', which mainly depends on the development of regulatory T (Treg) cells in mesenteric lymph nodes to which mucosal dendritic cells (DCs) carry exogenous antigens and become conditioned for induction of Treg cells. Mucosally induced tolerance appears to be a rather robust adaptive immune function in view of the fact that large amounts of food proteins pass through the gut, while overt and persistent food allergy is not so common. DCs are 'decision makers' in the immune system when they perform their antigen-presenting function, thus linking innate and adaptive immunity by sensing the exogenous mucosal impact (e.g. conserved microbial molecular patterns). A balanced indigenous microbiota is required to drive the normal development of both mucosa-associated lymphoid tissue, the epithelial barrier with its secretory IgA (and IgM) system, and mucosally induced tolerance mechanisms including the generation of Treg cells. Notably, polymeric Ig receptor (pIgR/SC) knock-out mice that lack secretory IgA and IgM antibodies show reduced epithelial barrier function and increased uptake of antigens from food and commensal bacteria. They therefore have a hyper-reactive immune system and show predisposition for systemic anaphylaxis after sensitisation; but this development is counteracted by enhanced oral tolerance induction as a homeostatic back-up mechanism.
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-
Abreu, M.T., Palladino, A.A., Arnold, E.T., Kwon, R.S. and McRoberts, J.A., 2000. Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells. Gastroenterology 119: 1524-1536.
'Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells ' () 119 Gastroenterology : 1524 -1536 .
-
Akbar, A.N., Vukmanovic-Stejic, M., Taams, L.S. and Macallan, D.C., 2007. The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nature Reviews Immunology 7: 231-237.
'The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery ' () 7 Nature Reviews Immunology : 231 -237 .
-
Alford, S.H., Zoratti, E., Peterson, E.L., Maliarik, M., Ownby, D.R. and Johnson, C.C., 2004. Parental history of atopic disease: disease pattern and risk of pediatric atopy in offspring. The Journal of Allergy and Clinical Immunology 114: 1046-1050.
'Parental history of atopic disease: disease pattern and risk of pediatric atopy in offspring ' () 114 The Journal of Allergy and Clinical Immunology : 1046 -1050 .
-
Artis, D., 2008. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nature Reviews Immunology 8: 411-420.
'Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut ' () 8 Nature Reviews Immunology : 411 -420 .
-
Barnes, M.J. and Powrie, F., 2009. Regulatory T cells reinforce intestinal homeostasis. Immunity 31: 401-411.
'Regulatory T cells reinforce intestinal homeostasis ' () 31 Immunity : 401 -411 .
-
Belkaid, Y. and Oldenhove, G., 2008. Tuning microenvironments: induction of regulatory T cells by dendritic cells. Immunity 29: 362-371.
'Tuning microenvironments: induction of regulatory T cells by dendritic cells ' () 29 Immunity : 362 -371 .
-
Bird, J.A. and Burks, A.W., 2009. Food allergy and asthma. Primary Care Respiratory Journal 18: 258-265.
'Food allergy and asthma ' () 18 Primary Care Respiratory Journal : 258 -265 .
-
Björkstén, B., 2009. The hygiene hypothesis: do we still believe in it? In: Brandtzaeg, P., Isolauri, E. and Prescott, S.L. (eds.) Microbial-host interaction: tolerance versus allergy. S. Karger AG, Basel, Switzerland, pp. 11-22.
-
Björkstén, B., Naaber, P., Sepp, E. and Mikelsaar, M., 1999. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clinical and Experimental Allergy 29: 342-346.
'The intestinal microflora in allergic Estonian and Swedish 2-year-old children ' () 29 Clinical and Experimental Allergy : 342 -346 .
-
Blümer, N., Herz, U., Wegmann, M. and Renz, H., 2005. Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma. Clinical and Experimental Allergy 35: 397-402.
'Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma ' () 35 Clinical and Experimental Allergy : 397 -402 .
-
Boirivant, M., Amendola, A., Butera, A., Sanchez, M., Xu, L., Marinaro, M., Kitani, A., Di Giacinto, C., Strober, W. and Fuss, I.J. , 2008. A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis. Gastroenterology 135: 1612-1623.e5.
-
Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., Greter, M., Liu, K., Jakubzick, C., Ingersoll, M.A., Leboeuf, M., Stanley, E.R., Nussenzweig, M., Lira, S.A., Randolph, G.J. and Merad, M., 2009. Origin of the lamina propria dendritic cell network. Immunity 31: 513-525.
'Origin of the lamina propria dendritic cell network ' () 31 Immunity : 513 -525 .
-
Brandtzaeg, P., 1996. History of oral tolerance and mucosal immunity. Annals of the New York Academy of Sciences 778: 1-27.
'History of oral tolerance and mucosal immunity ' () 778 Annals of the New York Academy of Sciences : 1 -27 .
-
Brandtzaeg, P., 1997. Mechanisms of gastrointestinal reactions to food. Environmental Toxicology and Pharmacology 4: 9-24.
'Mechanisms of gastrointestinal reactions to food ' () 4 Environmental Toxicology and Pharmacology : 9 -24 .
-
Brandtzaeg, P., 1998. Development and basic mechanisms of human gut immunity. Nutrition Reviews 56: S5-S18.
'Development and basic mechanisms of human gut immunity ' () 56 Nutrition Reviews : S5 -S18 .
-
Brandtzaeg, P., 2002. Role of local immunity and breast-feeding in mucosal homeostasis and defence against infections. In: Calder, P.C., Field, C.J. and Gill, H.S. (eds.) Nutrition and immune function. Frontiers in nutritional science, no. 1. CABI Publishing, Wallingford, UK, pp. 273-320.
-
Brandtzaeg, P., 2004. Impact of immunodeficiency on immunological homeostasis in the gut. In: Lukáš, M., Manns, M.P., Špičák, J. and Stange, E.F. (eds.) Falk symposium 135 – Immunological diseases of liver and gut. Kluwer Academic Publishers, Dordrecht, the Netherlands, pp. 180-209.
-
Brandtzaeg, P., 2009a. 'ABC' of mucosal immunology. In: Brandtzaeg, P., Isolauri, E. and Prescott, S.L. (eds.) Microbial-host interaction: tolerance versus allergy. S. Karger AG, Basel, Switzerland, pp. 23-43.
