Effects of Lactobacillus reuteri as an adjunct to the treatment of periodontitis in smokers: randomised clinical trial
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The aim of this randomised clinical trial was to evaluate the effect of Lactobacillus reuteri in chewable tablets as an adjunct to non-surgical periodontal treatment of chronic periodontitis in smoking patients. 34 patient smokers were selected and randomly divided into two groups. The SRP group (n=17) received scaling and root planing (SRP) in one session and a placebo; the PRO group (n=17) received SRP in one session and 2 probiotic tablets 2à per day, for 21 days. Bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR), and pockets with PDâ¥5 mm and bleeding were measured at baseline and 90 days. After 90 days of treatment, the PD and pockets with PDâ¥5 mm and bleeding were significantly lower in both groups compared to baseline (P<0.05). In the PRO group, the BOP had significantly reduced at 90 days when compared with the baseline (P<0.05). There was statistically significant reduction in PD between baseline and 90 days in the PRO group in deep pockets (P<0.05). There was no statistically significant difference between the groups in the reduction in PD (P=0.95) or gain in CAL (P=0.97) in moderate and deep pockets. The adjuvant use of L. reuteri in the treatment of chronic periodontitis was effective in controlling gingival inflammation because reduced bleeding on probing which means reduced gingival inflammation and was effective in reducing deep pocket in manner clinically relevant.
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Allaker, R.P. and Stephen, A.S., 2017. Use of probiotics and oral health. Currents Oral Health Reports 4: 309-318.
'Use of probiotics and oral health ' () 4 Currents Oral Health Reports : 309 -318.
-
Al-Zahrani, M.S. and Austah, O.N., 2011. Photodynamic therapy as an adjunctive to scaling and root planing in treatment of chronic periodontitis in smokers. Saudi Medical Journal 32: 1183-1188.
'Photodynamic therapy as an adjunctive to scaling and root planing in treatment of chronic periodontitis in smokers ' () 32 Saudi Medical Journal : 1183 -1188.
-
Ammenheuser, M.M., Hastings, D.A., Whorton Jr., E.B. and Ward Jr., J.B., 1997. Frequencies of hprt mutant lymphocytes in smokers, non-smokers, and former smokers. Environmental and Molecular Mutagenesis 30: 131-138.
'Frequencies of hprt mutant lymphocytes in smokers, non-smokers, and former smokers ' () 30 Environmental and Molecular Mutagenesis : 131 -138.
-
Armitage, G.C., 1999. Development of a classification system for periodontal diseases and conditions. Annals of Periodontology 4: 1-6.
'Development of a classification system for periodontal diseases and conditions ' () 4 Annals of Periodontology : 1 -6.
-
Assem, N.Z., Alves, M.L.F., Lopes, A.B., Gualberto, E.C.J., Garcia, V.G. and Theodoro, L.H., 2017. Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis. Brazilian Oral Research 3: e67.
'Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis ' () 3 Brazilian Oral Research : e67.
-
Badersten, A., Nilveus, R. and Egelberg, J., 1990. Scores of plaque, bleeding, suppuration and probing depth to predict probing attachment loss. 5 years of observation following nonsurgical periodontal therapy. Journal of Clinical Periodontology 17: 102-107.
'Scores of plaque, bleeding, suppuration and probing depth to predict probing attachment loss ' () 17 Journal of Clinical Periodontology : 102 -107.
-
Berezow, A.B. and Darveau, R.P., 2011. Microbial shift and periodontitis. Periodontology 2000 55: 36-47.
'Microbial shift and periodontitis ' () 55 Periodontology 2000 : 36 -47.
-
Casanova, L., Hughes, F.J. and Preshaw, P.M., 2014. Diabetes and periodontal disease: a two-way relationship. British Dental Journal 217: 433-437.
'Diabetes and periodontal disease: a two-way relationship ' () 217 British Dental Journal : 433 -437.
-
Cobb, C.M., 2002. Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. Journal of Clinical Periodontology 2: 6-16.
'Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing ' () 2 Journal of Clinical Periodontology : 6 -16.
-
Cohen, R.E., 2003. Position paper: periodontal maintenance. Journal of Periodontology 74: 1395-1401.
'Position paper: periodontal maintenance ' () 74 Journal of Periodontology : 1395 -1401.
