Time course of epigenetic modulation in response to concurrent exercise training in patients with schizophrenia
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Programa de Pós Graduação em Biociências e Reabilitação doCentro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Programa de Pós Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Brazil
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This study aimed to investigate the short and long-term effects of concurrent exercise training on anthropometric variables, HDCA2 activity and cortisol levels of individuals with schizophrenia (SZ). Therefore, 10 patients were submitted to the program (endurance and strength exercises in the same session, 60 min of duration, three times a week) and blood samples were collected before, 30 days and 180 days after the intervention started. Exercise training reduced the body mass index and body mass after 180 days of the intervention. A significant decrease on HDAC2 activity was found 180 days after intervention compared to before the intervention. The cortisol levels remained unchanged in any evaluated time-points. The concurrent exercise training was able to modulate HDAC2 activity in mononuclear cells and improve anthropometric variables in a time-dependent manner in patients with SZ.
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-
Adam, D., 2013. Mental health: on the spectrum. Nature 496: 416-418. https://doi.org/10.1038/496416a
-
American College of Sports Medicine, 2006. Guidelines for exercise testing and prescription, 7th ed. Lippincott Williams & Wilkins, Philadelphia, PA, USA.
'Guidelines for exercise testing and prescription, 7th ed', ().
-
Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J. and Ravasi, T., 2006. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB Journal 20: 1315-1327. https://doi.org/10.1096/fj.05-5360com
-
Bahari-Javan, S., Maddalena, A., Kerimoglu, C., Wittnam, J., Held, T., Bahr, M., Burkhardt, S., Delalle, I., Kugler, S., Fischer, A. and Sananbenesi, F., 2012. HDAC1 regulates fear extinction in mice. Journal of Neuroscience 32: 5062-5073. https://doi.org/10.1523/JNEUROSCI.0079-12.2012
-
Bhattacharya, T.K., Pence, B.D., Ossyra, J.M., Gibbons, T.E., Perez, S., McCusker, R.H., Kelley, K.W., Johnson, R.W., Woods, J.A. and Rhodes, J.S., 2015. Exercise but not (â)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice. Physiology and Behavior 145: 29-37. httpshttps://doi.org/10.1016/j.physbeh.2015.03.023
-
Bicalho, H.M.S., Gontijo, C.M. and Nogueira-Machado, J.A., 1981. A simple technique for simultaneous human leukocytes separation. Journal of Immunological Methods 40: 115-116. https://doi.org/10.1016/0022-1759(81)90087-9
-
Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248-254. https://doi.org/10.1016/0003-2697(76)90527-3
-
Bradley, A.J. and Dinan, T.G., 2010. Review: A systematic review of hypothalamic-pituitary-adrenal axis function in schizophrenia: implications for mortality. Journal of Psychopharmacology 24: 91-118. https://doi.org/10.1177/1359786810385491
-
Casey, D.E., Daniel, D.G., Tamminga, C., Kane, J.M., Tran-Johnson, T., Wozniak, P., Abi-Saab, W., Baker, J., Redden, L., Greco, N. and Saltarelli, M., 2009. Divalproex ER combined with olanzapine or risperidone for treatment of acute exacerbations of schizophrenia. Neuropsychopharmacology 34: 1330-1338. https://doi.org/10.1038/npp.2008.209
