Möchten Sie über diese Zeitschrift informiert bleiben? Klicken Sie bitte auf die Buttons, um unsere Alerts zu abonnieren.
Möchten Sie über diese Zeitschrift informiert bleiben? Klicken Sie bitte auf die Buttons, um unsere Alerts zu abonnieren.
Reduced rotavirus vaccine efficacy in protein malnourished human-faecal-microbiota-transplanted gnotobiotic pig model is in part attributed to the gut microbiota
in Beneficial MicrobesSearch for other papers by V. Srivastava in
Current site
Google Scholar
Search for other papers by L. Deblais in
Current site
Google Scholar
Search for other papers by H.-C. Huang in
Current site
Google Scholar
Search for other papers by A. Miyazaki in
Current site
Google Scholar
Search for other papers by S. Kandasamy in
Current site
Google Scholar
Search for other papers by S.N. Langel in
Current site
Google Scholar
Search for other papers by F.C. Paim in
Current site
Google Scholar
Search for other papers by J. Chepngeno in
Current site
Google Scholar
Search for other papers by D. Kathayat in
Current site
Google Scholar
Search for other papers by A.N. Vlasova in
Current site
Google Scholar
Search for other papers by L.J. Saif in
Current site
Google Scholar
Search for other papers by G. Rajashekara in
Current site
Google Scholar
The low efficacy of human rotavirus (HRV) vaccines in low- and middle-income countries (LMIC) remains a major challenge for global health. Protein-calorie malnutrition (kwashiorkor) affects the gut microbiota and compromises immune development, leading to environmental enteropathy, vaccine failures, and increased susceptibility to enteric diseases in young children. Relationship between diet and reduced vaccine efficacy in developing countries is not well established; therefore, we investigated the interconnections between the host-microbiota-nutrition-HRV vaccine using HRV-vaccinated, human infant faecal microbiota (HIFM)-transplanted neonatal gnotobiotic pigs fed with a protein deficient or sufficient diet. The microbiota from faecal, intestinal (duodenum, ileum, jejunum, and colon), and systemic tissue (liver, spleen, and mesenteric lymph node [MLN]) samples was analysed before and after HRV challenge using MiSeq 16S rRNA sequencing. Overall, microbiota from deficient fed HIFM pigs displayed, compared to the sufficient group, significantly higher Shannon index, especially in the faeces and lower intestines; higher level of Proteus and Enterococcus, and lower level of Bifidobacterium, Clostridium, and Streptococcus in the three types of samples collected (P<0.05); and higher unique operational taxonomic units (OTUs), especially in the systemic tissues. Further, the multivariate analysis between microbiota and immunologic data showed that 38 OTUs at the genus level correlated (r2≤0.5 or ≥-0.5; P<0.05) with at least one host immune response parameter (regulatory [Tregs and transforming growth factor-β], effectors [interferon (IFN)-γ+ CD4+ and CD8+ T cells, IFN-γ and interleukin (IL)-12], and inflammatory [tumour necrosis factor-α, IL-17 and IL-22]) and with opposite trends between diet groups. Differences described above were increased after HRV challenge. We demonstrated that a protein deficient diet affects the composition of the gut microbiota and those changes may further correlate with immune responses induced by HRV and perturbed by the deficient diet. Thus, our findings suggest that the reduced efficacy of HRV vaccine observed in Gn pig model is in part attributed to the altered microbiota composition.
Kauf
Sofortzugang erwerben (PDF-Download und unbegrenzter Online-Zugang):
Institutszugang
Melden Sie sich mit Open Athens, Shibboleth oder Ihren institutionellen Anmeldedaten an.
Persönliche Anmeldung
Melden Sie sich mit Ihrem brill.com-Konto an
-
Alexander, C. and Rietschel, E.T., 2001. Bacterial lipopolysaccharides and innate immunity. Journal of Endotoxin Research 7: 167-202.
'Bacterial lipopolysaccharides and innate immunity ' () 7 Journal of Endotoxin Research : 167 -202.