-
Brandtzaeg, P., 2009b. Mucosal immunity: induction, dissemination, and effector functions. Scandinavian Journal of Immunology 70: 505-515.
'Mucosal immunity: induction, dissemination, and effector functions ' () 70 Scandinavian Journal of Immunology : 505 -515 .
-
Brandtzaeg, P., 2010a. Functions of mucosa-associated lymphoid tissue in antibody formation. Immunological Investigations 39: 303-355.
'Functions of mucosa-associated lymphoid tissue in antibody formation ' () 39 Immunological Investigations : 303 -355 .
-
Brandtzaeg, P., 2010b. The mucosal immune system and its integration of the mammary glands. Journal of Pediatrics 156 Suppl. 1: S8-S15.
'The mucosal immune system and its integration of the mammary glands ' () 156 Journal of Pediatrics : S8 -S15 .
-
Brandtzaeg, P. and Johansen, F.-E., 2005. Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunological Reviews 206: 32-63.
'Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties ' () 206 Immunological Reviews : 32 -63 .
-
Brandtzaeg, P. and Prydz, H., 1984. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immuno-globulin. Nature 311: 71-73.
'Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immuno-globulin ' () 311 Nature : 71 -73 .
-
Brandtzaeg, P., Nilssen, D.E., Rognum, T.O. and Thrane, P.S., 1991. Ontogeny of the mucosal immune system and IgA deficiency. Gastroenterology Clinics of North America 20: 397-439.
'Ontogeny of the mucosal immune system and IgA deficiency ' () 20 Gastroenterology Clinics of North America : 397 -439 .
-
Broere, F., Du Pré, M.F., Van Berkel, L.A., Garssen, J., Schmidt-Weber, C.B., Lambrecht, B.N., Hendriks, R.W., Nieuwenhuis, E.E., Kraal, G. and Samsom, J.N., 2009. Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4. Mucosal Immunology 2: 254-264.
'Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4 ' () 2 Mucosal Immunology : 254 -264 .
-
Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M. and Demengeot, J., 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. Journal of Experimental Medicine 197: 403-411.
'Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide ' () 197 Journal of Experimental Medicine : 403 -411 .
-
Cianferoni, A. and Spergel, J.M., 2009. Food allergy: review, classification and diagnosis. Allergology International 58: 457-466.
'Food allergy: review, classification and diagnosis ' () 58 Allergology International : 457 -466 .
-
Conrad, M.L., Ferstl, R., Teich, R., Brand, S., Blümer, N., Yildirim, A.O., Patrascan, C.C., Hanuszkiewicz, A., Akira, S., Wagner, H., Holst, O., Von Mutius, E., Pfefferle, P.I., Kirschning, C.J., Garn, H. and Renz, H. , 2009. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. Journal of Experimental Medicine 206: 2869-2877.
'Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78 ' () 206 Journal of Experimental Medicine : 2869 -2877 .
-
Corthésy, B., 2007. Roundtrip ticket for secretory IgA: role in mucosal homeostasis? Journal of Immunology 178: 27-32.
'Roundtrip ticket for secretory IgA: role in mucosal homeostasis ' () 178 Journal of Immunology : 27 -32 .
-
Crabbé, P.A., Nash, D.R., Bazin, H., Eyssen, H. and Heremans, J.F. , 1970. Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice. Laboratory Investigations 22: 448-457.
'Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice ' () 22 Laboratory Investigations : 448 -457 .
-
Cupedo, T., Nagasawa, M., Weijer, K., Blom, B. and Spits, H. , 2005. Development and activation of regulatory T cells in the human fetus. European Journal of Immunology 35: 383-390.
'Development and activation of regulatory T cells in the human fetus ' () 35 European Journal of Immunology : 383 -390 .
-
Darrasse-Jèze, G., Marodon, G., Salomon, B.L., Catala, M. and Klatzmann, D., 2005. Ontogeny of CD4+CD25+ regulatory/ suppressor T cells in human fetuses. Blood 105: 4715-4721.
'Ontogeny of CD4+CD25+ regulatory/ suppressor T cells in human fetuses ' () 105 Blood : 4715 -4721 .
-
Denning, T.L., Wang, Y.C., Patel, S.R., Williams, I.R. and Pulendran, B. , 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nature Immunology 8: 1086-1094.
'Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses ' () 8 Nature Immunology : 1086 -1094 .
-
Duchmann, R., Neurath, M., Marker-Hermann, E. and Meyer Zum Buschenfelde, K.H., 1997. Immune responses towards intestinal bacteria – current concepts and future perspectives. Zeitschrift für Gastroenterologie 35: 337-346.
'Immune responses towards intestinal bacteria – current concepts and future perspectives ' () 35 Zeitschrift für Gastroenterologie : 337 -346 .
-
Duerkop, B.A., Vaishnava, S. and Hooper, L.V., 2009. Immune responses to the microbiota at the intestinal mucosal surface. Immunity 31: 368-376.
'Immune responses to the microbiota at the intestinal mucosal surface ' () 31 Immunity : 368 -376 .
-
Eder, W. and Von Mutius, E., 2005. Genetics in asthma: the solution to a lasting conundrum? Allergy 60: 1482-1484.
'Genetics in asthma: the solution to a lasting conundrum ' () 60 Allergy : 1482 -1484 .
-
Eggesbø, M., Botten, G., Stigum, H., Nafstad, P. and Magnus, P., 2003. Is delivery by cesarean section a risk factor for food allergy? The Journal of Allergy and Clinical Immunology 112: 420-426.
'Is delivery by cesarean section a risk factor for food allergy ' () 112 The Journal of Allergy and Clinical Immunology : 420 -426 .
-
Fallon, P.G. and Mangan, N.E., 2007. Suppression of TH2-type allergic reactions by helminth infection. Nature Reviews Immunology 7: 220-230.
'Suppression of TH2-type allergic reactions by helminth infection ' () 7 Nature Reviews Immunology : 220 -230 .
-
Frossard, C.P., Hauser, C. and Eigenmann, P.A., 2004. Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy. The Journal of Allergy and Clinical Immunology 114: 377-382.
'Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy ' () 114 The Journal of Allergy and Clinical Immunology : 377 -382 .
