The effect of eight weeks of circuit resistance training on Apo-B/A ratio and inflammatory status of sedentary postmenopausal women
äºComparative Exercise PhysiologySearch for other papers by E. Shakoor in
Current site
Google Scholar
Search for other papers by A. Qassemian in
Current site
Google Scholar
Search for other papers by S. Shams in
Current site
Google Scholar
Search for other papers by S. Amani-Shalamzari in
Current site
Google Scholar
Abstract
Exercise can be an effective non-pharmacological method to reduce the complications of menopause. This study aimed to investigate the effect of 8 weeks of circuit resistance training (CRT) on the levels of C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), apolipoprotein A (Apo-A), Apo-B, and their ratio in sedentary postmenopausal women. Thirty postmenopausal women (age 54 ± 3 years, body mass index 27.6 ± 1.97 kg/m2) without any serious diseases and no hormone therapy volunteered to participate in the research. The subjects were randomly divided into two groups: circuit resistance training (n = 15, CRT) and Control (n = 15) groups. Resistance training was performed for 8 weeks, 3 days a week, including 12 stations for the whole body in 3 sets and 8-12 repetitions. The exercises started at 40% of one repetition maximum (1RM) and gradually reached 75% of 1RM in the last week. Blood samples were taken before and 48 hours after the end of both interventions to measure CRP, ICAM-1, Apo-A-I, and Apo-B. To analyse the data, a two-way analysis of variance test was used. The CRT intervention by reducing Apo-B (â8.9% vs â0.1%; change percentage relative to pre-to-post values in each group) and increasing Apo-A1 (+4.7% vs â0.1%) led to a significant increase in the Apo-B/A ratio (â13.0% vs â0.08%) compared to the Control group. In addition, a substantial decrease in the inflammatory levels of CRP (â21.0% vs +6.3%) and ICAM-1 (â22.7% vs +1.6%) was observed after 8 weeks of CRT compared to the Control group. The observed changes were consistent with a reduction in body mass and an improvement in the waist-hip ratio (WHR). The findings indicated that CRT could reduce the complications of menopause by reducing inflammatory markers and improving the lipid profile.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Ambikairajah, A., Walsh, E. and Cherbuin, N., 2019. Lipid profile differences during menopause: a review with meta-analysis. Menopause 26: 1327-1333. https://doi.org/10.1097/gme.0000000000001403
-
Anagnostis, P., Antza, C., Trakatelli, C., Lambrinoudaki, I., Goulis, D.G. and Kotsis, V., 2023. The effect of menopause on lipoprotein (A) concentrations: A systematic review and meta-analysis. Maturitas 167: 39-45.
-
Burini, R.C., Anderson, E., Durstine, J.L. and Carson, J.A., 2020. Inflammation, physical activity, and chronic disease: An evolutionary perspective. Sports Medicine and Health Science 2: 1-6. https://doi.org/10.1016/j.smhs.2020.03.004
-
Camont, L., Chapman, M.J. and Kontush, A., 2011. Biological activities of HDL subpopulations and their relevance to cardiovascular disease. Trends in Molecular Medicine 17: 594-603. https://doi.org/10.1016/j.molmed.2011.05.013
-
Crouse, S.F., OâBrien, B.C., Grandjean, P.W., Lowe, R.C., Rohack, J.J. and Green, J.S., 1997. Effects of training and a single session of exercise on lipids and apolipoproteins in hypercholesterolemic men. Journal of Applied Physiology 83: 2019-2028. https://doi.org/10.1152/jappl.1997.83.6.2019
-
Daley, A.J., Stokes-Lampard, H., Thomas, A., Rees, M., Coleman, S., Roalfe, A., Hunter, M.S. and MacArthur, C., 2013. Aerobic exercise as a treatment for vasomotor menopausal symptoms: Randomised controlled trial protocol. Maturitas 76: 350-356. https://doi.org/10.1016/j.maturitas.2013.08.004
-
de Sousa, C.V., Sales, M.M., Rosa, T.S., Lewis, J.E., de Andrade, R.V. and SimoÌes, H.G., 2017. The antioxidant effect of exercise: a systematic review and meta-analysis. Sports Medicine 47: 277-293. https://doi.org/10.1007/s40279-016-0566-1
-