-
Covington, H.E., Maze, I., LaPlant, Q.C., Vialou, V.F., Ohnishi, Y.N., Berton, O., Fass, D.M., Renthal, W., Rush, A.J., Wu, E.Y., Ghose, S., Krishnan, V., Russo, S.J., Tamminga, C., Haggarty, S.J. and Nestler, E.J., 2009. Antidepressant actions of histone deacetylase inhibitors. Journal of Neuroscience 29: 11451. https://doi.org/10.1523/JNEUROSCI.1758-09.2009
-
Da Silva, I.R.V., de Araujo, C.L.P., Dorneles, G.P., Peres, A., Bard, A.L., Reinaldo, G., Teixeira, P.J.Z., Lago, P.D. and Elsner, V.R., 2017. Exercise-modulated epigenetic markers and inflammatory response in COPD individuals: a pilot study. Respiratory Physiology and Neurobiology 242: 89-95. https://doi.org/10.1016/j.resp.2017.04.004
-
De la Fuente Revenga, M., Ibi, D., Saunders, J.M., Cuddy, T., Ijaz, M.K., Toneatti, R., Kurita, M., Holloway, T., Shen, L., Seto, J., Dozmorov, M.G. and González-Maeso, J., 2018. HDAC2-dependent antipsychotic-like effects of chronic treatment with the HDAC inhibitor SAHA in mice. Neuroscience 388: 102-117. https://doi.org/10.1016/j.neuroscience.2018.07.010
-
Denham, J., OâBrien, B.J., Harvey, J.T. and Charchar, F.J., 2015. Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans. Epigenomics 7: 717-731. https://doi.org/10.2217/epi.15.29
-
Dorneles, G.P., Boeira, M.C.R., Schipper, L.L., Silva, I.R.V., Elsner, V.R., Dal Lago, P., Peres, A. and Romão, P.R.T., 2017. Acute strenuous exercise induces an imbalance on histone H4 acetylation/histone deacetylase 2 and increases the proinflammatory profile of PBMC of obese individuals. Oxidative Medicine and Cellular Longevity 2017: 1530230. https://doi.org/10.1155/2017/1530230
-
Dorneles, G.P., Haddad, D.O., Fagundes, V.O., Vargas, B.K., Kloecker, A., Romão, P.R.T. and Peres, A., 2016. High intensity interval exercise decreases IL-8 and enhances the immunomodulatory cytokine interleukin-10 in lean and overweight-obese individuals. Cytokine 77: 1-9. https://doi.org/10.1016/j.cyto.2015.10.003
-
Falkai, P., Malchow, B. and Schmitt, A., 2017. Aerobic exercise and its effects on cognition in schizophrenia. Current Opinion in Psychiatry 30: 171-175.
'Aerobic exercise and its effects on cognition in schizophrenia ' () 30 Current Opinion in Psychiatry : 171 -175.
-
Fervaha, G., Takeuchi, H., Lee, J., Foussias, G., Fletcher, P.J., Agid, O. and Remington, G., 2015. Antipsychotics and amotivation. Neuropsychopharmacology 40: 1539-1548. https://doi.org/10.1038/npp.2015.3
-
Figueiredo, A.I., Jose Cunha, J., Reichert Vital da Silva, I., Luna Martins, L., Bard, A., Reinaldo, G., Rostirola Elsner, V. and Padilha de Souza, M., 2017. Running-induced functional mobility improvement in the elderly males is driven by enhanced plasma BDNF levels and the modulation of global histone H4 acetylation status. Middle East Journal of Rehabilitation and Health Studies 4: e57486. https://doi.org/10.5812/mejrh.57486
-
Firth, J., Stubbs, B., Rosenbaum, S., Vancampfort, D., Malchow, B., Schuch, F., Elliott, R., Nuechterlein, K.H. and Yung, A.R., 2017. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophrenia Bulletin 43: 546-556. https://doi.org/10.1093/schbul/sbw115
-
Freedman, R., 2003. Schizophrenia. New England Journal of Medicine 349: 1738-1749.
'Schizophrenia ' () 349 New England Journal of Medicine : 1738 -1749.
