6. Mutagenesis for human nutrition
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Deficiencies of micronutrients, such as iron, zinc, and vitamin A (‘hidden hunger’) affect over three billion people. Currently there is an increasing preference among consumers for high quality foods that contain not only traditional nutrients but also provide other compounds beneficial to health and well-being. Food systems must be changed in ways that will provide that balanced nutrient supplies are available continuously to all people in the world in adequate affordable amounts. Biofortification, the enrichment of the nutritional properties to edible crops, can be achieved through a combination of agronomy and plant breeding. Among the tools available to plant breeders, induced mutation is highly efficient in altering the genetic constitution of plants, creating a wealth of genetic variability including desirable changes in crop quality, nutrient content and composition. Mutagenesis is also free of the regulatory restrictions imposed on genetically modified organisms. The forward genetic approach enables the identification of improved or novel phenotypes that can be exploited in conventional breeding programmes. Powerful reverse genetic strategies that allow the detection of induced point mutations in individuals of the mutagenized populations can address the major challenge of linking sequence information to the biological function of genes and can also identify novel variation for plant breeding. This review briefly discusses recent advances in the detection of mutants and the potential of mutagenesis for improving nutrient contents of different crops.