Faul, F., Erdfelder, E., Lang, A.G. and Buchner, A., 2007. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39: 175-191. https://doi.org/10.3758/bf03193146
-
Greendale, G.A., Lee, N.P. and Arriola, E.R., 1999. The menopause. The Lancet 353: 571-580. https://doi.org/10.1016/S0140-6736(98)05352-5
-
Greene, N.P., Martin, S.E. and Crouse, S.F., 2012. Acute exercise and training alter blood lipid and lipoprotein profiles differently in overweight and obese men and women. Obesity 20: 1618-1627. https://doi.org/10.1038/oby.2012.65
-
Holme, I., Høstmark, A.T. and Anderssen, S.A., 2007. ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men. Results from the 1-year randomized Oslo Diet and Exercise Study. Journal of Internal Medicine 262: 235-243. https://doi.org/10.1111/j.1365-2796.2007.01806.x
-
Howard, E.F., Chen, Q., Cheng, C., Carroll, J.E. and Hess, D., 1998. NF-κB is activated and ICAM-1 gene expression is upregulated during reoxygenation of human brain endothelial cells. Neuroscience Letters 248: 199-203. https://doi.org/10.1016/S0304-3940(98)00239-0
-
Iorga, A., Cunningham, C.M., Moazeni, S., Ruffenach, G., Umar, S. and Eghbali, M., 2017. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biology of Sex Differences 8: 33. https://doi.org/10.1186/s13293-017-0152-8
-
Jakimiuk, A.J., Bogusiewicz, M., Skorupski, P., Adamiak, A., MiotÅa, P., HaczynÌski, J. and Rechberger, T., 2007. Relationship between estrogen receptor-α polymorphism and serum levels of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, C-reactive protein and homocysteine in postmenopausal women. Gynecological Endocrinology 23: 584-589.
-
Kaneva, A.M., Potolitsyna, N.N., Bojko, E.R. and Odland, J., 2015. The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity. Disease Markers 2015: 591454. https://doi.org/10.1155/2015/591454
-
Kim, D.-Y. and Jung, S.-Y., 2014. Effect of aerobic exercise on risk factors of cardiovascular disease and the apolipoprotein B/apolipoprotein A-1 ratio in obese woman. Journal of Physical Therapy Science 26: 1825-1829.
-
Laaksonen, D.E., Atalay, M., Niskanen, L.K., Mustonen, J., Sen, C.K., Lakka, T.A. and Uusitupa, M.I., 2000. Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial. Medicine and Science in Sports and Exercise 32: 1541-1548. https://doi.org/10.1097/00005768-200009000-00003
-
Leon, A.S., Rice, T., Mandel, S., DespreÌs, J.P., Bergeron, J., Gagnon, J., Rao, D.C., Skinner, J.S., Wilmore, J.H. and Bouchard, C., 2000. Blood lipid response to 20 weeks of supervised exercise in a large biracial population: the HERITAGE Family Study. Metabolism 49: 513-520. https://doi.org/10.1016/s0026-0495(00)80018-9
-
Lin, Y.Y. and Lee, S.D., 2018. Cardiovascular Benefits of Exercise Training in Postmenopausal Hypertension. International Journal of Molecular Sciences 19: 2523. https://doi.org/10.3390/ijms19092523
-
McCarthy, M. and Raval, A.P., 2020. The peri-menopause in a womanâs life: a systemic inflammatory phase that enables later neurodegenerative disease. Journal of Neuroinflammation 17: 317. https://doi.org/10.1186/s12974-020-01998-9
-
Mesquita, P.H.C., Lamb, D.A., Godwin, J.S., Osburn, S.C., Ruple, B.A., Moore, J.H., Vann, C.G., Huggins, K.W., Fruge, A.D., Young, K.C., Kavazis, A.N. and Roberts, M.D., 2021. Effects of resistance training on the redox status of skeletal muscle in older adults. Antioxidants 10: 350. https://doi.org/10. https://doi.org/10.3390/antiox10030350
-
Mishra, P., Davies, D.A. and Albensi, B.C., 2023. The interaction between NF-κB and Estrogen in Alzheimerâs disease. Molecular Neurobiology 60: 1515-1526. https://doi.org/10.1007/s12035-022-03152-3
-
Mohammadi, H.R., Khoshnam, M.S. and Khoshnam, E., 2018. Effects of different modes of exercise training on body composition and risk factors for cardiovascular disease in middle-aged men. International Journal of Preventive Medicine 9: 9. https://doi.org/10.4103/ijpvm.IJPVM_209_16
-
Monteleone, P., Mascagni, G., Giannini, A., Genazzani, A.R. and Simoncini, T., 2018. Symptoms of menopause â global prevalence, physiology and implications. Nature Reviews Endocrinology 14: 199-215.
