Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6J mice
In: Beneficial MicrobesSearch for other papers by R. Pothuraju in
Current site
Google Scholar
Search for other papers by R.K. Sharma in
Current site
Google Scholar
Search for other papers by P.K. Kavadi in
Current site
Google Scholar
Search for other papers by J. Chagalamarri in
Current site
Google Scholar
Search for other papers by S. Jangra in
Current site
Google Scholar
Search for other papers by G. Bhakri in
Current site
Google Scholar
Search for other papers by S. De in
Current site
Google Scholar
The effect of dietary supplementation of milk fermented with indigenous probiotic Lactobacillus plantarum (LP625) alone and in combination with herbs (Aloe vera and Gymnema sylvestre) was investigated on high fat diet (HFD, 60 kcal% fat) fed mice for 12 weeks. Administration of LP625 alone or in combination with both herbs lowered the final body weight, however, a significant difference was observed with LP625 supplemented Gymnema sylvestre only as compared to the HFD fed group (25.06±0.18 vs 27.29±0.72 g, P<0.05). Similarly, the epididymal fat mass, fasting blood glucose and serum insulin levels were significantly (P<0.05) decreased by all treatment groups. In addition, a protective effect against the rise in serum and liver triglycerides, and in liver total cholesterol levels was found with the consumption of LP625 alone or in combination with herbs. Furthermore, the HFD fed mice showed a remarkable increase in the epididymal fat cell size, whereas administration of LP625 alone or in combination with herbs exhibited a significant decrease in the size. Finally, a significant increase in the relative mRNA expression of thermogenic proteins, i.e. uncoupling protein-2 (UCP-2, 1.16±0.25 fold change, P<0.05) and a decrease in pro-inflammatory markers, such as tumour necrosis factor-α and interleukin-6 (1.55±0.18 and 3.10±0.58 fold change, respectively, P<0.05) were due to LP625 supplementation in the HFD fed group. This shows that LP625 alone or supplemented with herbs seems to protect against diet induced obesity by decreasing the body and epididymal fat weight through upregulation of UCP-2 expression and reduced expression of pro-inflammatory cytokines.
Purchase
Buy instant access (PDF download and unlimited online access):
Institutional Login
Log in with Open Athens, Shibboleth, or your institutional credentials
Personal login
Log in with your brill.com account
-
Anderson, R.C., Cookson, A.L., McNabb, W.C., Kelly, W.J. and Roy, N.C., 2010. Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function. FEMS Microbiology Letters 309: 184-192.
'Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function ' () 309 FEMS Microbiology Letters : 184 -192.
-
Bluher, M., Michael, M.D., Peroni, O.D., Ueki, K., Carter, N., Kahn, B.B. and Kahn, C.R., 2012. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Development Cell 3: 25-38.
'Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance ' () 3 Development Cell : 25 -38.
-
Bunyapraphatsara, N., Yongchaiyudha, S., Rungpitarangsi, V. and Chokechaijaroenporn, O., 1996. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 3: 245-248.
'Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide ' () 3 Phytomedicine : 245 -248.
-
Cani, P.D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A., Delzenne, N. and Burcelin, R., 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57: 1470-1481.
'Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice ' () 57 Diabetes : 1470 -1481.
-
Chihara, T., Shimpo, K., Beppu, H., Tomatsu, A., Kaneko, T., Tanaka, M., Yamada, M., Abe, F. and Sonoda, S., 2013. Reduction of intestinal polyp formation in min mice fed a high-fat diet with Aloe vera gel extract. Asian Pacific Journal of Cancer Prevention 14: 4435-4440.
'Reduction of intestinal polyp formation in min mice fed a high-fat diet with Aloe vera gel extract ' () 14 Asian Pacific Journal of Cancer Prevention : 4435 -4440.
-
Considine, R.V., Sinha, M.K., Heiman, M.L., Kriauciunas, A., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., McKee, L.J. Bauer, T.L. and Caro, J.F., 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England Journal of Medicine 334: 292-295.
'Serum immunoreactive-leptin concentrations in normal-weight and obese humans ' () 334 The New England Journal of Medicine : 292 -295.
-
Cumbie, B.C., Hermayer, K.L., 2007. Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications. Vascular Health Risk and Management 3: 823-832.
'Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications ' () 3 Vascular Health Risk and Management : 823 -832.
-
De Man, J.D., Rogosa, M. and Sharpe, M.E., 1960. A medium for the cultivation of lactobacilli. Journal of Applied Bacteriology 23: 130-135.
'A medium for the cultivation of lactobacilli ' () 23 Journal of Applied Bacteriology : 130 -135.
