An isotope dilution model for partitioning phenylalanine uptake by the liver of lactating dairy cows

L.A. Crompton; C.K. Reynolds; J.A.N. Mills; J. France

An isotope dilution model for partitioning phenylalanine uptake by the liver of lactating dairy cows

In: Modelling nutrient digestion and utilisation in farm animals

Authors:

L.A. Crompton

L.A. Crompton ¹Animal Science Research Group, School of Agriculture, Policy and Development, University of Reading, Whiteknights, Reading RG6 6AR, United Kingdom; l.a.crompton@reading.ac.uk

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C.K. Reynolds

C.K. Reynolds ¹Animal Science Research Group, School of Agriculture, Policy and Development, University of Reading, Whiteknights, Reading RG6 6AR, United Kingdom; l.a.crompton@reading.ac.uk

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J.A.N. Mills

J.A.N. Mills ¹Animal Science Research Group, School of Agriculture, Policy and Development, University of Reading, Whiteknights, Reading RG6 6AR, United Kingdom; l.a.crompton@reading.ac.uk

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, and

J. France

J. France ²Centre for Nutrition Modelling, Department of Animal & Poultry Science, University of Guelph, Ontario N1G 2W1, Canada

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Type:: Chapter

Pages:: 218–224

DOI:: https://doi.org/10.3920/9789086867127_025

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An isotope dilution model for partitioning phenylalanine uptake by the liver of the lactating dairy cow was constructed and solved in the steady state. If assumptions are made, model solution permits calculation of the rate of phenylalanine uptake from portal vein and hepatic arterial blood supply, phenylalanine release into the hepatic vein, phenylalanine oxidation and synthesis, and degradation of hepatic constitutive and export proteins. The model requires the measurement of plasma flow rate through the liver in combination with phenylalanine concentrations and plateau isotopic enrichments in arterial, portal and hepatic plasma during a constant infusion of [1-¹³C]phenylalanine tracer. The model can be applied to other amino acids with similar metabolic fates and will provide a means for assessing the impact of hepatic metabolism on amino acid availability to peripheral tissues. This is of particular importance for the dairy cow when considering the requirements for milk protein synthesis and the negative environmental impact of excessive nitrogen excretion.

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Modelling nutrient digestion and utilisation in farm animals

E-Book ISBN:: 9789086867127

Publisher:: Wageningen Academic

Print Publication Date:: 30 Oct 2010

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- Life Sciences

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An isotope dilution model for partitioning phenylalanine uptake by the liver of lactating dairy cows

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Modelling nutrient digestion and utilisation in farm animals

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