-
Nappi, R.E. and Simoncini, T., 2021. Menopause transition: a golden age to prevent cardiovascular disease. The Lancet Diabetes and Endocrinology 9: 135-137.
-
Nunes, P.R.P., Barcelos, L.C., Oliveira, A.A., Furlanetto Jr., R., Martins, F.M., Orsatti, C.L., Resende, E.A.M.R. and Orsatti, F.L., 2016. Effect of resistance training on muscular strength and indicators of abdominal adiposity, metabolic risk, and inflammation in postmenopausal women: controlled and randomized clinical trial of efficacy of training volume. Age 38: 1-13.
-
Petersen, A.M. and Pedersen, B.K., 2005. The anti-inflammatory effect of exercise. Journal of Applied Physiology 98: 1154-1162. https://doi.org/10.1152/japplphysiol.00164.2004
-
Powers, S.K., Goldstein, E., Schrager, M. and Ji, L.L., 2022. Exercise training and skeletal muscle antioxidant enzymes: an update. Antioxidants 12: 39. https://doi.org/10.3390/antiox12010039
-
Sardeli, A.V., Tomeleri, C.M., Cyrino, E.S., Fernhall, B., Cavaglieri, C.R. and Chacon-Mikahil, M.P.T., 2018. Effect of resistance training on inflammatory markers of older adults: A meta-analysis. Experimental Gerontology 111: 188-196. https://doi.org/10.1016/j.exger.2018.07.021
-
Seip, R.L., Angelopoulos, T.J. and Semenkovich, C.F., 1995. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. American Physiological Society 268: E229-236. https://doi.org/10.1152/ajpendo.1995.268.2.E229
-
Shelness, G.S. and Sellers, J.A., 2001. Very-low-density lipoprotein assembly and secretion. Current Opinion in Lipidology 12: 151-157. https://doi.org/10.1097/00041433-200104000-00008
-
Shokri, G., Mohammadian, F., Noroozian, M., Amani-Shalamzari, S. and Suzuki, K., 2023. Effects of remote combine exercise-music training on physical and cognitive performance in patients with Alzheimerâs disease: a randomized controlled trial. Frontiers in Aging Neuroscience 15: 1283927. https://doi.org/10.3389/fnagi.2023.1283927
-
Son, W.-M., Pekas, E.J. and Park, S.-Y., 2020. Twelve weeks of resistance band exercise training improves age-associated hormonal decline, blood pressure, and body composition in postmenopausal women with stage 1 hypertension: a randomized clinical trial. Menopause 27: 199-207.
-
Stuenkel, C.A., Davis, S.R., Gompel, A., Lumsden, M.A., Murad, M.H., Pinkerton, J.V. and Santen, R.J., 2015. Treatment of symptoms of the menopause: an endocrine society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 100: 3975-4011.