-
Angel, J., Franco, M.A. and Greenberg, H.B., 2012. Rotavirus immune responses and correlates of protection. Current Opinion in Virology 2: 419-425. https://doi.org/10.1016/j.coviro.2012.05.003
-
Armah, G.E., Sow, S.O., Breiman, R.F., Dallas, M.J., Tapia, M.D., Feikin, D.R., Binka, F.N., Steele, A.D., Laserson, K.F., Ansah, N.A., Levine, M.M., Lewis, K., Coia, M.L., Attah-Poku, M., Ojwando, J., Rivers, S.B., Victor, J.C., Nyambane, G., Hodgson, A., Schodel, F., Ciarlet, M. and Neuzil, K.M., 2010. Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial. The Lancet 376: 606-614. https://doi.org/10.1016/s0140-6736(10)60889-6
-
Arrieta, M.C., Walter, J. and Finlay, B.B., 2016. Human microbiota-associated mice: a model with challenges. Cell Host & Microbe 19: 575-578. https://doi.org/10.1016/j.chom.2016.04.014
-
Azevedo, M.S.P., Yuan, L., Pouly, S., Gonzales, A.M., Jeong, K.I., Nguyen, T.V. and Saif, L.J., 2006. Cytokine responses in gnotobiotic pigs after infection with virulent or attenuated human rotavirus. Journal of Virology 80: 372-382. https://doi.org/10.1128/jvi.80.1.372-382.2006
-
Belkaid, Y. and Hand, T.W., 2014. Role of the microbiota in immunity and inflammation. Cell 157: 121-141. https://doi.org/10.1016/j.cell.2014.03.011
-
Biasucci, G., Benenati, B., Morelli, L., Bessi, E. and Boehm, G.N., 2008. Cesarean delivery may affect the early biodiversity of intestinal bacteria. Journal of Nutrition 138: 1796S-1800S. https://doi.org/10.1093/jn/138.9.1796S
-
Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., Fierer, N., Pena, A.G., Goodrich, J.K., Gordon, J.I., Huttley, G.A., Kelley, S.T., Knights, D., Koenig, J.E., Ley, R.E., Lozupone, C.A., McDonald, D., Muegge, B.D., Pirrung, M., Reeder, J., Sevinsky, J.R., Turnbaugh, P.J., Walters, W.A., Widmann, J., Yatsunenko, T., Zaneveld, J. and Knight, R., 2010. QIIME allows analysis of high-throughput community sequencing data. Nature Methods 7: 335-336. https://doi.org/10.1038/nmeth.f.303
-
Chattha, K.S., Vlasova, A.N., Kandasamy, S., Rajashekara, G. and Saif, L.J., 2013. Divergent immunomodulating effects of probiotics on T cell responses to oral attenuated human rotavirus vaccine and virulent human rotavirus infection in a neonatal gnotobiotic piglet disease model. Journal of Immunology 191: 2446-2456. https://doi.org/10.4049/jimmunol.1300678
-
Chen, M.-Y., Kirkwood, C.D., Bines, J., Cowley, D., Pavlic, D., Lee, K.J., Orsini, F., Watts, E., Barnes, G. and Danchin, M., 2017. Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand. Human Vaccines and Immunotherapeutics 13: 1126-1135. https://doi.org/10.1080/21645515.2016.1274474
-
Chilengi, R., Simuyandi, M., Beach, L., Mwila, K., Becker-Dreps, S., Emperador, D.M., Velasquez, D.E., Bosomprah, S. and Jiang, B., 2016. Association of maternal immunity with rotavirus vaccine immunogenicity in Zambian infants. PLoS ONE 11: e0150100. https://doi.org/10.1371/journal.pone.0150100
-
d’Hennezel, E., Abubucker, S., Murphy, L.O. and Cullen, T.W., 2017. Total lipopolysaccharide from the human gut microbiome silences toll-like receptor signaling. mSystems 2: e00046-00017.
'Total lipopolysaccharide from the human gut microbiome silences toll-like receptor signaling ' () 2 mSystems : e00046 -00017.
