Human exposure to fumonisins from home grown maize in Tanzania
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Fumonisins contaminate maize worldwide resulting in unacceptable fumonisin exposures in people relying on maize as staple food. This study determined fumonisins B1 (FB1) and B2 (FB2) in maize from 120 rural households: 30 from each of four main maize producing regions of Tabora, Ruvuma, Iringa and Kilimanjaro in Tanzania in order to estimate total fumonisin (FB1 + FB2) exposures to adult individuals in the households. The average daily per capita maize consumption of 771 g, recommended by the Tanzania Food and Nutrition Centre (TFNC) for an adult relying on it as a main meal, and also average daily per capita maize consumptions of 129, 308 and 356 g documented for Tanzania, were used in the exposure estimation. The fumonisins were determined by HPLC using fluorescence detection. Total fumonisins exposure (µg/kg body weight (bw)/day) was determined by multiplying average daily per capita maize consumption (kg) by fumonisin level in maize (µg/kg) from a given household and then dividing by an average bw of an adult of 60 kg. Of the 120 samples, 52% were contaminated with fumonisins at levels of up to 11,048 µg/kg (median; 363 µg/kg). Based on the recommended maize consumption of 771 g/person/day, fumonisin exposures to adult individuals in 38% of the households would exceed the provisional maximum tolerable daily intake (PMTDI) of 2 µg/kg bw, recommended by the Joint FAO/WHO Expert Committee on Food Additives. At the least documented maize consumption of 129 g/person/day, fumonisin exposures in 16% of the households were still above the PMTDI. Reduction of the maize consumption level to 40 g/person/day is an impractical, and reduction of the maximum contamination level to 155 µg/kg is a possibly practical, option for effective minimisation of fumonisin exposures in these communities. A relatively larger study is needed in order to generate comprehensive data for the formulation of appropriate strategies to minimise fumonisin exposures in Tanzania.
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-
Bhat, R.V., Shetty, H.P.K. and Vasanthi, S., 2000. Human and animal health significance of mycotoxins in sorghum with special reference to fumonisins. In: Technical and Institutional Options for sorghum grain mould management. Proceedings of an international consultation, 2000 May 18-19. ICRISAT. Patancheru: India, p. 107.
-
Chu, F.S. and Li, G.Y., 1994. Simultaneous occurrence of fumonisin B1 and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of oesophageal cancer. Applied Environmental Microbiology 60: 847-852.
'Simultaneous occurrence of fumonisin B1 and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of oesophageal cancer ' () 60 Applied Environmental Microbiology : 847 -852 .
-
Codex Alimentarius Commission, 2002. Suggested draft code of practice for the prevention (reduction) of mycotoxin contamination in cereals, including annexes on ochratoxin A, zearalenone, fumonisins and trichothecenes. Joint FAO/WHO Food Standards Programme, Rotterdam, The Netherlands.
-
Doko, M.B., Rapior, S., Visconti, A. and Schjoth, J.E., 1995. Incidence and levels of fumonisin contamination in maize genotypes grown in Europe and Africa. Journal of Agricultural and Food Chemistry 43: 429-434.
'Incidence and levels of fumonisin contamination in maize genotypes grown in Europe and Africa ' () 43 Journal of Agricultural and Food Chemistry : 429 -434 .
-
Doko, M.B., Canet, C., Brown, N., Sydenham, E.W., Mpuchane, S. and Siame, B.A., 1996. Natural co-occurrence of fumonisins and zearalenone in cereals and cereal-based foods from eastern and southern Africa. Journal of Agricultural and Food Chemistry 44: 3240-3243.
'Natural co-occurrence of fumonisins and zearalenone in cereals and cereal-based foods from eastern and southern Africa ' () 44 Journal of Agricultural and Food Chemistry : 3240 -3243 .
-
Food and Agricultural Organisation of the United Nations (FAO), 1992. Comparison of nutritive value of common maize and quality protein maize. Maize in human nutrition. Rome, Italy, pp. 81-104.
-
Fandohan, P., Zoumenou, D., Hounhouigan, D.J., Marasas, W.F.O., Wingfield, M.J. and Hell, K., 2005. Fate of aflatoxins and fumonisins during the processing of maize into food products in Benin. International Journal of Food Microbiology 98: 249-259.
'Fate of aflatoxins and fumonisins during the processing of maize into food products in Benin ' () 98 International Journal of Food Microbiology : 249 -259 .
-
Food Security Department (FSD), 1996. Tanzania Food Security Bulletin No 2, April/May 1996. Ministry of Agriculture, Dar es Salaam, Tanzania. 6 p.
-
Gamanya, R. and Sibanda, L., 2001. Survey of Fusarium moniliforme (F. verticillioides) and production of fumonisin B1 in cereal grains and oilseeds in Zimbabwe. International Journal of Food Microbiology 71: 145-149.
'Survey of Fusarium moniliforme (F. verticillioides) and production of fumonisin B1 in cereal grains and oilseeds in Zimbabwe ' () 71 International Journal of Food Microbiology : 145 -149 .
