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The effects of probiotics supplementation on serum markers of oxidative stress in relapsing-remitting multiple sclerosis: a randomised, double-blind, placebo-controlled clinical trial
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Research Center for Evidence-Based Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran
Tabriz USERN Office, Universal Scientific Education and Research Network (USERN), Tabriz, Iran
Search for other papers by A. Naseri in
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Abstract
Oxidative stress is a significant contributor to neuronal damage in multiple sclerosis (MS), marked by an imbalance in reactive oxygen species and antioxidant defences. Probiotics may modulate oxidative stress and improve antioxidant levels. This double-blind, randomised, placebo-controlled clinical trial aimed to evaluate the effects of probiotics supplementation on serum oxidative stress markers and endogenous antioxidants in patients with relapsing-remitting MS (RRMS). Ninety RRMS patients with expanded disability status scale [EDSS] < 4 were randomised into two groups: a probiotics group (Lactocare®) and a placebo group, and received the interventions twice daily for four months. Serum levels of oxidative stress markers (malondialdehyde [MDA]), endogenous antioxidants (glutathione peroxidase [GPx] activity, superoxide dismutase [SOD], catalase activity [CAT], glutathione [GSH]), and total antioxidant capacity (TAC) were measured at baseline and post-treatment. Fifty-five patients, including 26 patients in the probiotic group and 29 patients in the placebo group, completed the study. Both groups showed significant within-group improvements in GPx activity, SOD, and GSH levels, as well as reductions in MDA levels (
Iranian Registry of Clinical Trials: IRCT20220713055465N2, registration date: 2023.5.9
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| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 120 | 120 | 61 |
| Gesamttextansichten | 6 | 6 | 2 |
| PDF-Downloads | 15 | 15 | 5 |
The effects of probiotics supplementation on serum markers of oxidative stress in relapsing-remitting multiple sclerosis: a randomised, double-blind, placebo-controlled clinical trial
in Beneficial MicrobesSearch for other papers by N. Mohy in
Current site
Google Scholar
PubMed
Search for other papers by S. Sanaie in
Current site
Google Scholar
PubMed
Search for other papers by S. Rahnemayan in
Current site
Google Scholar
PubMed
Search for other papers by M. Yousefi in
Current site
Google Scholar
PubMed
Search for other papers by M. Talebi in
Current site
Google Scholar
PubMed
Research Center for Evidence-Based Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran
Tabriz USERN Office, Universal Scientific Education and Research Network (USERN), Tabriz, Iran
Search for other papers by A. Naseri in
Current site
Google Scholar
PubMed
Abstract
Oxidative stress is a significant contributor to neuronal damage in multiple sclerosis (MS), marked by an imbalance in reactive oxygen species and antioxidant defences. Probiotics may modulate oxidative stress and improve antioxidant levels. This double-blind, randomised, placebo-controlled clinical trial aimed to evaluate the effects of probiotics supplementation on serum oxidative stress markers and endogenous antioxidants in patients with relapsing-remitting MS (RRMS). Ninety RRMS patients with expanded disability status scale [EDSS] < 4 were randomised into two groups: a probiotics group (Lactocare®) and a placebo group, and received the interventions twice daily for four months. Serum levels of oxidative stress markers (malondialdehyde [MDA]), endogenous antioxidants (glutathione peroxidase [GPx] activity, superoxide dismutase [SOD], catalase activity [CAT], glutathione [GSH]), and total antioxidant capacity (TAC) were measured at baseline and post-treatment. Fifty-five patients, including 26 patients in the probiotic group and 29 patients in the placebo group, completed the study. Both groups showed significant within-group improvements in GPx activity, SOD, and GSH levels, as well as reductions in MDA levels (
Iranian Registry of Clinical Trials: IRCT20220713055465N2, registration date: 2023.5.9
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 120 | 120 | 61 |
| Gesamttextansichten | 6 | 6 | 2 |
| PDF-Downloads | 15 | 15 | 5 |
