Gut-borne Saccharomyces cerevisiae, a promising candidate for the formulation of feed additives, modulates immune system and gut microbiota
äºBeneficial MicrobesFellow of Consejo Nacional de Investigaciones CientÃficas y Técnicas (CONICET), Argentina.
Search for other papers by G. GarcÃa in
Current site
Google Scholar
Member of Consejo Nacional de Investigaciones CientÃficas y Técnicas (CONICET), Argentina.
Search for other papers by C. Dogi in
Current site
Google Scholar
Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, T4000ILC San Miguel de Tucumán, Tucumán, Argentina.
Search for other papers by A. de Moreno de LeBlanc in
Current site
Google Scholar
Search for other papers by C. Greco in
Current site
Google Scholar
Member of Consejo Nacional de Investigaciones CientÃficas y Técnicas (CONICET), Argentina.
Search for other papers by L. Cavaglieri in
Current site
Google Scholar
The aim was to evaluate the effect of Saccharomyces cerevisiae RC016 on immune parameters and gut microbiota in healthy mice. Animals received S. cerevisiae RC016 for 10 days. Microbial translocation to liver and changes in some bacterial populations in caecum were determined. Immune stimulation was assessed at gut level (measure of immunoglobulin A (IgA)+ cells and luminal cytokine profile) and by evaluating the activity of peritoneal macrophages. Oral administration of S. cerevisiae RC016 did not induce microbial translocation to liver. Mice that received yeast increased the number of IgA+ cells in their intestines, the phagocytic activity of peritoneal macrophages and decreased tumour necrosis factor alpha (TNF-α) levels in the small intestine with increases of interleukin-10/TNF-αratio. Administration of S. cerevisiae RC016 caused the decline of a logarithmic unit for Enterobacteriaceae counts compared to the control. The immune and gut microbiota modulation observed demonstrates that S. cerevisiae RC016 is a promising candidate for the formulation of feed additives to improve animal productivity. The beneficial in vivo effects observed for the potential probiotic S. cerevisiae RC016 with previously reported mycotoxin-binding properties, demonstrated that this strain could be suitable to be included in a novel product to improve animal productivity, with both probiotic and mycotoxin-binding properties. However, studies in the specific host will be necessary to confirm this potential.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Aluwong, T., Hassan, F., Dzenda, T., Kawu, M. and Ayo, J.J., 2013. Effect of different levels of supplemental yeast on body weight, thyroid hormone metabolism and lipid profile of broiler chickens. Journal of Veterinary Medical Science 75: 291-298.
'Effect of different levels of supplemental yeast on body weight, thyroid hormone metabolism and lipid profile of broiler chickens ' () 75 Journal of Veterinary Medical Science : 291 -298.
-
Armando, M.R., Dogi, C.A., Pizzolitto, R.P., Escobar, F., Peirano, M.S., Salvano, M.A., Sabini, L.I., Combina, M., Dalcero, A.M. and Cavaglieri, L.R., 2011. Saccharomyces cerevisiae strains from animal environmental with aflatoxin B1 binding ability and antipathogenic bacteria influence. World Mycotoxin Journal 1: 59-68.
'Saccharomyces cerevisiae strains from animal environmental with aflatoxin B1 binding ability and antipathogenic bacteria influence ' () 1 World Mycotoxin Journal : 59 -68.
-
Armando, M.R., Dogi, C.A., Rosa, C.A.R., Dalcero, A.M. and Cavaglieri, L.R., 2012. Saccharomyces cerevisiae strains and the reduction of Aspergillus parasiticus growth and aflatoxin B1 production at different interacting environmental conditions, in vitro. Food Additives and Contaminants Part A 29: 1443-1449.
'Saccharomyces cerevisiae strains and the reduction of Aspergillus parasiticus growth and aflatoxin B1 production at different interacting environmental conditions, in vitro ' () 29 Food Additives and Contaminants Part A : 1443 -1449.
-
Bermudez-Brito, M., Plaza-DÃaz, J., Muñoz-Quezada, S., Gómez-Llorente, C. and Gil, A., 2012. Probiotic mechanisms of action. Annals of Nutrition and Metabolism 61: 160-174.
'Probiotic mechanisms of action ' () 61 Annals of Nutrition and Metabolism : 160 -174.
-
Callaway, T.R., Edrington, T.S., Anderson, R.C., Byrd, J.A. and Nisbet, D.J., 2008. Gastrointestinal microbial ecology and the safety of our food supply as related to Salmonella. Journal of Animal Science 86: E163-E172.
