Global impacts of aflatoxin in maize: trade and human health
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Maize is one of the most important agricultural commodities worldwide in terms of amounts produced, consumed, and traded. Hence, naturally occurring aflatoxin contamination in maize has important ramifications for both global trade and health. Aflatoxin is produced by certain species of the genusAspergillus in a variety of food crops, including maize, peanuts, and tree nuts. Over 100 nations have aflatoxin regulations, which are intended to protect human and animal health, but also incur economic losses to nations that attempt to export maize and other aflatoxin-contaminated commodities. These economic effects must be balanced against the health protection afforded by the regulations. It is important to acknowledge that, even in nations that have aflatoxin regulations, many individuals consume maize that has undergone no regulatory inspection, especially in nations where subsistence farming is widespread. Hence, aflatoxin contamination, exposure, and lack of regulation can also contribute to adverse effects on trade and health worldwide. This review, part of a special issue on aflatoxin in maize, describes economic and health effects of aflatoxin in maize on a global level. It ends with a story of an intervention that reduced maize consumption in one population in China, which is likely the main determinant of the reduction in liver cancer mortality in that population over the last 30 years, from reduced aflatoxin exposure.
-
Azziz-Baumgartner, E., Lindblade, K., Gieseker, K., Rogers, H.S., Kieszak, S., Njapau, H., Schleicher, R., McCoy, L.F., Misore, A., DeCock, K., Rubin, C. and Slutsker, L., 2005. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environmental Health Perspective 113: 1779-1783.
'Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004 ' () 113 Environmental Health Perspective : 1779 -1783.
-
Bhat, R.V. and Krishnamachari, K.A., 1977. Follow-up study of aflatoxic hepatitis in parts of western India. Indian Journal of Medical Research 66: 55-58.
'Follow-up study of aflatoxic hepatitis in parts of western India ' () 66 Indian Journal of Medical Research : 55 -58.
-
Bhatnagar, D., Cary, J.W., Ehrlich, K., Yu, J. and Cleveland, T.E., 2006. Understanding the genetics of regulation of aflatoxin production andAspergillus flavus development. Mycopathologia 162: 155-166.
'Understanding the genetics of regulation of aflatoxin production and Aspergillus flavus development ' () 162 Mycopathologia : 155 -166.
-
Brown, R.L., Menkir, A., Chen, Z-Y., Bhatnagar, D., Yu, J., Yao, H. and Cleveland, T.E., 2013. Breeding aflatoxin resistant maize lines using recent advances in technologies-a review. Food Additives and Contaminants Part A 30: 1382-1391.
'Breeding aflatoxin resistant maize lines using recent advances in technologies-a review ' () 30 Food Additives and Contaminants Part A : 1382 -1391.
-
Bui-Klimke, T.R., Guclu, H., Kensler, T.W., Yuan, J.-M. and Wu, F., 2014. Aflatoxin regulations and global pistachio trade: Insights from a social network analysis. PLoS ONE 9: e92149.
'Aflatoxin regulations and global pistachio trade: Insights from a social network analysis ' () 9 PLoS ONE : e92149.
-
Chen, J.G., Egner, P.A., Ng, D., Jacobson, L.P., Munoz, A., Zhu, Y.R., Qian, G., Wu, F., Yuan, J.M., Groopman, J.D. and Kensler, T.W., 2013. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China. Cancer Prevention Research 6: 1038-1045.
'Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China ' () 6 Cancer Prevention Research : 1038 -1045.
-
Cleveland, T.E., Dowd, P.F., Desjardins, A.E., Bhatnagar, D. and Cotty, P.J., 2003. United States Department of Agriculture-Agricultural Research Service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops. Pest Management Science 59: 629-642.
'United States Department of Agriculture-Agricultural Research Service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops ' () 59 Pest Management Science : 629 -642.
-
Cotty, P.J., Antilla, L. and Wakelyn, P.J., 2007. Competitive exclusion of aflatoxin producers: farmer-driven research and development. In: Vincent, C., Goettel, M.S. and Lazarovits, G. (eds.) Biological control: a global perspective. CABI, Cambridge, MA, USA, pp. 241-253.
Biological control: a global perspective , () 241 -253.
-
Food and Agriculture Organization (FAO), 2004. Worldwide regulations for mycotoxins in food and feed in 2003. FAO Press, Rome, Italy.
-
Gong, Y., Cardwell, K., Hounsa, A., Egal, S., Turner, P.C., Hall, A.J. and Wild, C.P., 2002. Dietary aflatoxin exposure and impaired growth in young children from benin and togo: cross sectional study. British Medical Journal 325: 20-21.
'Dietary aflatoxin exposure and impaired growth in young children from benin and togo: cross sectional study ' () 325 British Medical Journal : 20 -21.