-
Goldberg, T.E., Greenberg, R.D., Griffin, S.J., Gold, J.M., Kleinman, J.E., Pickar, D., Schulz, S.C. and Weinberger, D.R., 1993. The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. British Journal of Psychiatry 162: 43-48. https://doi.org/10.1192/bjp.162.1.43
-
Gonzalez, A.J., Heaney, L.M., Podda, G., Oladipo, J.M., Grayson, B., Harte, M.K., Large, C. and Neill, J.C., 2017. Brain-derived neurotrophic factor and exercise-induced reversal of cognitive deficits of relevance to schizophrenia in the sub-chronic phencyclidine rat model. pA2 online, available at: http://www.pa2online.org/abstract/abstract.jsp?abid=33594
-
Gräff, J., Rei, D., Guan, J.-S., Wang, W.-Y., Seo, J., Hennig, K.M., Nieland, T.J.F., Fass, D.M., Kao, P.F., Kahn, M., Su, S.C., Samiei, A., Joseph, N., Haggarty, S.J., Delalle, I. and Tsai, L.-H., 2012. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483: 222-226. https://doi.org/10.1038/nature10849
-
Guan, J.-S., Haggarty, S.J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T.J.F., Zhou, Y., Wang, X., Mazitschek, R., Bradner, J.E., DePinho, R.A., Jaenisch, R. and Tsai, L.-H., 2009. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60. https://doi.org/10.1038/nature07925
-
Gunnar, M. and Quevedo, K., 2007. The neurobiology of stress and development. Annual Review of Psychology 58: 145-173. https://doi.org/10.1146/annurev.psych.58.110405.085605
-
Gury, C., 2004. Schizophrénie, diabète et antipsychotiques. LâEncéphale 30: 382-391. https://doi.org/10.1016/S0013-7006(04)95452-8
-
Hempel, R.J., Tulen, J.H.M., van Beveren, N.J.M., Röder, C.H., de Jong, F.H. and Hengeveld, M.W., 2010. Diurnal cortisol patterns of young male patients with schizophrenia. Psychiatry and Clinical Neurosciences 64: 548-554. https://doi.org/10.1111/j.1440-1819.2010.02121.x
-
Ho, R.T.H., Fong, T.C.T., Wan, A.H.Y., Au-Yeung, F.S.W., Chen, E.Y.H. and Spiegel, D., 2016. Associations between diurnal cortisol patterns and lifestyle factors, psychotic symptoms, and neurological deficits: A longitudinal study on patients with chronic schizophrenia. Journal of Psychiatric Research 81: 16-22. https://doi.org/10.1016/j.jpsychires.2016.06.014
-
Ho, R.T.H., Fong, T.C.T., Wan, A.H.Y., Au-Yeung, F.S.W., Wong, C.P.K., Ng, W.Y.H., Cheung, I.K.M., Lo, P.H.Y., Ng, S.M., Chan, C.L.W. and Chen, E.Y.H., 2016. A randomized controlled trial on the psychophysiological effects of physical exercise and Tai-chi in patients with chronic schizophrenia. Schizophrenia Research 171: 42-49. https://doi.org/10.1016/j.schres.2016.01.038
-
Ho, S.S., Dhaliwal, S.S., Hills, A.P. and Pal, S., 2012. The effect of 12 weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a randomized trial. BMC Public Health 12: 704. https://doi.org/10.1186/1471-2458-12-704
-
Hopkins, M.E., Nitecki, R. and Bucci, D.J., 2011. Physical exercise during adolescence versus adulthood: differential effects on object recognition memory and brain-derived neurotrophic factor levels. Neuroscience 194: 84-94. https://doi.org/10.1016/j.neuroscience.2011.07.071
-
Husa, A.P., Moilanen, J., Murray, G.K., Marttila, R., Haapea, M., Rannikko, I., Barnett, J.H., Jones, P.B., Isohanni, M., Remes, A.M., Koponen, H., Miettunen, J. and Jääskeläinen, E., 2017. Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort. Psychiatry Research 247: 130-138. https://doi.org/10.1016/j.psychres.2016.10.085
-
Ibi, D. and González-Maeso, J., 2015. Epigenetic signaling in schizophrenia. Cellular Signalling 27: 2131-2136. https://doi.org/10.1016/j.cellsig.2015.06.003
-
Ibi, D., de la Fuente Revenga, M., Kezunovic, N., Muguruza, C., Saunders, J.M., Gaitonde, S.A., Moreno, J.L., Ijaz, M.K., Santosh, V., Kozlenkov, A., Holloway, T., Seto, J., GarcÃa-Bea, A., Kurita, M., Mosley, G.E., Jiang, Y., Christoffel, D.J., Callado, L.F., Russo, S.J., Dracheva, S., López-Giménez, J.F., Ge, Y., Escalante, C.R., Meana, J.J., Akbarian, S., Huntley, G.W. and González-Maeso, J., 2017. Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects. Nature Neuroscience 20: 1247-1259. https://doi.org/10.1038/nn.4616
