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Effect of orally administered soy milk fermented with Lactobacillus plantarum LAB12 and physical exercise on murine immune responses
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Probiotics are live microorganisms that confer health benefits through the gastrointestinal microbiota. This nutritional supplement may benefit athletes who undergo rigorous training by maintaining their gastrointestinal functions and overall health. In this study the influence of moderate physical exercise using a graded treadmill exercise, alone or in combination with the consumption of a soy product fermented with Lactobacillus plantarum LAB12 (LAB12), on tumour necrosis factor alpha (TNF-α) responses was investigated in a murine model. Male BALB/c mice were randomly divided into four groups of six mice each (control, exercise alone, LAB12 and LAB12 + exercise). Mice treated with the potential probiotic LAB12 were orally gavaged for 42 days. At autopsy, blood and spleen from the animals were collected. The splenocytes were cultured in the presence of a mitogen, concanavalin A (Con A). The amount of TNF-α produced by the Con A-stimulated splenocytes was quantified using ELISA, while their proliferation was determined using the [3H]-thymidine incorporation method. This study shows that LAB12-supplemented and exercise-induced mice showed marked increase (P<0.05) in cell proliferation compared to the control animals. TNF-α production was suppressed (P<0.05) in the LAB12 group compared to the untreated mice. These results demonstrate that supplementation with LAB12 has immunomodulatory effects, under conditions of moderate physical exercise, which may have implications for human athletes. Further investigation in human trials is warranted to confirm and extrapolate these findings.
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Aoi, W., Naito, Y., Nakamura, T., Akagiri, S., Masuyama, A., Takano, T., Mizushima, K. and Yoshikawa, T., 2007. Inhibitory effect of fermented milk on delayed-onset muscle damage after exercise. Journal of Nutritional Biochemistry 18: 140-145.
'Inhibitory effect of fermented milk on delayed-onset muscle damage after exercise ' () 18 Journal of Nutritional Biochemistry : 140 -145.
-
Appukutty, M., Radhakrishnan, A.K., Ramasamy, K., Ramasamy, R., Majeed, A.B.A., Ismail, M.N., Safii, S.N., Poh, B.K., Chinna, K. and Haleagrahara, N., 2012. Colostrum supplementation protects against exercise – induced oxidative stress in the skeletal muscle in mice. BMC Research Notes 5: 649.
'Colostrum supplementation protects against exercise – induced oxidative stress in the skeletal muscle in mice ' () 5 BMC Research Notes : 649.
-
Asahara, T., Shimizu, K., Nomoto, K., Hamabata, T., Ozawa, A. and Takeda, Y., 2004. Probiotic bifidobacteria protect mice from lethal infection with Shiga toxin-producing Escherichia coli O157 : H7. Infection and Immunity 72: 2240-2247.
'Probiotic bifidobacteria protect mice from lethal infection with Shiga toxin-producing Escherichia coli O157 : H7 ' () 72 Infection and Immunity : 2240 -2247.
-
Bjerg, A.T., Kristensen, M., Ritz., C., Stark, K.D., Holst, J.J., Leser, T.D., Wellejus, A. and Astrup, A., 2015. Four weeks supplementation with Lactobacillus paracasei subsp. paracasei L. casei W8 shows modest effect on triacylglycerol in young healthy adults. Beneficial Microbes 6: 29-39.
'Four weeks supplementation with Lactobacillus paracasei subsp. paracasei L. casei W8 shows modest effect on triacylglycerol in young healthy adults ' () 6 Beneficial Microbes : 29 -39.
-
Clancy, R.L., Gleeson, M., Cox, A., Callister, R., Dorrington, M., D’Este, C., Pang, G., Pyne, D., Fricker, P. and Henriksson, A., 2006. Reversal in fatigued athletes of a defect in interferon-γ secretion after administration of Lactobacillus acidophilus. British Journal of Sports Medicine 40: 351-354.
'Reversal in fatigued athletes of a defect in interferon-γ secretion after administration of Lactobacillus acidophilus ' () 40 British Journal of Sports Medicine : 351 -354.
-
Gleeson, M., 2006a. Immune function in sport and exercise. Advances in sport and exercise series, Elsevier Publication, Edinburgh, UK.
'Immune function in sport and exercise ' () Advances in sport and exercise series, Elsevier Publication .
-
Gleeson, M., 2006b. Can nutrition limit exercise-induced immuno-depression? Nutrition Review 64: 119-131.
