Long-term effects of resistance exercise with and without vascular occlusion on TNF-α, IL-6 and IL-15 secretion in non-athletic women
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Abstract
Resistance training is associated with reduced risk of low-grade inflammation related diseases. This study aimed to consider the effect of two methods of resistance training with and without vascular occlusion on changes in some serum cytokines in young non-athlete women. Thirty non-athlete women (20 to 30 years of age) were randomly divided into three groups (n=10 in each): resistance training without vascular occlusion (traditional), resistance training with vascular occlusion, and a control group. Resistance training was conducted three sessions for 8 weeks. In the vascular occlusion group, prior to the main exercise, the proximal part of both thighs was closed with a rubber tourniquet and the resistance exercise was performed with an intensity of 20â30% 1-repetition maximum (1RM) until fatigue. In the group without vascular occlusion, the same exercise were performed with similar intensity (with 70â80% 1RM until fatigue). Serum interleukin (IL)-15, IL-6, and tumour necrosis factor-alpha (TNF-α) were measured by ELISA method. One-way ANOVA was employed to compare the changes in the studied variables. The results show that serum levels of IL-6 and TNF-α and IL-15 do not have a significant change in groups with and without obstruction (P>0.05). Numerous studies have evaluated the positive effects of vascular occlusion on muscle hypertrophy and strength during rehabilitation. According to the results of the present study, it seems that the use of vascular occlusion exercise has less effect on inflammatory or IL-15.
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Ajuwon, K.M. and Spurlock, M.E., 2004. Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes. American Journal of Physiology â Regulatory, Integrative and Comparative Physiology 287: R608-R611.
-
Andring, J.M., 2006. The consistency of inflammatory responses and muscle damage to high-force eccentric exercise. Montana State University, College of Education, Health & Human, Bozeman, MT, USA.
-
Apple, F., Hellsten, Y. and Clarkson, P., 1988. Early detection of skeletal muscle injury by assay of creatine kinase MM isoforms in serum after acute exercise. Clinical Chemistry 34: 1102-1104.
-
Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., Cardelli, P., Fallucca, S., Alessi, E., Letizia, C. and Jimenez, A., 2010. Antiinflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism and Cardiovascular Diseases 20: 608-617.
-
Bruunsgaard, H., Bjerregaard, E., Schroll, M. and Pedersen, B.K., 2004. Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. Journal of the American Geriatrics Society 52: 237-241.
-
Bugera, E.M., Duhamel, T.A., Peeler, J.D. and Cornish, S.M., 2018. The systemic myokine response of decorin, interleukin-6 (IL-6) and interleukin-15 (IL-15) to an acute bout of blood flow restricted exercise. European Journal of Applied Physiology 118: 2679-2686.
-
Chen, H.-T., Wu, H.-J., Chen, Y.-J., Ho, S.-Y. and Chung, Y.-C., 2018. Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia. Experimental Gerontology 112: 112-118.
-
Colbert, L.H., Visser, M., Simonsick, E.M., Tracy, R.P., Newman, A.B., Kritchevsky, S.B., Pahor, M., Taaffe, D.R., Brach, J. and Rubin, S., 2004. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society 52: 1098-1104.
-
Das, A. and Paton, B., 2022. Is there a minimum effective dose for vascular occlusion during blood flow restriction training? Frontiers in Physiology 13: 838115.
-
De Salles, B., Simao, R., Fleck, S., Dias, I., Kraemer-Aguiar, L. and Bouskela, E., 2010. Effects of resistance training on cytokines. International Journal of Sports Medicine 31: 441-450.
-
Figueras, M., Busquets, S.l., CarboÌ, N., Barreiro, E., Almendro, V., ArgileÌs, J.M. and LoÌpez-Soriano, F.J., 2004. Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats. FEBS Letters 569: 201-206.
-
Flack, K.D., Davy, K.P., Hulver, M.W., Winett, R.A., Frisard, M.I. and Davy, B.M., 2011. Aging, resistance training, and diabetes prevention. Journal of Aging Research 2011: 127315.
-
Fransson, D., Nielsen, T.S., Olsson, K., Christensson, T., Bradley, P.S., Fatouros, I.G., Krustrup, P., Nordsborg, N.B. and Mohr, M., 2018. Skeletal muscle and performance adaptations to high-intensity training in elite male soccer players: speed endurance runs versus small-sided game training. European Journal of Applied Physiology 118: 111-121.
-
Fujita, T., WF, B., Kurita, K., Sato, Y. and Abe, T., 2008. Increased muscle volume and strength following six days of low-intensity resistance training with restricted muscle blood flow. International Journal of KAATSU Training Research 4: 1-8.