-
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J.B., Massart, S., Collini, S., Pieraccini, G. and Lionetti, P., 2010. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the USA 107: 14691-14696. https://doi.org/10.1073/pnas.1005963107
-
Dehner, C., Fine, R. and Kriegel, M.A., 2019. The microbiome in systemic autoimmune disease: mechanistic insights from recent studies. Current Opinion in Rheumatology 31: 201-207. https://doi.org/10.1097/bor.0000000000000574
-
Dennehy, P.H., 2008. Rotavirus vaccines: an overview. Clinical Microbiology Reviews 21: 198-208. https://doi.org/10.1128/CMR.00029-07
-
Desselberger, U., 2017. Differences of rotavirus vaccine effectiveness by country: likely causes and contributing factors. Pathogens 6: 65. https://doi.org/10.3390/pathogens6040065
-
Fischer, D.D., Kandasamy, S., Paim, F.C., Langel, S.N., Alhamo, M.A., Shao, L., Chepngeno, J., Miyazaki, A., Huang, H.-C., Kumar, A., Rajashekara, G., Saif, L.J. and Vlasova, A.N., 2017. Protein malnutrition alters tryptophan and angiotensin-converting enzyme 2 homeostasis and adaptive immune responses in human rotavirus-infected gnotobiotic pigs with human infant fecal microbiota transplant. Clinical and Vaccine Immunology 24: e00172-00117. https://doi.org/10.1128/CVI.00172-17
-
Forbes, J.D., Van Domselaar, G. and Bernstein, C.N., 2016. The gut microbiota in immune-mediated inflammatory diseases. Frontiers in Microbiology 7: 1081-1081. https://doi.org/10.3389/fmicb.2016.01081
-
Garrett, W.S., Gallini, C.A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M.L., Punit, S., Karlsson, M., Bry, L., Glickman, J.N., Gordon, J.I., Onderdonk, A.B. and Glimcher, L.H., 2010. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host and Microbe 8: 292-300. https://doi.org/10.1016/j.chom.2010.08.004
-
Gilmartin, A.A. and Petri Jr, W.A., 2015. Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences 370: 20140143. https://doi.org/10.1098/rstb.2014.0143
-
Glass, R.I., Parashar, U., Patel, M., Gentsch, J. and Jiang, B., 2014. Rotavirus vaccines: successes and challenges. Journal of Infection 68, Suppl. 1: S9-18. https://doi.org/10.1016/j.jinf.2013.09.010
-
Gough, E.K., Stephens, D.A., Moodie, E.E., Prendergast, A.J., Stoltzfus, R.J., Humphrey, J.H. and Manges, A.R., 2015. Linear growth faltering in infants is associated with Acidaminococcus sp. and community-level changes in the gut microbiota. Microbiome 3: 24. https://doi.org/10.1186/s40168-015-0089-2
-
Gray, J., 2011. Rotavirus vaccines: safety, efficacy and public health impact. Journal of Internal Medicine 270: 206-214. https://doi.org/10.1111/j.1365-2796.2011.02409.x
-
Groome, M.J., Moon, S.S., Velasquez, D., Jones, S., Koen, A., Van Niekerk, N., Jiang, B., Parashar, U.D. and Madhi, S.A., 2014. Effect of breastfeeding on immunogenicity of oral live-attenuated human rotavirus vaccine: a randomized trial in HIV-uninfected infants in Soweto, South Africa. Bulletin of the World Health Organization 92: 238-245. https://doi.org/10.2471/blt.13.128066
-
Guerrant, R.L., Oriá, R.B., Moore, S.R., Oriá, M.O.B. and Lima, A.A.M., 2008. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutrition Reviews 66: 487-505. https://doi.org/10.1111/j.1753-4887.2008.00082.x
