Strategies for vitamin E transdermal delivery

S. Trombino

Strategies for vitamin E transdermal delivery

In: Handbook of diet, nutrition and the skin

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S. Trombino

S. Trombino University of Calabria, Department of Pharmaceutical Science, Edificio Polifunzionale, Arcavacata di Rende, Via Pietro Bucci, 87036, Arcavacata di Rende, Cosenza, Italy; sonia.trombino@unical.it

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Type:: Chapter

Pages:: 128–143

DOI:: https://doi.org/10.3920/9789086867295_009

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Long term UV exposure is known to induce cell damage which may cause skin carcinogenesis. Vitamin E (α-tocopherol), a natural biological antioxidant, has been shown to protect against UV light-induced cell damage, to treat skin diseases and several types of cancer or to decrease oxidative stress. For this reason vitamin E based formulations, may be employed as protective agents. To obtain an effective photoprotection, a significant amount of antioxidant needs to arrive at the site, but skin barrier properties and vitamin E poor stability, due to direct exposure to UV light, limit its use and deposition in the skin. Consequently, the choice of an appropriate carrier is particularly important for enhancing vitamin E penetration through the stratum corneum and improving its efficacy. There are numerous strategies to facilitate the transdermal delivery of vitamin E. Chemicals substances and methods that modify the properties of stratum corneum can be used. In addition, during the last years, particular increasing attention has been given to drug delivery systems that have proved efficacy in enhancing pharmacological effects, vitamin E photoprotection and favouring its transdermal delivery.

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Handbook of diet, nutrition and the skin

Series: Human Health Handbooks, Volume: 2

E-Book ISBN:: 9789086867295

Publisher:: Wageningen Academic

Print Publication Date:: 15 Nov 2012

Subjects
- Life Sciences
  - General
  - Food & Health

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Strategies for vitamin E transdermal delivery

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Handbook of diet, nutrition and the skin

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