-
Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO), 2001. Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Available at: http://tinyurl.com/8bccc3r.
-
Friedewald, W.T., Levy, R.I. and Fredrickson, D.S., 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clinical Chemistry 18: 499-502.
'Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge ' () 18 Clinical Chemistry : 499 -502.
-
Fugh-Berman, A., 2000. Herbs and dietary supplements in the prevention and treatment of cardiovascular disease. Preventive Cardiology 3: 24-32.
'Herbs and dietary supplements in the prevention and treatment of cardiovascular disease ' () 3 Preventive Cardiology : 24 -32.
-
Gregor, M.F. and Hotamisligil, G.S., 2011. Inflammatory mechanisms in obesity. Annual Reviews of Immunology 29: 415-445.
'Inflammatory mechanisms in obesity ' () 29 Annual Reviews of Immunology : 415 -445.
-
Hamad, E.M., Sato, M., Uzu, K., Yoshida, T., Higashi, S., Kawakami, H., Kadooka, Y., Matsuyama, H., Abd El-Gawad, I.A. and Imaizumi, K., 2009. Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats. British Journal of Nutrition 101: 716-724.
'Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats ' () 101 British Journal of Nutrition : 716 -724.
-
Hu, X., Wang, T., Li, W. and Wang, L., 2013. Effects of NS lactobacillus strains on lipid metabolism of rats fed a high-cholesterol diet. Lipids Health and Disease 12: 67.
'Effects of NS lactobacillus strains on lipid metabolism of rats fed a high-cholesterol diet ' () 12 Lipids Health and Disease : 67.
-
Ji. Y.S., Kim, H.N., Park, H.J., Lee, J.E., Yeo, S.Y., Yang, J.S., Park, S.Y., Yoon, H.S., Cho, G.S., Franz, C.M., Bomba, A., Shin, H.K. and Holzapfel, W.H., 2012. Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28. Beneficial Microbes 3: 13-22.
'Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28 ' () 3 Beneficial Microbes : 13 -22.
-
Kang, M.H., Lee, M.S., Choi, M.K., Min, K.S. and Shibamoto, T., 2012. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. Journal of Agricultural and Food Chemistry 60: 2517-2524.
'Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats ' () 60 Journal of Agricultural and Food Chemistry : 2517 -2524.
-
Karnik, A.A., Fields, A.V. and Shannon, R.P., 2007. Diabetic cardiomyopathy. Current Hypertension Reports 9: 467-473.
Diabetic cardiomyopathy Current Hypertension Reports 9 467 473
-
Kim, K., Kim, H., Kwon, J., Lee, S., Kong, H., Im, S.A., Lee, Y.H., Lee, Y.R., Oh, S.T., Jo, T.H., Park, Y.I., Lee, C.K. and Kim, K., 2009. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phytomedicine 16: 856-863.
'Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus ' () 16 Phytomedicine : 856 -863.
-
Kondo, S., Xiao, J.Z., Satoh, T., Odamaki, T., Takahashi, S., Sugahara, H., Yaeshima, T., Iwatsuki, K., Kamei, A. and Abe, K., 2010. Anti-obesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Bioscience, Biotechnology and Biochemistry 74: 1656-1661.
'Anti-obesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity ' () 74 Bioscience, Biotechnology and Biochemistry : 1656 -1661.
-
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., Sugiyama, T., Eto, K., Tsubamoto, Y., Okuno, A., Murakami, K., Sekihara, H., Hasegawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Kitamura, T., Fujita, T., Ezaki, O., Aizawa, S., Nagai, R., Tobe, K., Kimura, S. and Kadowaki, T., 1999. PPARγ mediates high-fat diet – induced adipocyte hypertrophy and insulin resistance. Molecular Cell 4: 597-609.
'PPARγ mediates high-fat diet – induced adipocyte hypertrophy and insulin resistance ' () 4 Molecular Cell : 597 -609.
-
Kumar, V., Bhandari, U., Tripathi, C.D. and Khanna G., 2012. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian Journal Pharmacology 44: 607-613.
'Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model ' () 44 Indian Journal Pharmacology : 607 -613.
-
Lee, H.Y., Park, J.H., Seok, S.H., Baek, M.W., Kim, D.J., Lee, K.E., Paek, K.S., Lee, Y. and Park, J.H., 2006. Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochimica et Biophysica Acta 1761: 736-744.
'Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice ' () 1761 Biochimica et Biophysica Acta : 736 -744.
-
Lee, K., Paek, K., Lee, H.Y., Park, J.H. and Lee, Y., 2007. Anti-obesity effect of trans-10, cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet induced obese mice. Applied Microbiology 103: 1140-1146.