-
Gerhold, K., Avagyan, A., Seib, C., Frei, R., Steinle, J., Ahrens, B., Dittrich, A.M., Blumchen, K., Lauener, R. and Hamelmann, E. , 2006. Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice. The Journal of Allergy and Clinical Immunology 118: 666-673.
'Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice ' () 118 The Journal of Allergy and Clinical Immunology : 666 -673 .
-
Grindebacke, H., Stenstad, H., Quiding-Järbrink, M., Waldenström, J., Adlerberth, I., Wold, A.E. and Rudin, A., 2009. Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T cells. Journal of Immunology 183: 4360-4370.
'Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T cells ' () 183 Journal of Immunology : 4360 -4370 .
-
Groschwitz, K.R. and Hogan, S.P., 2009. Intestinal barrier function: molecular regulation and disease pathogenesis. The Journal of Allergy and Clinical Immunology 124: 3-22.
'Intestinal barrier function: molecular regulation and disease pathogenesis ' () 124 The Journal of Allergy and Clinical Immunology : 3 -22 .
-
Guarner, F., Bourdet-Sicard, R., Brandtzaeg, P., Gill, H.S., McGuirk, P., Van Eden, W., Versalovic, J., Weinstock, J.V. and Rook, G.A., 2006. Mechanisms of disease: the hygiene hypothesis revisited. Nature Clinical Practice Gastroenterology and Hepatology 3: 275-284.
'Mechanisms of disease: the hygiene hypothesis revisited ' () 3 Nature Clinical Practice Gastroenterology and Hepatology : 275 -284 .
-
Haddeland, U., Karstensen, A.B., Farkas, L., Bø, K.O., Pirhonen, J., Karlsson, M., Kvåvik, W., Brandtzaeg, P. and Nakstad, B., 2005. Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk. Pediatric Allergy and Immunology 16: 104-112.
'Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk ' () 16 Pediatric Allergy and Immunology : 104 -112 .
-
Hammerschmidt, S.I., Ahrendt, M., Bode, U., Wahl, B., Kremmer, E., Förster, R. and Pabst, O., 2008. Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. Journal of Experimental Medicine 205: 2483-2490.
'Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo ' () 205 Journal of Experimental Medicine : 2483 -2490 .
-
Hanson, L.A., 2007. Feeding and infant development breast-feeding and immune function. The Proceedings of the Nutrition Society 66: 384-396.
'Feeding and infant development breast-feeding and immune function ' () 66 The Proceedings of the Nutrition Society : 384 -396 .
-
Helgeland, L. and Brandtzaeg, P., 2000. Development and function of intestinal B and T cells. Microbial Ecology in Health and Disease 2 Suppl. 2: 110-127.
'Development and function of intestinal B and T cells ' () 2 Microbial Ecology in Health and Disease : 110 -127 .
-
Herz, U., Lacy, P., Renz, H. and Erb, K., 2000. The influence of infections on the development and severity of allergic disorders. Current Opinion in Immunology 12: 632-640.
'The influence of infections on the development and severity of allergic disorders ' () 12 Current Opinion in Immunology : 632 -640 .
-
Hessle, C., Andersson, B. and Wold, A.E., 2000a. Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production. Infection and Immunity 68: 3581-3586.
'Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production ' () 68 Infection and Immunity : 3581 -3586 .
-
Hessle, C., Hanson, L.A. and Wold, A.E., 1999. Lactobacilli from human gastrointestinal mucosa are strong stimulators of IL-12 production. Clinical and Experimental Immunology 116: 276-282.
'Lactobacilli from human gastrointestinal mucosa are strong stimulators of IL-12 production ' () 116 Clinical and Experimental Immunology : 276 -282 .
-
Hessle, C., Hanson, L.A. and Wold, A.E., 2000b. Interleukin-10 produced by the innate immune system masks in vitro evidence of acquired T-cell immunity to E. coli. Scandinavian Journal of Immunology 52: 13-20.
'Interleukin-10 produced by the innate immune system masks in vitro evidence of acquired T-cell immunity to E. coli. ' () 52 Scandinavian Journal of Immunology : 13 -20 .
-
Holt, P.G., 2000. Parasites, atopy, and the hygiene hypothesis: resolution of a paradox? The Lancet 356: 1699-1701.
'Parasites, atopy, and the hygiene hypothesis: resolution of a paradox ' () 356 The Lancet : 1699 -1701 .
-
Holt, P.G. and Jones, C.A., 2000. The development of the immune system during pregnancy and early life. Allergy 55: 688-697.
'The development of the immune system during pregnancy and early life ' () 55 Allergy : 688 -697 .
-
Holt, P.G. and Thomas, W.R., 2005. Sensitization to airborne environmental allergens: unresolved issues. Nature Immunology 6: 957-960.
'Sensitization to airborne environmental allergens: unresolved issues ' () 6 Nature Immunology : 957 -960 .
-
Honda, K. and Takeda, K., 2009. Regulatory mechanisms of immune responses to intestinal bacteria. Mucosal Immunology 2: 187-196.
'Regulatory mechanisms of immune responses to intestinal bacteria ' () 2 Mucosal Immunology : 187 -196 .
-
Hong, X., Tsai, H.J. and Wang, X., 2009. Genetics of food allergy. Current Opinion in Pediatrics 21: 770-776.
'Genetics of food allergy ' () 21 Current Opinion in Pediatrics : 770 -776 .
-
Hooper, L.V., Wong, M.H., Thelin, A., Hansson, L., Falk, P.G. and Gordon, J.I., 2001. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291: 881-884.
'Molecular analysis of commensal host-microbial relationships in the intestine ' () 291 Science : 881 -884 .
-
Horwitz, D.A., Zheng, S.G. and Gray, J.D., 2008. Natural and TGF-β-induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other. Trends in Immunology 29: 429-435.
'Natural and TGF-β-induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other ' () 29 Trends in Immunology : 429 -435 .