-
Harris, V., Ali, A., Fuentes, S., Korpela, K., Kazi, M., Tate, J., Parashar, U., Wiersinga, W.J., Giaquinto, C., De Weerth, C. and de Vos, W.M., 2018. Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan. Gut Microbes 9: 93-101. https://doi.org/10.1080/19490976.2017.1376162
-
Harris, V.C., Armah, G., Fuentes, S., Korpela, K.E., Parashar, U., Victor, J.C., Tate, J., De Weerth, C., Giaquinto, C., Wiersinga, W.J., Lewis, K.D.C. and De Vos, W.M., 2017. Significant correlation between the infant gut microbiome and rotavirus vaccine response in rural Ghana. Journal of Infectious Diseases 215: 34-41. https://doi.org/10.1093/infdis/jiw518
-
Huang, H.C., Vlasova, A.N., Kumar, A., Kandasamy, S., Fischer, D.D., Deblais, L., Paim, F.C., Langel, S.N., Alhamo, M.A., Rauf, A., Shao, L., Saif, L.J. and Rajashekara, G., 2018. Effect of antibiotic, probiotic, and human rotavirus infection on colonisation dynamics of defined commensal microbiota in a gnotobiotic pig model. Beneficial Microbes 9: 71-86. https://doi.org/10.3920/bm2016.0225
-
Huda, M.N., Lewis, Z., Kalanetra, K.M., Rashid, M., Ahmad, S.M., Raqib, R., Qadri, F., Underwood, M.A., Mills, D.A. and Stephensen, C.B., 2014. Stool microbiota and vaccine responses of infants. Pediatrics 134: e362-e372. https://doi.org/10.1542/peds.2013-3937
-
Istrate, C., Hagbom, M., Vikström, E., Magnusson, K.-E. and Svensson, L., 2014. Rotavirus infection increases intestinal motility but not permeability at the onset of diarrhea. Journal of Virology 88: 3161. https://doi.org/10.1128/JVI.02927-13
-
Iturriza-Gómara, M. and Cunliffe, N.A., 2017. The gut microbiome as possible key to understanding and improving rotavirus vaccine performance in high-disease burden settings. Journal of Infectious Diseases 215: 8-10. https://doi.org/10.1093/infdis/jiw521
-
Kanareykina, S.K., Misautova, A.A., Zlatkina, A.R. and Levina, E.N., 1987. Proteus dysbioses in patients with ulcerative colitis. Nahrung 31: 557-561.
'Proteus dysbioses in patients with ulcerative colitis ' () 31 Nahrung : 557 -561.
-
Kers, J.G., Velkers, F.C., Fischer, E.A.J., Hermes, G.D.A., Stegeman, J.A. and Smidt, H., 2018. Host and environmental factors affecting the intestinal microbiota in chickens. Frontiers in Microbiology 9: 235-235. https://doi.org/10.3389/fmicb.2018.00235
-
Kim, Y.-G., 2017. Microbiota influences vaccine and mucosal adjuvant efficacy. Immune Network 17: 20-24. https://doi.org/10.4110/in.2017.17.1.20
-
Kumar, A., Vlasova, A.N., Deblais, L., Huang, H.-C., Wijeratne, A., Kandasamy, S., Fischer, D.D., Langel, S.N., Paim, F.C., Alhamo, M.A., Shao, L., Saif, L.J. and Rajashekara, G., 2018. Impact of nutrition and rotavirus infection on the infant gut microbiota in a humanized pig model. BMC Gastroenterology 18: 93. https://doi.org/10.1186/s12876-018-0810-2
-
Kuss, S.K., Best, G.T., Etheredge, C.A., Pruijssers, A.J., Frierson, J.M., Hooper, L.V., Dermody, T.S. and Pfeiffer, J.K., 2011. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science 334: 249-252. https://doi.org/10.1126/science.1211057