'Anti-obesity effect of trans-10, cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet induced obese mice ' () 103 Applied Microbiology : 1140 -1146.
-
Lin, S., Thomas, T., Storlien, L. and Huang, X., 2000. Development of high-fat diet-induced obesity and leptin resistance in C57Bl/6J mice. International Journal of Obesity and Related Metabolic Disorders 24: 639-646.
'Development of high-fat diet-induced obesity and leptin resistance in C57Bl/6J mice ' () 24 International Journal of Obesity and Related Metabolic Disorders : 639 -646.
-
Low Dog, T., 2006. A reason to season: the therapeutic benefits of spices and culinary herbs. Explore 2: 446-449.
'A reason to season: the therapeutic benefits of spices and culinary herbs ' () 2 Explore : 446 -449.
-
Misawa, E., Tanaka, M., Nabeshima, K., Nomaguchi, K., Nabeshima, K., Yamada, M., Toida, T. and Iwatsuki, K., 2013. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats. Journal of Agricultural and Food Chemistry 60: 2799-2806.
'Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats ' () 60 Journal of Agricultural and Food Chemistry : 2799 -2806.
-
Misawa, E., Tanaka, M., Nabeshima, K., Nomaguchi, K., Yamada, M., Toida, T. and Iwatsuki, K., 2012a. Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) rats. Journal of Nutritional Science and Vitaminology 58: 195-201.
'Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) rats ' () 58 Journal of Nutritional Science and Vitaminology : 195 -201.
-
Misawa, E., Tanaka, M., Nabeshima, K., Yamada, M., Toida, T. and Iwatsuki, K., 2012b. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats. Journal of Agricultural and Food Chemistry 60: 2799-2806.
'Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats ' () 60 Journal of Agricultural and Food Chemistry : 2799 -2806.
-
Misawa, E., Tanaka, M., Nomaguchi, K., Yamada, M., Toida, T., Takase, M., Iwatsuki, K. and Kawada, T., 2008. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats. Obese Research and Clinical Practice 2: 239-245.
'Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats ' () 2 Obese Research and Clinical Practice : 239 -245.
-
Murase, T., Nagasawa, A., Suzuki, J., Hase, T. and Tokimitsu, I., 2002. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. International Journal of Obesity and Related Metabolic Disorders 26: 1459-1464.
'Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver ' () 26 International Journal of Obesity and Related Metabolic Disorders : 1459 -1464.
-
Musso, G., Gambino, R. and Cassader, M., 2010. Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care 33: 2277-2284.
'Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? ' () 33 Diabetes Care : 2277 -2284.
-
Nadler, S.T., Attie, A.D., 2001. Please pass the chips: genomic insights into obesity and diabetes. Journal of Nutrition 131: 2078-2081.
'Please pass the chips: genomic insights into obesity and diabetes ' () 131 Journal of Nutrition : 2078 -2081.
-
Nazian, S.J., 2001. Leptin secretion from the epididymal fat pad is increased by the sexual maturation of the male rat. Journal of Andrology 22: 491-496.
'Leptin secretion from the epididymal fat pad is increased by the sexual maturation of the male rat ' () 22 Journal of Andrology : 491 -496.
-
Nomaguchi, K., Tanaka, M., Misawa, E., Yamada, M., Toida, T., Iwatsuki, K., Goto, T. and Kawada, T., 2011. Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity. Obesity Research and Clinical Practice 5: e190-e201.
'Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity ' () 5 Obesity Research and Clinical Practice : e190 -e201.
-
Park, D.Y., Ahn, Y.T., Huh, C.S., Jeon, S.M., Choi, M.S., 2011. The inhibitory effect of Lactobacillus plantarum KY1032 cell extract on the adipogenesis of 3T3-L1 cells. Journal of Medicinal Food 14: 670-675.
'The inhibitory effect of Lactobacillus plantarum KY1032 cell extract on the adipogenesis of 3T3-L1 cells ' () 14 Journal of Medicinal Food : 670 -675.
-
Park, D.Y., Ahn, Y.T., Park, S.H., Huh, C.S., Yoo, S.R., Yu, R., Sung, M.K., McGregor, R.A. and Choi, M.S., 2013a. Supplementation of Lactobacillus curvatus KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS ONE 8: e59470.
'Supplementation of Lactobacillus curvatus KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity ' () 8 PLoS ONE : e59470.
-
Park, J.E., Oh, S.H. and Cha, Y.S., 2013b. Lactobacillus plantarum LG42 isolated from gajami sik-hae inhibits adipogenesis in 3T3-L1 adipocyte. BioMed Research International 2013: 460927.