-
Ibrahim, M.H. and Tamminga, A.C., 2012. Treating impaired cognition in schizophrenia. Current Pharmaceutical Biotechnology 13: 1587-1594. https://doi.org/10.2174/138920112800784772
-
Ito, K., Barnes Peter, J. and Adcock Ian, M., 2000. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12. Molecular and Cellular Biology 20: 6891-6903. https://doi.org/10.1128/MCB.20.18.6891-6903.2000
-
Kaliman, P., Ãlvarez-López, M.J., CosÃn-Tomás, M., Rosenkranz, M.A., Lutz, A. and Davidson, R.J., 2014. Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators. Psychoneuroendocrinology 40: 96-107. https://doi.org/10.1016/j.psyneuen.2013.11.004
-
Kebir, O., Chaumette, B., Fatjó-Vilas, M., Ambalavanan, A., Ramoz, N., Xiong, L., Mouaffak, F., Millet, B., Jaafari, N., DeLisi, L.E., Levinson, D., Joober, R., Fañanás, L., Rouleau, G., Dubertret, C. and Krebs, M.-O., 2014. Family-based association study of common variants, rare mutation study and epistatic interaction detection in HDAC genes in schizophrenia. Schizophrenia Research 160: 97-103. https://doi.org/10.1016/j.schres.2014.09.029
-
Korb, A., Bertoldi, K., Lovatel, G.A., Delevatti, R.S., Elsner, V.R., Meireles, L.C.F., Kruel, L.F.M. and Siqueira, I.R., 2018. Acute exercise and periodized training in different environments affect histone deacetylase activity and interleukin-10 levels in peripheral blood of patients with type 2 diabetes. Diabetes Research and Clinical Practice 141: 132-139. https://doi.org/10.1016/j.diabres.2018.04.037
-
Kouzarides, T., 2007. Chromatin modifications and their function. Cell 128: 693-705. https://doi.org/10.1016/j.cell.2007.02.005
-
Kurita, M., Holloway, T., GarcÃa-Bea, A., Kozlenkov, A., Friedman, A.K., Moreno, J.L., Heshmati, M., Golden, S.A., Kennedy, P.J., Takahashi, N., Dietz, D.M., Mocci, G., Gabilondo, A.M., Hanks, J., Umali, A., Callado, L.F., Gallitano, A.L., Neve, R.L., Shen, L., Buxbaum, J.D., Han, M.-H., Nestler, E.J., Meana, J.J., Russo, S.J. and González-Maeso, J., 2012. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience 15: 1245-1254. https://doi.org/10.1038/nn.3181
-
Kurita, M., Moreno, J.L., Holloway, T., Kozlenkov, A., Mocci, G., GarcÃa-Bea, A., Hanks, J.B., Neve, R., Nestler, E.J., Russo, S.J. and González-Maeso, J., 2013. Repressive Epigenetic Changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Molecular Pharmacology 83: 1166. https://doi.org/10.1124/mol.112.084582
-
Laursen, T.M., 2011. Life expectancy among persons with schizophrenia or bipolar affective disorder. Schizophrenia Research 131: 101-104. https://doi.org/10.1016/j.schres.2011.06.008
-
Lavratti, C., Dorneles, G., Pochmann, D., Peres, A., Bard, A., de Lima Schipper, L., Dal Lago, P., Wagner, L.C. and Elsner, V.R., 2017. Exercise-induced modulation of histone H4 acetylation status and cytokines levels in patients with schizophrenia. Physiology and Behavior 168: 84-90. https://doi.org/10.1016/j.physbeh.2016.10.021
-
Lin, J.X., Lam, M.M.L., Chan, K.W., Chang, W.C., Joe, G. and Chiu, C.P.Y., 2011. The impacts of yoga and exercise on cognition and symptoms in early psychosis. In: The 13th International Congress on Schizophrenia Research (ICOSR 2011), Colorado Springs, CO, USA. Schizophrenia Bulletin 37: 171. https://doi.org/10.1093/schbul/sbq173
-
Lin, T.-W., Chen, S.-J., Huang, T.-Y., Chang, C.-Y., Chuang, J.-I., Wu, F.-S., Kuo, Y.-M. and Jen, C.J., 2012. Different types of exercise induce differential effects on neuronal adaptations and memory performance. Neurobiology of Learning and Memory 97: 140-147. https://doi.org/10.1016/j.nlm.2011.10.006
-