-
Gong, Y., Hounsa, A., Egal, S., Turner, P.C., Sutcliffe, A.E., Hall, A.J., Cardwell, K. and Wild, C.P., 2004. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environmental Health Perspectives 112: 1334-1338.
'Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa ' () 112 Environmental Health Perspectives : 1334 -1338.
-
Henry, S.H., Bosch, F.X., Troxell, T.C. and Bolger, P.M., 1999. Public health: reducing liver cancer - global control of aflatoxin. Science 286: 2453-2454.
'Public health: reducing liver cancer - global control of aflatoxin ' () 286 Science : 2453 -2454.
-
International Agency for Research on Cancer (IARC), 1993. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. IARC Scientific Publications No. 56, IARC, Lyon, France.
-
Joint FAO/WHO Expert Committee on Food Additives (JECFA), 1998. Aflatoxins. Safety evaluation of certain food additives and contaminants, The forty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives. WHO Food Additives Series 40, World Health Organization, Geneva, Switzerland.
-
Jiang, Y., Jolly, P.E., Preko, P., Wang, J.S., Ellis, W.O., Phillips, T.D. and Williams, J.H., 2008. Aflatoxin-related immune dysfunction in health and in human immunodeficiency virus disease. Clinical Developmental Immunology 2008: 1-12.
'Aflatoxin-related immune dysfunction in health and in human immunodeficiency virus disease ' () 2008 Clinical Developmental Immunology : 1 -12.
-
Jolly, P.E., Jiang, Y., Ellis, W.O., Wang, J.S. and Afriyie-Gyawu, E., 2008. Modulation of the human immune system by aflatoxin. In: Leslie, J.F., Bandyopadhyay, R. and Visconti, A. (eds.) Mycotoxins: detection methods, management, public health and agricultural trade. CAB International, Wallingford, UK, pp. 41-52.
Mycotoxins: detection methods, management, public health and agricultural trade , () 41 -52.
-
Kensler, T.W., Roebuck, B.D., Wogan, G.N. and Groopman, J.D., 2011. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences 120 Suppl. 1: S28-S48.
'Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology ' () 120 Toxicological Sciences : S28 -S48.
-
Khlangwiset, P. and Wu F., 2010. Costs and efficacy of public health interventions to reduce aflatoxin-induced human disease. Food Additives and Contaminants Part A 27: 998-1014.
'Costs and efficacy of public health interventions to reduce aflatoxin-induced human disease ' () 27 Food Additives and Contaminants Part A : 998 -1014.
-
Khlangwiset, P., Shephard, G.S. and Wu, F., 2011. Aflatoxins and growth impairment: a review. Critical Reviews in Toxicology 41: 740-755.
'Aflatoxins and growth impairment: a review ' () 41 Critical Reviews in Toxicology : 740 -755.
-
Krishnamachari, K.A., Bhat, R.V., Nagarajan, V. and Tilak, T.B. 1975. Hepatitis due to aflatoxicosis. An outbreak in western India. The Lancet 305: 1061-1063.
'Hepatitis due to aflatoxicosis. An outbreak in western India ' () 305 The Lancet : 1061 -1063.
-
Liu, Y. and Wu, F., 2010. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental Health Perspectives 118: 818-824.
'Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment ' () 118 Environmental Health Perspectives : 818 -824.
-
Liu, Y., Chang, C.C., Marsh, G.M. and Wu, F., 2012. Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis. European Journal of Cancer 48: 2125-2136.
'Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis ' () 48 European Journal of Cancer : 2125 -2136.
-
Lubulwa, A.S.G. and Davis, J.S., 1994. Estimating the social costs of the impacts of fungi and aflatoxins in maize and peanuts. In: Highley, E., Wright, E.J., Banks, H.J. and Champ, B.R. (eds.) Stored product protection: Proceedings of the 6th International Working Conference on Stored-product Protection. CAB International, Wallingford, UK, pp. 1017-1042.
Stored product protection: Proceedings of the 6th International Working Conference on Stored-product Protection , () 1017 -1042.
-
Lye, M.S., Ghazali, A.A., Mohan, J., Alwin, N. and Nair, R.C. 1995. An outbreak of acute hepatic encephalopathy due to severe aflatoxicosis in Malaysia. American Journal of Tropical Medicine and Hygiene 53: 68-72.
'An outbreak of acute hepatic encephalopathy due to severe aflatoxicosis in Malaysia ' () 53 American Journal of Tropical Medicine and Hygiene : 68 -72.
-
Mahdavi, R., Nikniaz, L., Arefhosseini, S.R. and Vahed Jabbari, M., 2010. Determination of aflatoxin M1 in breast milk samples in Tabriz-Iran. Maternal Child Health Journal 14: 141-145.
