Möchten Sie über diese Zeitschrift informiert bleiben? Klicken Sie bitte auf die Buttons, um unsere Alerts zu abonnieren.
Möchten Sie über diese Zeitschrift informiert bleiben? Klicken Sie bitte auf die Buttons, um unsere Alerts zu abonnieren.
This 10-months randomised, double-blind, parallel and placebo-controlled study evaluated the effects of Bifidobacterium longum BB536 on diarrhoea and/or upper respiratory illnesses in 520 healthy Malaysian pre-school children aged 2-6 years old. The subjects randomly received a one-gram sachet containing either BB536 (5×109 cfu) or placebo daily. Data analysis was performed on 219 subjects who fully complied over 10-months (placebo n=110, BB536 n=109). While BB536 did not exert significant effects against diarrhoea in children, Poisson regression with generalised estimating equations model indicated significant intergroup difference in the mean number of times of respiratory illnesses over 10 months. The duration of sore throat was reduced by 46% (P=0.018), with marginal reduction for duration of fever (reduced by 27%, P=0.084), runny nose (reduced by 15%, P=0.087) and cough (reduced by 16%, P=0.087) as compared to the placebo. Principal coordinate analysis at genus level of the gut microbiota revealed significant differences between 0 and 10 months in the BB536 group (P<0.01) but not in placebo group (P>0.05). The abundance of the genus Faecalibacterium which is associated with anti-inflammatory and immuno-modulatory properties was significantly higher in the BB536 group (P<0.05) compared to the placebo group. Altogether, our present study illustrated the potential protective effects of BB536 against upper respiratory illnesses in pre-school Malaysian children, with gut microbiota modulating properties.
Akatsu, H., Iwabuchi, N., Xiao, J.Z., Matsuyama, Z., Kurihara, R., Okuda, K., Yamamoto, T. and Maruyama, M., 2013. Clinical effects of probiotic Bifidobacterium longum BB536 on immune function and intestinal microbiota in elderly patients receiving enteral tube feeding. Journal of Parenteral and Enteral Nutrition 37: 631-640.
'Clinical effects of probiotic Bifidobacterium longum BB536 on immune function and intestinal microbiota in elderly patients receiving enteral tube feeding ' () 37 Journal of Parenteral and Enteral Nutrition : 631 -640.
Aronesty, E., 2013. Comparison of sequencing utility programs. Open Bioinforma 7: 1-8.
'Comparison of sequencing utility programs ' () 7 Open Bioinforma : 1 -8.
Audebert, C., Even, G., Cian, A., Loywick, A., Merlin, S., Viscogliosi, E. and Chabé, M., 2016. Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota. Nature Scientific Reports 6: 1-11.
'Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota ' () 6 Nature Scientific Reports : 1 -11.
Brestoff, J.R. and Artis, D., 2013. Commensal bacteria at the interface of host metabolism and the immune system. Nature Immunology 14: 676-684.
'Commensal bacteria at the interface of host metabolism and the immune system ' () 14 Nature Immunology : 676 -684.
Canani, B.R., De Filippis, F., Nocerino, R., Laiola, M., Paparo, L., Calignano, A., De Caro, C., Coretti, L., Chiariotti, L., Gilbert, J.A. and Ercolini, D., 2017. Specific signatures of the gut microbiota and increased levels of butyrate in children treated with fermented cow’s milk containing heat-killed Lactobacillus paracasei CBA L74. Applied and Environmental Microbiology 83: e01206-17.
'Specific signatures of the gut microbiota and increased levels of butyrate in children treated with fermented cow’s milk containing heat-killed Lactobacillus paracasei CBA L74 ' () 83 Applied and Environmental Microbiology : e01206 -17.
Cao, Y., Shen, J. and Ran, Z.H., 2014. Association between Faecalibacterium prausnitzii reduction and inflammatory bowel disease: a meta-analysis and systematic review of the literature. Gastroenterology Research and Practice 2014: 872725.
'Association between Faecalibacterium prausnitzii reduction and inflammatory bowel disease: a meta-analysis and systematic review of the literature ' () 2014 Gastroenterology Research and Practice : 872725.
Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., Fierer, N., Pena, A.G., Goodrich, J.K., Gordon, J.I., Huttley, G.A., Kelley, S.T., Knights, D., Koenig, J.E., Ley, R.E., Lozupone, C.A., McDonald, D., Muegge, B.D., Pirrung, M., Reeder, J., Sevinsky, J.R., Turnbaugh, P.J., Walters, W.A., Widmann, J., Yatsunenko, T., Zaneveld, J. and Knight, R., 2010. QIIME allows analysis of high-throughput community sequencing data. Nature Methods 7: 335-336.
'QIIME allows analysis of high-throughput community sequencing data ' () 7 Nature Methods : 335 -336.
Cheah, W.L., Lee, P.Y., Syed Alwi, S.A.R., Kamaruddin, K., Albela, H., Lau, E.H., Noraini, O. and Siti Sanaa, W.A., 2011. Acute gastroenteritis among indigenous paediatric patients – a descriptive study in a rural district hospital, Sarawak. Malaysian Journal of Medicine and Health Sciences 7: 3-7.
'Acute gastroenteritis among indigenous paediatric patients – a descriptive study in a rural district hospital, Sarawak ' () 7 Malaysian Journal of Medicine and Health Sciences : 3 -7.
Eccles, R., 2007. Mechanisms of symptoms of the common cold and influenza. British Journal of Hospital Medicine 68(2): 71.
'Mechanisms of symptoms of the common cold and influenza ' () 68 British Journal of Hospital Medicine : 71.
Edgar, R.C., Haas, B.J., Clemente, J.C., Quince, C. and Knight, R., 2011. UCHIME improves sensitivity and speed of chimera detection. Bioinformatics 27: 2194-2200.
'UCHIME improves sensitivity and speed of chimera detection ' () 27 Bioinformatics : 2194 -2200.
Ewe, J.A., Wan-Abdullah, W.N. and Liong, M.T., 2010. Viability and growth characteristics of Lactobacillus in soymilk supplemented with B-vitamins. International Journal of Food Sciences and Nutrition 61: 87-107.
'Viability and growth characteristics of Lactobacillus in soymilk supplemented with B-vitamins ' () 61 International Journal of Food Sciences and Nutrition : 87 -107.
Food and Agriculture Organisation / World Health Organisation (FAO/WHO), 2006. Probiotics in food: health and nutritional properties and guidelines for evaluation. WHO, Rome, Italy.
'Probiotics in food: health and nutritional properties and guidelines for evaluation ', in WHO, Rome, Italy , ().
Kim, S.W., Suda, W., Kim, S., Oshima, K., Fukuda, S., Ohno, H., Morita, H. and Hattori, M., 2013. Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing. DNA Research 20: 241-253.
'Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing ' () 20 DNA Research : 241 -253.
Kuczynski, J., Stombaugh, J., Walters, W.A., Gonzalez, A., Caporaso, J.G. and Knight, R., 2012. Using QIIME to analyze 16S rRNA gene sequences from microbial communities. Current Protocols in Microbiology 10: Unit 10.7.
'Using QIIME to analyze 16S rRNA gene sequences from microbial communities ' () 10 Current Protocols in Microbiology .
Kumpu, M., Kekkonen, R.A., Kautiainen, H., Jarvenpaa, S., Kristo, A., Huovinen, P., Pitkaranta, A., Korpela, R. and Hatakka, K., 2012. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. European Journal of Clinical Nutrition 66: 1020-1023.
'Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial ' () 66 European Journal of Clinical Nutrition : 1020 -1023.
Langmead, B. and Salzberg, S.L., 2012. Fast gapped-read alignment with Bowtie 2. Nature Methods 9: 357-359.
'Fast gapped-read alignment with Bowtie 2 ' () 9 Nature Methods : 357 -359.
Lau, A.S.Y., Xiao, J.Z. and Liong, M.T., 2015. Bifidobacterium for infants: essence and efficacy. In: Liong, M.T. (ed.) Beneficial microorganisms in medical and health applications. Microbiology Monographs. Springer International Publishing, Cham, Switzerland, pp. 39-72.