-
Tan, T.-W., Tan, H.-L., Hsu, M.-F., Huang, H.-L. and Chung, Y.-C., 2023. Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials. BMC Womenâs Health 23: 606. https://doi.org/10.1186/s12905-023-02749-7
-
Ward, L.J., Nilsson, S., Hammar, M., Lindh-AÌstrand, L., Berin, E., Lindblom, H., Spetz Holm, A.-C., RubeÌr, M. and Li, W., 2020. Resistance training decreases plasma levels of adipokines in postmenopausal women. Scientific Reports 10: 19837. https://doi.org/10.1038/s41598-020-76901-w
-
Wegge, J.K., Roberts, C.K., Ngo, T.H. and Barnard, R.J., 2004. Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease. Metabolism 53: 377-381. https://doi.org/10.1016/j.metabol.2003.10.016
-
Willis, L.H., Slentz, C.A., Bateman, L.A., Shields, A.T., Piner, L.W., Bales, C.W., Houmard, J.A. and Kraus, W.E., 2012. Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults. Journal of Applied Physiology 113: 1831-1837. https://doi.org/10.1152/japplphysiol.01370.2011
-
Witkowska, A.M., 2005. Soluble ICAM-1: A marker of vascular inflammation and lifestyle. Cytokine 31: 127-134. https://doi.org/10.1016/j.cyto.2005.04.007
-
Yasui, T., Maegawa, M., Tomita, J., Miyatani, Y., Yamada, M., Uemura, H., Matsuzaki, T., Kuwahara, A., Kamada, M., Tsuchiya, N., Yuzurihara, M., Takeda, S. and Irahara, M., 2007. Changes in serum cytokine concentrations during the menopausal transition. Maturitas 56: 396-403. https://doi.org/10.1016/j.maturitas.2006.11.002
-
Zoppini, G., Targher, G., Zamboni, C., Venturi, C., Cacciatori, V., Moghetti, P. and Muggeo, M., 2006. Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases 16: 543-549. https://doi.org/10.1016/j.numecd.2005.09.004
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 605 | 189 | 19 |
| å ¨ææµè§æ¬¡æ° | 10 | 5 | 0 |
| PDFä¸è½½æ¬¡æ° | 105 | 8 | 0 |
The effect of eight weeks of circuit resistance training on Apo-B/A ratio and inflammatory status of sedentary postmenopausal women
äºComparative Exercise PhysiologySearch for other papers by E. Shakoor in
Current site
Google Scholar
PubMed
Search for other papers by A. Qassemian in
Current site
Google Scholar
PubMed
Search for other papers by S. Shams in
Current site
Google Scholar
PubMed
Search for other papers by S. Amani-Shalamzari in
Current site
Google Scholar
PubMed
Abstract
Exercise can be an effective non-pharmacological method to reduce the complications of menopause. This study aimed to investigate the effect of 8 weeks of circuit resistance training (CRT) on the levels of C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), apolipoprotein A (Apo-A), Apo-B, and their ratio in sedentary postmenopausal women. Thirty postmenopausal women (age 54 ± 3 years, body mass index 27.6 ± 1.97 kg/m2) without any serious diseases and no hormone therapy volunteered to participate in the research. The subjects were randomly divided into two groups: circuit resistance training (n = 15, CRT) and Control (n = 15) groups. Resistance training was performed for 8 weeks, 3 days a week, including 12 stations for the whole body in 3 sets and 8-12 repetitions. The exercises started at 40% of one repetition maximum (1RM) and gradually reached 75% of 1RM in the last week. Blood samples were taken before and 48 hours after the end of both interventions to measure CRP, ICAM-1, Apo-A-I, and Apo-B. To analyse the data, a two-way analysis of variance test was used. The CRT intervention by reducing Apo-B (â8.9% vs â0.1%; change percentage relative to pre-to-post values in each group) and increasing Apo-A1 (+4.7% vs â0.1%) led to a significant increase in the Apo-B/A ratio (â13.0% vs â0.08%) compared to the Control group. In addition, a substantial decrease in the inflammatory levels of CRP (â21.0% vs +6.3%) and ICAM-1 (â22.7% vs +1.6%) was observed after 8 weeks of CRT compared to the Control group. The observed changes were consistent with a reduction in body mass and an improvement in the waist-hip ratio (WHR). The findings indicated that CRT could reduce the complications of menopause by reducing inflammatory markers and improving the lipid profile.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 605 | 189 | 19 |
| å ¨ææµè§æ¬¡æ° | 10 | 5 | 0 |
| PDFä¸è½½æ¬¡æ° | 105 | 8 | 0 |