'Can nutrition limit exercise-induced immuno-depression? ' () 64 Nutrition Review : 119 -131.
-
Gleeson, M., 2007. Immune function in sport and exercise. Journal of Applied Physiology 103: 693-699.
'Immune function in sport and exercise ' () 103 Journal of Applied Physiology : 693 -699.
-
Gorbach, S.L., 2000. Probiotics and gastrointestinal health. American Journal of Gastroenterology 95 Suppl. 1: S2-S4.
'Probiotics and gastrointestinal health ' () 95 American Journal of Gastroenterology : S2 -S4.
-
Gu, J.Y., Wakizono, Y., Sunada, Y., Hung, P., Nonaka, M., Sugano, M. and Yamada, K., 1997. Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in brown Norway rats. Nutrition Research 17: 339-350.
'Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in brown Norway rats ' () 17 Nutrition Research : 339 -350.
-
Heczko, P.B., Strus, M. and Kochan, P., 2006. Critical evaluation of probiotic activity of lactic acid bacteria and their effects. Journal of Physiology and Pharmacology 57: 5-12.
'Critical evaluation of probiotic activity of lactic acid bacteria and their effects ' () 57 Journal of Physiology and Pharmacology : 5 -12.
-
Heikkinen, T. and Järvinen, A., 2003. The common cold. The Lancet 361: 51-59.
'The common cold ' () 361 The Lancet : 51 -59.
-
ILSI Europe, 2013. ILSI Europe concise monograph on probiotics, prebiotics and the gut microbiota, 1st edition. ILSI Europe, Brussels, Belgium.
'ILSI Europe ' () ILSI Europe concise monograph on probiotics, prebiotics and the gut microbiota, 1st edition .
-
Mackinnon, L.T., 2000. Chronic exercise training effects on immune function. Medicine and Science in Sports Exercise 32 Suppl.: S369-S376.
'Chronic exercise training effects on immune function ' () 32 Medicine and Science in Sports Exercise : S369 -S376.
-
Marco, M.L., Pavan, S. and Kleerebezem, M., 2006. Towards understanding molecular modes of probiotic action. Current Opinion in Biotechnology 17: 204-210.
'Towards understanding molecular modes of probiotic action ' () 17 Current Opinion in Biotechnology : 204 -210.
-
Metchnikoff, E., 1905. Immunity in infective diseases. Cambridge University Press, Cambridge, UK.
'Immunity in infective diseases ' () Cambridge University Press .
-
Nichols, A.W., 2007. Probiotics and athletic performance: a systematic review. Current Sports Medicine Reports 6: 269-273.
'Probiotics and athletic performance: a systematic review ' () 6 Current Sports Medicine Reports : 269 -273.
-
Nieman, D.C., 2003. Current perspective on exercise immunology. Current Sports Medicine Reports 2: 239-242.
'Current perspective on exercise immunology ' () 2 Current Sports Medicine Reports : 239 -242.
-
Pederson, B.K. and Saltin, B., 2006. Evidence for prescribing exercise as therapy in chronic disease. Scandinavian Journal of Medicine and Science in Sports 16: 3-63.
'Evidence for prescribing exercise as therapy in chronic disease ' () 16 Scandinavian Journal of Medicine and Science in Sports : 3 -63.
-
Petrof, E.O., Claud, E.C., Gloor, G.B. and Allen-Vercoe, E., 2013. Microbial ecosystems therapeutics: a new paradigm in medicine? Beneficial Microbes 4: 53-65.
'Microbial ecosystems therapeutics: a new paradigm in medicine? ' () 4 Beneficial Microbes : 53 -65.
-
Pyne, D.B., West, N.P., Cox, A.J. and Cripps, A.W., 2014. Probiotics supplementation for athletes – clinical and physiological effects. European Journal Sport Science 23: 1-10.
'Probiotics supplementation for athletes – clinical and physiological effects ' () 23 European Journal Sport Science : 1 -10.
-
Radhakrishnan, A.K., Mahalingam, D., Selvaduray, K.R. and Nesaratnam, K., 2013. Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid. BioMed Research International 2013: 782067.
'Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid ' () 2013 BioMed Research International : 782067.
-
Rahman, Z.A, Abdullah, N., Singh, R. and Sosroseno, W., 2010. Effect of acute exercise on the levels of salivary cortisol, tumour necrosis factor-alpha and nitric oxide. Journal of Oral Science 52: 133-136.