'Bifidobacterium for infants: essence and efficacy ', in Beneficial microorganisms in medical and health applications , () 39 -72.
Liong, M.T. and Shah, N.P., 2005. Bile salt deconjugation and BSH activity of five bifidobacterial strains and their cholesterol co-precipitating properties. Food Research International 38: 135-142.
'Bile salt deconjugation and BSH activity of five bifidobacterial strains and their cholesterol co-precipitating properties ' () 38 Food Research International : 135 -142.
McDonald, D., Price, M.N., Goodrich, J., Nawrocki, E.P., DeSantis, T.Z., Probst, A., Andersen, G.L., Knight, R. and Hugenholtz, P., 2012. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea. ISME Journal 6: 610-618.
'An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea ' () 6 ISME Journal : 610 -618.
Mizuta, M., Endo, I., Yamamoto, S., Inokawa, H., Kubo, M., Udaka, T., Sogabe, O., Maeda, H., Shirakawa, K., Okazaki, E., Odamaki, T., Abe, F. and Xiao, J.Z., 2016. Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: a prospective, randomized clinical trial. Bioscience of Microbiota, Food and Health 35: 77-87.
'Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: a prospective, randomized clinical trial ' () 35 Bioscience of Microbiota, Food and Health : 77 -87.
Moens, F., Weckx, S. and De Vuyst, L., 2016. Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii. International Journal of Food Microbiology 231: 76-85.
'Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii ' () 231 International Journal of Food Microbiology : 76 -85.
Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.Z., Abe, F. and Osawa, R., 2016. Age-related changes in gut microbiota composition from new-born to centenarian: a cross-sectional study. BMC Microbiology 16: 90.
'Age-related changes in gut microbiota composition from new-born to centenarian: a cross-sectional study ' () 16 BMC Microbiology : 90.
Rerksuppaphol, S. and Rerksuppaphol, L., 2012. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatrics International 54: 682-687.
'Randomized controlled trial of probiotics to reduce common cold in schoolchildren ' () 54 Pediatrics International : 682 -687.
Rideout, J.R., He, Y., Navas-Molina, J.A., Walters, W.A., Ursell, L.K., Gibbons, S.M., Chase, J., McDonald, D., Gonzalez, A., Robbins-Pianka, A., Clemente, J.C., Gilbert, J.A., Huse, S.M., Zhou, H.W., Knight, R. and Caporaso, J.G., 2014. Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences. Peer J 2: e545.
'Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences ' () 2 Peer J : e545.
Rios-Covian, D., Gueimonde, M., Duncan, S.H., Flint, H.J. and De los Reyes-Gavilan, C.G., 2015. Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis. FEMS Microbiology Letters 362: fnv176.
'Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis ', in FEMS Microbiology Letters , ().
Rosa, A.M., Ignotti, E., Botelho, C., Castro, H.A. and Hacon, S.S., 2008. Respiratory disease and climatic seasonality in children under 15 years old in a town in the Brazilian Amazon. Jornal de Pediatría 84: 543-549.
'Respiratory disease and climatic seasonality in children under 15 years old in a town in the Brazilian Amazon ' () 84 Jornal de Pediatría : 543 -549.
Sam, I.C., Abdul-Murad, A., Karunakaran, R., Rampal, S., Chan, Y.F., Nathan, A.M. and Ariffin, H., 2010. Clinical features of Malaysian children hospitalized with community-acquired seasonal influenza. International Journal of Infectious Diseases 3: 36-40.
'Clinical features of Malaysian children hospitalized with community-acquired seasonal influenza ' () 3 International Journal of Infectious Diseases : 36 -40.
Simoes, E.A.F., Cherian, T., Chow, J., Shahid-Salles, S.A., Laxminarayan, R. and John, T.J., 2006. Acute respiratory infections in children. In: Jamison, D.T., Breman, J.G., Measham, A.R., Alleyne, G., Claeson, M., Evans, D.B., Jha, P., Mills, A. and Musgrove, P. (eds.) Disease control priorities in developing countries. Oxford University Press, New York, NY, USA.