'Lactobacillus plantarum LG42 isolated from gajami sik-hae inhibits adipogenesis in 3T3-L1 adipocyte ' () 2013 BioMed Research International : 460927.
-
Pothuraju, R., Sharma, R.K., Chagalamarri, J., Jangra, S. and Kavadi, P.K., 2014b. A systematic review of Gymnema sylvestre in obesity and diabetes management. Journal of the Science of Food and Agriculture 94: 834-840.
'A systematic review of Gymnema sylvestre in obesity and diabetes management ' () 94 Journal of the Science of Food and Agriculture : 834 -840.
-
Pothuraju, R., Sharma, R.K., Chagalamarri, J., Kavadi, P.K. and Jangra, S., 2015. Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6J mice. Food and Function 6: 3576-3584
'Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6J mice ' () 6 Food and Function : 3576 -3584.
-
Pothuraju, R., Sharma, R.K. and Panjagari, N.R., 2014a. Anti-hyperglycemic and hypolipidemic effects of different Aloe vera (Aloe Barbadensis Miller) extracts in the management of obesity and diabetes. Current Nutrition and Food Science 10: 241-250.
'Anti-hyperglycemic and hypolipidemic effects of different Aloe vera (Aloe Barbadensis Miller) extracts in the management of obesity and diabetes ' () 10 Current Nutrition and Food Science : 241 -250.
-
Reddy, R.M., Vijaya, T., Latha, P.B. and Rao, D.S., 2011. Saponins rich aqueous extract of Gymnema sylvestre R. Br reduces high fat diet induced obesity in Wistar rats. Journal of Pharmacological Research 4: 1237-1239.
'Saponins rich aqueous extract of Gymnema sylvestre R. Br reduces high fat diet induced obesity in Wistar rats ' () 4 Journal of Pharmacological Research : 1237 -1239.
-
Sakai, T., Taki, T., Nakamoto, A., Shuto, E., Tsutsumi, R., Toshimitsu, T., Makino, S. and Ikegami, S., 2013. Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet. Journal of Nutritional Science and Vitaminology 59: 144-147.
'Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet ' () 59 Journal of Nutritional Science and Vitaminology : 144 -147.
-
Shanmugasundaram, E.R.B., Gopinath, K.L., Shanmugasundaram, K.R. and Rajendran, V.M., 1990. Possible regeneration of the islets of Langerhans in streptozocin-diabetic rats given Gymnema sylvestre leaf extracts. Journal of Ethnopharmacology 30: 265-279.
'Possible regeneration of the islets of Langerhans in streptozocin-diabetic rats given Gymnema sylvestre leaf extracts ' () 30 Journal of Ethnopharmacology : 265 -279.
-
Shanmugasundaram, K.R., Paneerselvam, C., Samudram, P. and Shanmugasundaram, E.R.B., 1983. Enzyme changes and glucose utilization in diabetic rabbits: the effect of Gymnema sylvestre. Journal of Ethnopharmacology 7: 205-234.
'Enzyme changes and glucose utilization in diabetic rabbits: the effect of Gymnema sylvestre ' () 7 Journal of Ethnopharmacology : 205 -234.
-
Sharma, S.R., Dwivedi, S.K. and Swarup, D., 1996. Hypoglycaemic and hypolipidemic effects of Cinnamom tamala Nees leaves. Indian Journal of Experimental Biology 34: 372.
'Hypoglycaemic and hypolipidemic effects of Cinnamom tamala Nees leaves ' () 34 Indian Journal of Experimental Biology : 372.
-
Shin, E., Shim, K.S., Kong, H., Lee, S., Shin, S., Kwon, J., Jo, T.H., Park, Y.I., Lee, C.K. and Kim, K., 2011. Dietary Aloe improves insulin sensitivity via the suppression of obesity-induced inflammation in obese mice. Immune Network 11: 59-67.
'Dietary Aloe improves insulin sensitivity via the suppression of obesity-induced inflammation in obese mice ' () 11 Immune Network : 59 -67.
-
Song, Y.B., An, Y.R., Kim, S.J., Park, H.W., Jung, J.W., Kyung, J.S., Hwang, S.Y. and Kim, Y.S., 2012. Lipid metabolic effect of Korean red ginseng extract in mice fed on a highfat diet. Journal of the Science of Food and Agriculture 92: 388-396.
'Lipid metabolic effect of Korean red ginseng extract in mice fed on a highfat diet ' () 92 Journal of the Science of Food and Agriculture : 388 -396.