'Gastrointestinal microbial ecology and the safety of our food supply as related to Salmonella ' () 86 Journal of Animal Science : E163 -E172.
-
Chaucheyras-Durand, F., Walker, N.D. and Bach, A., 2008. Effects of active dry yeasts on the rumen microbial ecosystem: past, present and future. Animal Feed Science and Technology 145: 5-26.
'Effects of active dry yeasts on the rumen microbial ecosystem: past, present and future ' () 145 Animal Feed Science and Technology : 5 -26.
-
Cogliani, C., Goossens, H. and Greko, C., 2011. Restricting antimicrobial use in food animals: lessons from Europe. Microbe 6: 274-279.
'Restricting antimicrobial use in food animals: lessons from Europe ' () 6 Microbe : 274 -279.
-
Czerucka, D., Piche, T. and Rampal, P., 2007. Yeast as probiotics â Saccharomyces boulardii. Alimentary Pharmacology and Therapeutics 26: 767-778.
'Yeast as probiotics â Saccharomyces boulardii ' () 26 Alimentary Pharmacology and Therapeutics : 767 -778.
-
De Moreno de LeBlanc, A., Castillo, N.A. and Perdigon, G., 2010. Anti-infective mechanisms induced by a probiotic Lactobacillus strain against Salmonella enteric serovar Typhimurium infection. International Journal of Food Microbiology 138: 223-231.
'Anti-infective mechanisms induced by a probiotic Lactobacillus strain against Salmonella enteric serovar Typhimurium infection ' () 138 International Journal of Food Microbiology : 223 -231.
-
De Moreno de LeBlanc, A., Chaves, S., Carmuega, E., Weill, R., Antóine, J. and Perdigón, G., 2008. Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages. Immunobiology 213: 97-108.
'Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages ' () 213 Immunobiology : 97 -108.
-
De Moreno de LeBlanc, A., Del Carmen, S., Zurita-Turk, M., Santos Rocha, C., Van de Guchte, M., Azevedo, V., Miyoshi, A. and LeBlanc, J.G., 2011. Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases. ISRN Gastroenterology article ID 892971.
'Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases', ().
-
Delcenserie, V.D., Martel, M.D., Lamoureux, J.M., Amiot, Y., Boutin, Y. and Roy, D., 2008. Immunomodulatory effects of probiotics in the intestinal tract. Current Issues in Molecular Biology 10: 37-54.
'Immunomodulatory effects of probiotics in the intestinal tract ' () 10 Current Issues in Molecular Biology : 37 -54.
-
Dogi, C.A., Armando, R., Ludueña, R., De Moreno de LeBlanc, A., Dalcero, A. and Cavaglieri, L., 2011. Saccharomyces cerevisiae strains retain their viability and AFB1 binding ability under gastrointestinal conditions and improve ruminal fermentation. Food Additives and Contaminants Part A 28: 1705-1711.
'Saccharomyces cerevisiae strains retain their viability and AFB1 binding ability under gastrointestinal conditions and improve ruminal fermentation ' () 28 Food Additives and Contaminants Part A : 1705 -1711.
-
Dogi, C.A., Maldonado Galdeano, C. and Perdigón, G., 2008. Gut immune stimulation by non pathogenic Gram (+) and Gram (-) bacteria. Comparison with a probiotic strain. Cytokine 41: 223-231.
'Gut immune stimulation by non pathogenic Gram (+) and Gram (-) bacteria ' () 41 Cytokine : 223 -231.
-
Dugas, B., Mercenier, A., Lenoir-Wijnkoop, I., Arnaud, C., Dugas, N. and Postaire, E., 1999. Immunity and probiotics. Immunology Today 20: 387-390.
'Immunity and probiotics ' () 20 Immunology Today : 387 -390.
-
Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO), 2001. Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Available at: http://tinyurl.com/8bccc3r.
-
Galdeano, C.M., De Moreno de LeBlanc, A., Vinderola, G., Bonet, M.E. and Perdigón, G., 2007. Proposed model: mechanisms of immunomodulation induced by probiotic bacteria. Clinical and Vaccine Immunology 14: 485-492.
'Proposed model: mechanisms of immunomodulation induced by probiotic bacteria ' () 14 Clinical and Vaccine Immunology : 485 -492.