-
Høst, A., Halken, S., Muraro, A., Dreborg, S., Niggemann, B., Aalberse, R., Arshad, S.H., Von Berg, A., Carlsen, K.H., Duschén, K., Eigenmann, P.A., Hill, D., Jones, C., Mellon, M., Oldeus, G., Oranje, A., Pascual, C., Prescott, S., Sampson, H., Svartengren, M., Wahn, U., Warner, J.A., Warner, J.O., Vandenplas, Y., Wickman, M. and Zeiger, R.S., 2008. Dietary prevention of allergic diseases in infants and small children. Pediatric Allergy and Immunology 19: 1-4.
'Dietary prevention of allergic diseases in infants and small children ' () 19 Pediatric Allergy and Immunology : 1 -4 .
-
Huehn, J., Polansky, J.K. and Hamann, A., 2009. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nature Reviews Immunology 9: 83-89.
'Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage ' () 9 Nature Reviews Immunology : 83 -89 .
-
Husby, S., Mestecky, J., Moldoveanu, Z., Holland, S. and Elson, C.O., 1994. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. Journal of Immunology 152: 4663-4670.
'Oral tolerance in humans ' () 152 T cell but not B cell tolerance after antigen feeding. Journal of Immunology : 4663 -4670 .
-
Iliev, I.D., Spadoni, I., Mileti, E., Matteoli, G., Sonzogni, A., Sampietro, G.M., Foschi, D., Caprioli, F., Viale, G. and Rescigno, M., 2009. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 58: 1481-1489.
'Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells ' () 58 Gut : 1481 -1489 .
-
Isolauri, E., Grönlund, M.M., Salminen, S. and Arvilommi, H., 2000. Why don't we bud? Journal of Pediatric Gastroenterology and Nutrition 30: 214-216.
'Why don't we bud ' () 30 Journal of Pediatric Gastroenterology and Nutrition : 214 -216 .
-
Janzi, M., Kull, I., Sjöberg, R., Wan, J., Melén, E., Bayat, N., Ostblom, E., Pan-Hammarström, Q., Nilsson, P. and Hammarström, L., 2009. Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clinical Immunology 133: 78-85.
'Selective IgA deficiency in early life: association to infections and allergic diseases during childhood ' () 133 Clinical Immunology : 78 -85 .
-
Johansen, F.-E., Pekna, M., Norderhaug, I.N., Haneberg, B., Hietala, M.A., Krajci, P., Betsholtz, C. and Brandtzaeg, P., 1999. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. Journal of Experimental Medicine 190: 915-921.
'Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice ' () 190 Journal of Experimental Medicine : 915 -921 .
-
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S. and Isolauri, E., 2001. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. The Journal of Allergy and Clinical Immunology 107: 129-134.
'Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing ' () 107 The Journal of Allergy and Clinical Immunology : 129 -134 .
-
Karlsson, M.R., Rugtveit, J. and Brandtzaeg, P., 2004. Allergen-responsive CD+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. Journal of Experimental Medicine 199: 1679-1688.
'Allergen-responsive CD+CD25+ regulatory T cells in children who have outgrown cow's milk allergy ' () 199 Journal of Experimental Medicine : 1679 -1688 .
-
Karlsson, M.R., Johansen, F.E., Kahu, H., Macpherson, A. and Brandtzaeg, P., 2010. Hypersensitivity and oral tolerance in the absence of a secretory immune system. Allergy 65: 561-570.
'Hypersensitivity and oral tolerance in the absence of a secretory immune system ' () 65 Allergy : 561 -570 .
-
Konrad, A., Cong, Y., Duck, W., Borlaza, R. and Elson, C.O., 2006. Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota. Gastroenterology 130: 2050-2059.
'Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota ' () 130 Gastroenterology : 2050 -2059 .
-
Koplin, J., Allen, K., Gurrin, L., Osborne, N., Tang, M.L. and Dharmage, S., 2008. Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. Pediatric Allergy and Immunology 19: 682-687.
'Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review ' () 19 Pediatric Allergy and Immunology : 682 -687 .
-
Korenblat, P.E., Rothberg, R.M., Minden, P. and Farr, R.S., 1968. Immune responses of human adults after oral and parenteral exposure to bovine serum albumin. The Journal of Allergy 41: 226-235.
'Immune responses of human adults after oral and parenteral exposure to bovine serum albumin ' () 41 The Journal of Allergy : 226 -235 .
-
Kraus, T.A., Toy, L., Chan, L., Childs, J. and Mayer, L., 2004. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 126: 1771-1778.
'Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease ' () 126 Gastroenterology : 1771 -1778 .
-
Kraus, T.A., Brimnes, J., Muong, C., Liu, J.H., Moran, T.M., Tappenden, K.A., Boros, P. and Mayer, L., 2005. Induction of mucosal tolerance in Peyer's patch-deficient, ligated small bowel loops. The Journal of Clinical Investigation 115: 2234-2243.
'Induction of mucosal tolerance in Peyer's patch-deficient, ligated small bowel loops ' () 115 The Journal of Clinical Investigation : 2234 -2243 .
-
Kraus, T.A., Cheifetz, A., Toy, L., Meddings, J.B. and Mayer, L., 2006. Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease. Inflammatory Bowel Diseases 12: 82-88.
'Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease ' () 12 Inflammatory Bowel Diseases : 82 -88 .
-
Kuitunen, M., Kukkonen, K., Juntunen-Backman, K., Korpela, R., Poussa, T., Tuure, T., Haahtela, T. and Savilahti, E., 2009. Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort. The Journal of Allergy and Clinical Immunology 123: 335-341.
'Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort ' () 123 The Journal of Allergy and Clinical Immunology : 335 -341 .
-
Kukkonen, K., Kuitunen, M., Haahtela, T., Korpela, R., Poussa, T. and Savilahti, E., 2010. High intestinal IgA associates with reduced risk of IgE-associated allergic diseases. Pediatric Allergy and Immunology 21: 67-73.
'High intestinal IgA associates with reduced risk of IgE-associated allergic diseases ' () 21 Pediatric Allergy and Immunology : 67 -73 .
-
Latcham, F., Merino, F., Lang, A., Garvey, J., Thomson, M.A., Walker-Smith, J.A., Davies, S.E., Phillips, A.D. and Murch, S.H., 2003. A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy. The Journal of Pediatrics 143: 39-47.
'A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy ' () 143 The Journal of Pediatrics : 39 -47 .
-
Lavelle, E.C., Murphy, C., O'Neill, L.A. and Creagh, E.M., 2010. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunology 3: 17-28.