-
Takemura, N., Okubo, T. and Sonoyama, K., 2010. Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Experimental Biology and Medicine 235: 849-856.
'Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet ' () 235 Experimental Biology and Medicine : 849 -856.
-
Tundis, R., Loizzo, M.R. and Menichini, F., 2010. Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycemic potential in the treatment of diabetes: an update. Mini Reviews in Medicinal Chemistry 10: 315-331.
'Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycemic potential in the treatment of diabetes: an update ' () 10 Mini Reviews in Medicinal Chemistry : 315 -331.
-
Wang, L., Liu, K., Gao, D. and Hao, J., 2013. Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice. World Journal of Gastroenterology 19: 3150.
'Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice ' () 19 World Journal of Gastroenterology : 3150.
-
Wang, Z.Q., Zuberi, A.R., Zhang, X.H., Macgowan, J., Qin, J., Ye, X., Son, L., Wu, Q., Lian, K. and Cefalu, W.T., 2007. Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet. Metabolism 56: 1635-1642.
'Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet ' () 56 Metabolism : 1635 -1642.
-
Weisberg, S., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. and Ferrante, A., 2008. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 112: 1796-1808.
'Obesity is associated with macrophage accumulation in adipose tissue ' () 112 Journal of Clinical Investigation : 1796 -1808.
-
Xie, N., Cui, Y., Yin, Y., Zhao, X., Yang, J., Wang, Z., Fu, N., Tang, Y., Wang, X., Liu, X., Wang, C. and Lu, F., 2011. Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet. BMC Complementary and Alternative Medicine 11: 53.
'Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet ' () 11 BMC Complementary and Alternative Medicine : 53.
-
Yongchaiyudha, S., Rungpitarangsi, V., Bunyapraphatsara, N. and Chokechaijaroenporn, O., 1996. Antidiabetic activity of Aloe vera L. juice I. Clinical trial in new cases of diabetes mellitus. Phytomedicine 3: 241-243.
'Antidiabetic activity of Aloe vera L. juice I. Clinical trial in new cases of diabetes mellitus ' () 3 Phytomedicine : 241 -243.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 527 | 186 | 21 |
| Full Text Views | 19 | 3 | 0 |
| PDF Views & Downloads | 23 | 5 | 0 |
Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6J mice
In: Beneficial MicrobesSearch for other papers by R. Pothuraju in
Current site
Google Scholar
PubMed
Search for other papers by R.K. Sharma in
Current site
Google Scholar
PubMed
Search for other papers by P.K. Kavadi in
Current site
Google Scholar
PubMed
Search for other papers by J. Chagalamarri in
Current site
Google Scholar
PubMed
Search for other papers by S. Jangra in
Current site
Google Scholar
PubMed
Search for other papers by G. Bhakri in
Current site
Google Scholar
PubMed
Search for other papers by S. De in
Current site
Google Scholar
PubMed
The effect of dietary supplementation of milk fermented with indigenous probiotic Lactobacillus plantarum (LP625) alone and in combination with herbs (Aloe vera and Gymnema sylvestre) was investigated on high fat diet (HFD, 60 kcal% fat) fed mice for 12 weeks. Administration of LP625 alone or in combination with both herbs lowered the final body weight, however, a significant difference was observed with LP625 supplemented Gymnema sylvestre only as compared to the HFD fed group (25.06±0.18 vs 27.29±0.72 g, P<0.05). Similarly, the epididymal fat mass, fasting blood glucose and serum insulin levels were significantly (P<0.05) decreased by all treatment groups. In addition, a protective effect against the rise in serum and liver triglycerides, and in liver total cholesterol levels was found with the consumption of LP625 alone or in combination with herbs. Furthermore, the HFD fed mice showed a remarkable increase in the epididymal fat cell size, whereas administration of LP625 alone or in combination with herbs exhibited a significant decrease in the size. Finally, a significant increase in the relative mRNA expression of thermogenic proteins, i.e. uncoupling protein-2 (UCP-2, 1.16±0.25 fold change, P<0.05) and a decrease in pro-inflammatory markers, such as tumour necrosis factor-α and interleukin-6 (1.55±0.18 and 3.10±0.58 fold change, respectively, P<0.05) were due to LP625 supplementation in the HFD fed group. This shows that LP625 alone or supplemented with herbs seems to protect against diet induced obesity by decreasing the body and epididymal fat weight through upregulation of UCP-2 expression and reduced expression of pro-inflammatory cytokines.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 527 | 186 | 21 |
| Full Text Views | 19 | 3 | 0 |
| PDF Views & Downloads | 23 | 5 | 0 |