-
Lamberti, L.M., Ashraf, S., Walker, C.L.F. and Black, R.E., 2016. A systematic review of the effect of rotavirus vaccination on diarrhea outcomes among children younger than 5 years. Pediatric Infectious Disease Journal 35: 992-998. https://doi.org/10.1097/inf.0000000000001232
-
Marchesi, J.R., Adams, D.H., Fava, F., Hermes, G.D.A., Hirschfield, G.M., Hold, G., Quraishi, M.N., Kinross, J., Smidt, H., Tuohy, K.M., Thomas, L.V., Zoetendal, E.G. and Hart, A., 2016. The gut microbiota and host health: a new clinical frontier. Gut 65: 330-339. https://doi.org/10.1136/gutjnl-2015-309990
-
Marteau, P., Flourie, B., Pochart, P., Chastang, C., Desjeux, J.-F. and Rambaud, J.-C., 2007. Effect of the microbial lactase (EC 3.2.1.23) activity in yoghurt on the intestinal absorption of lactose: an in vivo study in lactase-deficient humans. British Journal of Nutrition 64: 71-79. https://doi.org/10.1079/BJN19900010
-
Meurens, F., Summerfield, A., Nauwynck, H., Saif, L. and Gerdts, V., 2012. The pig: a model for human infectious diseases. Trends in Microbiology 20: 50-57. https://doi.org/10.1016/j.tim.2011.11.002
-
Meyer, R.C., Bohl, E.H. and Kohler, E.M., 1964. Procurement and maintenance of germ-free swine for microbiological investigations. Applied Microbiology 12: 295-300.
'Procurement and maintenance of germ-free swine for microbiological investigations ' () 12 Applied Microbiology : 295 -300.
-
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., Lugli, G.A., Rodriguez, J.M., Bode, L., De Vos, W., Gueimonde, M., Margolles, A., Van Sinderen, D. and Ventura, M., 2017. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiology and Molecular Biology Reviews 81: e00036-00017.
'The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota ' () 81 Microbiology and Molecular Biology Reviews : e00036 -00017.
-
Miyazaki, A., Kandasamy, S., Michael, H., Langel, S.N., Paim, F.C., Chepngeno, J., Alhamo, M.A., Fischer, D.D., Huang, H.-C., Srivastava, V., Kathayat, D., Deblais, L., Rajashekara, G., Saif, L.J. and Vlasova, A.N., 2018. Protein deficiency reduces efficacy of oral attenuated human rotavirus vaccine in a human infant fecal microbiota transplanted gnotobiotic pig model. Vaccine 36: 6270-6281. https://doi.org/10.1016/j.vaccine.2018.09.008
-
Monedero, V., Buesa, J. and Rodríguez-Díaz, J., 2018. The interactions between host glycobiology, bacterial microbiota, and viruses in the gut. Viruses 10: 96. https://doi.org/10.3390/v10020096
-
Moore, T.A., Hanson, C.K. and Anderson-Berry, A., 2011. Colonization of the gastrointestinal tract in neonates: a review. Infant, Child, and Adolescent Nutrition 3: 291-295. https://doi.org/10.1177/1941406411421629
-
Muszer, M., Noszczyńska, M., Kasperkiewicz, K. and Skurnik, M., 2015. Human microbiome: when a friend becomes an enemy. Archivum Immunologiae et Therapiae Experimentalis 63: 287-298. https://doi.org/10.1007/s00005-015-0332-3
-
Mwape, I., Bosomprah, S., Mwaba, J., Mwila-Kazimbaya, K., Laban, N.M., Chisenga, C.C., Sijumbila, G., Simuyandi, M. and Chilengi, R., 2017. Immunogenicity of rotavirus vaccine (Rotarix™) in infants with environmental enteric dysfunction. PLoS ONE 12: e0187761. https://doi.org/10.1371/journal.pone.0187761