'The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis ' () 3 Mucosal Immunology : 17 -28 .
-
Lee, J., Mo, J.H., Katakura, K., Alkalay, I., Rucker, A.N., Liu, Y.T., Lee, H.K., Shen, C., Cojocaru, G., Shenouda, S., Kagnoff, M., Eckmann, L., Ben-Neriah, Y. and Raz, E., 2006. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nature Cell Biology 8: 1327-1336.
'Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells ' () 8 Nature Cell Biology : 1327 -1336 .
-
Lodinová, R., Jouja, V. and Wagner, V., 1973. Serum immunoglobulins and coproantibody formation in infants after artificial intestinal colonization with Escherichia coli 083 and oral lysozyme administration. Pediatric Research 7: 659–669.
'Serum immunoglobulins and coproantibody formation in infants after artificial intestinal colonization with Escherichia coli 083 and oral lysozyme administration ' () 7 Pediatric Research : 659 -669 .
-
Lotz, M., Gütle, D., Walther, S., Ménard, S., Bogdan, C. and Hornef, M.W., 2006. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. Journal of Experimental Medicine 203: 973-984.
'Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells ' () 203 Journal of Experimental Medicine : 973 -984 .
-
Macpherson, A.J., Geuking, M.B. and McCoy, K.D., 2005. Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology 115: 153-162.
'Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria ' () 115 Immunology : 153 -162 .
-
Martino, D.J. and Prescott, S.L., 2009. Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease. Allergy 65: 1-15.
'Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease ' () 65 Allergy : 1 -15 .
-
Martino, D.J., Currie, H., Taylor, A., Conway, P. and Prescott, S.L., 2008. Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development. Clinical and Experimental Allergy 38: 69-78.
'Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development ' () 38 Clinical and Experimental Allergy : 69 -78 .
-
Mellander, L., Carlsson, B., Jalil, F., Söderström, T. and Hanson, L.A., 1985. Secretory IgA antibody response against Escherichia coli antigens in infants in relation to exposure. The Journal of Pediatrics 107: 430-433.
'Secretory IgA antibody response against Escherichia coli antigens in infants in relation to exposure ' () 107 The Journal of Pediatrics : 430 -433 .
-
Michaëlsson, J., Mold, J.E., McCune, J.M. and Nixon, D.F., 2006. Regulation of T cell responses in the developing human fetus. Journal of Immunology 176: 5741-5748.
'Regulation of T cell responses in the developing human fetus ' () 176 Journal of Immunology : 5741 -5748 .
-
Miettinen, M., Matikainen, S., Vuopio-Varkila, J., Pirhonen, J., Varkila, K., Kurimoto, M. and Julkunen, I., 1998. Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18: and gamma interferon production in human peripheral blood mononuclear cells. Infection and Immunity 66: 6058-6062.
'Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18: and gamma interferon production in human peripheral blood mononuclear cells ' () 66 Infection and Immunity : 6058 -6062 .
-
Mileti, E., Matteoli, G., Iliev, I.D. and Rescigno, M., 2009. Comparison of the immunomodulatory properties of three probiotic strains of lactobacilli using complex culture systems: prediction for in vivo efficacy. PLoS One 4: e7056.
'Comparison of the immunomodulatory properties of three probiotic strains of lactobacilli using complex culture systems: prediction for in vivo efficacy ' () 4 PLoS One : e7056 .
-
Milling, S.W., Cousins, L. and MacPherson, G.G., 2005. How do DCs interact with intestinal antigens? Trends in Immunology 26: 349-352.
'How do DCs interact with intestinal antigens ' () 26 Trends in Immunology : 349 -352 .
-
Mora, J.R., Iwata, M. and Von Andrian, U.H., 2008. Vitamin effects on the immune system: vitamins A and D take centre stage. Nature Reviews Immunology 8: 685-698.
'Vitamin effects on the immune system: vitamins A and D take centre stage ' () 8 Nature Reviews Immunology : 685 -698 .
-
Moreau, M.C., Ducluzeau, R., Guy-Grand, D. and Muller, M.C., 1978. Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin. Infection and Immunity 21: 532-539.
'Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin ' () 21 Infection and Immunity : 532 -539 .
-
Mowat, A.M., 2003. Anatomical basis of tolerance and immunity to intestinal antigens. Nature Reviews Immunology 3: 331-341.
'Anatomical basis of tolerance and immunity to intestinal antigens ' () 3 Nature Reviews Immunology : 331 -341 .
-
Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C.L., Cheroutre, H. and Kronenberg, M., 2009. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature Immunology 10: 1178-1184.
'Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis ' () 10 Nature Immunology : 1178 -1184 .
-
Nahmias, A., Stoll, B., Hale, E., Ibegbu, C., Keyserling, H., Innis-Whitehouse, W., Holmes, R., Spira, T., Czerkinsky, C. and Lee, F., 1991. IgA-secreting cells in the blood of premature and term infants: normal development and effect of intrauterine infections. Advances in Experimental Medicine and Biology 310: 59-69.
'IgA-secreting cells in the blood of premature and term infants: normal development and effect of intrauterine infections ' () 310 Advances in Experimental Medicine and Biology : 59 -69 .
-
Neish, A.S., 2009. Microbes in gastrointestinal health and disease. Gastroenterology 136: 65-80.
'Microbes in gastrointestinal health and disease ' () 136 Gastroenterology : 65 -80 .
-
Neish, A.S., Gewirtz, A.T., Zeng, H., Young, A.N., Hobert, M.E., Karmali, V., Rao, A.S. and Madara, J.L., 2000. Prokaryotic regulation of epithelial responses by inhibition of IκB-α ubiquitination. Science 289: 1560-1563.
'Prokaryotic regulation of epithelial responses by inhibition of IκB-α ubiquitination ' () 289 Science : 1560 -1563 .
-
Nenci, A., Becker, C., Wullaert, A., Gareus, R., Van Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C., Madison, B., Gumucio, D., Neurath, M.F. and Pasparakis, M., 2007. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446: 557-561.
'Epithelial NEMO links innate immunity to chronic intestinal inflammation ' () 446 Nature : 557 -561 .
