Save

Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children

in Beneficial Microbes
Autor:innen:
A.S.-Y. Lau School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by A.S.-Y. Lau in
Current site
Google Scholar
PubMed
Close
,
N. Yanagisawa Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.

Search for other papers by N. Yanagisawa in
Current site
Google Scholar
PubMed
Close
,
Y.-Y. Hor School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by Y.-Y. Hor in
Current site
Google Scholar
PubMed
Close
,
L.-C. Lew School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by L.-C. Lew in
Current site
Google Scholar
PubMed
Close
,
J.-S. Ong School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by J.-S. Ong in
Current site
Google Scholar
PubMed
Close
,
L.-O. Chuah School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by L.-O. Chuah in
Current site
Google Scholar
PubMed
Close
,
Y.-Y. Lee School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.

Search for other papers by Y.-Y. Lee in
Current site
Google Scholar
PubMed
Close
,
S.-B. Choi School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by S.-B. Choi in
Current site
Google Scholar
PubMed
Close
,
F. Rashid School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.

Search for other papers by F. Rashid in
Current site
Google Scholar
PubMed
Close
,
N. Wahid Community Health Center, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by N. Wahid in
Current site
Google Scholar
PubMed
Close
,
H. Sugahara Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.

Search for other papers by H. Sugahara in
Current site
Google Scholar
PubMed
Close
,
J.-Z. Xiao Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.

Search for other papers by J.-Z. Xiao in
Current site
Google Scholar
PubMed
Close
, und
M.-T. Liong School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Search for other papers by M.-T. Liong in
Current site
Google Scholar
PubMed
Close

This 10-months randomised, double-blind, parallel and placebo-controlled study evaluated the effects of Bifidobacterium longum BB536 on diarrhoea and/or upper respiratory illnesses in 520 healthy Malaysian pre-school children aged 2-6 years old. The subjects randomly received a one-gram sachet containing either BB536 (5×109 cfu) or placebo daily. Data analysis was performed on 219 subjects who fully complied over 10-months (placebo n=110, BB536 n=109). While BB536 did not exert significant effects against diarrhoea in children, Poisson regression with generalised estimating equations model indicated significant intergroup difference in the mean number of times of respiratory illnesses over 10 months. The duration of sore throat was reduced by 46% (P=0.018), with marginal reduction for duration of fever (reduced by 27%, P=0.084), runny nose (reduced by 15%, P=0.087) and cough (reduced by 16%, P=0.087) as compared to the placebo. Principal coordinate analysis at genus level of the gut microbiota revealed significant differences between 0 and 10 months in the BB536 group (P<0.01) but not in placebo group (P>0.05). The abundance of the genus Faecalibacterium which is associated with anti-inflammatory and immuno-modulatory properties was significantly higher in the BB536 group (P<0.05) compared to the placebo group. Altogether, our present study illustrated the potential protective effects of BB536 against upper respiratory illnesses in pre-school Malaysian children, with gut microbiota modulating properties.

Kennzahlen

Insgesamt Letzte 365 Tage In den letzten 30 Tagen
Aufrufe von Kurzbeschreibungen 0 0 0
Gesamttextansichten 1317 488 44
PDF-Downloads 1387 643 64