-
Coretti, L., Cuomo, M., Florio, E., Palumbo, D., Keller, S., Pero, R., Chiariotti, L., Lembo, F. and Cafiero, C., 2017. Subgingival dysbiosis in smoker and nonsmoker patients with chronic periodontitis. Molecular Medicine Reports 15: 2007-2014.
'Subgingival dysbiosis in smoker and nonsmoker patients with chronic periodontitis ' () 15 Molecular Medicine Reports : 2007 -2014.
-
Darby, I.B., Mooney, J. and Kinane, D.F., 2001. Changes in subgingival microflora and humoral immune response following periodontal therapy. Journal of Clinical Periodontology 28: 796-805.
'Changes in subgingival microflora and humoral immune response following periodontal therapy ' () 28 Journal of Clinical Periodontology : 796 -805.
-
Dhingra, K., 2012. Methodological issues in randomized trials assessing probiotics for periodontal treatment. Journal of Periodontal Research 47: 15-26.
'Methodological issues in randomized trials assessing probiotics for periodontal treatment ' () 47 Journal of Periodontal Research : 15 -26.
-
Dietrich, T., Bernimoulin, J.P. and Glynn, R.J., 2004. The effect of cigarette smoking on gingival bleeding. Journal of Periodontology 75: 16-22.
'The effect of cigarette smoking on gingival bleeding ' () 75 Journal of Periodontology : 16 -22.
-
Eltas, A. and Orbak, R., 2012. Clinical effects of Nd:YAG laser applications during nonsurgical periodontal treatment in smoking and nonsmoking patients with chronic periodontitis. Photomedicine and Laser Surgery 30: 360-366.
'Clinical effects of Nd:YAG laser applications during nonsurgical periodontal treatment in smoking and nonsmoking patients with chronic periodontitis ' () 30 Photomedicine and Laser Surgery : 360 -366.
-
Faveri, M., Rebello, A., De Oliveira Dias, R., Borges-Junior, I., Duarte, P.M., Figueiredo, L.C. and Feres, M., 2014. Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers. Journal of Periodontology 85: 581-591.
'Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers ' () 85 Journal of Periodontology : 581 -591.
-
Garcia, V.G., Knoll, L.R., Longo, M., Novaes, V.C., Assem, N.Z., Ervolino, E., De Toledo, B.E., and Theodoro, L.H., 2016. Effect of the probiotic Saccharomyces cerevisiae on ligature-induced periodontitis in rats. Journal of Periodontal Research 51: 26-37.
'Effect of the probiotic Saccharomyces cerevisiae on ligature-induced periodontitis in rats ' () 51 Journal of Periodontal Research : 26 -37.
-
Haffajee, A.D., Cugini, M.A., Dibart, S., Smith, C., Kent Jr., R.L. and Socransky, S.S., 1997. The effect of SRP on the clinical and microbiological parameters of periodontal diseases. Journal of Clinical Periodontology 24: 324-334.
'The effect of SRP on the clinical and microbiological parameters of periodontal diseases ' () 24 Journal of Clinical Periodontology : 324 -334.
-
Ince, G., Gursoy, H., Ipci, S.D., Cakar, G., Emekli-Alturfan, E. and Yilmaz, S., 2015. Clinical and biochemical evaluation of lozenges containing Lactobacillus reuteri as an adjunct to non-surgical periodontal therapy in chronic periodontitis. Journal of Periodontology 86: 746-754.
'Clinical and biochemical evaluation of lozenges containing Lactobacillus reuteri as an adjunct to non-surgical periodontal therapy in chronic periodontitis ' () 86 Journal of Periodontology : 746 -754.
-
Indian Council of Medical Research Task Force, Co-ordinating Unit ICMR, Co-ordinating Unit DBT, 2011. ICMR-DBT guidelines for evaluation of probiotics in food. Indian Journal of Medical Research 134: 22-25.
-
Iniesta, M., Herrera, D., Montero, E., Zurbriggen, M., Matos, A.R., MarÃn, M.J., Sánchez-Beltrán, M.C., Llama-Palacio, A. and Sanz, M., 2012. Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial. Journal of Clinical Periodontology 39: 736-744.
'Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis ' () 134 Journal of Clinical Periodontology : 22 -25.