-
Neutra, M.R., Mantis, N.J. and Kraehenbuhl, J.P., 2001. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nature Immunology 2: 1004-1009.
'Collaboration of epithelial cells with organized mucosal lymphoid tissues ' () 2 Nature Immunology : 1004 -1009 .
-
Perez, P.F., Doré, J., Leclerc, M., Levenez, F., Benyacoub, J., Serrant, P., Segura-Roggero, I., Schiffrin, E.J. and Donnet-Hughes, A., 2007. Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics 119: e724-e732.
'Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics ' () 119 Pediatrics : e724 -e732 .
-
Peterson, D.A., McNulty, N.P., Guruge, J.L. and Gordon, J.I., 2007. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell. Host Microbe 2: 328-339.
'IgA response to symbiotic bacteria as a mediator of gut homeostasis ' () 2 Cell. Host Microbe : 328 -339 .
-
Prescott, S.L., 2009. Role of dietary immunomodulatory factors in the development of immune tolerance. In: Brandtzaeg, P., Isolauri, E. and Prescott, S.L. (eds.) Microbial-host interaction: tolerance versus allergy. S. Karger AG, Basel, Switzerland, pp. 185-200.
-
Prescott, S.L., Macaubas, C., Holt, B.J., Smallacombe, T.B., Loh, R., Sly, P.D. and Holt, P.G., 1998. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. Journal of Immunology 160: 4730-4737.
'Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile ' () 160 Journal of Immunology : 4730 -4737 .
-
Qiao, L., Braunstein, J., Golling, M., Schürmann, G., Autschbach, F., Möller, P. and Meuer, S., 1996. Differential regulation of human T cell responsiveness by mucosal versus blood monocytes. European Journal of Immunology 26: 922-927.
'Differential regulation of human T cell responsiveness by mucosal versus blood monocytes ' () 26 European Journal of Immunology : 922 -927 .
-
Rancé, F., Boguniewicz, M. and Lau, S., 2008. New visions for atopic eczema: an iPAC summary and future trends. Pediatric Allergy and Immunology 19 Suppl. 19: 17-25.
'New visions for atopic eczema: an iPAC summary and future trends ' () 19 Pediatric Allergy and Immunology : 17 -25 .
-
Rautava, S., Ruuskanen, O., Ouwehand, A., Salminen, S. and Isolauri, E., 2004. The hygiene hypothesis of atopic disease – an extended version. Journal of Pediatric Gastroenterology and Nutrition 38: 378-388.
'The hygiene hypothesis of atopic disease – an extended version ' () 38 Journal of Pediatric Gastroenterology and Nutrition : 378 -388 .
-
Renz, H., Blümer, N., Virna, S., Sel, S. and Garn, H., 2006. The immunological basis of the hygiene hypothesis. In: Crameri, R. (ed.) Allergy and asthma in modern society: a scientific approach. Chemical and immunological allergy, volume 91. S. Karger AG, Basel, Switzerland, pp. 30-48.
-
Renz, H., Pfefferle, P.I., Teich, R. and Garn, H., 2009. Development and regulation of immune responses to food antigens in pre-and postnatal life. In: Brandtzaeg, P., Isolauri, E. and Prescott, S.L. (eds.) Microbial-host interaction: tolerance versus allergy. S. Karger AG, Basel, Switzerland, pp. 139-157.
-
Rescigno, M., 2009. Before they were gut dendritic cells. Immunity 31: 454-456.
'Before they were gut dendritic cells ' () 31 Immunity : 454 -456 .
-
Rescigno, M., Lopatin, U. and Chieppa, M., 2008. Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance. Current Opinion in Immunology 20: 669-675.
'Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance ' () 20 Current Opinion in Immunology : 669 -675 .
-
Ridge, J.P., Fuchs, E.J. and Matzinger, P., 1996. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 271: 1723-1726.
'Neonatal tolerance revisited: turning on newborn T cells with dendritic cells ' () 271 Science : 1723 -1726 .
-
Rothberg, R.M. and Farr, R.S., 1965. Anti-bovine serum albumine and anti-alpha lactalbumin in the serum of children and adults. Pediatrics 35: 571-588.
'Anti-bovine serum albumine and anti-alpha lactalbumin in the serum of children and adults ' () 35 Pediatrics : 571 -588 .
-
Round, J.L. and Mazmanian, S.K., 2009. The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews Immunology 9: 313-323. Erratum in: Nature Reviews Immunology 9: 600.
-
Rowe, J., Kusel, M., Holt, B.J., Suriyaarachchi, D., Serralha, M., Hollams, E., Yerkovich, S.T., Subrata, L.S., Ladyman, C., Sadowska, A., Gillett, J., Fisher, E., Loh, R., Soderstrom, L., Ahlstedt, S., Sly, P.D. and Holt, P.G., 2007. Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort. The Journal of Allergy and Clinical Immunology 119: 1164-1173.
'Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort ' () 119 The Journal of Allergy and Clinical Immunology : 1164 -1173 .
-
Rugtveit, J., Nilsen, E.M., Bakka, A., Carlsen, H., Brandtzaeg, P. and Scott, H., 1997. Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease. Gastroenterology 112: 1493-1505.
'Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease ' () 112 Gastroenterology : 1493 -1505 .
-
Sait, L.C., Galic, M., Price, J.D., Simpfendorfer, K.R., Diavatopoulos, D.A., Uren, T.K., Janssen, P.H., Wijburg, O.L. and Strugnell, R.A., 2007. Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora. International Immunology 19: 257-265.
'Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora ' () 19 International Immunology : 257 -265 .
-
Sakaguchi, S., Wing, K. and Yamaguchi, T., 2009. Dynamics of peripheral tolerance and immune regulation mediated by Treg. European Journal of Immunology 39: 2331-2336.
'Dynamics of peripheral tolerance and immune regulation mediated by Treg ' () 39 European Journal of Immunology : 2331 -2336 .
-
Salminen, S., Collado, M.C., Isolauri, E. and Gueimonde, M., 2009. Microbial-host interactions: selecting the right probiotics and prebiotics for infants. In: Brandtzaeg, P., Isolauri, E. and Prescott, S.L. (eds.) Microbial-host interaction: tolerance versus allergy. S. Karger AG, Basel, Switzerland, pp. 201-217.