-
Gelderblom, W.C.A., Kriek, N.P.J., Marasas, W.F.O. and Thiel, P.G., 1991. Toxicity and Carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis 12: 1247-1251.
'Toxicity and Carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats ' () 12 Carcinogenesis : 1247 -1251 .
-
Kabak, B., Dobson, A.D.W. and Var, I., 2006. Strategies to prevent mycotoxin contamination of food and animal feed: a review. Critical reviews in Food Science and Nutrition 46: 593-619.
'Strategies to prevent mycotoxin contamination of food and animal feed: a review ' () 46 Critical reviews in Food Science and Nutrition : 593 -619 .
-
Kellerman, T.S., Marasas, W.F.O., Thiel, P.G., Gelderblom, W.C.A., Cawood, M. and Coetzer, J.A.W. 1990. Leukoencephalomalacia in two horses induced by oral dosing fumonisin B1. Onderstepoort Journal of Veteterinary Research 57: 722-727.
'Leukoencephalomalacia in two horses induced by oral dosing fumonisin B1 ' () 57 Onderstepoort Journal of Veteterinary Research : 722 -727 .
-
Kpodo, K., Thrane, U. and Hald, B., 2000. Fusarium and fumonisin in maize from Ghana and their co-occurrence with aflatoxins. International Journal of Food Microbiology 61: 147-157.
'Fusarium and fumonisin in maize from Ghana and their co-occurrence with aflatoxins ' () 61 International Journal of Food Microbiology : 147 -157 .
-
Marasas, W.F.O., 1997. Risk assessment of fumonsins produced by Fusarium moniliforme in corn. Cereal Research Communications 25: 399-406.
'Risk assessment of fumonsins produced by Fusarium moniliforme in corn ' () 25 Cereal Research Communications : 399 -406 .
-
Miller, J.D., 2001. Factors that affect the occurrence of fumonisin. Environmental Health Perspectives 109: 321-324.
'Factors that affect the occurrence of fumonisin ' () 109 Environmental Health Perspectives : 321 -324 .
-
Nkonya, E., Xavery, P., Akonaay, H., Mwangi, W., Anandajayasekeram, P., Verkuijl, H., Martella, D. and Moshi, A., 1998. Adoption of maize production technologies in Northern Tanzania. International Maize and Wheat Improvement Center (CIMMYT), The United Republic of Tanzania, and the Southern African Center for Cooperation in Agricultural Research (SACCAR), Mexico. 1, 16 p.
'Adoption of maize production technologies in Northern Tanzania ', in International Maize and Wheat Improvement Center (CIMMYT) , () 1 -16 .
-
Parmar, B., Miller, P.F. and Burt, R., 1997. Stepwise approaches for estimating the intakes of chemicals in food. Regulatory Toxicology and Pharmacology 26: 44-51.
'Stepwise approaches for estimating the intakes of chemicals in food ' () 26 Regulatory Toxicology and Pharmacology : 44 -51 .
-
Rheeder, J.P., Marasas, W.F.O., Thiel, P.G., Sydenham, E.W., Shephard, G.S. and Van Schalkwyk, D.J., 1992. Fusarium moniliforme and fumonisin in corn in relation to human esophageal cancer in Transkei. Phytopathology 82: 353-357.
'Fusarium moniliforme and fumonisin in corn in relation to human esophageal cancer in Transkei ' () 82 Phytopathology : 353 -357 .
-
Riley, R.T., Hinton, D.M., Chamberlain, W.J., Bacon, C.W., Wang, E., Merrill, A.H. and Voss, K.A., 1994. Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Spraque-Dawley rats: A new mechanism of nephrotoxicity. Journal of Nutrition 124: 594-603.
'Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Spraque-Dawley rats: A new mechanism of nephrotoxicity ' () 124 Journal of Nutrition : 594 -603 .
-
Samapundo, S., De Meulenaer, B., De Muer, N., Debevere, J. and Devlieghere, F., 2006. Influence of experimental parameters on the fluorescence response and recovery of the high-performance liquid chromatography analysis of fumonisin B1. Journal of Chromatography A, 1109: 312-316.
'Influence of experimental parameters on the fluorescence response and recovery of the high-performance liquid chromatography analysis of fumonisin B1 ' () 1109 Journal of Chromatography A : 312 -316 .
-
Shephard, G.S., Thiel, P.G., Stockenstrom, S. and Sydenham, E.W., 1996. World Survey of Fumonisins Contamination of Corn and Corn Based Products. Journal of AOAC International 79: 671 - 687
'World Survey of Fumonisins Contamination of Corn and Corn Based Products ' () 79 Journal of AOAC International : 671 -687 .
-
Shephard, G.S., Marasas, W.F.O., Burger, H.M., Somdyala, N.I.M., Rheeder, J.P., Van der Westhuizen, L., Gatyeni, P. and Van Schalkwyk, D.J., 2007. Exposure assessment for fumonisins in the former Transkei region of South Africa. Food Additives and Contaminants 24: 621-629.