-
Invernici, M.M., Salvador, S.L., Silva, P.H.F., Soares, M.S.M., Casarin, R., Palioto, D.B., Souza, S.L.S., Taba Jr., M., Novaes Jr., A.B., Furlaneto, F.A.C. and Messora, M.R., 2018. Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial. Journal of Clinical Periodontology 45: 1198-1210.
'Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial ' () 45 Journal of Clinical Periodontology : 1198 -1210.
-
Johannsen, A., Susin, C. and Gustafsson, A., 2014. Smoking and inflammation: evidence for a synergistic role in chronic disease. Periodontology 2000 64: 111-126.
'Smoking and inflammation: evidence for a synergistic role in chronic disease ' () 64 Periodontology 2000 : 111 -126.
-
Johnson, G.K. and Guthmiller, J.M., 2007. The impact of cigarette smoking on periodontal disease and treatment. Periodontology 2000 44: 178-194.
'The impact of cigarette smoking on periodontal disease and treatment ' () 44 Periodontology 2000 : 178 -194.
-
Krasse, P., Carlssona, B., Dahl, C., Paulsson, A., Nilsson, A. and Sinkewicz, G., 2006. Decreased gum bleending and reduced gingivitis by the probiotic Lactobacillus reuteri. Swedish Dental Journal 30: 55-60.
'Decreased gum bleending and reduced gingivitis by the probiotic Lactobacillus reuteri ' () 30 Swedish Dental Journal : 55 -60.
-
Labriola, A., Needleman, I. and Moles, D.R., 2005. Systematic review of the effect of smoking on nonsurgical periodontal therapy. Periodontology 2000 37: 124-137.
'Systematic review of the effect of smoking on nonsurgical periodontal therapy ' () 37 Periodontology 2000 : 124 -137.
-
Lang, N.P. and Tonetti, M.S., 2003. Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT). Oral Health & Preventive Dentistry 1: 7-16.
'Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT) ' () 1 Oral Health & Preventive Dentistry : 7 -16.
-
Matarazzo, F., Figueiredo, L.C., Cruz, S.E., Faveri, M. and Feres, M., 2008. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. Journal of Clinical Periodontology 35: 885-896.
'Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study ' () 35 Journal of Clinical Periodontology : 885 -896.
-
Matuliene, G., Pjetursson, B.E., Salvi, G.E., Schmidlin, K., Brägger, U., Zwahlen, M. and Lang, N.P., 2008. Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance. Journal of Clinical Periodontology 35: 685-695.
'Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance ' () 35 Journal of Clinical Periodontology : 685 -695.
-
Messora, M.R., Pereira, L.J., Foureaux, R., Oliveira, L.F., Sordi, C.G., Alves, A.J., Napimoga, M.H., Nagata, M.J., Ervolino, E. and Furlaneto, F.A., 2016. Favourable effects of Bacillus subtilis and Bacillus licheniformis on experimental periodontitis in rats. Archives of Oral Biology 66: 108-119.
'Favourable effects of Bacillus subtilis and Bacillus licheniformis on experimental periodontitis in rats ' () 66 Archives of Oral Biology : 108 -119.
-
Meurman, J.H. and Stamatova, I., 2007. Probiotics: contributions to oral health. Oral Diseases 13: 443-451.
'Probiotics: contributions to oral health ' () 13 Oral Diseases : 443 -451.
-
Moher, D., Hopewell, S., Schulz, K.F., Montori, V., Gøtzsche, P.C., Devereaux, P.J., Elbourne, D., Egger, M. and Altman, D.G., 2012. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. International Journal of Surgery 10: 28-55.
'CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials ' () 10 International Journal of Surgery : 28 -55.
-
Mombelli, A., 2005. Clinical parameters: biological validity and clinical utility. Periodontology 2000 39: 30-39.
'Clinical parameters: biological validity and clinical utility ' () 39 Periodontology 2000 : 30 -39.
-
Mombelli, A., Almaghlouth, A., Cionca, N., Courvoisier, D.S. and Giannopoulou, C., 2015. Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial. Journal of Periodontology 86: 367-375.
'Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial ' () 86 Journal of Periodontology : 367 -375.
-
Morales, A., Carvajal, P., Silva, N., Hernandez, M., Godoy, C., Rodriguez, G., Cabello, R., Garcia-Sesnich, J., Hoare, A., Diaz, P.I. and Gamonal, J., 2016. Clinical effects of Lactobacillus rhamnosus in non-surgical treatment of chronic periodontitis: a randomized placebo-controlled trial with 1-year follow-up. Journal of Periodontology 87: 944-952.