-
Mwila, K., Chilengi, R., Simuyandi, M., Permar, S.R. and Becker-Dreps, S., 2017. Contribution of maternal immunity to decreased rotavirus vaccine performance in low- and middle-income countries. Clinical and Vaccine Immunology 24: e00405-00416. https://doi.org/10.1128/CVI.00405-16
-
Parker, E.P.K., Praharaj, I., Zekavati, A., Lazarus, R.P., Giri, S., Operario, D.J., Liu, J., Houpt, E., Iturriza-Gómara, M., Kampmann, B., John, J., Kang, G. and Grassly, N.C., 2018. Influence of the intestinal microbiota on the immunogenicity of oral rotavirus vaccine given to infants in south India. Vaccine 36: 264-272. https://doi.org/10.1016/j.vaccine.2017.11.031
-
Parker, E.P.K., Ramani, S., Lopman, B.A., Church, J.A., Iturriza-Gómara, M., Prendergast, A.J. and Grassly, N.C., 2017. Causes of impaired oral vaccine efficacy in developing countries. Future Microbiology 13: 97-118. https://doi.org/10.2217/fmb-2017-0128
-
Ramig, R.F., 2004. Pathogenesis of intestinal and systemic rotavirus infection. Journal of Virology 78: 10213. https://doi.org/10.1128/JVI.78.19.10213-10220.2004
-
Rooks, M.G. and Garrett, W.S., 2016. Gut microbiota, metabolites and host immunity. Nature Reviews Immunology 16: 341. https://doi.org/10.1038/nri.2016.42
-
Saavedra, J.M., Bauman, N.A., Perman, J.A., Yolken, R.H., Saavedra, J.M., Bauman, N.A. and Oung, I., 1994. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. The Lancet 344: 1046-1049. https://doi.org/10.1016/S0140-6736(94)91708-6
-
Shin, N.R., Whon, T.W. and Bae, J.W., 2015. Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends in Biotechnology 33: 496-503. https://doi.org/10.1016/j.tibtech.2015.06.011
-
Sindhu, K.N.C., Cunliffe, N., Peak, M., Turner, M., Darby, A., Grassly, N., Gordon, M., Dube, Q., Babji, S., Praharaj, I., Verghese, V., Iturriza-Gómara, M. and Kang, G., 2017. Impact of maternal antibodies and infant gut microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants: protocol for a prospective cohort study. BMJ Open 7: e016577. https://doi.org/10.1136/bmjopen-2017-016577
-
Su, L., Shen, L., Clayburgh, D.R., Nalle, S.C., Sullivan, E.A., Meddings, J.B., Abraham, C. and Turner, J.R., 2009. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 136: 551-563. https://doi.org/10.1053/j.gastro.2008.10.081
-
Tate, J.E., Burton, A.H., Boschi-Pinto, C. and Parashar, U.D., 2016. Global, regional, and national estimates of rotavirus mortality in children <5 years of age, 2000-2013. Clinical Infectious Diseases 62, Suppl. 2: S96-S105. https://doi.org/10.1093/cid/civ1013
-
The, H.C., Florez de Sessions, P., Jie, S., Pham Thanh, D., Thompson, C.N., Nguyen Ngoc Minh, C., Chu, C.W., Tran, T.-A., Thomson, N.R., Thwaites, G.E., Rabaa, M.A., Hibberd, M. and Baker, S., 2018. Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children. Gut Microbes 9: 38-54. https://doi.org/10.1080/19490976.2017.1361093
-
Twitchell, E.L., Tin, C., Wen, K., Zhang, H., Becker-Dreps, S., Azcarate-Peril, M.A., Vilchez, S., Li, G., Ramesh, A., Weiss, M., Lei, S., Bui, T., Yang, X., Schultz-Cherry, S. and Yuan, L., 2016. Modeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs. Gut Pathogens 8: 51. https://doi.org/10.1186/s13099-016-0136-y
