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Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations
in Beneficial MicrobesCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), 2725 Ch Ste-Foy, Québec City, Quebec G1V 4G5, Canada.
Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
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Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
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Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
Département de médecine, Faculté de Médecine, Université Laval, 1050 Av. de la Médecine, Québec City, Quebec G1V 0A6, Canada.
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Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
Département de médecine, Faculté de Médecine, Université Laval, 1050 Av. de la Médecine, Québec City, Quebec G1V 0A6, Canada.
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Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
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Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), 2725 Ch Ste-Foy, Québec City, Quebec G1V 4G5, Canada.
Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
Département de médecine, Faculté de Médecine, Université Laval, 1050 Av. de la Médecine, Québec City, Quebec G1V 0A6, Canada.
Joint International Unit between the National Research Council (CNR) of Italy and Université Laval on Chemical and Biomolecular Research on the Microbiome and its Impact on Metabolic Health and Nutrition (UMI-MicroMeNu), Institute of Biomolecular Chemistry, CNR, Pozzuoli, Italy.
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Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
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Probiotics represent a promising tool to improve metabolic health, including lipid profiles and cholesterol levels. Modulation of the gut microbiome and the endocannabinoidome – two interrelated systems involved in several metabolic processes influenced by probiotics – has been proposed as a potential mechanism of action. This study establishes the impact of probiotics on metabolic health, gut microbiota composition and endocannabinoidome mediators in an animal model of hypercholesterolaemia. Syrian hamsters were fed either a low-fat low-cholesterol or high-fat high-cholesterol (HFHC) diet to induce hypercholesterolaemia and gavaged for 6 weeks with either Lactobacillus acidophilus CL1285, Lactiplantibacillus plantarum CHOL-200 or a combination of the two. Globally, probiotic interventions ameliorated, at least partially, lipid metabolism in HFHC-fed hamsters. The interventions, especially those including L. acidophilus, modified the gut microbiota composition of the small intestine and caecum in ways suggesting reversal of HFHC-induced dysbiosis. Several associations were observed between changes in gut microbiota composition and endocannabinoidome mediators following probiotic interventions and both systems were also associated with improved metabolic health parameters. For instance, potential connexions between the Eubacteriaceae and Deferribacteraceae families, levels of 2‑palmitoylglycerol, 2‑oleoylglycerol, 2‑linoleoylglycerol or 2‑eicosapentaenoylglycerol and improved lipid profiles were found. Altogether, our results suggest a potential crosstalk between gut microbiota and the endocannabinoidome in driving metabolic benefits associated with probiotics, especially those including L. acidophilus, in an animal model of hypercholesterolaemia.
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Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations
in Beneficial MicrobesCentre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), 2725 Ch Ste-Foy, Québec City, Quebec G1V 4G5, Canada.
Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
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Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
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École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
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Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), 2725 Ch Ste-Foy, Québec City, Quebec G1V 4G5, Canada.
Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
Département de médecine, Faculté de Médecine, Université Laval, 1050 Av. de la Médecine, Québec City, Quebec G1V 0A6, Canada.
Joint International Unit between the National Research Council (CNR) of Italy and Université Laval on Chemical and Biomolecular Research on the Microbiome and its Impact on Metabolic Health and Nutrition (UMI-MicroMeNu), Institute of Biomolecular Chemistry, CNR, Pozzuoli, Italy.
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Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), 2725 Ch Ste-Foy, Québec City, Quebec G1V 4G5, Canada.
Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, Canada.
École de nutrition, Faculté des sciences de l’agriculture et de l’alimentation (FSAA), Université Laval, 2425 Rue de l’Agriculture, Québec City, Quebec G1V 0A6, Canada.
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Probiotics represent a promising tool to improve metabolic health, including lipid profiles and cholesterol levels. Modulation of the gut microbiome and the endocannabinoidome – two interrelated systems involved in several metabolic processes influenced by probiotics – has been proposed as a potential mechanism of action. This study establishes the impact of probiotics on metabolic health, gut microbiota composition and endocannabinoidome mediators in an animal model of hypercholesterolaemia. Syrian hamsters were fed either a low-fat low-cholesterol or high-fat high-cholesterol (HFHC) diet to induce hypercholesterolaemia and gavaged for 6 weeks with either Lactobacillus acidophilus CL1285, Lactiplantibacillus plantarum CHOL-200 or a combination of the two. Globally, probiotic interventions ameliorated, at least partially, lipid metabolism in HFHC-fed hamsters. The interventions, especially those including L. acidophilus, modified the gut microbiota composition of the small intestine and caecum in ways suggesting reversal of HFHC-induced dysbiosis. Several associations were observed between changes in gut microbiota composition and endocannabinoidome mediators following probiotic interventions and both systems were also associated with improved metabolic health parameters. For instance, potential connexions between the Eubacteriaceae and Deferribacteraceae families, levels of 2‑palmitoylglycerol, 2‑oleoylglycerol, 2‑linoleoylglycerol or 2‑eicosapentaenoylglycerol and improved lipid profiles were found. Altogether, our results suggest a potential crosstalk between gut microbiota and the endocannabinoidome in driving metabolic benefits associated with probiotics, especially those including L. acidophilus, in an animal model of hypercholesterolaemia.
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