'Acute respiratory infections in children ', in Disease control priorities in developing countries , ().
Sugahara, H., Odamaki, T., Fukuda, S., Kato, T., Xiao, J.Z., Abe, F., Kikuchi, J. and Ohno, H., 2015. Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community. Nature Scientific Reports 5: 13548.
'Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community ' () 5 Nature Scientific Reports : 13548.
Tekverk, K., Urbaszewski, B., Fraley, T.D. and McMahon, K.S., 2015. Climate change and respiratory health. Environmental Health White Paper Series of the Respiratory Health Association. Chicago, IL, USA, pp. 1-32.
'Climate change and respiratory health ', in Environmental Health White Paper Series of the Respiratory Health Association , () 1 -32.
Tomosada, Y., Villena, J., Murata, K., Chiba, E., Shimazu, T., Aso, H., Iwabuchi, N., Xiao, J.Z., Saito, T. and Kitazawa, H., 2013. Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression. PLoS ONE 8: e59259.
'Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression ' () 8 PLoS ONE : e59259.
Wang, Y., Li, X.L., Ge, T., Xiao, Y., Liao, Y., Cui, Y., Zhang, Y., Ho, W., Yu, G. and Zhang, T., 2016. Probiotics for prevention and treatment of respiratory tract infections in children: a systematic review and meta-analysis of randomized controlled trials. Systematic Review and Meta-Analysis 95: 1-12.
'Probiotics for prevention and treatment of respiratory tract infections in children: a systematic review and meta-analysis of randomized controlled trials ' () 95 Systematic Review and Meta-Analysis : 1 -12.
Weizman, Z., Asli, G. and Alsheikh, A., 2005. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics 115: 5-9.
'Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents ' () 115 Pediatrics : 5 -9.
World Health Organisation (WHO), 2013. Diarrhoeal disease. Available at: http://tinyurl.com/y8zedatj.
Xiao, J.Z., 2009. Probiotic Bifidobacterium longum BB536. In: Lee, K.L. and Salminen, S. (eds.) Handbook of probiotics and prebiotics. John Wiley and Sons Inc., Hoboken, NJ, USA, pp. 488-491.
'Probiotic Bifidobacterium longum BB536 ', in Handbook of probiotics and prebiotics , () 488 -491.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 0 | 0 | 0 |
| Gesamttextansichten | 1317 | 488 | 44 |
| PDF-Downloads | 1387 | 643 | 64 |
This 10-months randomised, double-blind, parallel and placebo-controlled study evaluated the effects of Bifidobacterium longum BB536 on diarrhoea and/or upper respiratory illnesses in 520 healthy Malaysian pre-school children aged 2-6 years old. The subjects randomly received a one-gram sachet containing either BB536 (5×109 cfu) or placebo daily. Data analysis was performed on 219 subjects who fully complied over 10-months (placebo n=110, BB536 n=109). While BB536 did not exert significant effects against diarrhoea in children, Poisson regression with generalised estimating equations model indicated significant intergroup difference in the mean number of times of respiratory illnesses over 10 months. The duration of sore throat was reduced by 46% (P=0.018), with marginal reduction for duration of fever (reduced by 27%, P=0.084), runny nose (reduced by 15%, P=0.087) and cough (reduced by 16%, P=0.087) as compared to the placebo. Principal coordinate analysis at genus level of the gut microbiota revealed significant differences between 0 and 10 months in the BB536 group (P<0.01) but not in placebo group (P>0.05). The abundance of the genus Faecalibacterium which is associated with anti-inflammatory and immuno-modulatory properties was significantly higher in the BB536 group (P<0.05) compared to the placebo group. Altogether, our present study illustrated the potential protective effects of BB536 against upper respiratory illnesses in pre-school Malaysian children, with gut microbiota modulating properties.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 0 | 0 | 0 |
| Gesamttextansichten | 1317 | 488 | 44 |
| PDF-Downloads | 1387 | 643 | 64 |