'Clinical effects of Lactobacillus rhamnosus in non-surgical treatment of chronic periodontitis: a randomized placebo-controlled trial with 1-year follow-up ' () 87 Journal of Periodontology : 944 -952.
-
Nociti Jr., F.H., Casati, M.Z. and Duarte, P.M., 2015. Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontology 2000 67: 187-210.
'Current perspective of the impact of smoking on the progression and treatment of periodontitis ' () 67 Periodontology 2000 : 187 -210.
-
Oliveira, L.F., Salvador, S.L., Silva, P.H., Furlaneto, F.A., Figueiredo, L., Casarin, R., Ervolino, E., Palioto, D.B., Souza, S.L., Taba Jr., M., Novaes Jr., A.B. and Messora, M.R., 2017. Benefits of Bifidobacterium animalis subsp. lactis probiotic in experimental periodontitis. Journal of Periodontology 88: 197-208.
'Benefits of Bifidobacterium animalis subsp ' () 88 Journal of Periodontology : 197 -208.
-
Pradeep, A.R., Bajaj, P., Agarwal, E., Rao, N.S., Naik, S.B., Kalra, N. and Priyanka, N., 2013. Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers. Australian Dental Journal 58: 34-40.
'Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers ' () 58 Australian Dental Journal : 34 -40.
-
Ribeiro Edel, P., Bittencourt, S., Zanin, I.C., Bovi Ambrosano, G.M., Sallum, E.A., Nociti, F.H., Gonçalves, R.B. and Casati, M.Z., 2009. Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis. Journal of Periodontology 80: 1254-1264.
'Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis ' () 80 Journal of Periodontology : 1254 -1264.
-
Roberts, F.A. and Darveau, R.P., 2015. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontology 2000 69: 18-27.
'Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis ' () 69 Periodontology 2000 : 18 -27.
-
Silva, M.P., Feres, M., Sirotto, T.A., Soares, G.M., Mendes, J.A., Faveri, M. and Figueiredo, L.C., 2011. Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. Journal of Clinical Periodontology 38: 828-837.
'Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial ' () 38 Journal of Clinical Periodontology : 828 -837.
-
Staab, B., Eick, S., Knofler, G. and Jentsch, H., 2009. The influence of a probiotic milk drink on the development of gingivitis: a pilot study. Journal of Clinical Periodontology 36: 850-856.
'The influence of a probiotic milk drink on the development of gingivitis: a pilot study ' () 36 Journal of Clinical Periodontology : 850 -856.
-
Szkaradkiewicz, A.K., Stopa, J. and Karpinski, T.M., 2014. Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis. Archivum Immunologiae et Therapiae Experimentalis 62: 495-500.
'Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis ' () 62 Archivum Immunologiae et Therapiae Experimentalis : 495 -500.
-
Tekce, M., Ince, G., Gursoy, H., Dirikan Ipci, S., Cakar, G., Kadir, T. and Yılmaz, S., 2015. Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1-year follow-up study. Journal of Clinical Periodontology 42: 363-372.
'Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1-year follow-up study ' () 42 Journal of Clinical Periodontology : 363 -372.
-
Teughels, W., Durukan, A., Ozcelik, O., Pauwels, M., Quirynen, M. and Haytac, M.C., 2013. Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. Journal of Clinical Periodontology 40: 1025-1035.
'Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study ' () 40 Journal of Clinical Periodontology : 1025 -1035.
-
Teughels, W., Newman, M.G., Coucke, W., Haffajee, A.D., Van der Mei, H.C., Haake, S.K., Schepers, E., Cassiman, J.J., Van Eldere, J., Van Steenberghe, D. and Quirynen, M., 2007. Guiding periodontal pocket recolonization: a proof of concept. Journal of Dental Research 86: 1078-1082.
'Guiding periodontal pocket recolonization: a proof of concept ' () 86 Journal of Dental Research : 1078 -1082.
-
Theodoro, L.H., Assem, N.Z., Longo, M., Alves, M.L.F., Duque, C., Stipp, R.N., Vizoto, N.L. and Garcia, V.G., 2018. Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: a randomized clinical trial. Photodiagnosis and Photodynamic Therapy 22: 217-222.
'Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: a randomized clinical trial ' () 22 Photodiagnosis and Photodynamic Therapy : 217 -222.
-
Theodoro, L.H., Lopes, A.B., Nuernberg, M.A.A., Cláudio, M.M., Miessi, D.M.J., Alves, M.L.F., Duque, C., Mombelli, A. and Garcia, V.G., 2017. Comparison of repeated applications of aPDT with amoxicillin and metronidazole in the treatment of chronic periodontitis: a short-term study. Journal of Photochemistry and Photobiology B, Biology 174: 364-369.
'Comparison of repeated applications of aPDT with amoxicillin and metronidazole in the treatment of chronic periodontitis: a short-term study ' () 174 Journal of Photochemistry and Photobiology B, Biology : 364 -369.
-
Tomar, S.L. and Asma, S., 2000. Smoking-attributable periodontitis in the United States: findings from NHANES III. National Health and Nutrition Examination Survey. Journal of Periodontology 71: 743-751.
'Smoking-attributable periodontitis in the United States: findings from NHANES III ' () 71 Journal of Periodontology : 743 -751.
-
Vicario, M., Santos, A., Violant, D., Nart, J. and Giner, L., 2013. Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial. Acta Odontologica Scandinavica 71: 813-819.
'Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial ' () 71 Acta Odontologica Scandinavica : 813 -819.
-
Vivekananda, M.R., Vandana, K.L. and Bhat, K.G., 2010. Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial. Journal of Oral Microbiology 2. DOI: https://doi.org/10.3402/jom.v2i0.5344
-
Warnakulasuriya, S., Dietrich, T., Bornstein, M.M., Casals Peidró, E., Preshaw, P.M., Walter, C., Wennström, J.L. and Bergström, J., 2010. Oral health risks of tobacco use and effects of cessation. International Dental Journal 60: 7-30.
'Oral health risks of tobacco use and effects of cessation ' () 60 International Dental Journal : 7 -30.
-
White, P.C., Hirschfeld, J., Milward, M.R., Cooper, P.R., Wright, H.J., Matthews, J.B. and Chapple, I.L.C., 2018. Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. Journal of Periodontal Research 53: 525-535.
'Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression ' () 53 Journal of Periodontal Research : 525 -535.
-
World Health Organisation (WHO), 2011. WHO urges more countries to require large, graphic health warnings on tobacco packaging: the WHO report on the global tobacco epidemic, 2011 examines anti-tobacco mass-media campaigns. Central European Journal of Public Health 19: 133-151.
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Effects of Lactobacillus reuteri as an adjunct to the treatment of periodontitis in smokers: randomised clinical trial
äºBeneficial MicrobesSearch for other papers by L.H. Theodoro in
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The aim of this randomised clinical trial was to evaluate the effect of Lactobacillus reuteri in chewable tablets as an adjunct to non-surgical periodontal treatment of chronic periodontitis in smoking patients. 34 patient smokers were selected and randomly divided into two groups. The SRP group (n=17) received scaling and root planing (SRP) in one session and a placebo; the PRO group (n=17) received SRP in one session and 2 probiotic tablets 2à per day, for 21 days. Bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR), and pockets with PDâ¥5 mm and bleeding were measured at baseline and 90 days. After 90 days of treatment, the PD and pockets with PDâ¥5 mm and bleeding were significantly lower in both groups compared to baseline (P<0.05). In the PRO group, the BOP had significantly reduced at 90 days when compared with the baseline (P<0.05). There was statistically significant reduction in PD between baseline and 90 days in the PRO group in deep pockets (P<0.05). There was no statistically significant difference between the groups in the reduction in PD (P=0.95) or gain in CAL (P=0.97) in moderate and deep pockets. The adjuvant use of L. reuteri in the treatment of chronic periodontitis was effective in controlling gingival inflammation because reduced bleeding on probing which means reduced gingival inflammation and was effective in reducing deep pocket in manner clinically relevant.
| å ¨é¨æé´ | è¿å»ä¸å¹´ | è¿å»30天 | |
|---|---|---|---|
| æè¦æµè§æ¬¡æ° | 1422 | 528 | 33 |
| å ¨ææµè§æ¬¡æ° | 50 | 25 | 0 |
| PDFä¸è½½æ¬¡æ° | 77 | 33 | 0 |