-
Saurer, L. and Mueller, C., 2009. T cell-mediated immunoregulation in the gastrointestinal tract. Allergy 64: 505-519.
'T cell-mediated immunoregulation in the gastrointestinal tract ' () 64 Allergy : 505 -519 .
-
Schnoeller, C., Rausch, S., Pillai, S., Avagyan, A., Wittig, B.M., Loddenkemper, C., Hamann, A., Hamelmann, E., Lucius, R. and Hartmann, S., 2008. A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages. Journal of Immunology 180: 4265-4272.
'A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages ' () 180 Journal of Immunology : 4265 -4272 .
-
Schulz, O., Jaensson, E., Persson, E.K., Liu, X., Worbs, T., Agace, W.W. and Pabst, O., 2009. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. Journal of Experimental Medicine 206: 3101-3114.
'Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions ' () 206 Journal of Experimental Medicine : 3101 -3114 .
-
Scott, H., Rognum, T.O., Midtvedt, T. and Brandtzaeg, P., 1985. Age-related changes of human serum antibodies to dietary and colonic bacterial antigens measured by an enzyme-linked immunosorbent assay. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Section C 93: 65-70.
'Age-related changes of human serum antibodies to dietary and colonic bacterial antigens measured by an enzyme-linked immunosorbent assay ' () 93 Acta Pathologica, Microbiologica et Immunologica Scandinavica, Section C : 65 -70 .
-
Scurlock, A.M., Burks, A.W. and Jones, S.M., 2009. Oral immunotherapy for food allergy. Current Allergy and Asthma Reports 9: 186-193.
'Oral immunotherapy for food allergy ' () 9 Current Allergy and Asthma Reports : 186 -193 .
-
Sepp, E., Julge, K., Vasar, M., Naaber, P., Björksten, B. and Mikelsaar, M., 1997. Intestinal microflora of Estonian and Swedish infants. Acta Paediatrica 86: 956-961.
'Intestinal microflora of Estonian and Swedish infants ' () 86 Acta Paediatrica : 956 -961 .
-
Shale, M. and Ghosh, S., 2009. How intestinal epithelial cells tolerise dendritic cells and its relevance to inflammatory bowel disease. Gut 58: 1291-1299.
'How intestinal epithelial cells tolerise dendritic cells and its relevance to inflammatory bowel disease ' () 58 Gut : 1291 -1299 .
-
Siegrist, C.A. and Aspinall, R., 2009. B-cell responses to vaccination at the extremes of age. Nature Reviews Immunology 9: 185-194.
'B-cell responses to vaccination at the extremes of age ' () 9 Nature Reviews Immunology : 185 -194 .
-
Skripak, J.M., Matsui, E.C., Mudd, K. and Wood, R.A., 2007. The natural history of IgE-mediated cow's milk allergy. The Journal of Allergy and Clinical Immunology 120: 1172-1177.
'The natural history of IgE-mediated cow's milk allergy ' () 120 The Journal of Allergy and Clinical Immunology : 1172 -1177 .
-
Smith, M., Tourigny, M.R., Noakes, P., Thornton, C.A., Tulic, M.K. and Prescott, S.L., 2008. Children with egg allergy have evidence of reduced neonatal CD4+CD25+CD127lo/-regulatory T cell function. The Journal of Allergy and Clinical Immunology 121: 1460-1466.
'Children with egg allergy have evidence of reduced neonatal CD4+CD25+CD127lo/-regulatory T cell function ' () 121 The Journal of Allergy and Clinical Immunology : 1460 -1466 .
-
Smith, P.D., Smythies, L.E., Mosteller-Barnum, M., Sibley, D.A., Russell, M.W., Merger, M., Sellers, M.T., Orenstein, J.M., Shimada, T., Graham, M.F. and Kubagawa, H., 2001. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS-and IgA-mediated activities. Journal of Immunology 167: 2651-2656.
'Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS-and IgA-mediated activities ' () 167 Journal of Immunology : 2651 -2656 .
-
Smythies, L.E., Sellers, M., Clements, R.H., Mosteller-Barnum, M., Meng, G., Benjamin, W.H., Orenstein, J.M. and Smith, P.D., 2005. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. The Journal of Clinical Investigation 115: 66-75.
'Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity ' () 115 The Journal of Clinical Investigation : 66 -75 .
-
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W. and Remaut, E., 2000. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289: 1352-1355.
'Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 ' () 289 Science : 1352 -1355 .
-
Stoll, B.J., Lee, F.K., Hale, E., Schwartz, D., Holmes, R., Ashby, R., Czerkinsky, C. and Nahmias, A.J., 1993. Immunoglobulin secretion by the normal and the infected newborn infant. The Journal of Pediatrics 122: 780-786.
'Immunoglobulin secretion by the normal and the infected newborn infant ' () 122 The Journal of Pediatrics : 780 -786 .
-
Takahashi, K., Sugi, Y., Hosono, A. and Kaminogawa, S., 2009. Epigenetic regulation of TLR4 gene expression in intestinal epithelial cells for the maintenance of intestinal homeostasis. Journal of Immunology 183: 6522-6529.
'Epigenetic regulation of TLR4 gene expression in intestinal epithelial cells for the maintenance of intestinal homeostasis ' () 183 Journal of Immunology : 6522 -6529 .
-
Tang, M.L., 2009. Probiotics and prebiotics: immunological and clinical effects in allergic disease. In: Brandtzaeg, P., Isolauri, E. and Prescott, S.L. (eds.) Microbial-host interaction: tolerance versus allergy. S. Karger AG, Basel, Switzerland, pp. 219-238.
-
Turner, J.R., 2009. Intestinal mucosal barrier function in health and disease. Nature Reviews in Immunology 9: 799-809.
'Intestinal mucosal barrier function in health and disease ' () 9 Nature Reviews in Immunology : 799 -809 .
-
U.S. Department of Health and Human Services, 2007. Breastfeeding and maternal and infant health outcomes in developed countries. Publication No. 07-E007: Evidence Report/Technology Assessment Report No. 153. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD, USA. Available at: http://www.ahrq.gov/downloads/pub/evidence/pdf/brfout/brfout.pdf
-
Van der Kleij, D., Latz, E., Brouwers, J.F., Kruize, Y.C., Schmitz, M., Kurt-Jones, E.A., Espevik, T., De Jong, E.C., Kapsenberg, M.L., Golenbock, D.T., Tielens, A.G. and Yazdanbakhsh, M., 2002. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization. The Journal of Biological Chemistry 277: 48122-48129.
