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Stenocarpella maydis and its toxic metabolites: a South African perspective on diplodiosis
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Stenocarpella maydis is one of the most prevalent ear and stalk rot pathogens of maize globally, causing reductions of grain quality and yield. Various molecular methods, including polymerase chain reaction (PCR)-based techniques and nucleotide microarrays, have been developed for the identification ofS. maydis infestation in maize grain. In addition to diplodiatoxin, new metabolites, namely dipmatol, diplonine and chaetoglobosins K and L, have been isolated fromS. maydis infected cultures.S. maydis infected maize is also associated with intoxication in ruminants. Diplodiosis, a nervous disorder of cattle and sheep, results from ingestion of mouldy ears, kernels and maize stubble infected byS. maydis. Although this disease is most common in southern Africa, it has also been reported in Australia, Argentina and Brazil. Diplodiosis is characterised by reluctance of the animals to move, a wide-based stance, incoordination, paralysis and death. Myelin degeneration (status spongiosis) is the only histopathological change observed in affected animals, especially in cases of perinatal mortality. To date, none of the purifiedS. maydis metabolites has been administered to ruminants in order to reproduce diplodiosis. However, recent studies have focused on investigating the toxicity of the metabolites on cell cultures. Cytotoxicity studies where cultured cells were exposed to theS. maydis metabolites indicated that diplodiatoxin and dipmatol affected the activity of the mitochondrial succinate dehydrogenase enzyme and the overall viability of the cells. More detailedin vitro toxicity studies are still required to elucidate how the currently availableS. maydis metabolites influence parameters such as the mechanism of cell death. Development of analytical test methods to quantify and establish the presence and distribution of these mycotoxins in infected maize commodities also needs investigation. It is also critical that the role ofS. maydis stalk rot be evaluated as a potential source and cause of diplodiosis.
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Stenocarpella maydis and its toxic metabolites: a South African perspective on diplodiosis
in World Mycotoxin JournalSearch for other papers by M.G. Masango in
Current site
Google Scholar
PubMed
Search for other papers by B.C. Flett in
Current site
Google Scholar
PubMed
Search for other papers by C.E. Ellis in
Current site
Google Scholar
PubMed
Search for other papers by C.J. Botha in
Current site
Google Scholar
PubMed
Stenocarpella maydis is one of the most prevalent ear and stalk rot pathogens of maize globally, causing reductions of grain quality and yield. Various molecular methods, including polymerase chain reaction (PCR)-based techniques and nucleotide microarrays, have been developed for the identification ofS. maydis infestation in maize grain. In addition to diplodiatoxin, new metabolites, namely dipmatol, diplonine and chaetoglobosins K and L, have been isolated fromS. maydis infected cultures.S. maydis infected maize is also associated with intoxication in ruminants. Diplodiosis, a nervous disorder of cattle and sheep, results from ingestion of mouldy ears, kernels and maize stubble infected byS. maydis. Although this disease is most common in southern Africa, it has also been reported in Australia, Argentina and Brazil. Diplodiosis is characterised by reluctance of the animals to move, a wide-based stance, incoordination, paralysis and death. Myelin degeneration (status spongiosis) is the only histopathological change observed in affected animals, especially in cases of perinatal mortality. To date, none of the purifiedS. maydis metabolites has been administered to ruminants in order to reproduce diplodiosis. However, recent studies have focused on investigating the toxicity of the metabolites on cell cultures. Cytotoxicity studies where cultured cells were exposed to theS. maydis metabolites indicated that diplodiatoxin and dipmatol affected the activity of the mitochondrial succinate dehydrogenase enzyme and the overall viability of the cells. More detailedin vitro toxicity studies are still required to elucidate how the currently availableS. maydis metabolites influence parameters such as the mechanism of cell death. Development of analytical test methods to quantify and establish the presence and distribution of these mycotoxins in infected maize commodities also needs investigation. It is also critical that the role ofS. maydis stalk rot be evaluated as a potential source and cause of diplodiosis.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 375 | 155 | 24 |
| Gesamttextansichten | 29 | 1 | 0 |
| PDF-Downloads | 27 | 0 | 0 |