'Determination of aflatoxin M1 in breast milk samples in Tabriz-Iran ' () 14 Maternal Child Health Journal : 141 -145.
-
Munkvold, G.P., 2003. Cultural and genetic approaches to managing mycotoxins in maize. Annual Reviews of Phytopathology 41: 99-116.
'Cultural and genetic approaches to managing mycotoxins in maize ' () 41 Annual Reviews of Phytopathology : 99 -116.
-
Okoth, S.A. and Ohingo, M., 2004. Dietary aflatoxin exposure and impaired growth in young children from Kisumu District, Kenya: cross sectional study. African Journal of Health Science 11: 43-54.
'Dietary aflatoxin exposure and impaired growth in young children from Kisumu District, Kenya: cross sectional study ' () 11 African Journal of Health Science : 43 -54.
-
Otsuki, T., Wilson, J.S. and Sewadeh, M., 2001. Saving two in a billion: quantifying the trade effect of European food safety standards on African exports. Food Policy 26: 495-514.
'Saving two in a billion: quantifying the trade effect of European food safety standards on African exports ' () 26 Food Policy : 495 -514.
-
Qian, G.S., Ross, R.K., Yu, M.C., Yuan, J.M., Gao, Y.T., Henderson, B.E., Wogan, G.N. and Groopman, J.D., 1994. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiology Biomarkers Prevention 3: 3-10.
'A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China ' () 3 Cancer Epidemiology Biomarkers Prevention : 3 -10.
-
Ricci, K., Girosi, F., Tarr, P., Lim, Y., Mason, C., Miller, M., Hughes, J., Von Seidlein, L., Agosti, J. and Guerrant, R., 2006. Reducing stunting among children: the potential contribution of diagnostics. Nature 444: 29-38.
'Reducing stunting among children: the potential contribution of diagnostics ' () 444 Nature : 29 -38.
-
Robens, J. and Cardwell, K., 2003. The costs of mycotoxin management to the USA: Management of aflatoxins in the United States. Journal of Toxicology, Toxin Reviews 2-3: 143-156.
'The costs of mycotoxin management to the USA: Management of aflatoxins in the United States ' () 2-3 Journal of Toxicology, Toxin Reviews : 143 -156.
-
Sadeghi, N., Oveisi, M., Jannat, B., Hajimahmoodi, M., Bonyani, H., and Jannat, F., 2009. Incidence of aflatoxin M1 in human breast milk in Tehran, Iran. Food Control 20: 75-78.
'Incidence of aflatoxin M1 in human breast milk in Tehran, Iran ' () 20 Food Control : 75 -78.
-
Shuaib, F.M., Jolly, P.E., Ehiri, J.E., Yatich, N., Jiang, Y., Funkhouser, E., Person, S.D., Wilson, C., Ellis, W.O., Wang, J.S. and Williams, J.H., 2010. Association between birth outcomes and aflatoxin B1 biomarker blood levels in pregnant women in Kumasi Ghana. Tropical Medicine and International Health 15: 160-167.
'Association between birth outcomes and aflatoxin B1 biomarker blood levels in pregnant women in Kumasi Ghana ' () 15 Tropical Medicine and International Health : 160 -167.
-
Strosnider, H., Azziz-Baumgartner, E., Banziger, M., Bhat, R.V., Breiman, R., Brune, M.N., DeCock, K., Dilley, A., Groopman, J., Hell, K., Henry, S.H., Jeffers, D., Jolly, C., Jolly, P., Kibata, G.N., Lewis, L., Liu, X., Luber, G., McCoy, L., Mensah, P., Miraglia, M., Misore, A., Njapau, H., Ong, C.N., Onsongo, M.T., Page, S.W., Park, D., Patel, M., Phillips, T., Pineiro, M., Pronczuk, J., Rogers, H.S., Rubin, C., Sabino, M., Schaafsma, A., Shephard, G., Stroka, J., Wild, C., Williams, J.T. and Wilson, D., 2006. Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries. Environmental Health Perspectives 114: 1898-1903.
'Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries ' () 114 Environmental Health Perspectives : 1898 -1903.
-
Turner, P.C., Collinson, A.C., Cheung, Y.B., Gong, Y., Hall, A.J., Prentice, A.M. and Wild, C.P., 2007. Aflatoxin exposure in utero causes growth faltering in Gambian infants. International Journal of Epidemiology 36: 1119-1125.
'Aflatoxin exposure in utero causes growth faltering in Gambian infants ' () 36 International Journal of Epidemiology : 1119 -1125.
-
Turner, P.C., Moore, S.E., Hall, A.J., Prentice, A.M. and Wild, C.P., 2003. Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environmental Health Perspectives 111: 217-220.