Liu, J., Chen, J., Ehrlich, S., Walton, E., White, T., Perrone-Bizzozero, N., Bustillo, J., Turner, J.A. and Calhoun, V.D., 2014. Methylation patterns in whole blood correlate with symptoms in schizophrenia patients. Schizophrenia Bulletin 40: 769-776. https://doi.org/10.1093/schbul/sbt080
-
Marzolini, S., Jensen, B. and Melville, P., 2009. Feasibility and effects of a group-based resistance and aerobic exercise program for individuals with severe schizophrenia: A multidisciplinary approach. Mental Health and Physical Activity 2: 29-36. https://doi.org/10.1016/j.mhpa.2008.11.001
-
Meltzer, H.Y., Bonaccorso, S., Bobo, W. V., Chen, Y. and Jayathilake, K., 2011. A 12-month randomized, open-label study of the metabolic effects of olanzapine and risperidone in psychotic patients: influence of valproic acid augmentation. Journal of Clinical Psychiatry 72: 1602-1610. https://doi.org/10.4088/JCP.10m05997
-
Meyer, J.M. and Lehman, D., 2006. Bone mineral density in male schizophrenia patients: a review. Annals of Clinical Psychiatry 18: 43-48. https://doi.org/10.1080/10401230500464687
-
Millan, M.J., Agid, Y., Brüne, M., Bullmore, E.T., Carter, C.S., Clayton, N.S., Connor, R., Davis, S., Deakin, B., DeRubeis, R.J., Dubois, B., Geyer, M.A., Goodwin, G.M., Gorwood, P., Jay, T.M., Joëls, M., Mansuy, I.M., Meyer-Lindenberg, A., Murphy, D., Rolls, E., Saletu, B., Spedding, M., Sweeney, J., Whittington, M. and Young, L.J., 2012. Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery 11: 141-168. https://doi.org/10.1038/nrd3628
-
Mitsadali, I., Grayson, B., Idris, N. F., Watson, L., Burgess, M. and Neill, J., 2020. Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model. Journal of Psychopharmacology 34: 695-708.
'Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model ' () 34 Journal of Psychopharmacology : 695 -708.
-
Mondelli, V., Dazzan, P., Hepgul, N., Di Forti, M., Aas, M., DâAlbenzio, A., Di Nicola, M., Fisher, H., Handley, R., Marques, T.R., Morgan, C., Navari, S., Taylor, H., Papadopoulos, A., Aitchison, K.J., Murray, R.M. and Pariante, C.M., 2010. Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment. Schizophrenia Research 116: 234-242. https://doi.org/10.1016/j.schres.2009.08.013
-
Morris, M.J., Mahgoub, M., Na, E.S., Pranav, H. and Monteggia, L.M., 2013. Loss of histone deacetylase 2 improves working memory and accelerates extinction learning. Journal of Neuroscience 33: 6401. https://doi.org/10.1523/JNEUROSCI.1001-12.2013
-
Nielsen, R.E., Levander, S., Kjaersdam Telléus, G., Jensen, S.O.W., Ãstergaard Christensen, T. and Leucht, S., 2015. Second-generation antipsychotic effect on cognition in patients with schizophrenia â a meta-analysis of randomized clinical trials. Acta Psychiatrica Scandinavica 131: 185-196. https://doi.org/10.1111/acps.12374
-
Nugent, K.L., Chiappelli, J., Sampath, H., Rowland, L.M., Thangavelu, K., Davis, B., Du, X., Muellerklein, F., Daughters, S., Kochunov, P. and Hong, L.E., 2015. Cortisol reactivity to stress and its association with white matter integrity in adults with schizophrenia. Psychosomatic Medicine 77: 733-742.
'Cortisol reactivity to stress and its association with white matter integrity in adults with schizophrenia ' () 77 Psychosomatic Medicine : 733 -742.
-
Oliveira, G.S.D., Iraci, L., Pinheiro, G.S., Casal, M.Z., Haas, A.N., Pochmann, D., Martinez, F.G., Elsner, V. and Dani, C., 2020. Effect of exercise and grape juice on epigenetic modulation and functional outcomes in PD: A randomized clinical trial. Physiology and Behavior 227: 113135. https://doi.org/10.1016/j.physbeh.2020.113135
-
Poulin, M. J., Chaput, J. P., Simard, V., Vincent, P., Bernier, J., Gauthier, Y., Lanctôt, G., Saindon, J., Vincent, A., Gagnon, S. and Tremblay, A., 2007. Management of antipsychotic-induced weight gain: prospective naturalistic study of the effectiveness of a supervised exercise programme. Australian and New Zealand Journal of Psychiatry 41: 980-989.