-
González Pereyra, M.L., Dogi, C., Torres Lisa, A., Wittouck, P., OrtÃz, M., Escobar, F., Bagnis, G., Yaciuk, R., Poloni, L., Torres, A., Dalcero, A.M. and Cavaglieri, L.R., 2014. Genotoxicity and cytotoxicity evaluation of probiotic Saccharomyces cerevisiae RC016: a 60-day subchronic oral toxicity study in rats. Journal of Applied Microbiology 117: 824-833.
'Genotoxicity and cytotoxicity evaluation of probiotic Saccharomyces cerevisiae RC016: a 60-day subchronic oral toxicity study in rats ' () 117 Journal of Applied Microbiology : 824 -833.
-
Lebeis, S.L., Sherman, M.A. and Kalman, D., 2008. Protective and destructive innate immune responses to enteropathogenic Escherichia coli and related A/E pathogens. Future Microbiology 3: 315-328.
'Protective and destructive innate immune responses to enteropathogenic Escherichia coli and related A/E pathogens ' () 3 Future Microbiology : 315 -328.
-
LeBlanc, J.G., Garro, M.S., Savoy de Giori, G. and Font de Valdez, G.A., 2004. Novel functional soy-based food fermented by lactic acid bacteria: effect of heat treatment. Journal of Food Science 69: M246-M250.
'Novel functional soy-based food fermented by lactic acid bacteria: effect of heat treatment ' () 69 Journal of Food Science : M246 -M250.
-
Ley, R.E., Hamady, M., Lozupone, C., Turnbaugh, P.J., Ramey, R.R., Bircher, J.S., Schlegel, M.L., Tucker, T.A., Schrenzel, M.D., Knight, R. and Gordon, J.I., 2008. Evolution of mammals and their gut microbes. Science 320: 1647-1651.
'Evolution of mammals and their gut microbes ' () 320 Science : 1647 -1651.
-
Madsen, K., Cornish, A., Soper, P., Mckaigney, C., Jijon, H., Yachimec, C., Doyle, J., Jewell, L. and De Simone, C., 2001. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121: 580-591.
'Probiotic bacteria enhance murine and human intestinal epithelial barrier function ' () 121 Gastroenterology : 580 -591.
-
McKay, D.M. and Baird, A.W., 1999. Cytokine regulation of epithelial permeability and ion transport. Gut 44: 282-289.
'Cytokine regulation of epithelial permeability and ion transport ' () 44 Gut : 282 -289.
-
Perdigón, G., Medina, M., Vintini, E. and Valdez, J.C., 2000. Intestinal pathway of internalization of lactic acid bacteria and gut mucosal immunostimulation. International Journal of Immunopathology and Pharmacology 13: 141-150.
'Intestinal pathway of internalization of lactic acid bacteria and gut mucosal immunostimulation ' () 13 International Journal of Immunopathology and Pharmacology : 141 -150.
-
Pié, S., Lallès, J.P., Blazy, F., Laffitte, J., Sève, B. and Oswald I.P., 2004. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. Journal of Nutrition 134: 641-647.
'Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets ' () 134 Journal of Nutrition : 641 -647.
-
Pluske, J.R., 2013. Feed- and feed additives-related aspects of gut health and development in weanling pigs. Journal of Animal Science and Biotechnology 4: 1-7.
'Feed- and feed additives-related aspects of gut health and development in weanling pigs ' () 4 Journal of Animal Science and Biotechnology : 1 -7.
-
Reinecker, H.C., Loh, E.Y., Ringler, D.J., Mehta, A., Rombeau, J.L. and MacDermott, R.P., 1995. Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 108: 40-50.
'Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa ' () 108 Gastroenterology : 40 -50.
-
Rist, V.T., Weiss, E., Eklund, M. and Mosenthin, R., 2013. Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: a review. Animal 7: 1067-1078.
'Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: a review ' () 7 Animal : 1067 -1078.
-
Rodriguez, A.V., Baigori, M.D., Alvarez, S., Castro, G.R. and Oliver, C., 2001. Phosphatidylinositol-specific phospholipase C activity in Lactobacillus rhamnosus with capacity to translocate. FEMS Microbiology Letters 204: 33-38.
'Phosphatidylinositol-specific phospholipase C activity in Lactobacillus rhamnosus with capacity to translocate ' () 204 FEMS Microbiology Letters : 33 -38.
-
Rydström, A. and Wick, M.J., 2009. Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines. European Journal of Immunology 39: 3019-3030.
'Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines ' () 39 European Journal of Immunology : 3019 -3030.
-
Sainte-Marie, G., 1962. A paraffin embedding technique for studies employing immunofluorescence. Journal of Histochemistry and Cytochemistry 10: 250-256.
'A paraffin embedding technique for studies employing immunofluorescence ' () 10 Journal of Histochemistry and Cytochemistry : 250 -256.
-
Simon, O., Jadamus, A. and Vahjen, W., 2001. Probiotic feed additives effectiveness and expected modes of action. Journal of Animal and Feed Sciences 10: 51-67.
'Probiotic feed additives effectiveness and expected modes of action ' () 10 Journal of Animal and Feed Sciences : 51 -67.
-
Soren, N.M., Tripathi, M.K., Bhatt, R.S. and Karim, S.A., 2013. Effect of yeast supplementation on the growth performance of Malpura lambs. Tropical Animal Health and Production 45(2): 547-554.
'Effect of yeast supplementation on the growth performance of Malpura lambs ' () 45 Tropical Animal Health and Production : 547 -554.
-
Thomas, C.M. and Versalovic, J., 2010. Probiotics-host communication: modulation of signaling pathways in the intestine. Gut Microbes 1: 148-163.
'Probiotics-host communication: modulation of signaling pathways in the intestine ' () 1 Gut Microbes : 148 -163.
-
Valdez, J., Rachid, M., Gobbato, N. and Perdigon, G., 2001. Lactic acid bacteria induce apoptosis inhibition in Salmonella typhimurium infected macrophages. Food and Agricultural Immunology 13: 189-197.
'Lactic acid bacteria induce apoptosis inhibition in Salmonella typhimurium infected macrophages ' () 13 Food and Agricultural Immunology : 189 -197.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 322 | 141 | 6 |
| å ¨ææµè§æ¬¡æ° | 19 | 1 | 1 |
| PDFä¸è½½æ¬¡æ° | 16 | 0 | 0 |
Gut-borne Saccharomyces cerevisiae, a promising candidate for the formulation of feed additives, modulates immune system and gut microbiota
äºBeneficial MicrobesFellow of Consejo Nacional de Investigaciones CientÃficas y Técnicas (CONICET), Argentina.
Search for other papers by G. GarcÃa in
Current site
Google Scholar
PubMed
Member of Consejo Nacional de Investigaciones CientÃficas y Técnicas (CONICET), Argentina.
Search for other papers by C. Dogi in
Current site
Google Scholar
PubMed
Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, T4000ILC San Miguel de Tucumán, Tucumán, Argentina.
Search for other papers by A. de Moreno de LeBlanc in
Current site
Google Scholar
PubMed
Search for other papers by C. Greco in
Current site
Google Scholar
PubMed
Member of Consejo Nacional de Investigaciones CientÃficas y Técnicas (CONICET), Argentina.
Search for other papers by L. Cavaglieri in
Current site
Google Scholar
PubMed
The aim was to evaluate the effect of Saccharomyces cerevisiae RC016 on immune parameters and gut microbiota in healthy mice. Animals received S. cerevisiae RC016 for 10 days. Microbial translocation to liver and changes in some bacterial populations in caecum were determined. Immune stimulation was assessed at gut level (measure of immunoglobulin A (IgA)+ cells and luminal cytokine profile) and by evaluating the activity of peritoneal macrophages. Oral administration of S. cerevisiae RC016 did not induce microbial translocation to liver. Mice that received yeast increased the number of IgA+ cells in their intestines, the phagocytic activity of peritoneal macrophages and decreased tumour necrosis factor alpha (TNF-α) levels in the small intestine with increases of interleukin-10/TNF-αratio. Administration of S. cerevisiae RC016 caused the decline of a logarithmic unit for Enterobacteriaceae counts compared to the control. The immune and gut microbiota modulation observed demonstrates that S. cerevisiae RC016 is a promising candidate for the formulation of feed additives to improve animal productivity. The beneficial in vivo effects observed for the potential probiotic S. cerevisiae RC016 with previously reported mycotoxin-binding properties, demonstrated that this strain could be suitable to be included in a novel product to improve animal productivity, with both probiotic and mycotoxin-binding properties. However, studies in the specific host will be necessary to confirm this potential.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 322 | 141 | 6 |
| å ¨ææµè§æ¬¡æ° | 19 | 1 | 1 |
| PDFä¸è½½æ¬¡æ° | 16 | 0 | 0 |