-
Uchiyama, R., Chassaing, B., Zhang, B. and Gewirtz, A.T., 2014. Antibiotic treatment suppresses rotavirus infection and enhances specific humoral immunity. Journal of Infectious Diseases 210: 171-182. https://doi.org/10.1093/infdis/jiu037
-
Valdez, Y., Brown, E.M. and Finlay, B.B., 2014. Influence of the microbiota on vaccine effectiveness. Trends in Immunology 35: 526-537. https://doi.org/10.1016/j.it.2014.07.003
-
Vatanen, T., Kostic, A.D., d’Hennezel, E., Siljander, H., Franzosa, E.A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T.D., Hämäläinen, A.-M., Peet, A., Tillmann, V., Uibo, R., Mokurov, S., Dorshakova, N., Ilonen, J., Virtanen, S.M., Szabo, S.J., Porter, J.A., Lähdesmäki, H., Huttenhower, C., Gevers, D., Cullen, T.W., Knip, M. and Xavier, R.J., 2016. Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans. Cell 165: 842-853. https://doi.org/10.1016/j.cell.2016.04.007
-
Velasquez, D.E., Parashar, U. and Jiang, B., 2018. Decreased performance of live attenuated, oral rotavirus vaccines in low-income settings: causes and contributing factors. Expert Review of Vaccines 17: 145-161. https://doi.org/10.1080/14760584.2018.1418665
-
Vlasova, A.N., Paim, F.C., Kandasamy, S., Alhamo, M.A., Fischer, D.D., Langel, S.N., Deblais, L., Kumar, A., Chepngeno, J., Shao, L., Huang, H.-C., Candelero-Rueda, R.A., Rajashekara, G. and Saif, L.J., 2017. Protein malnutrition modifies innate immunity and gene expression by intestinal epithelial cells and human rotavirus infection in neonatal gnotobiotic pigs. mSphere 2: e00046-00017. https://doi.org/10.1128/mSphere.00046-17
-
Wallace, T.C., Guarner, F., Madsen, K., Cabana, M.D., Gibson, G., Hentges, E. and Sanders, M.E., 2011. Human gut microbiota and its relationship to health and disease. Nutrition Reviews 69: 392-403. https://doi.org/10.1111/j.1753-4887.2011.00402.x
-
Wang, M. and Donovan, S.M., 2015. Human microbiota-associated swine: current progress and future opportunities. ILAR Journal 56: 63-73. https://doi.org/10.1093/ilar/ilv006
-
Wu, H.J. and Wu, E., 2012. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3: 4-14. https://doi.org/10.4161/gmic.19320
-
Yatsunenko, T., Rey, F.E., Manary, M.J., Trehan, I., Dominguez-Bello, M.G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R.N., Anokhin, A.P., Heath, A.C., Warner, B., Reeder, J., Kuczynski, J., Caporaso, J.G., Lozupone, C.A., Lauber, C., Clemente, J.C., Knights, D., Knight, R. and Gordon, J.I., 2012. Human gut microbiome viewed across age and geography. Nature 486: 222. https://doi.org/10.1038/nature11053
-
Yuan, L., Ward, L.A., Rosen, B.I., To, T.L. and Saif, L.J., 1996. Systematic and intestinal antibody-secreting cell responses and correlates of protective immunity to human rotavirus in a gnotobiotic pig model of disease. Journal of Virology 70: 3075.
'Systematic and intestinal antibody-secreting cell responses and correlates of protective immunity to human rotavirus in a gnotobiotic pig model of disease ' () 70 Journal of Virology : 3075.