'Management of antipsychotic-induced weight gain: prospective naturalistic study of the effectiveness of a supervised exercise programme ' () 41 Australian and New Zealand Journal of Psychiatry : 980 -989.
-
Ryan, M.C.M. and Thakore, J.H., 2002. Physical consequences of schizophrenia and its treatment: The metabolic syndrome. Life Sciences 71: 239-257. https://doi.org/10.1016/S0024-3205(02)01646-6
-
Scheewe, T.W., van Haren, N.E.M., Sarkisyan, G., Schnack, H.G., Brouwer, R.M., de Glint, M., Hulshoff Pol, H.E., Backx, F.J.G., Kahn, R.S. and Cahn, W., 2013. Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls. European Neuropsychopharmacology 23: 675-685. https://doi.org/10.1016/j.euroneuro.2012.08.008
-
Silva, B.A., Cassilhas, R.C., Attux, C., Cordeiro, Q., Gadelha, A.L., Telles, B.A., Bressan, R.A., Ferreira, F.N., Rodstein, P.H., Daltio, C.S., Tufik, S. and De Mello, M.T., 2015. A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial. Brazilian Journal of Psychiatry 37: 271-279. https://doi.org/10.1590/1516-4446-2014-1595
-
Subramaniapillai, M., Tremblay, L., Grassmann, V., Remington, G. and Faulkner, G., 2016. The effect of an acute bout of exercise on executive function among individuals with schizophrenia. Psychiatry Research 246: 637-643. https://doi.org/10.1016/j.psychres.2016.10.075
-
Vancampfort, D., Knapen, J., Probst, M., Scheewe, T., Remans, S. and De Hert, M., 2012. A systematic review of correlates of physical activity in patients with schizophrenia. Acta Psychiatrica Scandinavica 125: 352-362. https://doi.org/10.1111/j.1600-0447.2011.01814.x
-
Vancampfort, D., Probst, M., Scheewe, T., De Herdt, A., Sweers, K., Knapen, J., van Winkel, R. and De Hert, M., 2013. Relationships between physical fitness, physical activity, smoking and metabolic and mental health parameters in people with schizophrenia. Psychiatry Research 207: 25-32. https://doi.org/10.1016/j.psychres.2012.09.026
-
Visceglia, E. and Lewis, S., 2011. Yoga therapy as an adjunctive treatment for schizophrenia: a randomized, controlled pilot study. Journal of Alternative and Complementary Medicine 17: 601-607. https://doi.org/10.1089/acm.2010.0075
-
Walker, E., Kestler, L., Bollini, A. and Hochman, K.M., 2004. Schizophrenia: etiology and course. Annual Review of Psychology 55: 401-430. https://doi.org/10.1146/annurev.psych.55.090902.141950
-
Walker, E., Mittal, V. and Tessner, K., 2008. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annual Review of Clinical Psychology 4: 189-216. https://doi.org/10.1146/annurev.clinpsy.4.022007.141248
-
Zhang, Y., Hashimoto, S., Fujii, C., Hida, S., Ito, K., Matsumura, T., Sakaizawa, T., Morikawa, M., Masuki, S., Nose, H., Higuchi, K., Nakajima, K. and Taniguchi, S., 2015. NFκB2 gene as a novel candidate that epigenetically responds to interval walking training. International Journal of Sports Medicine 36: 769-775.
'NFκB2 gene as a novel candidate that epigenetically responds to interval walking training ' () 36 International Journal of Sports Medicine : 769 -775.
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Time course of epigenetic modulation in response to concurrent exercise training in patients with schizophrenia
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Programa de Pós Graduação em Biociências e Reabilitação doCentro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Programa de Pós Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Brazil
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This study aimed to investigate the short and long-term effects of concurrent exercise training on anthropometric variables, HDCA2 activity and cortisol levels of individuals with schizophrenia (SZ). Therefore, 10 patients were submitted to the program (endurance and strength exercises in the same session, 60 min of duration, three times a week) and blood samples were collected before, 30 days and 180 days after the intervention started. Exercise training reduced the body mass index and body mass after 180 days of the intervention. A significant decrease on HDAC2 activity was found 180 days after intervention compared to before the intervention. The cortisol levels remained unchanged in any evaluated time-points. The concurrent exercise training was able to modulate HDAC2 activity in mononuclear cells and improve anthropometric variables in a time-dependent manner in patients with SZ.
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