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IL-6/STAT3 growth signalling induced by exercise conditioning promotes regeneration of injured rat sciatic nerve: return to an old cytokine
in Comparative Exercise PhysiologySearch for other papers by H. Ashour in
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Search for other papers by L.A. Rashed in
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The effects of interleukin-6 (IL-6), a growth promoting myokine through signal transduction, and activator of transcription 3 (STAT3), as a growth promoting signal, in peripheral nerve injury (PNI) are still unclear, including whether exercise pre- and/or post-conditioning are useful in nerve regeneration. Four groups were included in the study: sham for sciatic nerve injury (control), sciatic nerve injury group (SNI), exercise post-conditioning (SNI+Ex) and exercise pre- and post-conditioning (Ex+SNI+Ex). IL-6 levels were measured in serum, muscle, nerve and its surrounding fascia. Elevated levels of IL-6 in serum, nerve, muscle and fascia revealed that IL-6 induced in nerve by exercise were: (1) local nerve tissue expression; (2) serum diffused as a myokine from contracting muscle; and (3) diffused for surrounding peri-tendinous region. Evaluation of nerve functions shows that, exercise post-conditioning significantly improved (P<0.05) nerve functions in the form of nerve conduction velocity (NCV) (19.21±4.30 vs 10.96±3.08 m/s), compound muscle action potential amplitude (CMAP) (0.26±0.06 vs 0.18±0.06 mv), histologic improvement in myelination% (35.63±3.92 vs 21.13±4.26) and number of nerve fibres (181.75±9.6 vs 145.75±9.67). However, combined pre- and post-conditioning improved NCV (26.95±2.41 vs 19.21±4.30 m/s) and % myelination (43.50±3.16 vs 35.63±3.92) (P<0.05) when compared with the exercise post-conditioning group. In conclusion, IL-6 induced by exercise is valuable in nerve regeneration. The IL-6/STAT3 growth pathway could be a treatment target in clinical trials in PNI conditions.
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| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
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IL-6/STAT3 growth signalling induced by exercise conditioning promotes regeneration of injured rat sciatic nerve: return to an old cytokine
in Comparative Exercise PhysiologySearch for other papers by H. Ashour in
Current site
Google Scholar
PubMed
Search for other papers by L.A. Rashed in
Current site
Google Scholar
PubMed
Search for other papers by M.M. Sabry in
Current site
Google Scholar
PubMed
The effects of interleukin-6 (IL-6), a growth promoting myokine through signal transduction, and activator of transcription 3 (STAT3), as a growth promoting signal, in peripheral nerve injury (PNI) are still unclear, including whether exercise pre- and/or post-conditioning are useful in nerve regeneration. Four groups were included in the study: sham for sciatic nerve injury (control), sciatic nerve injury group (SNI), exercise post-conditioning (SNI+Ex) and exercise pre- and post-conditioning (Ex+SNI+Ex). IL-6 levels were measured in serum, muscle, nerve and its surrounding fascia. Elevated levels of IL-6 in serum, nerve, muscle and fascia revealed that IL-6 induced in nerve by exercise were: (1) local nerve tissue expression; (2) serum diffused as a myokine from contracting muscle; and (3) diffused for surrounding peri-tendinous region. Evaluation of nerve functions shows that, exercise post-conditioning significantly improved (P<0.05) nerve functions in the form of nerve conduction velocity (NCV) (19.21±4.30 vs 10.96±3.08 m/s), compound muscle action potential amplitude (CMAP) (0.26±0.06 vs 0.18±0.06 mv), histologic improvement in myelination% (35.63±3.92 vs 21.13±4.26) and number of nerve fibres (181.75±9.6 vs 145.75±9.67). However, combined pre- and post-conditioning improved NCV (26.95±2.41 vs 19.21±4.30 m/s) and % myelination (43.50±3.16 vs 35.63±3.92) (P<0.05) when compared with the exercise post-conditioning group. In conclusion, IL-6 induced by exercise is valuable in nerve regeneration. The IL-6/STAT3 growth pathway could be a treatment target in clinical trials in PNI conditions.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 307 | 139 | 30 |
| Gesamttextansichten | 9 | 0 | 0 |
| PDF-Downloads | 7 | 0 | 0 |