'A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization ' () 277 The Journal of Biological Chemistry : 48122 -48129 .
-
Van Elburg, R.M., Uil, J.J., De Monchy, J.G. and Heymans, H.S., 1992. Intestinal permeability in pediatric gastroenterology. Scandinavian Journal of Gastroenterology 194 Suppl.: 19-24.
'Intestinal permeability in pediatric gastroenterology ' () 194 Scandinavian Journal of Gastroenterology : 19 -24 .
-
Van Odijk, J., Kull, I., Borres, M.P., Brandtzaeg, P., Edberg, U., Hanson, L.A., Høst, A., Kuitunen, M., Olsen, S.F., Skerfving, S., Sundell, J. and Wille, S., 2003. Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations. Allergy 58: 833-843.
'Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations ' () 58 Allergy : 833 -843 .
-
Vercelli, D., 2008. Discovering susceptibility genes for asthma and allergy. Nature Reviews Immunology 8: 169-182.
'Discovering susceptibility genes for asthma and allergy ' () 8 Nature Reviews Immunology : 169 -182 .
-
Vickery, B.P. and Burks, A.W., 2009. Immunotherapy in the treatment of food allergy: focus on oral tolerance. Current Opinion in Allergy and Clinical Immunology 9: 364-370.
'Immunotherapy in the treatment of food allergy: focus on oral tolerance ' () 9 Current Opinion in Allergy and Clinical Immunology : 364 -370 .
-
Von Hertzen, L.C., Savolainen, J., Hannuksela, M., Klaukka, T., Lauerma, A., Mäkelä, M.J., Pekkanen, J., Pietinalho, A., Vaarala, O., Valovirta, E., Vartiainen, E. and Haahtela, T., 2009. Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance. Allergy 64: 678-701.
'Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance ' () 64 Allergy : 678 -701 .
-
Waldo, F.B., Van den Wall Bake, A.W., Mestecky, J. and Husby, S., 1994. Suppression of the immune response by nasal immunization. Clinical Immunology and Immunopathology 72: 30-34.
'Suppression of the immune response by nasal immunization ' () 72 Clinical Immunology and Immunopathology : 30 -34 .
-
Weber, B., Saurer, L. and Mueller, C., 2009. Intestinal macrophages: differentiation and involvement in intestinal immunopathologies. Seminars in Immunopathology 31: 171-184.
'Intestinal macrophages: differentiation and involvement in intestinal immunopathologies ' () 31 Seminars in Immunopathology : 171 -184 .
-
Weinstock, J.V. and Elliott, D.E., 2009. Helminths and the IBD hygiene hypothesis. Inflammatory Bowel Diseases 15: 128-133.
'Helminths and the IBD hygiene hypothesis ' () 15 Inflammatory Bowel Diseases : 128 -133 .
-
Westendorf, A.M., Fleissner, D., Groebe, L., Jung, S., Gruber, A.D., Hansen, W. and Buer, J., 2009. CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. Gut 58: 211-219.
'CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells ' () 58 Gut : 211 -219 .
-
Wilson, C.B., Rowell, E. and Sekimata, M., 2009. Epigenetic control of T-helper-cell differentiation. Nature Reviews Immunology 9: 91-105.
'Epigenetic control of T-helper-cell differentiation ' () 9 Nature Reviews Immunology : 91 -105 .
-
Worbs, T., Bode, U., Yan, S., Hoffmann, M.W., Hintzen, G., Bernhardt, G., Förster, R. and Pabst, O., 2006. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. Journal of Experimental Medicine 203: 519-527.
'Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells ' () 203 Journal of Experimental Medicine : 519 -527 .
-
Yamanaka, T., Helgeland, L., Farstad, I.N., Fukushima, H., Midtvedt, T. and Brandtzaeg, P., 2003. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. Journal of Immunology 170: 816-822.
'Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches ' () 170 Journal of Immunology : 816 -822 .
-
Zeiger, R.S., 2000. Dietary aspects of food allergy prevention in infants and children. Journal of Pediatric Gastroenterology and Nutrition 30 Suppl.: S77-S86.
'Dietary aspects of food allergy prevention in infants and children ' () 30 Journal of Pediatric Gastroenterology and Nutrition : S77 -S86 .
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Homeostatic impact of indigenous microbiota and secretory immunity
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In the process of evolution, the mucosal immune system has generated two layers of anti-inflammatory defence: (1) immune exclusion performed by secretory IgA (and secretory IgM) antibodies to modulate or inhibit surface colonisation of microorganisms and dampen penetration of potentially dangerous antigens; and (2) suppressive mechanisms to avoid local and peripheral hypersensitivity to innocuous antigens, particularly food proteins and components of commensal bacteria. When induced via the gut, the latter phenomenon is called 'oral tolerance', which mainly depends on the development of regulatory T (Treg) cells in mesenteric lymph nodes to which mucosal dendritic cells (DCs) carry exogenous antigens and become conditioned for induction of Treg cells. Mucosally induced tolerance appears to be a rather robust adaptive immune function in view of the fact that large amounts of food proteins pass through the gut, while overt and persistent food allergy is not so common. DCs are 'decision makers' in the immune system when they perform their antigen-presenting function, thus linking innate and adaptive immunity by sensing the exogenous mucosal impact (e.g. conserved microbial molecular patterns). A balanced indigenous microbiota is required to drive the normal development of both mucosa-associated lymphoid tissue, the epithelial barrier with its secretory IgA (and IgM) system, and mucosally induced tolerance mechanisms including the generation of Treg cells. Notably, polymeric Ig receptor (pIgR/SC) knock-out mice that lack secretory IgA and IgM antibodies show reduced epithelial barrier function and increased uptake of antigens from food and commensal bacteria. They therefore have a hyper-reactive immune system and show predisposition for systemic anaphylaxis after sensitisation; but this development is counteracted by enhanced oral tolerance induction as a homeostatic back-up mechanism.
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