-
Gielen, S., Adams, V., Möbius-Winkler, S., Linke, A., Erbs, S., Yu, J., Kempf, W., Schubert, A., Schuler, G. and Hambrecht, R., 2003. Antiinflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology 42: 861-868.
-
Greiwe, J.S., Cheng, B., Rubin, D.C., Yarasheski, K.E. and Semenkovich, C.F., 2001. Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans. FASEB Journal 15: 475-482.
-
Haghighi, A., Ravassi, A., Gaeini, A., Aminian, T. and Hamedi-Nia, M., 2005. Effects of resistance training on cytokines mediated inflammation and resistance to insulin in obese. Olympic 2: 19-29.
-
Holm, L., Reitelseder, S., Pedersen, T.G., Doessing, S., Petersen, S.G., Flyvbjerg, A., Andersen, J.L., Aagaard, P. and Kjaer, M., 2008. Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity. Journal of Applied Physiology 105: 1454-1461.
-
Karabulut, M., Abe, T., Sato, Y. and Bemben, M., 2007. Overview of neuromuscular adaptations of skeletal muscle to KAATSU Training. International Journal of KAATSU Training Research 3: 1-9.
-
Kawada, S., 2005. What phenomena do occur in blood flow-restricted muscle? International Journal of KAATSU Training Research 1: 37-44.
-
Laurent, M.R., Dedeyne, L., Dupont, J., Mellaerts, B., Dejaeger, M. and Gielen, E., 2019. Age-related bone loss and sarcopenia in men. Maturitas 122: 51-56.
-
Levinger, I., Goodman, C., Peake, J., Garnham, A., Hare, D.L., Jerums, G. and Selig, S., 2009. Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors. Diabetic Medicine 26: 220-227.
-
Libardi, C.A., De Souza, G.V., Cavaglieri, C.R., Madruga, V.A. and Chacon-Mikahil, M.P.T., 2012. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Medicine and Science in Sports and Exercise 44: 50-56.
-
Linke, A., Adams, V., Schulze, P.C., Erbs, S., Gielen, S., Fiehn, E., Mo?bius-Winkler, S., Schubert, A., Schuler, G. and Hambrecht, R., 2005. Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation 111: 1763-1770.
-
Loenneke, J.P. and Pujol, T.J., 2009. The use of occlusion training to produce muscle hypertrophy. Strength and Conditioning Journal 31: 77-84.
-
MaceÌdo Santiago, L.AÌ., Neto, L.G.L., Borges Pereira, G., Leite, R.D., Mostarda, C.T., de Oliveira Brito Monzani, J., Sousa, W.R., Rodrigues Pinheiro, A.J.M. and Navarro, F., 2018. Effects of resistance training on immunoinflammatory response, TNF-alpha gene expression, and body composition in elderly women. Journal of Aging Research 2018: 1467025.
-
Manini, T.M. and Clark, B.C., 2009. Blood flow restricted exercise and skeletal muscle health. Exercise and Sport Sciences Reviews 37: 78-85.
-
Nassis, G.P., Papantakou, K., Skenderi, K., Triandafillopoulou, M., Kavouras, S.A., Yannakoulia, M., Chrousos, G.P. and Sidossis, L.S., 2005. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 54: 1472-1479.
-
Nicklas, B.J., Ambrosius, W., Messier, S.P., Miller, G.D., Penninx, B.W., Loeser, R.F., Palla, S., Bleecker, E. and Pahor, M., 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. American Journal of Clinical Nutrition 79: 544-551.
-
Nielsen, A.R. and Pedersen, B.K., 2007. The biological roles of exerciseinduced cytokines: IL-6, IL-8, and IL-15. Applied Physiology, Nutrition, and Metabolism 32: 833-839.
-
Nunes, J.P., Grgic, J., Cunha, P.M., Ribeiro, A.S., Schoenfeld, B.J., de Salles, B.F. and Cyrino, E.S., 2021. What influence does resistance exercise order have on muscular strength gains and muscle hypertrophy? A systematic review and meta-analysis. European Journal of Sport Science 21: 149-157.
-
PeÌrez-LoÌpez, A., McKendry, J., Martin-Rincon, M., Morales-Alamo, D., PeÌrez-Köhler, B., ValadeÌs, D., BujaÌn, J., Calbet, J. and Breen, L., 2018. Skeletal muscle IL-15/IL-15Rα and myofibrillar protein synthesis after resistance exercise. Scandinavian Journal of Medicine and Science in Sports 28: 116-125.
-
Phillips, M.D., Patrizi, R.M., Cheek, D.J., Wooten, J.S., Barbee, J.J. and Mitchell, J.B., 2012. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Medicine and Science in Sports and Exercise 44: 2099-2110.