'Effect of acute exercise on the levels of salivary cortisol, tumour necrosis factor-alpha and nitric oxide ' () 52 Journal of Oral Science : 133 -136.
-
Ramasamy, K., Nor Zaihana, A.R., Sieo, C.C., Nur Jahan, A., Norhani, A. and Ho, Y.W., 2012. Probiotic potential of lactic acid bacteria from fermented Malaysian food or milk products. International Journal of Food Science and Technology 47: 2175-2183.
'Probiotic potential of lactic acid bacteria from fermented Malaysian food or milk products ' () 47 International Journal of Food Science and Technology : 2175 -2183.
-
Ramasamy, R., Chih, K.T., Seng, H.F., Vidyadaran, S. and Dazzi, F., 2008. The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function. Cellular Immunology 25: 131-136.
'The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function ' () 25 Cellular Immunology : 131 -136.
-
Shephard, R.J. and Shek, P.N., 1996. Physical activity and immune changes: a potential model of subclinical inflammation and sepsis. Critical Review Rehabilitation Physical Medicine 8: 153-181.
'Physical activity and immune changes: a potential model of subclinical inflammation and sepsis ' () 8 Critical Review Rehabilitation Physical Medicine : 153 -181.
-
Wei, H., Xu, Y. and Cheng, B., 2007. Synergistic effects of Lactobacillusrhamnosus ZDY114 and bovine colostrums on the immunological function of mouse in vivo and in vitro. Applied Microbiology Biotechnology 75: 427-434.
'Synergistic effects of Lactobacillusrhamnosus ZDY114 and bovine colostrums on the immunological function of mouse in vivo and in vitro ' () 75 Applied Microbiology Biotechnology : 427 -434.
-
West, N.P, Pyne, D.B., Peake, J.M. and Cripps, A.W., 2009. Probiotics, immunity and exercise: a review. Exercise Immunology Review 15: 107-126.
'Probiotics, immunity and exercise: a review ' () 15 Exercise Immunology Review : 107 -126.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 582 | 197 | 29 |
| Gesamttextansichten | 27 | 0 | 0 |
| PDF-Downloads | 20 | 0 | 0 |
Effect of orally administered soy milk fermented with Lactobacillus plantarum LAB12 and physical exercise on murine immune responses
in Beneficial MicrobesSearch for other papers by M. Appukutty in
Current site
Google Scholar
PubMed
Search for other papers by K. Ramasamy in
Current site
Google Scholar
PubMed
Search for other papers by S. Rajan in
Current site
Google Scholar
PubMed
Search for other papers by S. Vellasamy in
Current site
Google Scholar
PubMed
Search for other papers by R. Ramasamy in
Current site
Google Scholar
PubMed
Search for other papers by A.K. Radhakrishnan in
Current site
Google Scholar
PubMed
Probiotics are live microorganisms that confer health benefits through the gastrointestinal microbiota. This nutritional supplement may benefit athletes who undergo rigorous training by maintaining their gastrointestinal functions and overall health. In this study the influence of moderate physical exercise using a graded treadmill exercise, alone or in combination with the consumption of a soy product fermented with Lactobacillus plantarum LAB12 (LAB12), on tumour necrosis factor alpha (TNF-α) responses was investigated in a murine model. Male BALB/c mice were randomly divided into four groups of six mice each (control, exercise alone, LAB12 and LAB12 + exercise). Mice treated with the potential probiotic LAB12 were orally gavaged for 42 days. At autopsy, blood and spleen from the animals were collected. The splenocytes were cultured in the presence of a mitogen, concanavalin A (Con A). The amount of TNF-α produced by the Con A-stimulated splenocytes was quantified using ELISA, while their proliferation was determined using the [3H]-thymidine incorporation method. This study shows that LAB12-supplemented and exercise-induced mice showed marked increase (P<0.05) in cell proliferation compared to the control animals. TNF-α production was suppressed (P<0.05) in the LAB12 group compared to the untreated mice. These results demonstrate that supplementation with LAB12 has immunomodulatory effects, under conditions of moderate physical exercise, which may have implications for human athletes. Further investigation in human trials is warranted to confirm and extrapolate these findings.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 582 | 197 | 29 |
| Gesamttextansichten | 27 | 0 | 0 |
| PDF-Downloads | 20 | 0 | 0 |