-
Yuan, L., Wen, K., Azevedo, M.S.P., Gonzalez, A.M., Zhang, W. and Saif, L.J., 2008. Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs. Vaccine 26: 3322-3331. https://doi.org/10.1016/j.vaccine.2008.03.085
-
Zaman, K., Dang, D.A., Victor, J.C., Shin, S., Yunus, M., Dallas, M.J., Podder, G., Vu, D.T., Le, T.P., Luby, S.P., Le, H.T., Coia, M.L., Lewis, K., Rivers, S.B., Sack, D.A., Schodel, F., Steele, A.D., Neuzil, K.M. and Ciarlet, M., 2010. Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial. The Lancet 376: 615-623. https://doi.org/10.1016/s0140-6736(10)60755-6
-
Zhang, H., Wang, H., Shepherd, M., Wen, K., Li, G., Yang, X., Kocher, J., Giri-Rachman, E., Dickerman, A., Settlage, R. and Yuan, L., 2014. Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs. Gut Pathogens 6: 39-39. https://doi.org/10.1186/s13099-014-0039-8
-
Zijlstra, R.T., Donovan, S.M., Odle, J., Gelberg, H.B., Petschow, B.W. and Gaskins, H.R., 1997. Protein-energy malnutrition delays small-intestinal recovery in neonatal pigs infected with rotavirus. Journal of Nutrition 127: 1118-1127. https://doi.org/10.1093/jn/127.6.1118
Supplementary Materials
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 1004 | 206 | 24 |
| Gesamttextansichten | 17 | 5 | 0 |
| PDF-Downloads | 36 | 10 | 0 |
Reduced rotavirus vaccine efficacy in protein malnourished human-faecal-microbiota-transplanted gnotobiotic pig model is in part attributed to the gut microbiota
in Beneficial MicrobesSearch for other papers by V. Srivastava in
Current site
Google Scholar
PubMed
Search for other papers by L. Deblais in
Current site
Google Scholar
PubMed
Search for other papers by H.-C. Huang in
Current site
Google Scholar
PubMed
Search for other papers by A. Miyazaki in
Current site
Google Scholar
PubMed
Search for other papers by S. Kandasamy in
Current site
Google Scholar
PubMed
Search for other papers by S.N. Langel in
Current site
Google Scholar
PubMed
Search for other papers by F.C. Paim in
Current site
Google Scholar
PubMed
Search for other papers by J. Chepngeno in
Current site
Google Scholar
PubMed
Search for other papers by D. Kathayat in
Current site
Google Scholar
PubMed
Search for other papers by A.N. Vlasova in
Current site
Google Scholar
PubMed
Search for other papers by L.J. Saif in
Current site
Google Scholar
PubMed
Search for other papers by G. Rajashekara in
Current site
Google Scholar
PubMed
The low efficacy of human rotavirus (HRV) vaccines in low- and middle-income countries (LMIC) remains a major challenge for global health. Protein-calorie malnutrition (kwashiorkor) affects the gut microbiota and compromises immune development, leading to environmental enteropathy, vaccine failures, and increased susceptibility to enteric diseases in young children. Relationship between diet and reduced vaccine efficacy in developing countries is not well established; therefore, we investigated the interconnections between the host-microbiota-nutrition-HRV vaccine using HRV-vaccinated, human infant faecal microbiota (HIFM)-transplanted neonatal gnotobiotic pigs fed with a protein deficient or sufficient diet. The microbiota from faecal, intestinal (duodenum, ileum, jejunum, and colon), and systemic tissue (liver, spleen, and mesenteric lymph node [MLN]) samples was analysed before and after HRV challenge using MiSeq 16S rRNA sequencing. Overall, microbiota from deficient fed HIFM pigs displayed, compared to the sufficient group, significantly higher Shannon index, especially in the faeces and lower intestines; higher level of Proteus and Enterococcus, and lower level of Bifidobacterium, Clostridium, and Streptococcus in the three types of samples collected (P<0.05); and higher unique operational taxonomic units (OTUs), especially in the systemic tissues. Further, the multivariate analysis between microbiota and immunologic data showed that 38 OTUs at the genus level correlated (r2≤0.5 or ≥-0.5; P<0.05) with at least one host immune response parameter (regulatory [Tregs and transforming growth factor-β], effectors [interferon (IFN)-γ+ CD4+ and CD8+ T cells, IFN-γ and interleukin (IL)-12], and inflammatory [tumour necrosis factor-α, IL-17 and IL-22]) and with opposite trends between diet groups. Differences described above were increased after HRV challenge. We demonstrated that a protein deficient diet affects the composition of the gut microbiota and those changes may further correlate with immune responses induced by HRV and perturbed by the deficient diet. Thus, our findings suggest that the reduced efficacy of HRV vaccine observed in Gn pig model is in part attributed to the altered microbiota composition.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 1004 | 206 | 24 |
| Gesamttextansichten | 17 | 5 | 0 |
| PDF-Downloads | 36 | 10 | 0 |