-
Pitsavos, C., Panagiotakos, D.B., Chrysohoou, C., Kavouras, S. and Stefanadis, C., 2005. The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome: the ATTICA study. European Journal of Cardiovascular Prevention and Rehabilitation 12: 151-158.
-
Quinn, L.S., Anderson, B.G., Drivdahl, R.H., Alvarez, B. and ArgileÌs, J.M., 2002. Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders. Experimental Cell Research 280: 55-63.
-
Sato, Y., 2005. The history and future of KAATSU training. International Journal of KAATSU Training Research 1: 1-5.
-
Souissi, W., Bouzid, M.A., Farjallah, M.A., Ben Mahmoud, L., Boudaya, M., Engel, F.A. and Sahnoun, Z., 2020. Effect of different running exercise modalities on post-exercise oxidative stress markers in trained athletes. International Journal of Environmental Research and Public Health 17: 3729.
-
Starkie, R., Hargreaves, M., Rolland, J. and Febbraio, M.A., 2005. Heat stress, cytokines, and the immune response to exercise. Brain, Behavior, and Immunity 19: 404-412.
-
Starkie, R., Ostrowski, S.R., Jauffred, S., Febbraio, M. and Pedersen, B.K., 2003. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-α production in humans. FASEB Journal 17: 884-886.
-
Strasser, B., Arvandi, M. and Siebert, U., 2012. Resistance training, visceral obesity and inflammatory response: a review of the evidence. Obesity Reviews 13: 578-591.
-
Tolouei Azar, J., Shabkhiz, F. and Khalafi, M., 2021. The effects of eight weeks of resistance training on serum levels IL-15, IL-6, TNF-α and insulin resistance in older type 2 diabetic men. Journal of Sport Biosciences 12: 391-406.
-
Tsukui, S., Kanda, T., Nara, M., Nishino, M., Kondo, T. and Kobayashi, I., 2000. Moderate-intensity regular exercise decreases serum tumor necrosis factor-? and HbA 1c levels in healthy women. International Journal of Obesity 24: 1207-1211.
-
White, L.J., Castellano, V. and Mc Coy, S.C., 2006. Cytokine responses to resistance training in people with multiple sclerosis. Journal of Sports Sciences 24: 911-914.
-
Xie, C., Kang, J., Ferguson, M.E., Nagarajan, S., Badger, T.M. and Wu, X., 2011. Blueberries reduce pro-inflammatory cytokine TNF-α and IL-6 production in mouse macrophages by inhibiting NF-κB activation and the MAPK pathway. Molecular Nutrition and Food Research 55: 1587-1591.
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Long-term effects of resistance exercise with and without vascular occlusion on TNF-α, IL-6 and IL-15 secretion in non-athletic women
In: Comparative Exercise PhysiologySearch for other papers by T. Jahandarlashaki in
Current site
Google Scholar
PubMed
Search for other papers by A. Abbassi Daloii in
Current site
Google Scholar
PubMed
Search for other papers by H. Shirvani in
Current site
Google Scholar
PubMed
Search for other papers by M. Samadi in
Current site
Google Scholar
PubMed
Search for other papers by E. Arabzadeh in
Current site
Google Scholar
PubMed
Abstract
Resistance training is associated with reduced risk of low-grade inflammation related diseases. This study aimed to consider the effect of two methods of resistance training with and without vascular occlusion on changes in some serum cytokines in young non-athlete women. Thirty non-athlete women (20 to 30 years of age) were randomly divided into three groups (n=10 in each): resistance training without vascular occlusion (traditional), resistance training with vascular occlusion, and a control group. Resistance training was conducted three sessions for 8 weeks. In the vascular occlusion group, prior to the main exercise, the proximal part of both thighs was closed with a rubber tourniquet and the resistance exercise was performed with an intensity of 20â30% 1-repetition maximum (1RM) until fatigue. In the group without vascular occlusion, the same exercise were performed with similar intensity (with 70â80% 1RM until fatigue). Serum interleukin (IL)-15, IL-6, and tumour necrosis factor-alpha (TNF-α) were measured by ELISA method. One-way ANOVA was employed to compare the changes in the studied variables. The results show that serum levels of IL-6 and TNF-α and IL-15 do not have a significant change in groups with and without obstruction (P>0.05). Numerous studies have evaluated the positive effects of vascular occlusion on muscle hypertrophy and strength during rehabilitation. According to the results of the present study, it seems that the use of vascular occlusion exercise has less effect on inflammatory or IL-15.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 378 | 104 | 29 |
| PDF Views & Downloads | 405 | 92 | 8 |