'Modification of immune function through exposure to dietary aflatoxin in Gambian children ' () 111 Environmental Health Perspectives : 217 -220.
-
Turner, P.C., Sylla, A., Gong, Y.Y., Diallo, M.S., Sutcliffe, A.E., Hall, A.J. and Wild, C.P., 2005. Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study. The Lancet 365: 1950-1956.
'Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study ' () 365 The Lancet : 1950 -1956.
-
Vardon, P., McLaughlin, C. and Nardinelli, C., 2003. Potential economic costs of mycotoxins in the United States. In: Council for Agricultural Science and Technology (CAST). Mycotoxins: risks in plant, animal, and human systems; Task Force Report No. 139: Ames, Iowa.
-
Wang, P., Afriyie-Gyawu, E., Tang, Y., Johnson, N.M., Xu, L., Tang, L., Huebner, H.J., Ankrah, N.A., Ofori-Adjei, D., Ellis, W., Jolly, P.E., Williams, J.H., Wang, J.S. and Phillips, T.D., 2008. NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine. Food Additives and Contaminates Part A 25: 622-634.
'NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine ' () 25 Food Additives and Contaminates Part A : 622 -634.
-
World Bank, 2005. Food safety and agricultural health standards: challenges and opportunities for developing country exports. Report No. 31207. World Bank, Washington, DC, USA. Available at:http://tinyurl.com/n8krlxv
-
Wu, F., 2004. Mycotoxin risk assessment for the purpose of setting international regulatory standards. Environmental Science and Technology 38: 4049-4055.
'Mycotoxin risk assessment for the purpose of setting international regulatory standards ' () 38 Environmental Science and Technology : 4049 -4055.
-
Wu, F., 2006. Mycotoxin reduction in Bt corn: Potential economic, health and regulatory impacts. Transgenic Research 15: 277-289.
'Mycotoxin reduction in Bt corn: Potential economic, health and regulatory impacts ' () 15 Transgenic Research : 277 -289.
-
Wu, F. and Guclu, H., 2012. Aflatoxin regulations in a network of global maize trade. PLoS ONE 7: e45141.
'Aflatoxin regulations in a network of global maize trade ' () 7 PLoS ONE : e45141.
-
Wu, F. and Guclu, H., 2013. Global maize trade and food security: implications from a social network model. Risk Analysis 33: 2168-2178.
'Global maize trade and food security: implications from a social network model ' () 33 Risk Analysis : 2168 -2178.
-
Wu, F., Groopman, J.D. and Pestka, J.J., 2014. Public health impacts of foodborne mycotoxins. Annual Reviews of Food Science and Technology 5: 351-372.
'Public health impacts of foodborne mycotoxins ' () 5 Annual Reviews of Food Science and Technology : 351 -372.
-
Wu, F., Liu, Y. and Bhatnagar, D., 2008. Cost-effectiveness of aflatoxin control methods: Economic incentives. Toxin Reviews 27: 203-225.
'Cost-effectiveness of aflatoxin control methods: Economic incentives ' () 27 Toxin Reviews : 203 -225.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 0 | 0 | 0 |
| å ¨ææµè§æ¬¡æ° | 1932 | 1067 | 59 |
| PDFä¸è½½æ¬¡æ° | 1962 | 1036 | 46 |
Global impacts of aflatoxin in maize: trade and human health
äºWorld Mycotoxin JournalSearch for other papers by F. Wu in
Current site
Google Scholar
PubMed
Maize is one of the most important agricultural commodities worldwide in terms of amounts produced, consumed, and traded. Hence, naturally occurring aflatoxin contamination in maize has important ramifications for both global trade and health. Aflatoxin is produced by certain species of the genusAspergillus in a variety of food crops, including maize, peanuts, and tree nuts. Over 100 nations have aflatoxin regulations, which are intended to protect human and animal health, but also incur economic losses to nations that attempt to export maize and other aflatoxin-contaminated commodities. These economic effects must be balanced against the health protection afforded by the regulations. It is important to acknowledge that, even in nations that have aflatoxin regulations, many individuals consume maize that has undergone no regulatory inspection, especially in nations where subsistence farming is widespread. Hence, aflatoxin contamination, exposure, and lack of regulation can also contribute to adverse effects on trade and health worldwide. This review, part of a special issue on aflatoxin in maize, describes economic and health effects of aflatoxin in maize on a global level. It ends with a story of an intervention that reduced maize consumption in one population in China, which is likely the main determinant of the reduction in liver cancer mortality in that population over the last 30 years, from reduced aflatoxin exposure.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 0 | 0 | 0 |
| å ¨ææµè§æ¬¡æ° | 1932 | 1067 | 59 |
| PDFä¸è½½æ¬¡æ° | 1962 | 1036 | 46 |