'Exposure assessment for fumonisins in the former Transkei region of South Africa ' () 24 Food Additives and Contaminants : 621 -629 .
-
Soriano, J.M. and Dragacci, S., 2004. Intake, decontamination and legislation of fumonisins in foods. Food Research International 37: 367-374.
'Intake, decontamination and legislation of fumonisins in foods ' () 37 Food Research International : 367 -374 .
-
Sydenham, E.W., Shephard, G.S. and Thiel, P.G., 1992. Liquid Chromatographic determination of fumonisins B1, B2 and B3 in foods and feeds. Journal of AOAC International 75: 313-318.
'Liquid Chromatographic determination of fumonisins B1, B2 and B3 in foods and feeds ' () 75 Journal of AOAC International : 313 -318 .
-
Tanzania Food and Nutrition Centre (TFNC), 1997. Matumizi ya kadi ya uhakika wa chakula katika kaya. Mwongozo kwa wafanyakazi wa ugani. TFNC, Dar es Salaam, Tanzania, 14 p.
-
United Republic of Tanzania (URT), 1989. Strategies and recommendations for mycotoxin control in Tanzania. Report prepared for the Government of Tanzania by FAO/UNEP/USSR/ Tanzania Project FP/7101/86/03. Centre for International Projects. USSR State Committee for Environment Protection. Moscow, Russia, 74 p.
-
United Republic of Tanzania (URT), 2005. Tanzania Poverty and Human Development Report 2005. The Research and Analysis Working Group. Mkuki and Nyota Publishers, Dar es Salaam, Tanzania, 55 p.
-
Van Egmond, H.P., Schothorst, R.C. and Jonker, M.A., 2007. Regulations relating to mycotoxins in food. Analytical and Bioanalytical Chemistry 389: 147-157.
'Regulations relating to mycotoxins in food ' () 389 Analytical and Bioanalytical Chemistry : 147 -157 .
-
World Health Organization (WHO), 1997. Food consumption and exposure assessment of chemicals. Report of FAO/WHO consultation. World Health Organisation (WHO), Geneva, Switzerland, 10 p.
-
World Health Organization (WHO), 2002. Evaluation of certain mycotoxins in food. Fifty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives, WHO Technical Report Series 906, World Health Organization (WHO), Geneva, Switzerland, 24 p.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 196 | 79 | 13 |
| å ¨ææµè§æ¬¡æ° | 41 | 1 | 0 |
| PDFä¸è½½æ¬¡æ° | 3 | 0 | 0 |
Human exposure to fumonisins from home grown maize in Tanzania
äºWorld Mycotoxin JournalSearch for other papers by M. Kimanya in
Current site
Google Scholar
PubMed
Search for other papers by B. De Meulenaer in
Current site
Google Scholar
PubMed
Search for other papers by B. Tiisekwa in
Current site
Google Scholar
PubMed
Search for other papers by M. Ndomondo-Sigonda in
Current site
Google Scholar
PubMed
Search for other papers by P. Kolsteren in
Current site
Google Scholar
PubMed
Fumonisins contaminate maize worldwide resulting in unacceptable fumonisin exposures in people relying on maize as staple food. This study determined fumonisins B1 (FB1) and B2 (FB2) in maize from 120 rural households: 30 from each of four main maize producing regions of Tabora, Ruvuma, Iringa and Kilimanjaro in Tanzania in order to estimate total fumonisin (FB1 + FB2) exposures to adult individuals in the households. The average daily per capita maize consumption of 771 g, recommended by the Tanzania Food and Nutrition Centre (TFNC) for an adult relying on it as a main meal, and also average daily per capita maize consumptions of 129, 308 and 356 g documented for Tanzania, were used in the exposure estimation. The fumonisins were determined by HPLC using fluorescence detection. Total fumonisins exposure (µg/kg body weight (bw)/day) was determined by multiplying average daily per capita maize consumption (kg) by fumonisin level in maize (µg/kg) from a given household and then dividing by an average bw of an adult of 60 kg. Of the 120 samples, 52% were contaminated with fumonisins at levels of up to 11,048 µg/kg (median; 363 µg/kg). Based on the recommended maize consumption of 771 g/person/day, fumonisin exposures to adult individuals in 38% of the households would exceed the provisional maximum tolerable daily intake (PMTDI) of 2 µg/kg bw, recommended by the Joint FAO/WHO Expert Committee on Food Additives. At the least documented maize consumption of 129 g/person/day, fumonisin exposures in 16% of the households were still above the PMTDI. Reduction of the maize consumption level to 40 g/person/day is an impractical, and reduction of the maximum contamination level to 155 µg/kg is a possibly practical, option for effective minimisation of fumonisin exposures in these communities. A relatively larger study is needed in order to generate comprehensive data for the formulation of appropriate strategies to minimise fumonisin exposures in Tanzania.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 196 | 79 | 13 |
| å ¨ææµè§æ¬¡æ° | 41 | 1 | 0 |
| PDFä¸è½½æ¬¡æ° | 3 | 0 | 0 |
